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1. 发明申请

US20060165811A1 Method and system for automatic decoding of motor cortical activity 审中-公开
标题翻译：运动皮质活动自动解码方法及系统
公开(公告)号：US20060165811A1
公开(公告)日：2006-07-27
申请号：US11086956
申请日：2005-03-22
申请人： Michael Black , Frank Wood , Wei Wu
发明人： Michael Black , Frank Wood , Wei Wu
IPC分类号： A61K35/30
CPC分类号： G06K9/00536 , A61B5/0476 , A61B5/4041 , A61B5/7267
摘要： A Switching Kalman Filter Model for the real-time inference of hand kinematics from a population of motor cortical neurons. Firing rates are modeled as a Gaussian mixture where the mean of each Gaussian component is a linear function of hand kinematics. A “hidden state” models the probability of each mixture component and evolves over time in a Markov chain. Gaussian mixture models and Expectation Maximization (EM) techniques are extended for automatic spike sorting. Good initialization of EM is achieved via spectral clustering. To account for noise, the mixture model is extended to include a uniform outlier process. A greedy optimization algorithm that selects models with different numbers of neurons according to their decoding accuracy is used to automatically determine the number of neurons recorded per electrode. Closed loop neural control of external events are demonstrated using neural control of a computer curser.
摘要翻译：一种切换卡尔曼滤波器模型，用于从运动皮层神经元群体的手运动学的实时推断。发射速率被模拟为高斯混合，其中每个高斯分量的平均值是手动运动学的线性函数。 “隐藏状态”模拟了马可夫链中每个混合分量的概率随时间推移。高斯混合模型和期望最大化（EM）技术被扩展用于自动尖峰分类。通过光谱聚类实现EM的良好初始化。为了解决噪音，混合模型被扩展到包括一个统一的离群过程。使用根据其解码精度选择具有不同数目神经元的模型的贪心优化算法来自动确定每个电极记录的神经元数量。外部事件的闭环神经控制使用计算机光标的神经控制进行演示。

2. 发明授权

US10149707B2 Bone fixation plate system and method 有权
公开(公告)号：US10149707B2
公开(公告)日：2018-12-11
申请号：US13211761
申请日：2011-08-17
申请人： Michael Black
发明人： Michael Black
IPC分类号： A61B17/80
摘要： A fastener, for example a bone screw, is sized to pass through a hole of an implant, for example a bone plate, the fastener having a shaft or anchor portion engageable with body tissue, and a head portion. A locking cap secures to the bone plate and covers the head to block the head and inhibit screw back out. Alternatively or additionally, a locking disc located in the plate hole resiliently deflects downward to allow screw insertion, but is blocked to limit or prevent upward deflection so that screw back out is inhibited.

3. 发明授权

US09877747B2 Spine stabilization system 有权
公开(公告)号：US09877747B2
公开(公告)日：2018-01-30
申请号：US12874845
申请日：2010-09-02
申请人： Michael Black , Michal Zentko , Jason Pastor
发明人： Michael Black , Michal Zentko , Jason Pastor
IPC分类号： A61B17/70
CPC分类号： A61B17/7044 , A61B17/7055
摘要： The present invention is directed to a spine stabilization system and method for stabilizing the spine. In particular, the present invention is directed to a spinal stabilization system having an occipital plate configured with a central portion and at least two extension portions extending from the central portion. At least two rod receivers are positioned on each one of the at least two extension portions and the at least two rod receivers are adapted and configured to receive at least two elongated rods. At least two locking assemblies are adapted and configured to retain the at least two elongated rods within the at least two rod receivers. The occipital plate further includes a plurality of holes for receiving bone fasteners and includes a slot for receiving each one of the at least two rod receivers, and the rod receivers being capable of translating and rotating within the slots.

4. 发明授权

US08641698B2 Pivot point arm for robotic system used to perform a surgical procedure 有权
标题翻译：用于执行外科手术的机器人系统的枢轴点臂
公开(公告)号：US08641698B2
公开(公告)日：2014-02-04
申请号：US11357392
申请日：2006-02-17
申请人： Dan Sanchez , Michael Black , Scott Hammond
发明人： Dan Sanchez , Michael Black , Scott Hammond
IPC分类号： A61B1/01
CPC分类号： A61B19/2203 , A61B34/30 , A61B34/70 , A61B90/11 , A61B90/50 , A61B2017/00243 , A61B2090/5025 , A61B2090/506 , Y10S901/28 , Y10S901/41
摘要： A pivot port that can provide a pivot point for a surgical instrument. The pivot port may be held in a stationary position by a support arm assembly that is attached to a table. The pivot port may include either an adapter or a ball joint that can support the surgical instrument. The pivot port allows the instrument to pivot relative to a patient.
摘要翻译：可以为外科器械提供枢轴点的枢轴端口。枢转端口可以通过附接到工作台的支撑臂组件保持在静止位置。枢转端口可以包括可以支撑外科器械的适配器或球窝接头。枢轴端口允许仪器相对于患者转动。

