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1. 发明授权

US08172395B2 Medical devices having antimicrobial coatings thereon 有权
标题翻译：在其上具有抗微生物涂层的医疗装置
公开(公告)号：US08172395B2
公开(公告)日：2012-05-08
申请号：US10722256
申请日：2003-11-25
申请人： Fiona Patricia Carney , Manal M. Gabriel , Carol Ann Morris , John Martin Lally
发明人： Fiona Patricia Carney , Manal M. Gabriel , Carol Ann Morris , John Martin Lally
IPC分类号： G02C7/02
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可以赋予医学更高的表面亲水性和相对高的抗微生物活性以及低的细胞毒性。本发明的抗微生物涂层对隐形眼镜的期望体积特性具有最小的不利影响，例如透氧性，离子渗透性和光学性质。本发明的抗微生物涂层可以在延长佩戴的隐形眼镜中发现特别有用。此外，本发明提供了制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

2. 发明申请

US20110114517A1 HYDROGEN PEROXIDE SOLUTION AND KIT FOR DISINFECTING CONTACT LENSES 审中-公开
标题翻译：过氧化氢溶液和用于消毒接触镜的工具包
公开(公告)号：US20110114517A1
公开(公告)日：2011-05-19
申请号：US12948195
申请日：2010-11-17
申请人： Kasey Jon Minick , Manal M. Gabriel , Leroy Wainaina Muya , Walter Lee Nash , George Edward Minno
发明人： Kasey Jon Minick , Manal M. Gabriel , Leroy Wainaina Muya , Walter Lee Nash , George Edward Minno
IPC分类号： B65D69/00 , A01N59/00 , A01P1/00
CPC分类号： A01N59/00 , A61L12/128
摘要： The present invention relates to a hydrogen peroxide solution for disinfecting contact lenses. The hydrogen peroxide solution contains an effective amount of a homopolymer or copolymer of vinylpyrrolidone to an increased residual hydrogen peroxide concentration when in the presence of a catalyst, thereby prolonging the effective life of the solution and providing greater comfort to the weather. The present invention also relates to a kit for use in the disinfection of contact lenses comprising: a) an aqueous hydrogen peroxide solution, wherein the aqueous hydrogen peroxide solution comprising a homopolymer or copolymer of vinylpyrrolidone and an effectively disinfecting amount of hydrogen peroxide, and b) a container for holding a given amount of hydrogen peroxide solution, wherein the container containing a disc, wherein the disc comprising a substrate and a catalyst coating thereon, wherein, when the given amount of hydrogen peroxide is added to the container to entirely submerge the catalyst coated disc, the aqueous hydrogen peroxide solution decomposes over a period time of six hours to provide a residual hydrogen peroxide concentration of less than 100 ppm.
摘要翻译：本发明涉及一种用于消毒隐形眼镜的过氧化氢溶液。当存在催化剂时，过氧化氢溶液含有有效量的乙烯基吡咯烷酮的均聚物或共聚物与增加的剩余过氧化氢浓度，从而延长溶液的有效寿命并为天气提供更大的舒适度。本发明还涉及一种用于隐形眼镜消毒的试剂盒，包括：a）过氧化氢水溶液，其中包含乙烯基吡咯烷酮的均聚物或共聚物和有效消毒量的过氧化氢的过氧化氢水溶液和b ）用于保持给定量的过氧化氢溶液的容器，其中所述容器包含盘，其中所述盘包括基底和其上的催化剂涂层，其中当将给定量的过氧化氢加入到容器中以完全浸没催化剂涂覆的圆盘，过氧化氢水溶液在六小时的时间段内分解，以提供小于100ppm的残余过氧化氢浓度。

3. 发明授权

US06940580B2 Polymeric articles having a lubricious coating and method for making the same 有权
标题翻译：具有光滑涂层的聚合物及其制造方法
公开(公告)号：US06940580B2
公开(公告)日：2005-09-06
申请号：US10338631
申请日：2003-01-08
申请人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
发明人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
IPC分类号： A61L27/34 , A61L31/10 , G02B1/04 , G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层，电荷与润滑涂层材料的电荷相反。本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持所需的体积特性如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

4. 发明申请

US20120276278A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：US20120276278A1
公开(公告)日：2012-11-01
申请号：US13547286
申请日：2012-07-12
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Nicholas Kotov , Manal M. Gabriel , Xinming Qian
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Nicholas Kotov , Manal M. Gabriel , Xinming Qian
IPC分类号： B05D7/00 , B29C39/38
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选隐形眼镜，其中芯材和含抗微生物金属的LbL涂层不共价连接到医疗装置上，并且可以赋予医疗装置增加的亲水性。本发明的隐形眼镜上的抗微生物金属包衣对于包括革兰氏阳性和革兰氏阴性细菌在内的微生物具有高抗微生物效力，并且具有低毒性，同时保持所需的体积特性，如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。另外，本发明提供了制造其上具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法。

5. 发明授权

US07798639B2 Method for applying lubricious coating to a polymeric article 有权
标题翻译：将润滑涂层施加到聚合物制品上的方法
公开(公告)号：US07798639B2
公开(公告)日：2010-09-21
申请号：US11076391
申请日：2005-03-09
申请人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
发明人： Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Manal M. Gabriel
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层，电荷与润滑涂层材料的电荷相反。本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持所需的体积特性如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

6. 发明申请

US20080260804A1 Medical devices having antimicrobial coatings thereon 审中-公开
标题翻译：具有抗微生物涂层的医疗装置
公开(公告)号：US20080260804A1
公开(公告)日：2008-10-23
申请号：US12214321
申请日：2008-06-18
申请人： Carol Ann Morris , Manal M. Gabriel , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Marcia Kay Ash , Fiona Patricia Carney , Courtney Flem Morgan
发明人： Carol Ann Morris , Manal M. Gabriel , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Marcia Kay Ash , Fiona Patricia Carney , Courtney Flem Morgan
IPC分类号： A01N25/34 , A01N33/12 , A61K38/40 , G01N19/02
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和透镜材料的离子透过率。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

7. 发明授权

US07402318B2 Medical devices having antimicrobial coatings thereon 有权
公开(公告)号：US07402318B2
公开(公告)日：2008-07-22
申请号：US10287091
申请日：2002-11-04
申请人： Carol Ann Morris , Manal M. Gabriel , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Marcia Kay Ash , Fiona Patricia Carney , Courtney Flem Morgan
发明人： Carol Ann Morris , Manal M. Gabriel , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Marcia Kay Ash , Fiona Patricia Carney , Courtney Flem Morgan
IPC分类号： A61F13/00
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

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