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1. 发明授权

US6035225A Detection of cancerous lesions by measuring nitric oxide concentrations in tissue 失效
标题翻译：通过测量组织中的一氧化氮浓度来检测癌性病变
公开(公告)号：US6035225A
公开(公告)日：2000-03-07
申请号：US76532
申请日：1998-05-12
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： G01N33/84 , A61B5/00 , A61B10/00 , A61B17/22 , G01N33/574 , G06T7/00 , A61B5/05
CPC分类号： G06T7/0012 , A61B5/015 , G01N33/574 , G01N33/57415 , A61B2010/008 , A61B5/7257 , G06T2207/30068
摘要： The present invention involves the measurement of nitric oxide in interstitial fluid extracted by a thin needle from a body tissue, and particularly a human breast. The diffuse nature of nitric oxide means that the sample of body fluid does not need to be taken directly from the lesion to indicate that cancerous cells are present in the vicinity. Therefore, the presence of nitric oxide in the extracted body fluid is a direct indicator of the presence of a cancerous lesion in the vicinity.
摘要翻译：本发明涉及通过细针从身体组织，特别是人乳房提取的间质液中的一氧化氮的测量。一氧化氮的弥漫性意味着体液样本不需要直接从病变中取出，表明癌细胞存在于附近。因此，提取体液中一氧化氮的存在是附近存在癌性病变的直接指标。

2. 发明授权

US5810010A Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues 失效
标题翻译：通过对周围组织中灌注周期性调节的影响来检测癌性病变
公开(公告)号：US5810010A
公开(公告)日：1998-09-22
申请号：US368161
申请日：1995-01-03
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： A61B5/00 , A61B10/00 , G01N33/574 , G06T7/00 , A61B6/00
CPC分类号： A61B5/015 , G01N33/574 , G01N33/57415 , G06T7/0012 , A61B2010/008 , A61B5/7257
摘要： The present invention comprises methods and apparatus for cancer detection involving the measurement of temporal periodic changes in blood perfusion associated with immune response, occurring in neoplastic lesions and their surrounding tissues. Particularly, the method for cancer detection involves the detection of non-neuronal thermoregulation of blood perfusion, aberrant modulation of blood perfusion, aberrant temperature oscillations associated with blood perfusion, aberrant thermoregulatory frequencies associated with blood perfusion, and periodic changes in the spatial homogeneity of skin temperature.
摘要翻译：本发明包括用于癌症检测的方法和装置，涉及测量与肿瘤病变及其周围组织中发生的免疫应答相关的血液灌注的时间周期性变化。特别地，癌症检测方法涉及血液灌注的非神经元温度调节，血液灌注异常调节，与血液灌注相关的异常温度振荡，与血液灌注相关的异常体温调节频率以及皮肤空间均匀性的周期性变化温度。

3. 发明授权

US5272340A Infrared imaging system for simultaneous generation of temperature, emissivity and fluorescence images 失效
标题翻译：用于同时产生温度，辐射率和荧光图像的红外成像系统
公开(公告)号：US5272340A
公开(公告)日：1993-12-21
申请号：US953990
申请日：1992-09-29
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： G01J5/00 , G01N21/64 , G01N25/72 , G01N25/00
CPC分类号： G01N21/6456 , G01J3/32 , G01J5/0022 , G01J5/0025 , G01J5/522 , G01J5/601 , G01J5/602 , G01N25/72 , G01J2005/0074 , G01J2005/0077
摘要： The present invention comprises a method and apparatus for determining actual temperature, reflectivity and fluorescence of a surface and comprises in the preferred embodiment a two-dimensional focal plane array of rapidly tunable infrared detectors, 11, adapted to detect the emitted infrared flux from a surface of interest, 10, across pre-selected spectral segments in the 4-15 .mu.m range. The invention further comprises a computer having deconvolution algorithms, 13, for isolating the effects of reflectivity, fluorescence and environmental factors affecting infrared emission for each pixel of the generated image at various spectral segments in the 4-15 .mu.m range. The device further includes means for generating images of temperature, emissivity and fluorescence for diagnostic use. The preferred embodiment of the invention also contemplates the use of thermostated black body reference emitters, 12, at the edges of the field of view for enhancing and speeding deconvolution of the detected data across the 4-15 .mu.m spectrum.
摘要翻译：本发明包括用于确定表面的实际温度，反射率和荧光的方法和装置，并且在优选实施例中包括快速可调谐红外检测器11的二维焦平面阵列，其适于从表面检测发射的红外线通量感兴趣的，10个，在4-15亩范围内的预选光谱段之间。本发明还包括具有去卷积算法的计算机，13，用于分离在4-15μm范围内的各种光谱段处产生的图像的每个像素影响红外发射的反射率，荧光和环境因素的影响。该装置还包括用于产生用于诊断使用的温度，发射率和荧光图像的装置。本发明的优选实施例还考虑在视场边缘使用恒温黑体参考发射体12，以增强和加速所检测数据在4-15μm光谱上的去卷积。

