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1. 发明申请

US20110082353A1 Implanting Optical Cavity Structures 有权
标题翻译：植入光腔结构
公开(公告)号：US20110082353A1
公开(公告)日：2011-04-07
申请号：US12968115
申请日：2010-12-14
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/00
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

2. 发明申请

US20080181827A1 Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity 有权
标题翻译：实现空间调制激发或发射的方法和系统，用于增强灵敏度的粒子表征
公开(公告)号：US20080181827A1
公开(公告)日：2008-07-31
申请号：US11698409
申请日：2007-01-26
申请人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
发明人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
IPC分类号： A61L2/28 , G01N33/00 , G01N21/75 , G01N21/76
CPC分类号： G01N21/6486 , G01N15/1427 , G01N15/147 , G01N2015/1447 , G01N2015/1454 , Y10T436/143333 , Y10T436/17
摘要： A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
摘要翻译：提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。可以使用记录两条条纹上的发射的单个检测器。用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。

3. 发明授权

US08821799B2 Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity 有权
标题翻译：实现空间调制激发或发射的方法和系统，用于增强灵敏度的粒子表征
公开(公告)号：US08821799B2
公开(公告)日：2014-09-02
申请号：US11698409
申请日：2007-01-26
申请人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
发明人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
IPC分类号： G01N33/00 , G01N21/75 , C12Q1/68
CPC分类号： G01N21/6486 , G01N15/1427 , G01N15/147 , G01N2015/1447 , G01N2015/1454 , Y10T436/143333 , Y10T436/17
摘要： A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
摘要翻译：提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。可以使用记录两条条纹上的发射的单个检测器。用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。

4. 发明授权

US08040526B2 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US08040526B2
公开(公告)日：2011-10-18
申请号：US12968115
申请日：2010-12-14
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

5. 发明授权

US07852490B2 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US07852490B2
公开(公告)日：2010-12-14
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

6. 发明申请

US20080186483A1 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US20080186483A1
公开(公告)日：2008-08-07
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01N1/10
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

7. 发明授权

US08320983B2 Controlling transfer of objects affecting optical characteristics 有权
标题翻译：控制影响光学特性的物体的传递
公开(公告)号：US08320983B2
公开(公告)日：2012-11-27
申请号：US11957610
申请日：2007-12-17
申请人： Joerg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Joerg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

8. 发明申请

US20100157291A1 Causing Relative Motion 有权
标题翻译：导致相对运动
公开(公告)号：US20100157291A1
公开(公告)日：2010-06-24
申请号：US12337796
申请日：2008-12-18
申请人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
发明人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
IPC分类号： G01N21/01
CPC分类号： G01N15/1429 , G01N15/1459 , G01N21/532 , G01N21/645 , G01N21/65 , G01N2015/1075
摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.
摘要翻译：传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或调制的相对运动，其在感测区域内完成至少一个调制周期。可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。

9. 发明申请

US20090195852A1 Producing Filters With Combined Transmission and/or Reflection Functions 有权
标题翻译：生产具有组合传输和/或反射功能的滤波器
公开(公告)号：US20090195852A1
公开(公告)日：2009-08-06
申请号：US12025394
申请日：2008-02-04
申请人： Michael Bassler , Peter Kiesel , Markus Beck , Alex Hegyi , Tobias Buergel , Noble M. Johnson
发明人： Michael Bassler , Peter Kiesel , Markus Beck , Alex Hegyi , Tobias Buergel , Noble M. Johnson
IPC分类号： G02F1/01
CPC分类号： G01N21/645 , G01N21/0303 , G01N21/05 , G01N21/53 , G01N21/6486 , G01N2021/0346 , G01N2021/6421 , G01N2021/6471
摘要： A transmissive and/or reflective optical filter can receive input light, which can emanate from objects traveling along paths past the filter, e.g. from biological cells, viruses, colored spots or other markings on documents, and so forth. In response, the filter can provide output light in accordance with a combined transmission function that is approximately equal to a superposition or scaled superposition of a set of simpler transmission functions. The set can include two or more non-uniform transmission functions, a subset of which can be different from each other and positioned relative to each other so that the output light has time variation in accordance with each of the functions in the subset. The subset could include, for example, a random function and a periodic function, a chirp function and a periodic function, or any other suitable combination of two or more simpler functions.
摘要翻译：透射和/或反射光学滤光器可以接收输入光，其可以从沿着过滤器的路径行进的物体发射，例如，来自生物细胞，病毒，彩色斑点或文件上的其他标记等等。作为响应，滤波器可以根据组合传输函数提供输出光，其大致等于一组更简单的传输函数的叠加或缩放叠加。该集合可以包括两个或多个非均匀传输函数，其子集可以彼此不同并且相对于彼此定位，使得输出光具有根据子集中的每个功能的时间变化。子集可以包括例如随机函数和周期函数，啁啾函数和周期函数，或两个或更多个更简单函数的任何其它合适的组合。

10. 发明授权

US08263955B2 Causing relative motion 有权
标题翻译：造成相对运动
公开(公告)号：US08263955B2
公开(公告)日：2012-09-11
申请号：US12337796
申请日：2008-12-18
申请人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
发明人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
IPC分类号： G01N21/55 , G01N21/25 , G01N21/00
CPC分类号： G01N15/1429 , G01N15/1459 , G01N21/532 , G01N21/645 , G01N21/65 , G01N2015/1075
摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.
摘要翻译：传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或调制的相对运动，其在感测区域内完成至少一个调制周期。可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。

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