5. 发明申请

US20130238033A1 OCCIPITAL PLATE SYSTEMS 有权
标题翻译：办公板系统
公开(公告)号：US20130238033A1
公开(公告)日：2013-09-12
申请号：US13417800
申请日：2012-03-12
申请人： Michael Black
发明人： Michael Black
IPC分类号： A61B17/80
CPC分类号： A61B17/7055 , A61B17/70 , A61B17/7047 , A61B17/7053 , A61B17/7056 , A61B17/7061
摘要： Occipital plate systems are described. The occipital plate systems can include a novel occipital plate having an upper portion and lower portion. The lower portion can include an opening for receiving one or more lateral members therethrough. The lateral members include top and/or side apertures for receiving lateral connectors that are attached to polyaxial screw receiving members. The occipital plate systems can also include low-profile clamping arms that are operably attached to an occipital plate via an extension member and articulating joint member. The clamping arms, along with tension cables attached intermittently along its length, can be used in addition to or instead of screws and hooks to secure an occipital plate system to vertebrae.
摘要翻译：枕形板系统被描述。枕骨板系统可以包括具有上部和下部的新颖的枕骨板。下部可以包括用于接收通过其中的一个或多个横向构件的开口。横向构件包括用于接收附接到多轴螺旋接收构件的横向连接器的顶部和/或侧面孔。枕骨板系统还可以包括通过延伸构件和铰接接头构件可操作地附接到枕骨板的低轮廓夹紧臂。夹持臂以及沿着其长度间断连接的张力电缆可以用于螺钉和钩子之外或代替螺钉和钩子，以将枕骨板系统固定到椎骨上。

6. 发明申请

US20110144693A1 Dynamic Spine Stabilizers 有权
标题翻译：动态脊柱稳定器
公开(公告)号：US20110144693A1
公开(公告)日：2011-06-16
申请号：US12635819
申请日：2009-12-11
申请人： Michael Black
发明人： Michael Black
IPC分类号： A61B17/70
CPC分类号： A61B17/7019 , A61B17/7005 , A61B17/7007 , A61B17/7008 , A61B17/701 , A61B17/7011 , A61B17/7014 , A61B17/702 , A61B17/7025 , A61B17/7026 , A61B17/7031 , A61B17/7032 , A61B17/7038 , A61B17/7043 , A61B17/7049 , A61B2017/564
摘要： Treatment of spinal irregularities, including, in one or more embodiments, dynamic spine stabilizers and systems that can be used to stabilize one or more motion segments in a patient's spine. Spine stabilization systems may comprise a first bone fastener configured to attach the spine stabilization system to a first vertebra. Spine stabilization systems further may comprise a second bone fastener configured to attach the spine stabilization system to a second vertebra. Spine stabilization systems further may comprise a dynamic spine stabilizer configured to connect the first bone fastener and the second bone fastener with at least some relative movement between the first bone fastener and the second bone fastener.
摘要翻译：包括在一个或多个实施例中的脊柱不规则处理，动态脊柱稳定器和可用于稳定患者脊柱中的一个或多个运动节段的系统。脊柱稳定系统可以包括构造成将脊柱稳定系统附接到第一椎骨的第一骨紧固件。脊柱稳定系统还可包括构造成将脊柱稳定系统附接到第二椎骨的第二骨紧固件。脊柱稳定系统还可包括动态脊柱稳定器，该动态脊柱稳定器被配置为将第一骨紧固件和第二骨紧固件与第一骨紧固件和第二骨紧固件之间的至少一些相对移动连接。

7. 发明申请

US20100298647A1 Screw Guide and Tissue Retractor Instrument 有权
标题翻译：螺丝导板和组织牵引器
公开(公告)号：US20100298647A1
公开(公告)日：2010-11-25
申请号：US12781583
申请日：2010-05-17
申请人： Michael Black , Gary Dix , Carl Lauryssen
发明人： Michael Black , Gary Dix , Carl Lauryssen
IPC分类号： A61B1/32 , A61B17/56
CPC分类号： A61B17/1757 , A61B17/0218 , A61B17/025 , A61B17/1703 , A61B2017/0046 , A61B2017/0256
摘要： An apparatus is provided for performing spinal surgery having a handle assembly, a screw guide, and a retractor. A shaft is provided with a handle, a neck portion and a connecting portion. The screw guide is provided with a connecting element coupled to the connecting portion of the handle assembly. A retractor for retracting tissue is coupled to the screw guide, wherein the neck portion of the handle assembly is provided with a spring loaded sleeve adapted to engage one of a plurality of holes positioned on a portion of the connecting element. The connecting portion is pivotably coupled to the connecting element.
摘要翻译：提供一种用于执行具有手柄组件，螺钉引导件和牵开器的脊柱手术的装置。轴设置有把手，颈部和连接部。螺钉导向器设置有联接到手柄组件的连接部分的连接元件。用于缩回组织的牵开器联接到螺钉引导件，其中手柄组件的颈部部分设置有弹簧加载的套筒，其适于接合位于连接元件的一部分上的多个孔中的一个孔。连接部分可枢转地联接到连接元件。

