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1. 发明申请

US20110262534A1 POLYSACCHARIDE CAPSULE ENCLOSING A FATTY ACID OIL-CONTAINING EMULSION 审中-公开
标题翻译：多糖包装脂肪酸含油乳剂
公开(公告)号：US20110262534A1
公开(公告)日：2011-10-27
申请号：US13062997
申请日：2009-09-10
申请人： Gunnar Berge , Svein Olaf Hustvedt , Thomas Andersen , Olav Gåserød , Peder Oscar Andersen , Christian Klein Larsen
发明人： Gunnar Berge , Svein Olaf Hustvedt , Thomas Andersen , Olav Gåserød , Peder Oscar Andersen , Christian Klein Larsen
IPC分类号： A61K9/48 , A61K31/232 , A61P3/06 , A61P9/00 , A61P9/10 , A61P37/02 , A61P3/08 , A61P25/00 , A61P9/04 , A61K31/202 , A61P27/02
CPC分类号： A61K9/4816 , A61K9/107 , A61K9/5036 , A61K31/202 , A61K31/232 , A61K35/60 , A61K47/36 , A61K47/44
摘要： Novel capsules where an outer shell comprises a polysaccharide, e.g. an alginate. In the capsules there is an emulsion comprising a fatty acid oil mixture and at least one surfactant. Preferred fatty acid oils are eicosapentaenoic acid (EPA) and doccosahexaenoic acid (DHA).
摘要翻译：新颖的胶囊，其中外壳包含多糖，例如藻酸盐在胶囊中存在包含脂肪酸油混合物和至少一种表面活性剂的乳液。优选的脂肪酸油是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）。

2. 发明授权

US08153037B2 Method and apparatus for the preparation of capsules 有权
标题翻译：用于制备胶囊的方法和装置
公开(公告)号：US08153037B2
公开(公告)日：2012-04-10
申请号：US12827697
申请日：2010-06-30
申请人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
发明人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
IPC分类号： B29B9/00
CPC分类号： A61J3/07 , A23L17/35 , A61K9/4816 , B01J13/04 , Y10T428/2985
摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
摘要翻译：提供了一种用于连续封装工艺的设备。该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。振动管是扁平线圈，立管螺旋或水槽。封装装置包括具有设置在水凝胶溶液中的线圈的绕组。绕组可围绕其纵向中心轴线旋转。绕组具有形成多个室的相邻间隔的线圈。要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

3. 发明申请

US20110195101A1 Polysaccharide Capsules and Methods of Preparation 审中-公开
标题翻译：多糖胶囊及其制备方法
公开(公告)号：US20110195101A1
公开(公告)日：2011-08-11
申请号：US13089972
申请日：2011-04-19
申请人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
发明人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
IPC分类号： B01J13/04 , A61K9/48 , A61K8/11 , A61K9/66 , A23L1/30 , A23P1/04
CPC分类号： A61K9/4883 , A61K9/4816
摘要： The present invention is directed to seamless capsules and methods for making seamless capsules having a high oil content as described herein. More specifically, the present invention is directed to seamless capsules, and methods for making seamless capsules, made from a process involving the steps of: (a) preparing an emulsion comprising oil, water, an emulsifier, and at least one of a water-soluble monovalent metal salt, polyvalent metal salt, and an acid, wherein said oil is present in an amount of at least 50% by weight of said emulsion; with the proviso that said emulsion does not contain marmelo mucilage; and (b) adding portions of said emulsion to an aqueous gelling bath comprised of at least one ionic polysaccharide thereby encapsulating said portions of said emulsion in a polysaccharide gel membrane, and optionally (c) drying the resulting capsules by removing water.Improved methods are described for preparing seamless capsules comprising oil and water emulsions containing high concentrations of oil, where the emulsions are suitable for encapsulation into capsules of a polysaccharide gel. Of particular interest are emulsions of oil and water, where the oil is present in an amount of at least 50% by weight of the emulsion and the capsule is, for example, an alginate gel. Oils that are a pharmaceutical active agent, a nutritional supplement or a food; or oils that act as a carrier therefore, are also of particular interest. According to a preferred embodiment of the present invention the emulsion may contain further solid or liquid or gaseous components and be mixed to a dispersion before the encapsulation. The capsules of the invention are suitable for a variety of applications, e.g., pharmaceutical, nutraceutical, veterinary, agricultural, cosmetic, or food applications.
摘要翻译：本发明涉及无缝胶囊和制备具有高油含量的无缝胶囊的方法，如本文所述。更具体地说，本发明涉及无缝胶囊和制造无缝胶囊的方法，该方法包括以下步骤：（a）制备包含油，水，乳化剂和至少一种水溶性乳液的乳液，可溶性一价金属盐，多价金属盐和酸，其中所述油以所述乳液的至少50重量％的量存在; 条件是所述乳液不含马尔默粘液; 和（b）将所述乳液的一部分加入到由至少一种离子多糖组成的水性凝胶浴中，从而将所述乳液的所述部分包封在多糖凝胶膜中，并任选地（c）通过除去水干燥所得胶囊。描述了用于制备包含含有高浓度油的油和水乳液的无缝胶囊的改进方法，其中乳液适于包封在多糖凝胶的胶囊中。特别令人感兴趣的是油和水的乳液，其中油以乳液的至少50重量％的量存在，并且胶囊是例如藻酸盐凝胶。作为药物活性剂，营养补充剂或食物的油; 或作为载体的油也是特别有意义的。根据本发明的优选实施方案，乳液可以含有另外的固体或液体或气体组分，并且在包封之前与分散体混合。本发明的胶囊适用于各种应用，例如药物，营养，兽医，农业，化妆品或食品应用。

