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1. 发明授权

US4521732A Pulse sequence for use in performing nuclear magnetic resonance spectroscopy 失效
标题翻译：用于执行核磁共振光谱的脉冲序列
公开(公告)号：US4521732A
公开(公告)日：1985-06-04
申请号：US466543
申请日：1983-02-15
申请人： David T. Pegg , David M. Doddrell , Max R. Bendall
发明人： David T. Pegg , David M. Doddrell , Max R. Bendall
IPC分类号： G01R33/46 , G01R33/08
CPC分类号： G01R33/4608
摘要： A liquid sample comprising a system made up of two types of heteronuclei is pulsed in a particular manner in a nuclear magnetic resonance (NMR) experiment so that the resulting NMR signal from the one type of heteronucleus depends on the scalar-coupled interaction with the other type of heteronucleus. The sequence of radiofrequency pulses is such that the two types of heteronuclei interact via the phenomenon of polarization transfer and by the phenomenon of the correlated motion of the two types of heteronuclei in the transverse plane of the doubly rotating reference frame. The combination of these two phenomena in the one pulse sequence provides NMR signals which are easily made less dependent on the exact magnitude of the heteronuclear scalar coupling constant. The coupled NMR signals for polarization transfer from a system of multiple spin-half nuclei have multiplet components in the normal ratio. Consequently the pulse sequence provides an improved method for obtaining chemical structural information. Applications include the provision of accurate edited subspectra; polarization transfer between any number of one type of heteronucleus of any spin number and any number of a second type of heteronucleus of any spin number; and two-dimensional NMR spectroscopy.
摘要翻译：包含由两种异种核构成的系统的液体样品在核磁共振（NMR）实验中以特定方式脉冲化，使得来自一种类型的异核的所得NMR信号取决于与其他类型的异核的标量耦合相互作用异源核型。射频脉冲的序列是这样的两种类型的异核通过极化转移的现象和双重参考帧的横向平面中的两种异核的相关运动的现象相互作用。这两个现象在一个脉冲序列中的组合提供了NMR信号，这些信号容易使得较少依赖于异核标量耦合常数的精确幅度。用于从多个半自旋半核系统进行极化转移的耦合NMR信号具有正常比例的多重分量。因此，脉冲序列提供了获得化学结构信息的改进方法。申请包括提供准确编辑的子;; 任何数量的任何自旋数的异核的任何数量的任何自旋数的任意数量的第二类异源核之间的极化转移; 和二维NMR光谱。

2. 发明授权

US4727324A Method and apparatus for obtaining nuclear magnetic resonance spectra 失效
标题翻译：用于获得核磁共振谱的方法和装置
公开(公告)号：US4727324A
公开(公告)日：1988-02-23
申请号：US769269
申请日：1985-07-29
申请人： Max R. Bendall , David T. Pegg
发明人： Max R. Bendall , David T. Pegg
IPC分类号： G01R33/483 , G01R33/20
CPC分类号： G01R33/4831
摘要： A method of obtaining a localized nuclear magnetic reasonance signal from a sample using a radiofrequency irradiation coil which provides an inhomogeneous radiofrequency field, comprisesapplying to the sample a plurality of radiofrequency pulse sequences, each pulse sequence including an excitation pulse, and at least two other pulses, the pulse sequences differing only in the phase of one or more of the said other pulses, and the phases of at least two of the said other pulses being shifted by 180.degree. in selected sequences of the said plurality, the number of sequences in the said plurality being such that a sequence exists for each possible combination of the said phase shifts for each of the said other pulses, and there being no sequences in the said plurality in which the phases of the said at least two of the said other pulses is shifted by 90.degree.,acquiring an N.M.R. signal after each pulse sequence,and combining the N.M.R. signals obtained to produce a localized N.M.R. signal from selected regions of the sample.The method may be used in any N.M.R. method in which localization is desired.
摘要翻译：使用提供非均匀射频场的射频照射线圈从样本获得局部核磁致动信号的方法包括向样本施加多个射频脉冲序列，每个脉冲序列包括激励脉冲和至少两个其它脉冲，所述脉冲序列仅在一个或多个所述其他脉冲的相位上不同，并且所述另一个脉冲中的至少两个脉冲的相位在所述多个的选定序列中移位180°，所述多个信号使得对于每个所述其它脉冲的所述相移的每个可能的组合存在序列，并且在所述多个中不存在所述多个的所述至少两个所述其他脉冲的相位的序列转移90°，获得NMR 每个脉冲序列后的信号，并组合N.M.R. 获得的信号以产生局部的N.M.R. 来自样品的选定区域的信号。该方法可用于任何N.M.R. 需要定位的方法。

