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1. 发明授权

US09986916B2 Catheter comprising capacitive micromachined ultrasonic transducers with an adjustable focus 有权
公开(公告)号：US09986916B2
公开(公告)日：2018-06-05
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61B8/08 , A61B8/12 , A61B5/01 , A61N7/02 , B06B1/02 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00 , A61B5/06 , A61B6/12 , A61B8/00 , A61B18/00 , A61N7/00 , A61B90/00
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) includes a shaft with distal (808, 906, 1004, 208) and proximal ends (1006). The distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210). A connector (1012) at the proximal end supplies the at least one array of capacitive micromachined ultrasound transducers with electrical power and controls the adjustable focus.

2. 发明申请

US20140005521A1 CATHETER COMPRISING CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCERS WITH AN ADJUSTABLE FOCUS 有权
标题翻译：包含具有可调焦点的电容式微超声波超声波传感器的导管
公开(公告)号：US20140005521A1
公开(公告)日：2014-01-02
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61N7/02 , A61B5/055 , A61B5/01 , A61B6/00 , A61B8/12 , A61B8/00 , A61B5/00 , A61B6/03
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) comprising: a shaft with distal (808, 906, 1004, 208) and proximal ends (1006),wherein the distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210); and a connector (1012) at the proximal end for supplying the at least one array of capacitive micromachined ultrasound transducers with electrical power and for controlling the adjustable focus.
摘要翻译：导管（700,800,1206）包括：具有远端（808,906,1004,208）和近端（1006）的轴，其中所述远端包括至少一个电容微加工超声换能器阵列（308,402，具有可调焦点，用于可控制地加热目标区域（806,104,1210）; 以及在所述近端处的用于向所述至少一个电容微加工超声换能器阵列供电并用于控制所述可调焦点的连接器（1012）。

3. 发明授权

US08193685B2 Thin film detector for presence detection 有权
标题翻译：用于存在检测的薄膜检测器
公开(公告)号：US08193685B2
公开(公告)日：2012-06-05
申请号：US12666831
申请日：2008-06-30
申请人： Mareike Klee , Ronald Dekker , Harry Van Esch , Marco De Wild , Ruediger Mauczok , Chris Van Heesch , Willem Franke Pasveer , Engel Johannes Knibbe , Remco Alphonsus Hendrikus Breen , Klaus Reimann , Biju Kumar Sreedharan Nair , Roger Peter Anna Delnoij , Henri Marie Joseph Boots , Christina Adriana Renders , Olaf Wunnicke , Derk Reefman , Peter Dirksen
发明人： Mareike Klee , Ronald Dekker , Harry Van Esch , Marco De Wild , Ruediger Mauczok , Chris Van Heesch , Willem Franke Pasveer , Engel Johannes Knibbe , Remco Alphonsus Hendrikus Breen , Klaus Reimann , Biju Kumar Sreedharan Nair , Roger Peter Anna Delnoij , Henri Marie Joseph Boots , Christina Adriana Renders , Olaf Wunnicke , Derk Reefman , Peter Dirksen
IPC分类号： H01L41/08
CPC分类号： B06B1/0603 , B06B1/0292 , G08B13/1645 , H01L27/20 , H01L41/0973 , H01L41/314 , Y10T29/42
摘要： A transducer (800) is provided where a membrane (830) is formed over a front substrate (615); and a piezoelectric layer (820) is formed over the membrane (830) at an active portion (821) and peripheral portions located adjacent the active portion (821). A patterned conductive layer including first and second electrodes (840, 845) is formed over the piezoelectric layer (820). Further, a back substrate structure is provided having supports (822, 824) located at the peripheral portions adjacent the active portion (821). The height (826) of the supports (822, 824) is greater than a combined height (828) of the patterned piezoelectric layer and the patterned conductive layer. Many transducers may be connected to form an array, where a controller may be provided for controlling the array, such as steering a beam of the array, and processing signals received by the array, for presence or motion detection and/or imaging, for example.
摘要翻译：提供换能器（800），其中膜（830）形成在前基板（615）上方; 并且在有源部分（821）和靠近有效部分（821）的周边部分之间在膜（830）上形成压电层（820）。包括第一和第二电极（840,845）的图案化导电层形成在压电层（820）上方。此外，背面基板结构设置有位于与活动部分（821）相邻的周边部分处的支撑件（822,824）。支撑件（822,824）的高度（826）大于图案化压电层和图案化导电层的组合高度（828）。可以连接许多换能器以形成阵列，其中可以提供用于控制阵列的控制器，例如转向阵列的波束，以及处理由阵列接收的信号，用于存在或运动检测和/或成像，例如。