4. 发明申请

US20110059166A1 HIGH STRENGTH SEAMLESS ALGINATE CAPSULES 有权
标题翻译：高强度无缝粘合胶囊
公开(公告)号：US20110059166A1
公开(公告)日：2011-03-10
申请号：US12874618
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A23L1/0532 , A23P1/04
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1:1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.
摘要翻译：本发明涉及一种无缝藻酸盐胶囊，其具有封装填充材料的膜，其中该膜包含藻酸盐，非结晶增塑剂和甘油，并且其中非结晶增塑剂与甘油在该膜中的重量比为约1:1 约8：1。本发明还涉及制备无缝藻酸盐胶囊和通过该方法制成的胶囊的方法。胶囊具有优异的断裂强度并且耐填充材料的氧化。

5. 发明授权

US09895672B2 High strength seamless alginate capsules 有权
公开(公告)号：US09895672B2
公开(公告)日：2018-02-20
申请号：US12874618
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A23L1/0532 , A23P1/04 , B01J13/04 , A61K47/02 , A61K47/36 , B01J13/20 , A23K40/30 , A23P10/30
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1:1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.

6. 发明申请

US20100266848A1 Method and Apparatus for the Preparation of Capsules 有权
标题翻译：制备胶囊的方法和装置
公开(公告)号：US20100266848A1
公开(公告)日：2010-10-21
申请号：US12827697
申请日：2010-06-30
申请人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
发明人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
IPC分类号： B01J13/02 , B32B15/02
CPC分类号： A61J3/07 , A23L17/35 , A61K9/4816 , B01J13/04 , Y10T428/2985
摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
摘要翻译：提供了一种用于连续封装工艺的设备。该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。振动管是扁平线圈，立管螺旋或水槽。封装装置包括具有设置在水凝胶溶液中的线圈的绕组。绕组可围绕其纵向中心轴线旋转。绕组具有形成多个室的相邻间隔的线圈。要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

7. 发明授权

US09017720B2 Polysaccharide capsules and method of preparation 有权
标题翻译：多糖胶囊及其制备方法
公开(公告)号：US09017720B2
公开(公告)日：2015-04-28
申请号：US13089972
申请日：2011-04-19
申请人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
发明人： Peder Oscar Andersen , Olav Gåseröd , Christian Klein Larsen
IPC分类号： A61K9/48
CPC分类号： A61K9/4883 , A61K9/4816
摘要： The present invention is directed to seamless capsules and methods for making seamless capsules having a high oil content as described herein. More specifically, the present invention is directed to seamless capsules, and methods for making seamless capsules, made from a process involving the steps of: (a) preparing an emulsion comprising oil, water, an emulsifier, and at least one of a water-soluble monovalent metal salt, polyvalent metal salt, and an acid, wherein said oil is present in an amount of at least 50% by weight of said emulsion; with the proviso that said emulsion does not contain marmelo mucilage; and (b) adding portions of said emulsion to an aqueous gelling bath comprised of at least one ionic polysaccharide thereby encapsulating said portions of said emulsion in a polysaccharide gel membrane, and optionally (c) drying the resulting capsules by removing water.Improved methods are described for preparing seamless capsules comprising oil and water emulsions containing high concentrations of oil, where the emulsions are suitable for encapsulation into capsules of a polysaccharide gel. Of particular interest are emulsions of oil and water, where the oil is present in an amount of at least 50% by weight of the emulsion and the capsule is, for example, an alginate gel. Oils that are a pharmaceutical active agent, a nutritional supplement or a food; or oils that act as a carrier therefore, are also of particular interest. According to a preferred embodiment of the present invention the emulsion may contain further solid or liquid or gaseous components and be mixed to a dispersion before the encapsulation. The capsules of the invention are suitable for a variety of applications, e.g., pharmaceutical, nutraceutical, veterinary, agricultural, cosmetic, or food applications.
摘要翻译：本发明涉及无缝胶囊和制备具有高油含量的无缝胶囊的方法，如本文所述。更具体地说，本发明涉及无缝胶囊和制造无缝胶囊的方法，该方法包括以下步骤：（a）制备包含油，水，乳化剂和至少一种水溶性乳液的乳液，可溶性一价金属盐，多价金属盐和酸，其中所述油以所述乳液的至少50重量％的量存在; 条件是所述乳液不含马尔默粘液; 和（b）将所述乳液的一部分加入到由至少一种离子多糖组成的水性凝胶浴中，从而将所述乳液的所述部分包封在多糖凝胶膜中，并任选地（c）通过除去水干燥所得胶囊。描述了用于制备包含含有高浓度油的油和水乳液的无缝胶囊的改进方法，其中乳液适于包封在多糖凝胶的胶囊中。特别令人感兴趣的是油和水的乳液，其中油以乳液的至少50重量％的量存在，并且胶囊是例如藻酸盐凝胶。作为药物活性剂，营养补充剂或食物的油; 或作为载体的油也是特别有意义的。根据本发明的优选实施方案，乳液可以含有另外的固体或液体或气体组分，并且在包封之前与分散体混合。本发明的胶囊适用于各种应用，例如药物，营养，兽医，农业，化妆品或食品应用。

