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1. 发明申请

WO2017136275A1 HEART VALVE PROSTHESES HAVING MULTIPLE SUPPORT ARMS AND METHODS FOR PERCUTANEOUS HEART VALVE REPLACEMENT 审中-公开
标题翻译：具有多支撑臂的心脏瓣膜和用于经皮心脏瓣膜置换的方法
公开(公告)号：WO2017136275A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/015627
申请日：2017-01-30
申请人： MEDTRONIC INC.
发明人： QUILL, Jason , SAVAGE, Padraig , DWORK, Joshua , GARDE, Kshitija , AHLBERG, Sarah , KOVALSKY, Igor
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2230/001 , A61F2230/005 , A61F2250/0037
摘要： Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm (142) configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms (144) disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.
摘要翻译：本文公开了用于经皮或经导管心脏瓣膜置换的假体心脏瓣膜装置和相关方法。根据本文构造的心脏瓣膜假体包括具有瓣膜支撑件和从其延伸的多个支撑臂的框架。所述多个支撑臂可以包括主支撑臂（142），所述主支撑臂（142）被配置为从所述瓣膜支撑件延伸，以当所述瓣膜假体处于展开构型并且部署在所述瓣膜支撑件内时用于捕获天然心脏瓣膜瓣膜瓣叶的至少一部分原生心脏瓣膜。另外，所述多个支撑臂可以包括围绕所述瓣膜支撑件的圆周布置的多个辅助支撑臂（144），所述多个辅助支撑臂（144）在以展开构型展开时被配置为至少部分地接合天然心脏瓣膜处的环形组织。

2. 发明申请

WO2010123734A2 SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 审中-公开
标题翻译：用于关闭组织内部开放的系统和方法，例如转接开关
公开(公告)号：WO2010123734A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031074
申请日：2010-04-14
申请人： MEDTRONIC INC. , AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译：一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。每个夹子具有相对的夹子端部和中间部分。柔性系绳联接到嵌入的夹子上以围绕开口周边形成环。将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。环路端部被固定以将目标部位保持在关闭状态。在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。

3. 发明授权

EP2421444B1 SYSTEM FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 有权
公开(公告)号：EP2421444B1
公开(公告)日：2020-03-25
申请号：EP10714785.2
申请日：2010-04-14
申请人： Medtronic, Inc
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04

4. 发明公开

EP2421444A2 SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 有权
标题翻译：系统和方法内部组织开口的闭合，如A心尖介入开幕
公开(公告)号：EP2421444A2
公开(公告)日：2012-02-29
申请号：EP10714785.2
申请日：2010-04-14
申请人： Medtronic, Inc
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.

5. 发明公开

EP3689261A1 SYSTEM FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 有权
公开(公告)号：EP3689261A1
公开(公告)日：2020-08-05
申请号：EP20164928.2
申请日：2010-04-14
申请人： Medtronic, Inc.
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04 , A61B17/064
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips (30) into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends (52, 54) and an intermediate segment (50). A flexible tether (24) is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.

6. 发明公开

EP3410985A1 HEART VALVE PROSTHESES HAVING MULTIPLE SUPPORT ARMS AND METHODS FOR PERCUTANEOUS HEART VALVE REPLACEMENT 审中-公开
公开(公告)号：EP3410985A1
公开(公告)日：2018-12-12
申请号：EP17704910.3
申请日：2017-01-30
申请人： Medtronic Inc.
发明人： QUILL, Jason , SAVAGE, Padraig , DWORK, Joshua , GARDE, Kshitija , AHLBERG, Sarah , KOVALSKY, Igor
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2230/001 , A61F2230/005 , A61F2250/0037
摘要： Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.

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