4. 发明申请

US20100277040A1 THIN FILM DETECTOR FOR PRESENCE DETECTION 有权
标题翻译：薄膜检测器用于存在检测
公开(公告)号：US20100277040A1
公开(公告)日：2010-11-04
申请号：US12666831
申请日：2008-06-30
申请人： Mareike Klee , Klaus Reimann , Biju K. Sreedharan Nair , Roger Peter Anna Delnoij , Henri M. J. Boots , Christina A. Renders , Olaf Wunnicke , Derk Reefman , Peter Dirksen , Ronald Dekker , Harry Van Esch , Marco De Wild , Ruediger Mauczok , Chris Van Heesch , Willem F. Pasveer , Engel Johannes Knibbe , Remco A.H. Breen
发明人： Mareike Klee , Klaus Reimann , Biju K. Sreedharan Nair , Roger Peter Anna Delnoij , Henri M. J. Boots , Christina A. Renders , Olaf Wunnicke , Derk Reefman , Peter Dirksen , Ronald Dekker , Harry Van Esch , Marco De Wild , Ruediger Mauczok , Chris Van Heesch , Willem F. Pasveer , Engel Johannes Knibbe , Remco A.H. Breen
IPC分类号： H01L41/04 , H04R17/00 , H01L41/053
CPC分类号： B06B1/0603 , B06B1/0292 , G08B13/1645 , H01L27/20 , H01L41/0973 , H01L41/314 , Y10T29/42
摘要： A transducer (800) is provided where a membrane (830) is formed over a front substrate (615); and a piezoelectric layer (820) is formed over the membrane (830) at an active portion (821) and peripheral portions located adjacent the active portion (821). A patterned conductive layer including first and second electrodes (840, 845) is formed over the piezoelectric layer (820). Further, a back substrate structure is provided having supports (822, 824) located at the peripheral portions adjacent the active portion (821). The height (826) of the supports (822, 824) is greater than a combined height (828) of the patterned piezoelectric layer and the patterned conductive layer. Many transducers may be connected to form an array, where a controller may be provided for controlling the array, such as steering a beam of the array, and processing signals received by the array, for presence or motion detection and/or imaging, for example.
摘要翻译：提供换能器（800），其中膜（830）形成在前基板（615）上方; 并且在有源部分（821）和靠近有效部分（821）的周边部分之间在膜（830）上形成压电层（820）。包括第一和第二电极（840,845）的图案化导电层形成在压电层（820）上方。此外，背面基板结构设置有位于与活动部分（821）相邻的周边部分处的支撑件（822,824）。支撑件（822,824）的高度（826）大于图案化压电层和图案化导电层的组合高度（828）。可以连接许多换能器以形成阵列，其中可以提供用于控制阵列的控制器，例如控制阵列的波束，以及处理由阵列接收的信号，用于存在或运动检测和/或成像，例如。

5. 发明申请

US20130149215A1 SYSTEM-IN-PACKAGE PLATFORM FOR ELECTRONIC-MICROFLUIDIC DEVICES 有权
标题翻译：用于电子微流体装置的系统级封装平台
公开(公告)号：US20130149215A1
公开(公告)日：2013-06-13
申请号：US13755293
申请日：2013-01-31
申请人： Ronald Dekker , Remco Henricus Wilhelmus Pijnenburg , Nicolaas Johannes Anthonius Van Veen
发明人： Ronald Dekker , Remco Henricus Wilhelmus Pijnenburg , Nicolaas Johannes Anthonius Van Veen
IPC分类号： H01L37/00 , B01L3/00
CPC分类号： H01L37/00 , B01J2219/00783 , B01J2219/0095 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2200/14 , B01L2300/0645 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , B81B2201/058 , B81C1/0023 , H01L2224/11 , Y10T436/11
摘要： The present invention relates to an integrated electronic-microfluidic device an integrated electronic-microfluidic device, comprising a semiconductor substrate (106) on a first (122) support, an electronic circuit (102, 104) on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. The signal interface structure is arranged on the first semiconductor-substrate side and configured to receive electrical signals from the electronic circuit. A microfluidic structure (126) is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away form the first support. The electronic-microfluidic device forms a flexible platform for the formation of various System-in-Package applications. It achieves a clear separation between electrical and wet-chemical interfaces. The claimed method for fabricating the device of the invention also allows a simple formation of thermally isolated microfluidic structures.
摘要翻译：本发明涉及一种集成电子微流体装置，集成的电子微流体装置，其包括在第一（122）支撑件上的半导体衬底（106），电子电路（102,104）的第一半导体衬底半导体衬底和与外部设备的信号接口结构。信号接口结构布置在第一半导体衬底侧并被配置为从电子电路接收电信号。微流体结构（126）形成在半导体衬底中，并且被配置为限制流体并允许仅在与第一半导体衬底相反的第二半导体衬底侧上流体流过微流体结构，衬底侧面和背面形成第一支撑件。电子微流体装置形成用于形成各种系统级封装应用的灵活平台。它实现了电气和湿化学界面之间的清晰分离。所要求的制造本发明装置的方法还允许简单地形成热分离的微流体结构。