8. 发明申请

US20120177727A1 Method and Apparatus for the Preparation of Capsules 有权
标题翻译：制备胶囊的方法和装置
公开(公告)号：US20120177727A1
公开(公告)日：2012-07-12
申请号：US13418797
申请日：2012-03-13
申请人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
发明人： Peder Oscar Andersen , Robert Kopesky , Christian Klein Larsen , Olav Gaserod , David Harvey , Sanhuang Tung
IPC分类号： A61K9/48 , A23D7/00
CPC分类号： A61J3/07 , A23L17/35 , A61K9/4816 , B01J13/04 , Y10T428/2985
摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
摘要翻译：提供了一种用于连续封装工艺的设备。该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。振动管是扁平线圈，立管螺旋或水槽。封装装置包括具有设置在水凝胶溶液中的线圈的绕组。绕组可围绕其纵向中心轴线旋转。绕组具有形成多个室的相邻间隔的线圈。要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

9. 发明申请

US20110059165A1 SEAMLESS ALGINATE CAPSULES 有权
标题翻译：无缝粘合胶囊
公开(公告)号：US20110059165A1
公开(公告)日：2011-03-10
申请号：US12874567
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A61K35/60 , A61P3/02 , B01J13/20
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) said alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps when measured as a monovalent metal ion alginate in a 3.5% water solution at 20° C. using a Brookfield LV viscometer at 60 rpm and spindle #1; (ii) said alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of said fill material; (iii) said dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes in a solution of 0.1 M NaCl and HCl, pH of 3, at 37° C.; and (iv) said dried seamless capsule has a dry break force strength of at least 7 kg. The present invention is also directed to methods of making and using such dried seamless capsules.
摘要翻译：本发明涉及一种干燥无缝胶囊，其包含包封填充材料的藻酸盐壳膜，其中：（i）所述藻酸盐壳膜包含多价金属离子藻酸盐，其具有：（a）平均M含量为50％-62％基于M和G含量的重量，和（b）当在20℃下在3.5％水溶液中测量时，作为一价金属离子藻酸盐测定时的粘度为35至80cps，使用Brookfield LV粘度计在60℃ rpm和锭子＃1; （ii）所述藻酸盐壳膜包封以所述填充材料的至少50重量％的量存在的油; （iii）所述干燥的无缝胶囊在37℃在0.1M NaCl和HCl的pH为3的溶液中预处理20分钟后，在肠缓冲液中的崩解时间小于12分钟。和（iv）所述干燥的无缝胶囊具有至少7kg的干燥断裂强度。本发明还涉及制造和使用这种干燥无缝胶囊的方法。

10. 发明授权

US08980312B2 Seamless alginate capsules 有权
标题翻译：无缝藻酸盐胶囊
公开(公告)号：US08980312B2
公开(公告)日：2015-03-17
申请号：US12874567
申请日：2010-09-02
申请人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
发明人： Olav Gaserod , Christian Klein Larsen , Peder Oscar Andersen
IPC分类号： A61K9/48 , A61K35/60 , A61P3/02 , B01J13/20 , B01J13/04 , A23L1/00 , A61K47/02 , A61K47/36
CPC分类号： B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
摘要： The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) the alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps; (ii) the alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of the fill material; (iii) the dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes; and (iv) the dried seamless capsule has a dry break force strength of at least 7 kg.
摘要翻译：本发明涉及一种包含填充材料的藻酸盐壳膜的干燥无缝胶囊，其中：（i）藻酸盐壳膜包含多价金属离子藻酸盐，其具有：（a）平均M含量为50％-62％基于M和G含量的重量，和（b）35至80cps的粘度; （ii）藻酸盐壳膜包封以至少填充材料的50重量％的量存在的油; （iii）干燥的无缝胶囊在预处理20分钟后的肠缓冲液中的崩解时间小于12分钟; 和（iv）干燥的无缝胶囊具有至少7kg的干燥断裂强度。

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