4. 发明授权

US4022876A Mass spectrometric immunoassay 失效
标题翻译：质谱免疫测定
公开(公告)号：US4022876A
公开(公告)日：1977-05-10
申请号：US372197
申请日：1973-06-21
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： G01N33/58 , G21H5/02 , G01N33/16 , B01D59/44
CPC分类号： G21H5/02 , G01N33/58 , Y10S436/804 , Y10S436/806 , Y10S436/807
摘要： A method and means of making an immunological assay is provided whereby stable isotopes of certain elements, or long-lived radioisotopes of these elements are used to tag antigens or antibodies. A known amount of the tagged antibodies or antigens are then mixed with the unknown number of antigens or antibodies forming an antigen-antibody complex, (bound) and free tagged antigens, or antibodies, (unbound). The bound antigens or antibodies are separated from the unbound, and their quantity is determined by negative ion mass spectrometry. An aliquot of the unbound or bound antigens or antibodies is taken and dried in a metal crucible, for example, which is then inserted into a negative ion mass spectrometer where the sample is vaporized, ionized and the number of tagging atoms is then counted. From the information provided by the count, an immunoassay can be established.
摘要翻译：提供了进行免疫学测定的方法和手段，其中使用某些元件的稳定同位素或这些元件的长寿命放射性同位素来标记抗原或抗体。然后将已知量的标记的抗体或抗原与形成抗原 - 抗体复合物（结合）和游离标记的抗原或抗体（未结合）的未知数量的抗原或抗体混合。结合的抗原或抗体与未结合分离，其量通过负离子质谱法测定。将未结合或结合的抗原或抗体的等分试样取出并在例如金属坩埚中干燥，然后将其插入负离子质谱仪中，其中样品蒸发，电离，然后计数标记原子的数量。根据计数提供的信息，可以建立免疫测定。

5. 发明申请

US20130084619A1 MODIFIED CELLULASES WITH ENHANCED THERMOSTABILITY 审中-公开
标题翻译：具有增强热稳定性的改性细胞
公开(公告)号：US20130084619A1
公开(公告)日：2013-04-04
申请号：US13702711
申请日：2011-06-06
申请人： Edward A. Bayer , Michael Anbar
发明人： Edward A. Bayer , Michael Anbar
IPC分类号： C12N9/42 , C12N1/20
CPC分类号： C12Y302/01004 , C12N9/2437
摘要： The present invention relates to modified family-8 cellulases that exhibit enhanced thermostability compared to the corresponding wild-type enzyme, polynucleotides encoding the modified cellulases, compositions comprising same and uses thereof. The variant family-8 cellulases are advantageous for the bioconversion process of cellulosic substrates.
摘要翻译：本发明涉及与相应的野生型酶相比显示增强的热稳定性，编码改性纤维素酶的多核苷酸，包含其的组合物及其用途的改良的家族-8纤维素酶。变体家族-8纤维素酶对于纤维素基质的生物转化过程是有利的。

