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1. 发明申请

US20060141565A1 Novel fibroblast growth factor and uses thereof 审中-公开
标题翻译：新型成纤维细胞生长因子及其用途
公开(公告)号：US20060141565A1
公开(公告)日：2006-06-29
申请号：US11005836
申请日：2004-12-06
申请人： Meera Patturajan , Isabelle Millet , Sampath Kumar , Charles Miller , Peter Mezes , Denise Lepley , Catherine Burgess , Richard Shimkets
发明人： Meera Patturajan , Isabelle Millet , Sampath Kumar , Charles Miller , Peter Mezes , Denise Lepley , Catherine Burgess , Richard Shimkets
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C07K14/50
CPC分类号： C07K14/50
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-22), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译：本发明一般涉及核酸，蛋白质和抗体。本发明更具体涉及成纤维细胞生长因子-20（FGF-22）或其片段，衍生物，变体，同源物，类似物或其组合的核酸分子，蛋白质和抗体。

2. 发明申请

US20060084054A1 Novel proteins and nucleic acids encoding same 审中-公开
标题翻译：新型蛋白质和编码相同的核酸
公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/00
CPC分类号： C07K16/40 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

3. 发明授权

US07141549B2 Proteins and nucleic acids encoding same 失效
公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

4. 发明申请

US20060013813A1 Proteins and nucleic acids encoding same 失效
公开(公告)号：US20060013813A1
公开(公告)日：2006-01-19
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , A61K39/395 , C07K14/705 , C07K16/18
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

5. 发明申请

US20060009634A1 Proteins and nucleic acids encoding same 审中-公开
公开(公告)号：US20060009634A1
公开(公告)日：2006-01-12
申请号：US11019711
申请日：2004-12-21
申请人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
发明人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
IPC分类号： C07H21/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

6. 发明申请

US20050266431A1 Nucleic acids, polypeptides, single nucleotide polymorphisms and methods of use thereof 审中-公开
标题翻译：核酸，多肽，单核苷酸多态性及其使用方法
公开(公告)号：US20050266431A1
公开(公告)日：2005-12-01
申请号：US11064246
申请日：2005-02-22
申请人： William Grosse , John Alsobrook , Denise Lepley , Catherine Burgess , Joel Bader , Aruna Bansal , Carol Pena , Richard Shimkets , Ramesh Kekuda , Bryan Zerhusen , Glennda Smithson , David Anderson , Mei Zhong , Charles Miller , Corine Vernet , Tord Hjalt
发明人： William Grosse , John Alsobrook , Denise Lepley , Catherine Burgess , Joel Bader , Aruna Bansal , Carol Pena , Richard Shimkets , Ramesh Kekuda , Bryan Zerhusen , Glennda Smithson , David Anderson , Mei Zhong , Charles Miller , Corine Vernet , Tord Hjalt
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N1/21 , C12Q1/68 , C07H21/04 , C07K16/40 , C12N9/12 , C12N15/09 , C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： Disclosed herein is a nucleic acid sequence that encodes a novel polypeptide. Also disclosed is a polypeptide encoded by the nucleic acid sequence, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human nucleic acid and protein. The invention also provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequences, as well as methods of using the nucleic acids.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由核酸序列编码的多肽和免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防涉及该新型人核酸和蛋白质的病症的治疗，诊断和研究方法。本发明还提供含有针对转录的人序列鉴定的单核苷酸多态性的核酸，以及使用该核酸的方法。

7. 发明授权

US08754646B2 Rapid sample exchange for miniaturized NMR spectrometer 有权
标题翻译：用于小型化NMR光谱仪的快速样品交换
公开(公告)号：US08754646B2
公开(公告)日：2014-06-17
申请号：US13171230
申请日：2011-06-28
申请人： John C. Price , Charles Miller , Erick Winston
发明人： John C. Price , Charles Miller , Erick Winston
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01R33/302 , G01R33/445
摘要： A method is provided for acquiring multiple NMR response signal data in rapid succession for averaging NMR spectral data from a sample. The fluid sample is placed in a capillary that extends through the magnetic field of the NMR spectrometer, including through the center of the magnetic field to place a segment of the sample in the magnetic center. After the sample fluid, initially magnetized by the magnetic field, is activated to emit an NMR pulse signal, the fluid in the capillary is advanced rapidly to put another pre-magnetized segment of the sample fluid in the fluid center, acquiring an NRM pulse signal, and continuing the cycle until a desired number of NMR response data signals from the sample have been acquired. Those response data from multiple acquisitions are then averaged.
摘要翻译：提供一种快速连续获取多个NMR响应信号数据的方法，用于对来自样品的NMR光谱数据进行平均。将流体样品置于穿过NMR光谱仪的磁场的毛细管中，包括通过磁场的中心，将样品的一段放置在磁性中心。在初始被磁场磁化的样品流体被激活以发射NMR脉冲信号之后，毛细管中的流体被快速前进，以将样品流体的另一个预先磁化的区段放在流体中心，获得NRM脉冲信号并继续循环，直到获得了来自样品的所需数量的NMR响应数据信号。然后对来自多次获取的响应数据进行平均。

