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1. 发明授权

US08257727B2 Medical devices coated with a fast dissolving biocompatible coating 失效
标题翻译：涂有快速溶解生物相容性涂层的医疗器械
公开(公告)号：US08257727B2
公开(公告)日：2012-09-04
申请号：US11486836
申请日：2006-07-14
申请人： Michael Dornish , Christian Klein Larsen , Therese Andersen
发明人： Michael Dornish , Christian Klein Larsen , Therese Andersen
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61L27/34 , A61L29/10 , A61L29/14 , A61L31/14 , C08L5/00 , C08L5/04 , C08L5/08
摘要： The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body fluid.
摘要翻译：本发明涉及一种包括粘附在其上的生物相容性医用涂层的医疗装置，其中该涂层包括以下中的至少一种：非交联的水溶性盐，其中：（i）藻酸，（ii）透明质酸或（iii）壳聚糖其中所述涂层容易溶于至少一种哺乳动物体液中。

2. 发明申请

US20100178313A1 Implantable Degradable Biopolymer Fiber Devices 审中-公开
标题翻译：可植入降解生物聚合物纤维装置
公开(公告)号：US20100178313A1
公开(公告)日：2010-07-15
申请号：US12663641
申请日：2008-06-13
申请人： Christian Klein Larsen , Therese Andersen
发明人： Christian Klein Larsen , Therese Andersen
IPC分类号： A61K9/00 , A61K38/00 , A61K38/22 , A61K38/08 , A61K38/10 , A61P43/00
CPC分类号： A61L31/042 , A61L31/14 , A61L31/148
摘要： Degradable fibers that include biopolymers, as well as implantable devices including one or more fibers made from degradable biopolymers, e.g., alginate, chitosan, hyaluronans or their derivatives. The devices provide a combination of degradability and biocompatibility with physical properties suitable for use of the devices as implants. Exemplary devices are fastening devices including one or more biopolymer fibers. The use of such degradable biopolymers minimizes or eliminates the need for a second surgery to remove the implant, thereby eliminating the additional cost and potential complications of such a second surgery and should reduce the likelihood of secondary fractures resulting from the stress-shielding effect or the presence of screws holes that serve as stress concentrators. Methods for the fabrication of the degradable biopolymer fibers of the present invention are also provided, as well as methods for the fabrication of implantable degradable devices of the present invention which contain one or more degradable biopolymer fibers.
摘要翻译：包括生物聚合物的可降解纤维，以及包括由可降解生物聚合物制成的一种或多种纤维的可植入装置，例如藻酸盐，壳聚糖，透明质酸或其衍生物。这些装置提供降解性和生物相容性与适合于使用装置作为植入物的物理性质的组合。示例性装置是包括一种或多种生物聚合物纤维的紧固装置。使用这种可降解的生物聚合物可最大限度地减少或消除第二次手术去除植入物的需要，从而消除这种第二次手术的额外成本和潜在的并发症，并且应降低由应力屏蔽效应引起的继发性骨折的可能性或存在用作应力集中器的螺钉孔。还提供了用于制造本发明的可降解生物聚合物纤维的方法，以及用于制造本发明的可植入式可降解装置的方法，其包含一种或多种可降解的生物聚合物纤维。

3. 发明申请

US20100172953A1 Biopolymer Based Implantable Degradable Devices 审中-公开
标题翻译：基于生物聚合物的植入式可降解设备
公开(公告)号：US20100172953A1
公开(公告)日：2010-07-08
申请号：US12663591
申请日：2008-06-13
申请人： Christian Klein Larsen , Therese Andersen
发明人： Christian Klein Larsen , Therese Andersen
IPC分类号： A61K38/18 , A61F2/00 , A61P19/04
CPC分类号： A61L31/042 , A61L31/14 , A61L31/148
摘要： Implantable degradable devices for tissue repair or reconstruction comprising biopolymers, as well as to methods of manufacture and use thereof. The implantable device is formed by the application of pressure and the device may include up to about 65% by weight of water, based on the total weight of the implantable degradable fastening device. Methods for making implantable, degradable devices from biopolymers by application of pressure are also disclosed. The invention provides the ability to customize the device in various ways to influence properties such as mechanical strength, degradation rate and swellability.
摘要翻译：用于组织修复或重建的可植入可降解装置，包括生物聚合物，以及其制造和使用方法。可植入装置通过施加压力而形成，并且基于可植入式可降解紧固装置的总重量，该装置可以包括高达约65重量％的水。还公开了通过施加压力从生物聚合物制造可植入的可降解装置的方法。本发明提供以各种方式定制装置以影响诸如机械强度，降解速率和溶胀性等性能的能力。