8. 发明申请

US20060259019A1 Pivot point arm for robotic system used to perform a surgical procedure 有权
标题翻译：用于执行外科手术的机器人系统的枢轴点臂
公开(公告)号：US20060259019A1
公开(公告)日：2006-11-16
申请号：US11357392
申请日：2006-02-17
申请人： Dan Sanchez , Michael Black , Scott Hammond
发明人： Dan Sanchez , Michael Black , Scott Hammond
IPC分类号： A61B17/00
CPC分类号： A61B19/2203 , A61B34/30 , A61B34/70 , A61B90/11 , A61B90/50 , A61B2017/00243 , A61B2090/5025 , A61B2090/506 , Y10S901/28 , Y10S901/41
摘要： A pivot port that can provide a pivot point for a surgical instrument. The pivot port may be held in a stationary position by a support arm assembly that is attached to a table. The pivot port may include either an adapter or a ball joint that can support the surgical instrument. The pivot port allows the instrument to pivot relative to a patient.
摘要翻译：可以为外科器械提供枢轴点的枢轴端口。枢转端口可以通过附接到工作台的支撑臂组件保持在静止位置。枢转端口可以包括可以支撑外科器械的适配器或球窝接头。枢轴端口允许仪器相对于患者转动。

9. 发明申请

US20060183072A1 Device for application of multiple hygienic effects 审中-公开
标题翻译：应用多种卫生效果的设备
公开(公告)号：US20060183072A1
公开(公告)日：2006-08-17
申请号：US11338442
申请日：2006-01-23
申请人： Michael Black
发明人： Michael Black
IPC分类号： A61C3/00 , A61H1/00 , A61B18/18
CPC分类号： A61N5/0613 , A61C15/02 , A61C17/222 , A61H7/005 , A61H2201/10 , A61N5/0617 , A61N2005/0606 , A61N2005/0644 , A61N2005/0652 , A61N2005/0663
摘要： Hygiene applicator devices for application of two or more hygienic effects to body structures are provided with the objective to effectively apply multiple hygienic effects preferably simultaneously. The applicator includes rotating element(s) rotatable relative to the handle. Two or more light sources, producing at least two unique light treatments, are connected to the rotating element(s). A transparent hollow cover is attached to the handle and covers the light sources. At least part of the cover is transparent to the unique light treatments. The cover allows the light sources to rotate within its hollow structure. Several different embodiments are described related to a comb, a brush, a toothbrush, a toothpick, a facemask, a glove or a skin-massaging wand.
摘要翻译：提供了用于对身体结构施加两种或更多种卫生效果的卫生施用装置，其目的是有效地应用多种卫生效果同时优选。施加器包括相对于把手可旋转的旋转元件。产生至少两个独特的光处理的两个或多个光源连接到旋转元件。透明的中空盖连接到手柄并覆盖光源。至少部分封面对于独特的光线处理是透明的。盖子允许光源在其中空结构内旋转。描述了与梳子，刷子，牙刷，牙签，面罩，手套或皮肤按摩棒有关的几个不同的实施例。

10. 发明申请

US20050032161A1 Novel xanthine phosphoribosyl transferase 审中-公开
标题翻译：新型黄嘌呤磷酸核糖转移酶
公开(公告)号：US20050032161A1
公开(公告)日：2005-02-10
申请号：US10818093
申请日：2004-04-05
申请人： Michael Black , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Robert Stodola , Martin Burnham
发明人： Michael Black , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Robert Stodola , Martin Burnham
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/46 , C07H21/04
CPC分类号： C12N9/1077 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides xanthine phosphoribosyl transferase polypeptides and DNA (RNA) encoding xanthine phosphoribosyl transferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing xanthine phosphoribosyl transferase polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了黄嘌呤磷酸核糖基转移酶多肽和编码黄嘌呤磷酸核糖转移酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。还提供了利用黄嘌呤磷酸核糖转移酶多肽筛选抗菌化合物的方法。

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