8. 发明申请

US20130168082A1 METHOD AND SYSTEM FOR TREATING A SUBTERRANEAN FORMATION USING DIVERSION 有权
标题翻译：使用分流处理地下室形成的方法和系统
公开(公告)号：US20130168082A1
公开(公告)日：2013-07-04
申请号：US13547159
申请日：2012-07-12
申请人： W. E. Clark , Doug Bentley , John Daniels , Christopher N. Fredd , Charles Miller , John Lassek
发明人： W. E. Clark , Doug Bentley , John Daniels , Christopher N. Fredd , Charles Miller , John Lassek
IPC分类号： E21B43/12
CPC分类号： E21B43/12 , E21B43/14 , E21B43/25
摘要： A method of well treatment includes establishing fluid connectivity between a wellbore and at least one target zone for treatment within a subterranean formation. The method includes injecting a treatment composition into the wellbore. The method includes contacting a subterranean formation with the treatment composition, providing a diversion agent to a desired interval in the wellbore and measuring a wellbore parameter while performing at least one of the contacting the target zone and the providing the diversion agent.
摘要翻译：井处理的方法包括建立井眼与至少一个目标区域之间的流体连通性，以在地层内进行处理。该方法包括将处理组合物注入井眼。该方法包括使地下地层与处理组合物接触，在井眼中提供所需间隔的转移剂并且在执行接触目标区域和提供转移剂的至少一个时测量井筒参数。

9. 发明申请

US20100253374A1 Method and apparatus for Terminating A Test Signal Applied To Multiple Semiconductor Loads Under Test 有权
标题翻译：用于终止被测试的多个半导体负载的测试信号的方法和装置
公开(公告)号：US20100253374A1
公开(公告)日：2010-10-07
申请号：US12416375
申请日：2009-04-01
申请人： Guang Chen , Charles Miller , David Pritzkau
发明人： Guang Chen , Charles Miller , David Pritzkau
IPC分类号： G01R31/02 , G01R31/26
CPC分类号： G01R31/31905
摘要： Apparatus for terminating a test signal applied to multiple semiconductor loads under test is described—for example apparatus for interfacing a test signal between a tester and a semiconductor device under test (DUT). In some examples, a probe card assembly may include at least one probe substrate each having test probes configured to contact test features of a DUT; a wiring substrate, coupled to the at least one probe substrate, having a connector configured for coupling with a source termination of a tester; a signal path formed on and/or in the wiring substrate and the at least one probe substrate, the signal path having a trace and trace stubs fanning out from the trace, an input of the trace being coupled to the connector and outputs of the trace stubs being coupled to the test probes; and a resistive termination coupled between the trace and at least one potential.
摘要翻译：描述了用于终止施加到被测试的多个半导体负载的测试信号的装置，例如用于在测试器和待测半导体器件（DUT）之间接合测试信号的装置。在一些示例中，探针卡组件可以包括至少一个探针基板，每个探针基板具有被配置为接触DUT的测试特征的测试探针; 耦合到所述至少一个探针衬底的布线衬底，具有被配置为与测试器的源端接耦合的连接器; 形成在布线基板和至少一个探针基板上和/或布线基板和至少一个探针基板上的信号路径，该信号路径具有从迹线扇出的迹线和迹线短线，迹线的输入耦合到连接器和迹线的输出桩被耦合到测试探针; 以及耦合在迹线和至少一个电位之间的电阻终端。

10. 发明授权

US07569383B2 Chimeric flavivirus vectors 失效
标题翻译：嵌合黄病毒载体
公开(公告)号：US07569383B2
公开(公告)日：2009-08-04
申请号：US10160939
申请日：2002-05-31
申请人： Harold Kleanthous , Charles Miller , Larisa Oros
发明人： Harold Kleanthous , Charles Miller , Larisa Oros
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , C12N2770/24143
摘要： The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
摘要翻译：本发明提供嵌合黄病毒载体，包括插入到载体的包膜蛋白中的外源肽和使用这些载体的方法。

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