6. 发明申请

US20120116209A1 HIGH MAGNETIC FIELD COMPATIBLE INTERVENTIONAL NEEDLE AND INTEGRATED NEEDLE TRACKING SYSTEM 有权
标题翻译：高磁场兼容传统针和集成针脚追踪系统
公开(公告)号：US20120116209A1
公开(公告)日：2012-05-10
申请号：US13265387
申请日：2010-04-13
申请人： Mareike Klee , Axel Winkel , John Brean Mills , Ronald Dekker , Bernardus Hendrikus Wilhelmus Hendriks
发明人： Mareike Klee , Axel Winkel , John Brean Mills , Ronald Dekker , Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： A61B5/055 , H01L21/822 , H01F41/00
CPC分类号： G01R33/287 , G01R33/34007 , G01R33/34084 , Y10T29/4902
摘要： An elongate device (e.g. a catheter) for interventional MRI has one or more passive LC-circuits (wireless markers) attached to its distal tip portion for position tracking. The LC-circuits comprise an inductor winding (480) and a three-dimensional “trench” capacitor (420-440) and are integrated in a piece of silicon (410). Optical fibres may be included in the device for optical probing of tissue surrounding the distal tip portion.
摘要翻译：用于介入MRI的细长装置（例如，导管）具有附接到其远侧末端部分的位置跟踪的一个或多个无源LC电路（无线标记）。 LC电路包括电感器绕组（480）和三维“沟槽”电容器（420-440）并且集成在一块硅片（410）中。光纤可以包括在用于光学探测围绕远端尖端部分的组织的装置中。

7. 发明申请

US20120094323A1 CARDIOMYOCYTES-CONTAINING DEVICE AND METHOD FOR MANUFACTURING AND USING THE SAME 失效
标题翻译：含有血小板活性的装置及其制造和使用方法
公开(公告)号：US20120094323A1
公开(公告)日：2012-04-19
申请号：US13147607
申请日：2010-02-02
申请人： Ronald Dekker , Anja Van De Stolpe
发明人： Ronald Dekker , Anja Van De Stolpe
IPC分类号： C12Q1/18 , H01B13/00 , B05D5/00 , C12M1/34 , B05D1/36
CPC分类号： G01N1/30 , C12N5/0657 , C12N2503/02 , C12N2535/10 , G01N33/5061
摘要： Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.
摘要翻译：公开了一种用于确定化合物的心脏毒性的装置，包括承载可变形叠层（34）的基底（10），所述叠层通过空腔（32）部分地与基底分离，允许外部变形所述堆叠包括夹在所述第一和第二可变形层之间的第一可变形层（16），第二可变形层（20）和多电极结构（18），所述第二可变形层承载心肌细胞图案（28 ）和安装在基板上的用于将心肌细胞暴露于化合物的液体容器（26）。还公开了制造这种装置的方法。本发明还涉及该装置用于药物靶发现和/或药物开发的用途，以及用于开发由细胞拉伸，特别是心脏疾病模型引起或改变的疾病的疾病模型的方法。