3. 发明授权

US4820983A Method and apparatus for performing an NMR experiment 失效
标题翻译：用于进行NMR实验的方法和装置
公开(公告)号：US4820983A
公开(公告)日：1989-04-11
申请号：US92919
申请日：1987-08-06
申请人： Max R. Bendall , David T. Pegg
发明人： Max R. Bendall , David T. Pegg
IPC分类号： A61B5/055 , G01R33/46 , G01R33/48 , G01R33/20
CPC分类号： G01R33/446
摘要： In a method for NMR excitation of a sample, an Rf pulse is applied to an irradiation coil (6) proximate the sample, in the presence of an external DC magnetic field and an adiabatic passage is performed wherein the Rf pulse is controlled such that:B.sub.1 =V A sin 2.pi..nu.t and .DELTA.H=A(cos 2.pi..nu.t+s),orB.sub.1 =v A cos 2.pi..nu.t and .DELTA.H=A(sin 2.pi..nu.t+s),where s=S/A, where S is the frequency offset of a nucleus from the center of the spectrum, and where v allows for variation of B.sub.1 throughout the sample, .DELTA.H is the resonance offset of the nuclear spins, and B.sub.1 is the rf field of a spin-lock pulse.
摘要翻译： PCT No.PCT / AU86 / 00353 Sec。 371日期1987年8月6日 102（e）日期1987年8月6日PCT公布1986年11月20日PCT公布。公开号WO87 / 03370 日本1987年6月4日。在样品的NMR激发的方法中，在存在外部DC磁场的情况下，将Rf脉冲施加到靠近样品的照射线圈（6），并且进行绝热通道，其中控制Rf脉冲，使得：B1 = VA sin 2 pi nu t和DELTA H = A（cos 2 pi nu t + s）或B1 = v A cos 2 pi nu t和DELTA H = A（sin 2 pi nu t + s），其中s = S / A，其中S是核从频谱中心的频偏，并且其中v允许整个样本中的B1的变化，DELTA H是核自旋的共振偏移，B1是自旋锁定脉冲的rf场。

4. 发明授权

US4682107A Method of operating a nuclear magnetic resonance spectrometer 失效
标题翻译：操作核磁共振光谱仪的方法
公开(公告)号：US4682107A
公开(公告)日：1987-07-21
申请号：US715244
申请日：1985-03-25
申请人： Max R. Bendall , David T. Pegg
发明人： Max R. Bendall , David T. Pegg
IPC分类号： G01R33/20 , G01N24/08 , G01R33/341 , G01R33/44 , G01R33/465 , G01R33/483
CPC分类号： G01R33/341 , G01R33/465 , G01R33/4831
摘要： In a method of operating a nuclear magnetic resonance (NMR) spectrometer in relation to a sample comprising two types of nuclei, a sequence of radiofrequency pulses and delay periods is applied using two different radiofrequency coils, one for each type of nucleus, each coil providing an inhomogeneous radiofrequency field, so that the two coils generate separate but overlapping sensitive volumes for each of the two types of nuclear species, whereby signal intensity is substantially limited to the overlap volume.
摘要翻译：相对于包含两种类型的核的样品来操作核磁共振（NMR）光谱仪的方法，使用两种不同的射频线圈施加射频脉冲和延迟周期序列，每种类型的核一个，每个线圈提供两个线圈对于两种类型的核物种中的每一种产生分开但重叠的灵敏体积，由此信号强度基本上限于重叠体积。

