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1. 发明申请

US20130079811A1 DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS 有权
标题翻译：用于处理假肢和其他身体开放和穿刺的装置和方法
公开(公告)号：US20130079811A1
公开(公告)日：2013-03-28
申请号：US13247156
申请日：2011-09-28
申请人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
发明人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

2. 发明授权

US09474514B2 Devices and methods for treating fistulae and other bodily openings and passageways 有权
标题翻译：用于治疗瘘管和其他身体开口和通道的装置和方法
公开(公告)号：US09474514B2
公开(公告)日：2016-10-25
申请号：US13247156
申请日：2011-09-28
申请人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
发明人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
IPC分类号： A61B17/08 , A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

3. 发明授权

US10143457B2 Fistula plugs having increased column strength and fistula plug delivery apparatuses and methods 有权
公开(公告)号：US10143457B2
公开(公告)日：2018-12-04
申请号：US12098701
申请日：2008-04-07
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61B17/00 , A61B17/12 , A61B17/34 , A61B90/00
摘要： The present invention provides, in certain aspects, medical devices deliverable into passageways and other open spaces in the body. In one embodiment, the invention provides a fistula plug for delivery into a fistula tract. This fistula plug includes an elongate plug body, and a removable core material that is received in the plug body and effective to increase the column strength of the plug body. The plug body may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. The present invention also provides apparatuses and methods for delivering these and other medical devices into the body. One such apparatus includes a fistula plug having a plug body, and a removable delivery device received in the plug body, wherein the delivery device is effective to deliver the plug body into a fistula tract when advanced therethrough.

4. 发明授权

US08323332B2 Methods of reducing retrograde flow 有权
标题翻译：降低逆行流量的方法
公开(公告)号：US08323332B2
公开(公告)日：2012-12-04
申请号：US12689101
申请日：2010-01-18
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2230/0026 , A61F2230/0095 , A61F2240/001
摘要： Methods of reducing retrograde fluid flow through a valve within a body vessel are provided. The methods can include the steps of identifying a valve exhibiting an undesirable amount of retrograde fluid flow within a body vessel, such as a venous valve or a heart valve, and providing a means for reducing the retrograde fluid flow. A medical device providing a desired amount of retrograde fluid flow can be modified after permitting the medical device to remain in a body cavity for a remodeling-effective time period. The implanted medical device can be modified by subsequently reducing the amount of retrograde fluid flow permitted across the implanted prosthetic valve within the body vessel.
摘要翻译：提供了通过体内血管中的瓣膜减少逆行液体流动的方法。所述方法可以包括以下步骤：识别在体内容器（例如静脉瓣膜或心脏瓣膜）中呈现不期望量的逆行流体流动的瓣膜，并提供减少逆行流体流动的装置。提供所需量的逆行流体流动的医疗装置可以在允许医疗装置保持在体腔中用于重塑有效时间段之后被修改。可以通过随后减少允许穿过体内容器内植入的假体瓣膜的逆行流体流量来修改植入的医疗装置。

5. 发明授权

US08257314B2 Spiral shaft catheter 有权
标题翻译：螺旋轴导管
公开(公告)号：US08257314B2
公开(公告)日：2012-09-04
申请号：US11595829
申请日：2006-11-10
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61M5/178 , A61M31/00 , A61M37/00 , A61F2/02
CPC分类号： A61M25/0021 , A61F2/958 , A61M25/0113 , A61M25/10 , A61M25/1011 , A61M29/02 , A61M2025/0008 , A61M2025/0183 , A61M2025/1072
摘要： A spiral catheter device and mechanism for placement thereof. The spiral catheter device comprises a catheter body including at least one helically coiled portion, with the interior region of the helix forming a tracking region for passage of a wire guide.
摘要翻译：螺旋导管装置及其放置机构。螺旋导管装置包括导体主体，其包括至少一个螺旋卷绕的部分，螺旋的内部区域形成用于导线引导件通过的跟踪区域。

6. 发明申请

US20120143123A1 DIALYSIS CATHETER 有权
公开(公告)号：US20120143123A1
公开(公告)日：2012-06-07
申请号：US13310014
申请日：2011-12-02
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61M25/14
CPC分类号： A61M25/0075 , A61M1/3653 , A61M1/3658 , A61M1/3659 , A61M1/3661 , A61M25/04 , A61M2025/0025 , A61M2025/0031 , A61M2025/0035 , A61M2025/0039 , A61M2025/0079
摘要： A catheter assembly used for extracorporeal treatment, such as dialysis, of blood or other body fluid, includes an outer and inner catheter in a coaxial relationship. A fluid path is provided by a passageway defined between the catheters and a distal end of the outer catheter, and another fluid path is provided through a lumen and a distal end of the inner catheter. A sealing member is coupled to one of the catheters. The member in a first position is configured to permit the distal ends of the catheters to transport fluid, while in a second position the member is configured to inhibit at least one of the distal ends from transporting fluid. The sealing member may include a flared portion for enhance sealing. The sealing member may also have a portion extending outward from the catheters to position the distal ends away from vessel contact.
摘要翻译：用于体外治疗（例如透析，血液或其他体液）的导管组件包括同轴关系的外导管和内导管。流体通道由限定在导管和外导管的远端之间的通道提供，并且另一流体路径通过内导管和内导管的远端提供。密封构件联接到导管之一。第一位置的构件构造成允许导管的远端输送流体，而在第二位置，构件被构造成阻止远端中的至少一个输送流体。密封构件可以包括用于增强密封的扩口部分。密封构件还可以具有从导管向外延伸的部分，以将远端远离血管接触。

