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1. 发明授权

US08309117B2 Method for making medical devices having antimicrobial coatings thereon 有权
标题翻译：制造具有抗微生物涂层的医疗装置的方法
公开(公告)号：US08309117B2
公开(公告)日：2012-11-13
申请号：US10732543
申请日：2003-12-10
申请人： Michael F. Rubner , Sung Yun Yang , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
发明人： Michael F. Rubner , Sung Yun Yang , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
IPC分类号： A61K9/00
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译：本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层，通过还原与带负电荷的聚离子材料的-COO-基团相关联的Ag +离子形成的-COOAg基团和/或银纳米颗粒。此外，本发明提供了根据本发明的方法制备的医疗装置。

2. 发明授权

US06940580B2 Polymeric articles having a lubricious coating and method for making the same 有权
标题翻译：具有光滑涂层的聚合物及其制造方法
公开(公告)号：US06940580B2
公开(公告)日：2005-09-06
申请号：US10338631
申请日：2003-01-08
申请人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
发明人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
IPC分类号： A61L27/34 , A61L31/10 , G02B1/04 , G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层，电荷与润滑涂层材料的电荷相反。本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持所需的体积特性如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

3. 发明授权

US06858248B2 Method for applying a coating to a medical device 有权
标题翻译：将涂层施加到医疗装置的方法
公开(公告)号：US06858248B2
公开(公告)日：2005-02-22
申请号：US10153007
申请日：2002-05-22
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
IPC分类号： A61L27/34 , B05D1/18 , G02B1/10 , B05C3/05 , B05C3/09 , G02C7/04
CPC分类号： G02B1/10 , A61L27/34 , B05D1/18 , B29D11/00865 , Y10S134/901
摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.
摘要翻译：本发明提供了一种有效地将涂层施加到从由眼科镜片，用于制造眼镜片的模具和其他医疗装置组成的组中的多个物体中的每一个上的方法，所述方法包括将多个物体浸入含有具有涂料的涂布溶液; 并且以手段产生对流电流，从而迫使在多个眼科镜片中的每一个上流动的涂覆溶液。在优选实施例中，多个物体被保持在篮子中，篮子被预处理成具有第一层聚电解质和第二层水溶液，或者在篮子的表面上具有聚电解质和水溶液的混合层。

4. 发明授权

US06815074B2 Polymeric materials for making contact lenses 有权
标题翻译：用于制作隐形眼镜的聚合材料
公开(公告)号：US06815074B2
公开(公告)日：2004-11-09
申请号：US10153040
申请日：2002-05-22
申请人： Celeste Aguado , Paul Clement Nicolson , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Jacalyn Mary Schremmer
发明人： Celeste Aguado , Paul Clement Nicolson , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Jacalyn Mary Schremmer
IPC分类号： B32B904
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/34 , A61L2430/16 , Y10T428/31663 , C08L51/085
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

5. 发明授权

US06926965B2 LbL-coated medical device and method for making the same 有权
公开(公告)号：US06926965B2
公开(公告)日：2005-08-09
申请号：US10654566
申请日：2003-09-03
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/34 , A61L31/10 , G02B1/04 , B32B25/20 , B32B27/08 , B32B27/30
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.

6. 发明授权

US06896926B2 Method for applying an LbL coating onto a medical device 有权
标题翻译：将LbL涂层施加到医疗装置上的方法
公开(公告)号：US06896926B2
公开(公告)日：2005-05-24
申请号：US10654340
申请日：2003-09-03
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa
IPC分类号： G02C7/04 , A61L27/00 , A61L27/34 , A61L29/00 , A61L31/00 , B05D1/18 , G02B1/04 , G02C13/00 , B05D1/36 , B05D1/38
CPC分类号： A61L27/34 , B05D1/185 , G02B1/043
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
摘要翻译：本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性作为透镜材料的透氧性和离子透过性。

7. 发明授权

US06852353B2 Process for surface modifying substrates and modified substrates resulting therefrom 有权
标题翻译：用于表面改性基材和由其得到的改性基材的方法
公开(公告)号：US06852353B2
公开(公告)日：2005-02-08
申请号：US09911218
申请日：2001-07-23
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
IPC分类号： A61L27/34 , C08J7/16 , G02B1/04 , A61L27/00 , B05D1/02 , B05D1/18 , B05D1/36 , B05D1/38
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043
摘要： The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.
摘要翻译：本发明总体上涉及一种通过用具有反应性位点的聚合物连接层至少部分地涂覆这些基底的表面来改性基底例如隐形眼镜和其它生物医学制品的表面的方法。然后可以通过经典的化学附着机制将其它部分与反应性位点反应，将各种其它部分化学连接到制品表面。

8. 发明申请

US20120276278A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：US20120276278A1
公开(公告)日：2012-11-01
申请号：US13547286
申请日：2012-07-12
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Nicholas Kotov , Manal M. Gabriel , Xinming Qian
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Nicholas Kotov , Manal M. Gabriel , Xinming Qian
IPC分类号： B05D7/00 , B29C39/38
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选隐形眼镜，其中芯材和含抗微生物金属的LbL涂层不共价连接到医疗装置上，并且可以赋予医疗装置增加的亲水性。本发明的隐形眼镜上的抗微生物金属包衣对于包括革兰氏阳性和革兰氏阴性细菌在内的微生物具有高抗微生物效力，并且具有低毒性，同时保持所需的体积特性，如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。另外，本发明提供了制造其上具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法。

9. 发明授权

US07798639B2 Method for applying lubricious coating to a polymeric article 有权
标题翻译：将润滑涂层施加到聚合物制品上的方法
公开(公告)号：US07798639B2
公开(公告)日：2010-09-21
申请号：US11076391
申请日：2005-03-09
申请人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
发明人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层，电荷与润滑涂层材料的电荷相反。本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持所需的体积特性如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

10. 发明授权

US07582327B2 LbL-coated medical device and method for making the same 有权
标题翻译： LbL涂层医疗器械及其制造方法
公开(公告)号：US07582327B2
公开(公告)日：2009-09-01
申请号：US11137181
申请日：2005-05-25
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
摘要翻译：本发明提供一种医疗装置，优选为眼科装置，更优选隐形眼镜，其包括非共价连接到所述芯材料的芯材料和生物相容性LbL涂层。生物相容的LbL涂层包含至少一个电荷/非电荷双层，其中所述电荷/非电荷双层以无特别的顺序由一层带电荷的聚合物材料和一层非带电聚合物材料组成，其中能够非共价地键合到带电的聚合物材料上。

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