5. 发明授权

US4486709A Depth and refocusing pulses for use with inhomogeneous radiofrequency coils in nuclear magnetic resonance spectroscopy 失效
标题翻译：用于核磁共振光谱学中不均匀射频线圈的深度和重聚焦脉冲
公开(公告)号：US4486709A
公开(公告)日：1984-12-04
申请号：US443607
申请日：1982-11-22
申请人： Max R. Bendall
发明人： Max R. Bendall
IPC分类号： G01R33/341 , G01R33/465 , G01R33/48 , G01R33/08
CPC分类号： G01R33/446 , G01R33/341 , G01R33/465
摘要： In a pulsed nuclear magnetic resonance method of analysis, in which a single radiofrequency pulse is applied using an irradiation coil which provides an inhomogeneous radiofrequency field across the sample volume, the inhomogeneity of this field ensures that some sample regions experience a radiofrequency pulse which is closer to a .pi./2 pulse angle than for other regions, resulting in a larger signal intensity from the former regions as compared to the latter. If a second pulse is applied after the first, prior to acquisition of the signal, and if the phase of this pulse is alternated through the four phases: 0.degree., 90.degree., 180.degree. and 270.degree., during a series of transients, then, provided the receiver phase is changed by 180.degree. when the second pulse phase is changed by 90.degree., the signal intensity will accumulate from regions where the second pulse angle is .pi. radians and there will be discrimination against regions where the second pulse angle differs markedly from .pi. radians. This discrimination towards certain sample regions can be improved by adding further pulses after the second pulse provided the phase of each additional pulse is alternated through all four 90.degree. phase shifts, during a series of transients, independently of the phase alternation of the other pulses, and provided that for each individual 90.degree. phase shift, the receiver phase is changed by 180.degree.. In its simplest form, such a series of pulses may be represented by .theta.;(2.theta.[.+-.x,.+-.y]).sub.n indicating n phase alternated pulses additional to the first excitation pulse, where these additional pulses are twice as long as the first pulse.
摘要翻译：在脉冲核磁共振分析方法中，使用在样品体积上提供不均匀的射频场的照射线圈施加单个射频脉冲，该场的不均匀性确保了一些采样区域经历更接近的射频脉冲与其他区域相比为π/ 2脉冲角，导致与后者相比较，来自前一个区域的信号强度较大。如果在第一次施加第二个脉冲之后，在采集信号之前，如果在一系列瞬变期间该脉冲的相位在0°，90°，180°和270°四个相位之间交替，则只要第二个脉冲相位改变90°，接收机相位改变180°，信号强度将从第二个脉冲角度为pi弧度的区域累积，并且将区分第二个脉冲角度明显不同的区域从pi弧度。通过在第二脉冲之后添加进一步脉冲，可以改善对某些采样区域的区分，只要每一个附加脉冲的相位在一系列瞬变期间在所有四个90°相移之间交替，而与其它脉冲的相位交替无关，并且对于每个单独的90°相移，接收器相位改变180°。在其最简单的形式中，这样的一系列脉冲可以由θ表示;（2θ[+/- x，+ / - y]）n表示第一激励脉冲附加的n相交变脉冲，其中这些附加脉冲是两倍只要第一脉冲。