7. 发明授权

US08043352B2 Medical device delivery system with captive inner member 有权
标题翻译：医疗器械输送系统与内部成员
公开(公告)号：US08043352B2
公开(公告)日：2011-10-25
申请号：US11420036
申请日：2006-05-24
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/9517
摘要： Delivery systems for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. The delivery systems comprise a sheath member and an inner member slideably disposed within a cavity formed by the sheath member. An expandable intraluminal medical device is disposed about the inner member and is initially positioned within the delivery system. A means for preventing axial movement of the inner member holds the inner member in position so that, while the delivery system and medical device are positioned at a desired point of treatment, the sheath member can be retracted while an axial position of the inner member is substantially maintained.
摘要翻译：提供用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的递送系统。输送系统包括护套构件和可滑动地设置在由护套构件形成的空腔内的内构件。可扩展的管腔内医疗装置围绕内部构件设置并且最初位于输送系统内。用于防止内部构件的轴向运动的装置将内部构件保持在适当位置，使得当输送系统和医疗装置位于期望的处理点处时，护套构件可以缩回，而内部构件的轴向位置是基本保持。

8. 发明授权

US08038708B2 Implantable device with remodelable material and covering material 有权
标题翻译：具有可重塑材料和覆盖材料的植入式装置
公开(公告)号：US08038708B2
公开(公告)日：2011-10-18
申请号：US11640674
申请日：2006-12-18
申请人： Brian C. Case , Charles W. Agnew
发明人： Brian C. Case , Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078
摘要： Medical devices for implantation within a body vessel can include a remodelable material, such as an extracellular matrix material, positioned within a lumen defined by an outer covering material. The covering material is preferably substantially non-remodelable, and can be supported by a radially expandable frame. The medical device can also include a valve means positioned within the covering material. The valve means can include one or more valve leaflets formed from the remodelable material, and a separate valve support frame. One or more therapeutic agents can be associated with the remodelable material or the covering material.
摘要翻译：用于植入体内容器的医疗装置可以包括位于由外覆盖材料限定的内腔内的可重塑材料，例如细胞外基质材料。覆盖材料优选基本上不可重塑，并且可以由可径向扩张的框架支撑。医疗装置还可以包括定位在覆盖材料内的阀装置。阀装置可以包括由可重塑材料形成的一个或多个瓣膜单元和单独的阀支撑框架。一种或多种治疗剂可与可重塑材料或覆盖材料相关联。

9. 发明申请

US20100114300A1 MEDICAL DEVICE WITH LEAK PATH 审中-公开
标题翻译：医疗设备与泄漏路径
公开(公告)号：US20100114300A1
公开(公告)日：2010-05-06
申请号：US12688827
申请日：2010-01-15
申请人： Brian C. Case , Charles W. Agnew
发明人： Brian C. Case , Charles W. Agnew
IPC分类号： A61F2/82 , A61F2/86
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0026 , A61F2230/0067 , A61F2230/0095
摘要： Medical devices that provide valves for regulating fluid flow through a body vessel are provided. The valves include a support frame having one or more adaptations for forming a leak path between the support frame and an interior wall of a body vessel in which the valve is implanted. A controlled amount of retrograde flow is able to flow through the leak path when the valve is implanted in a body vessel.
摘要翻译：提供了提供用于调节通过身体容器的流体流动的阀的医疗装置。所述阀包括支撑框架，所述支撑框架具有一个或多个适配件，用于在所述支撑框架与所述阀被植入的主体容器的内壁之间形成泄漏路径。当阀被植入人体容器时，受控量的逆行流能够流过泄漏路径。

10. 发明申请

US20080167705A1 SHORT WIRE STENT DELIVERY SYSTEM WITH SPLITTABLE OUTER SHEATH 审中-公开
标题翻译：短距离输送系统与可分离的外部管道
公开(公告)号：US20080167705A1
公开(公告)日：2008-07-10
申请号：US11970347
申请日：2008-01-07
申请人： Charles W. Agnew
发明人： Charles W. Agnew
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/97
摘要： A delivery system and method for introducing a self-expanding prosthesis into a work site of a patient. The delivery system is introduced to the work site over an elongate guiding member. The delivery system is subsequently uncoupled from the guiding member upon deployment of the prosthesis while remaining within the work site. In an exemplary embodiment of the invention, the delivery system comprises an elongate outer member slidably disposed about an elongate inner member. A self-expanding prosthesis is disposed within the outer member and is laterally constrained thereby in a compressed delivery configuration, and is constrained against longitudinal movement relative to the inner member. The inner member further comprises a passageway extending through the distal portion thereof the passageway extending between a distal opening near the distal end of the inner member and a proximal opening spaced proximally from the distal end of the inner member. The outer member comprises an opening in communication with the proximal opening of the inner member. The inner and outer members are configured to allow a guiding member disposed through the passageway and openings to pass laterally out of the passageway and openings upon proximal movement of the outer member relative to the inner member and deployment of the prosthesis.
摘要翻译：一种用于将自扩张假体引入患者的工作现场的递送系统和方法。输送系统通过细长的引导构件引入到工作现场。随后在部署假体的同时将输送系统与引导构件脱离，同时保持在工作现场内。在本发明的示例性实施例中，输送系统包括可细长的外部构件，其可滑动地设置在细长的内部构件周围。自扩张假体设置在外部构件内并且由此以横向约束为压缩的输送构型，并且被限制为相对于内部构件的纵向移动。内部构件还包括通过其远端部分延伸的通道，该通道在内部构件的远端附近的远侧开口和从内部构件的远端向近侧间隔开的近侧开口之间延伸。外部构件包括与内部构件的近侧开口连通的开口。内部构件和外部构件构造成允许穿过通道和开口设置的引导构件在外部构件相对于内部构件和假体展开时近侧移动时横向通过通道和开口。

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