4. 发明申请

US20110262534A1 POLYSACCHARIDE CAPSULE ENCLOSING A FATTY ACID OIL-CONTAINING EMULSION 审中-公开
标题翻译：多糖包装脂肪酸含油乳剂
公开(公告)号：US20110262534A1
公开(公告)日：2011-10-27
申请号：US13062997
申请日：2009-09-10
申请人： Gunnar Berge , Svein Olaf Hustvedt , Thomas Andersen , Olav Gåserød , Peder Oscar Andersen , Christian Klein Larsen
发明人： Gunnar Berge , Svein Olaf Hustvedt , Thomas Andersen , Olav Gåserød , Peder Oscar Andersen , Christian Klein Larsen
IPC分类号： A61K9/48 , A61K31/232 , A61P3/06 , A61P9/00 , A61P9/10 , A61P37/02 , A61P3/08 , A61P25/00 , A61P9/04 , A61K31/202 , A61P27/02
CPC分类号： A61K9/4816 , A61K9/107 , A61K9/5036 , A61K31/202 , A61K31/232 , A61K35/60 , A61K47/36 , A61K47/44
摘要： Novel capsules where an outer shell comprises a polysaccharide, e.g. an alginate. In the capsules there is an emulsion comprising a fatty acid oil mixture and at least one surfactant. Preferred fatty acid oils are eicosapentaenoic acid (EPA) and doccosahexaenoic acid (DHA).
摘要翻译：新颖的胶囊，其中外壳包含多糖，例如藻酸盐在胶囊中存在包含脂肪酸油混合物和至少一种表面活性剂的乳液。优选的脂肪酸油是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）。

5. 发明授权

US07727404B2 Method for removal of materials from a liquid stream 有权
标题翻译：从液体流中去除材料的方法
公开(公告)号：US07727404B2
公开(公告)日：2010-06-01
申请号：US11694665
申请日：2007-03-30
申请人： Atle Mundheim Ylikangas , Christian Klein Larsen
发明人： Atle Mundheim Ylikangas , Christian Klein Larsen
IPC分类号： C02F1/54
CPC分类号： C02F1/56
摘要： A method for removal of dissolved materials and/or particles from a liquid stream comprising flocculation by vigorously mixing polysaccharides or hydrocolloids into the liquid stream and subsequent gelation of the polysaccharides or hydrocolloids with cations capable of gelling same. Large, strong gelled agglomerates of pollutant and polysaccharide or hydrocolloid are formed with the help of suitable cations. The gelled agglomerates are well suited to separation from a liquid stream by flotation, in a sieve, in a centrifuge, in a cyclone or via other conventional separation processes. Also described is a method for mixing of un-dissolved polysaccharide or hydrocolloid with a polluted aqueous stream by shearing the polysaccharide or hydrocolloid into the aqueous stream to improve logistics and provide economic savings in treatment of large volumes of water. Also described is the use of dilute solutions of polysaccharides for treatment of a variety of effluent streams. An application of the invention is provided for removal of hydrocarbons within the oil industry, but also for other kinds of oil-containing water and also water with organic or particulate pollution.
摘要翻译：通过将多糖或水胶体强力混合到液体流中并随后使能够胶凝的阳离子使多糖或水胶体凝胶化，从液体流中除去溶解的物质和/或颗粒的方法，其中包括絮凝。借助于合适的阳离子，形成大量强烈的凝胶状污染物和多糖或水胶体聚集体。凝胶聚集体非常适合于通过浮选，筛网，离心机，旋风分离器或经由其它常规分离方法从液体流中分离。还描述了通过将多糖或水胶体剪切成水流来混合未溶解的多糖或水胶体与污染的含水流的方法，以改善物流并提供经济上的节省来处理大量的水。还描述了使用稀释的多糖溶液来处理各种流出物流。提供了本发明的应用，用于除去石油工业中的烃，而且还用于其它种类的含油水以及有机或颗粒污染的水。

6. 发明授权

US08153037B2 Method and apparatus for the preparation of capsules 有权
标题翻译：用于制备胶囊的方法和装置
公开(公告)号：US08153037B2
公开(公告)日：2012-04-10
申请号：US12827697
申请日：2010-06-30
申请人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
发明人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
IPC分类号： B29B9/00
CPC分类号： A61J3/07 , A23L17/35 , A61K9/4816 , B01J13/04 , Y10T428/2985
摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
摘要翻译：提供了一种用于连续封装工艺的设备。该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。振动管是扁平线圈，立管螺旋或水槽。封装装置包括具有设置在水凝胶溶液中的线圈的绕组。绕组可围绕其纵向中心轴线旋转。绕组具有形成多个室的相邻间隔的线圈。要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