6. 发明授权

US4742303A Depth and refocusing pulses for use with inhomogeneous radiofrequency coils in nuclear magnetic resonance spectroscopy 失效
标题翻译：用于核磁共振光谱学中不均匀射频线圈的深度和重聚焦脉冲
公开(公告)号：US4742303A
公开(公告)日：1988-05-03
申请号：US775573
申请日：1985-09-13
申请人： Max R. Bendall
发明人： Max R. Bendall
IPC分类号： G01R33/341 , G01R33/465 , G01R33/48 , G01R33/20
CPC分类号： G01R33/446 , G01R33/341 , G01R33/465
摘要： In a pulsed nuclear magnetic resonance method of analysis, a series of phase cycled radiofrequency pulses of the form 2.theta.; .theta.[.+-.x]; (2.theta.[.+-.,.+-.y]).sub.4, called a depth pulse scheme, may be applied using an irradiation coil which provides an inhomogeneous radiofrequency field across the sample volume, so that signals may only be detected from sample regions where the pulse angle .theta. is close to m.pi./2, where m is an odd integer. However, signals from regions where .theta.=3.pi./2 or 5.pi./2, if such regions exist, can be eliminated by varying some of the pulses from their ideal .theta. of 2.theta. values. The sample discrimination afforded by means of these pulse schemes may be improved by using static or pulsed magnetic field gradients or by using more than one radiofrequency coil.
摘要翻译：在脉冲核磁共振分析方法中，一系列相位循环射频脉冲形式为2θ; theta [+/- x]; 称为深度脉冲方案的2θ[+ / - ，+ / - y]）4可以使用在样本体积上提供不均匀的射频场的照射线圈来施加，使得仅可以从样本区域检测信号其中脉冲角θ接近于m pi / 2，其中m是奇整数。然而，如果存在这样的区域，则θ=3π/ 2或5π/ 2的区域的信号可以通过从它们的2θ值的理想θ中改变一些脉冲来消除。通过使用静态或脉冲磁场梯度或通过使用多于一个射频线圈，可以改善通过这些脉冲方案提供的样本鉴别。

7. 发明授权

US4728896A Method and apparatus for obtaining N.M.R. spectra and coils for use therein 失效
标题翻译：用于获得N.M.R.的方法和装置光谱和线圈
公开(公告)号：US4728896A
公开(公告)日：1988-03-01
申请号：US759881
申请日：1985-07-29
申请人： Max R. Bendall , Jamie M. McKendry
发明人： Max R. Bendall , Jamie M. McKendry
IPC分类号： G01R33/28 , G01R33/34 , G01R33/36 , G01R33/465 , G01R33/483 , G01R33/20
CPC分类号： G01R33/341 , G01R33/28 , G01R33/34046 , G01R33/3628 , G01R33/465 , G01R33/4831
摘要： Use of a switch at the end of a .lambda./4 cable inserted between the Rf coil and ground allows the coil to be tuned and detuned at will. This detune switch essentially eliminates coupling between adjacent coils permitting operation of multiple transmit coils at the same frequency. These switches have been employed to prove a previously proposed method of complete sensitive-volume localization using multiple Rf coils and depth pulse schemes. The example illustrated is the case of two coaxial coplanar surface coils. There are important uses in in-vivo spectroscopy.
摘要翻译：在RF线圈和地线之间插入的λ/ 4电缆末端使用开关可以使线圈被调谐并随意失谐。该分路开关基本上消除了相邻线圈之间的耦合，允许在相同频率下操作多个发射线圈。已经使用这些开关来证明先前提出的使用多个Rf线圈和深度脉冲方案的完全灵敏体积定位的方法。所示的示例是两个同轴共面表面线圈的情况。在体内光谱学中有重要的用途。

8. 发明授权

US4812764A Calibrated decoupling of tightly coupled concentric surface coils 失效
标题翻译：紧密耦合的同心面线圈的校准去耦
公开(公告)号：US4812764A
公开(公告)日：1989-03-14
申请号：US175700
申请日：1988-03-31
申请人： Max R. Bendall
发明人： Max R. Bendall
IPC分类号： A61B5/055 , G01R33/34 , G01R33/36 , G01R33/20
CPC分类号： G01R33/365 , G01R33/3664
摘要： A pair of coupled surface coils are arranged to provide active detuning whereby the shape of the RF field due to the RF current in one coil is modified in a calibrated fashion by the RF current in the second coil whereby a selected fraction of the RF field of one coil may be selectively added or substracted from the RF field of the one other coil thereby shaping the RF field.

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