6. 发明授权

US5999843A Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature 失效
标题翻译：通过其对皮肤温度的空间均匀性的影响来检测癌性病变
公开(公告)号：US5999843A
公开(公告)日：1999-12-07
申请号：US63129
申请日：1998-04-20
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： G01J5/10 , A61B5/00 , A61B5/01 , A61B10/00 , G01J5/48 , G01N33/574 , G06T7/00 , A61B6/00
CPC分类号： G01N33/574 , A61B5/015 , G01N33/57415 , G06T7/0012 , G06T7/402 , A61B2010/008 , A61B5/7257 , G06T2207/10048 , G06T2207/20056 , G06T2207/30068 , G06T2207/30096
摘要： The present invention comprises methods for cancer detection involving the measurement of temporal periodic changes in blood perfusion, associated with immune response, occurring in neoplastic lesions and their surrounding tissues. Particularly, the method for cancer detection involves the detection of non-neuronal thermoregulation of blood perfusion, periodic changes in the spatial homogeneity of skin temperature, aberrant oscillations of spatial homogeneity of skin temperature and aberrant thermoregulatory frequencies associated with periodic changes in the spatial homogeneity of skin temperature.
摘要翻译：本发明包括用于癌症检测的方法，涉及测量与肿瘤病变及其周围组织中发生的免疫应答有关的血液灌注的时间周期性变化。特别地，癌症检测方法涉及检测血液灌注的非神经元温度调节，皮肤温度的空间均匀性的周期性变化，皮肤温度的空间均匀性的异常振荡和与空间均匀性的周期性变化相关的异常体温调节频率皮肤温度。

7. 发明授权

US5961466A Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue 失效
标题翻译：通过其对温度调节和组织均匀性的空间分布的影响来检测癌性病变的方法
公开(公告)号：US5961466A
公开(公告)日：1999-10-05
申请号：US85627
申请日：1998-05-27
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： G01J5/48 , A61B5/00 , A61B5/01 , A61B10/00 , G01N33/574 , G06T7/00 , A61B6/00
CPC分类号： G01N33/574 , A61B5/015 , G01N33/57415 , G06T7/0012 , G06T7/402 , A61B2010/008 , A61B5/7257 , G06T2207/10048 , G06T2207/20056 , G06T2207/30088
摘要： A method for measuring the periodicity of changes in blood perfusion over large regions of skin so as to identify a locally impaired neuronal control, thereby providing a quick and inexpensive screening test for relatively shallow neoplastic lesions, such as breast cancer, is described. The present method is predicated on infrared imaging of the skin to detect changes in the spectral structure and spatial distribution of thermoregulatory frequencies (TRFs) over different areas of the skin.
摘要翻译：一种测量大面积皮肤区域血液灌注周期性的方法，以便识别局部受损的神经元控制，从而为相对较浅的肿瘤性病变（例如乳腺癌）提供快速和便宜的筛查试验。本方法基于皮肤的红外成像，以检测不同皮肤区域的温度调节频率（TRF）的光谱结构和空间分布的变化。

8. 发明授权

US3970474A Method and apparatus for electrochemical generation of power from carbonaceous fuels 失效
标题翻译：从碳质燃料电化学发电的方法和装置
公开(公告)号：US3970474A
公开(公告)日：1976-07-20
申请号：US603591
申请日：1975-08-11
申请人： Michael Anbar , Donald F. McMillen , Robert D. Weaver , Paul J. Jorgensen
发明人： Michael Anbar , Donald F. McMillen , Robert D. Weaver , Paul J. Jorgensen
IPC分类号： H01M8/18
CPC分类号： H01M8/18 , Y02E60/528
摘要： Method and apparatus for the pollution-free generation of electrical power from carbonaceous fuels in which molten lead is electrochemically oxidized to produce lead oxide and electricity in a single integrated cell in which the resulting lead oxide is simultaneously converted back to lead metal by carbothermic reduction with a carbonaceous fuel, the entire process being carried out in a single cell using a molten carbonate as electrolyte in a temperature range of 500.degree. to 900.degree. C. The entire cycle thus consumes only carbon and oxygen and produces electricity. It is found that by thus coupling the electrochemical cell and the thermochemical regeneration system, the resulting integrated carbon-lead-air cell will maintain a voltage well above that provided by a simple lead-air cell approaching that of a hypothetical carbon-air cell.
摘要翻译：用于从碳质燃料中无电解生成电力的方法和装置，其中熔融铅被电化学氧化以在单个集成电池中产生氧化铅和电，其中所得氧化铅同时通过碳热还原而转化回铅金属，碳质燃料，整个过程在单个电池中使用熔融碳酸盐作为电解质在500至900℃的温度范围内进行。因此，整个循环仅消耗碳和氧并产生电。发现通过这样耦合电化学电池和热化学再生系统，所得到的集成碳 - 铅 - 空气电池将保持远远高于靠近假想碳 - 空气电池的简单铅电池提供的电压。