7. 发明申请

US20110195101A1 Polysaccharide Capsules and Methods of Preparation 审中-公开
标题翻译：多糖胶囊及其制备方法
公开(公告)号：US20110195101A1
公开(公告)日：2011-08-11
申请号：US13089972
申请日：2011-04-19
申请人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
发明人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
IPC分类号： B01J13/04 , A61K9/48 , A61K8/11 , A61K9/66 , A23L1/30 , A23P1/04
CPC分类号： A61K9/4883 , A61K9/4816
摘要： The present invention is directed to seamless capsules and methods for making seamless capsules having a high oil content as described herein. More specifically, the present invention is directed to seamless capsules, and methods for making seamless capsules, made from a process involving the steps of: (a) preparing an emulsion comprising oil, water, an emulsifier, and at least one of a water-soluble monovalent metal salt, polyvalent metal salt, and an acid, wherein said oil is present in an amount of at least 50% by weight of said emulsion; with the proviso that said emulsion does not contain marmelo mucilage; and (b) adding portions of said emulsion to an aqueous gelling bath comprised of at least one ionic polysaccharide thereby encapsulating said portions of said emulsion in a polysaccharide gel membrane, and optionally (c) drying the resulting capsules by removing water.Improved methods are described for preparing seamless capsules comprising oil and water emulsions containing high concentrations of oil, where the emulsions are suitable for encapsulation into capsules of a polysaccharide gel. Of particular interest are emulsions of oil and water, where the oil is present in an amount of at least 50% by weight of the emulsion and the capsule is, for example, an alginate gel. Oils that are a pharmaceutical active agent, a nutritional supplement or a food; or oils that act as a carrier therefore, are also of particular interest. According to a preferred embodiment of the present invention the emulsion may contain further solid or liquid or gaseous components and be mixed to a dispersion before the encapsulation. The capsules of the invention are suitable for a variety of applications, e.g., pharmaceutical, nutraceutical, veterinary, agricultural, cosmetic, or food applications.
摘要翻译：本发明涉及无缝胶囊和制备具有高油含量的无缝胶囊的方法，如本文所述。更具体地说，本发明涉及无缝胶囊和制造无缝胶囊的方法，该方法包括以下步骤：（a）制备包含油，水，乳化剂和至少一种水溶性乳液的乳液，可溶性一价金属盐，多价金属盐和酸，其中所述油以所述乳液的至少50重量％的量存在; 条件是所述乳液不含马尔默粘液; 和（b）将所述乳液的一部分加入到由至少一种离子多糖组成的水性凝胶浴中，从而将所述乳液的所述部分包封在多糖凝胶膜中，并任选地（c）通过除去水干燥所得胶囊。描述了用于制备包含含有高浓度油的油和水乳液的无缝胶囊的改进方法，其中乳液适于包封在多糖凝胶的胶囊中。特别令人感兴趣的是油和水的乳液，其中油以乳液的至少50重量％的量存在，并且胶囊是例如藻酸盐凝胶。作为药物活性剂，营养补充剂或食物的油; 或作为载体的油也是特别有意义的。根据本发明的优选实施方案，乳液可以含有另外的固体或液体或气体组分，并且在包封之前与分散体混合。本发明的胶囊适用于各种应用，例如药物，营养，兽医，农业，化妆品或食品应用。

8. 发明申请

US20110059166A1 HIGH STRENGTH SEAMLESS ALGINATE CAPSULES 有权
标题翻译：高强度无缝粘合胶囊
公开(公告)号：US20110059166A1
公开(公告)日：2011-03-10
申请号：US12874618
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A23L1/0532 , A23P1/04
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1:1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.
摘要翻译：本发明涉及一种无缝藻酸盐胶囊，其具有封装填充材料的膜，其中该膜包含藻酸盐，非结晶增塑剂和甘油，并且其中非结晶增塑剂与甘油在该膜中的重量比为约1:1 约8：1。本发明还涉及制备无缝藻酸盐胶囊和通过该方法制成的胶囊的方法。胶囊具有优异的断裂强度并且耐填充材料的氧化。

9. 发明授权

US09895672B2 High strength seamless alginate capsules 有权
公开(公告)号：US09895672B2
公开(公告)日：2018-02-20
申请号：US12874618
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A23L1/0532 , A23P1/04 , B01J13/04 , A61K47/02 , A61K47/36 , B01J13/20 , A23K40/30 , A23P10/30
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1:1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.

10. 发明申请

US20100266848A1 Method and Apparatus for the Preparation of Capsules 有权
标题翻译：制备胶囊的方法和装置
公开(公告)号：US20100266848A1
公开(公告)日：2010-10-21
申请号：US12827697
申请日：2010-06-30
申请人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
发明人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
IPC分类号： B01J13/02 , B32B15/02
CPC分类号： A61J3/07 , A23L17/35 , A61K9/4816 , B01J13/04 , Y10T428/2985
摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
摘要翻译：提供了一种用于连续封装工艺的设备。该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。振动管是扁平线圈，立管螺旋或水槽。封装装置包括具有设置在水凝胶溶液中的线圈的绕组。绕组可围绕其纵向中心轴线旋转。绕组具有形成多个室的相邻间隔的线圈。要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

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