8. 发明授权

US07915707B2 Deformable integrated circuit device 有权
标题翻译：可变形集成电路器件
公开(公告)号：US07915707B2
公开(公告)日：2011-03-29
申请号：US12377673
申请日：2007-08-07
申请人： Ronald Dekker , Antoon Marie Henrie Tombeur , Theodoros Zoumpoulidis
发明人： Ronald Dekker , Antoon Marie Henrie Tombeur , Theodoros Zoumpoulidis
IPC分类号： H01L29/00
CPC分类号： H01L23/49833 , H01L23/5387 , H01L2924/0002 , H01L2924/00
摘要： An integrated-circuit device includes a rigid substrate island having a main substrate surface with a circuit region circuit elements and at least one fold structure. The fold structure is attached to the substrate island and is unfoldable from a relaxed, folded state to a strained unfolded state. The fold structure contains at least one passive electrical component. The fold structure further has in its folded state at least one surface with an area vector that includes a non-vanishing area-vector component in a direction parallel to the main substrate surface, which area-vector component is diminished or vanishes when deforming the fold structure from the folded into the unfolded state.
摘要翻译：集成电路器件包括具有主衬底表面的刚性衬底岛，其具有电路区域电路元件和至少一个折叠结构。折叠结构附接到基底岛，并且可以从松弛的折叠状态展开到应变展开状态。折叠结构包含至少一个无源电组件。折叠结构在其折叠状态下进一步具有面向向的至少一个表面，该区域向量在平行于主衬底表面的方向上包括非消失的面积 - 矢量分量，该区域 - 矢量分量在折叠变形时减少或消失结构从折叠到展开状态。

9. 发明授权

US07893632B2 LED luminaire with optical feedback by image mapping on segmented light sensors 有权
标题翻译：具有光分路光传感器图像映射的光学反馈的LED灯具
公开(公告)号：US07893632B2
公开(公告)日：2011-02-22
申请号：US11719298
申请日：2005-11-15
申请人： Eduard Johannes Meijer , Ronald Dekker , Eugene Timmering , Christoph Gerard August Hoelen , Johannes Petrus Maria Ansems
发明人： Eduard Johannes Meijer , Ronald Dekker , Eugene Timmering , Christoph Gerard August Hoelen , Johannes Petrus Maria Ansems
IPC分类号： H05B37/00 , F21V5/00 , F21V5/04
CPC分类号： F21V23/0442 , F21S10/02 , F21V23/0457 , F21Y2115/10 , G01J1/04 , G01J1/0411 , G01J1/0414 , G01J1/32 , G02B19/0028 , G02B19/0066 , G02B19/0085 , H01L25/167 , H01L2924/0002 , H05B33/0869 , H05B37/029 , H01L2924/00
摘要： The present invention relates to a luminaire comprising an array of LEDs emitting light of at least one color, and a control system for controlling the light output of the luminaire. The control system comprises photosensor array for detecting light output of the luminaire. An imaging unit is arranged in front of the photosensor array such that it maps an image of said array of LEDs on said photosensor array. The photosensor array is divided into subareas each detecting light output from a single one of the LEDs. The control system uses the output of the subareas for controlling the luminaire light output. Thus, it is possible to act on different LED light colors or the light output of individual LEDs without having to separate them in time by means of a time pulsing method.
摘要翻译：本发明涉及一种包括发射至少一种颜色的光的LED阵列的照明器和用于控制照明器的光输出的控制系统。控制系统包括用于检测照明器的光输出的光电传感器阵列。成像单元布置在光电传感器阵列的前面，使得它将所述LED阵列的图像映射在所述光传感器阵列上。光传感器阵列被分成每个检测来自单个LED的光输出的子区域。控制系统使用子区域的输出来控制照明器光输出。因此，可以通过时间脉冲方式对不同的LED光颜色或各个LED的光输出作用，而不必在时间上分离它们。

10. 发明授权

US07891836B2 Semiconductor light-emitting device with improved heatsinking 有权
标题翻译：具有改善散热效果的半导体发光器件
公开(公告)号：US07891836B2
公开(公告)日：2011-02-22
申请号：US11577367
申请日：2005-10-17
申请人： Ronald Dekker , Eduard Johannes Meijer , Eugene Timmering , Marc Andre De Samber
发明人： Ronald Dekker , Eduard Johannes Meijer , Eugene Timmering , Marc Andre De Samber
IPC分类号： F21V4/00
CPC分类号： H01L33/647 , H01L33/62 , H01L33/642 , H01L2224/16 , H01L2924/00011 , H01L2924/00014 , H01L2224/0401
摘要： The present invention relates to a light-emitting device comprising a substrate, a circuitry, a LED in electrical connection with said circuitry, and a heat sink arranged to transport heat away from the LED, wherein the LED is in thermal contact with said heat sink through an opening in said substrate. The present invention also relates to methods for the manufacture of such a device.
摘要翻译：本发明涉及一种发光装置，其包括基板，电路，与所述电路电连接的LED，以及布置成将热量从LED传送的散热器，其中所述LED与所述散热片热接触通过所述衬底中的开口。本发明还涉及制造这种装置的方法。

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