9. 发明授权

US5771261A Telethermometric psychological evaluation by monitoring of changes in skin perfusion induced by the autonomic nervous system 失效
标题翻译：通过监测由自主神经系统诱导的皮肤灌注变化的远程心理学心理评估
公开(公告)号：US5771261A
公开(公告)日：1998-06-23
申请号：US527522
申请日：1995-09-13
申请人： Michael Anbar
发明人： Michael Anbar
IPC分类号： A61B5/00 , A61B5/103 , A61B5/16 , G01K13/00 , A61B5/02
CPC分类号： A61B5/01 , A61B5/164 , A61B5/168 , A61B5/4035 , A61B5/441 , A61B5/7257
摘要： The present invention comprises methods and apparatus for assessment of the effects mental stress involving the measurement of periodic changes in skin perfusion. Using a remotely mounted infrared camera, dynamic area telethermometry (DAT) measures the autonomic nervous activity by monitoring and quantitatively analyzing the modulation of cutaneous perfusion. When people gets "nervous" their sympathetics "act up" and they blush (vasodilates) or becomes pale (vasoconstricts). A DAT test of the face proves to be a superior "lie detector" test since emotional stress is reflected in an autonomic nervous response that can be measured remotely. DAT is much more sensitive than any visual assessment of skin color or than instrumental measurement of diaphoresis. Not only is it more reliable than currently used polygraph tests, but its non-contact administration is so simple and innocuous that it could be done without the subject's awareness. Furthermore, the same device can be used to meet the needs of a variety of psychiatric and psychological evaluation problems, including depression, drug addiction and dementia, as well as psychological learning disabilities.
摘要翻译：本发明包括用于评估涉及测量皮肤灌注周期性变化的精神压力的方法和装置。使用远程安装的红外摄像机，动态区域远摄测量（DAT）通过监测和定量分析皮肤灌注的调节来测量自主神经活动。当人们“紧张”他们的交感神经病“起作用”，他们会脸红（血管扩张）或变得苍白（血管收缩）。脸部的DAT测试被证明是一个优秀的“谎言检测器”测试，因为情绪压力反映在远程测量的自主神经反应中。 DAT比皮肤颜色的任何视觉评估更敏感，或者比透视的仪器测量更敏感。它不仅比目前使用的测谎测试更可靠，而且它的非接触式管理非常简单无害，可以在没有主体意识的情况下完成。此外，同样的设备可以用于满足各种精神和心理评估问题的需求，包括抑郁症，吸毒成瘾和痴呆症以及心理学习障碍。

10. 发明授权

US4427884A Method for detecting and quantifying carbon isotopes 失效
标题翻译：碳同位素检测和定量方法
公开(公告)号：US4427884A
公开(公告)日：1984-01-24
申请号：US342147
申请日：1982-01-25
申请人： Michael Anbar , Robert C. Abbott
发明人： Michael Anbar , Robert C. Abbott
IPC分类号： G01N23/00 , G01N31/00 , B01D59/44 , H01J49/26
CPC分类号： G01N31/00 , G01N23/00 , G01N2223/202 , Y10T436/24
摘要： A method for detecting and quantifying a carbon isotope at quantities of less than 1.times.10.sup.-12 gram at a statistical precision of better than 5% in a time period of less than 5 minutes by producing a carbon compound, selected from CO,CS.sub.2,CO.sub.2 and elemental carbon, from the carbon containing composition to be analyzed; and producing and detecting sufficient C.sup.- ions from the carbon compound at a known efficiency to provide at least 80 counts of carbon isotope ions per minute by mass spectrometry.
摘要翻译：通过生产选自CO，CS2，CO2的碳化合物，在小于5分钟的时间内，以小于1×10-12克的碳同位素的统计精度优于5％的方法，元素碳，来自待分析的含碳组合物; 并以已知的效率从碳化合物产生和检测足够的C-离子，通过质谱每分钟提供至少80个计数的碳同位素离子。

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