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    • 1. 发明授权
    • Normalization apparatus for panel detector PET scanners
    • 面板检测仪PET扫描仪的归一化装置
    • US06963065B2
    • 2005-11-08
    • US10418520
    • 2003-04-18
    • Maurizio ContiJames J. HamillMichael E. CaseyMu Chen
    • Maurizio ContiJames J. HamillMichael E. CaseyMu Chen
    • G01D18/00G01T1/172G01T1/29G12B13/00
    • G01T1/2985A61B6/037
    • A normalization apparatus and method for a PET scanner with panel detectors for obtaining an estimate of a normalization array, for correction for count rate effects on the normalization array, and for measurement of the relation between the normalization array and the count rate. The method of the present invention is based on two quasi-independent radial and axial components, which are count rate dependent due to sensitivity changes across the detector blocks. A scatter source is disposed at the center of the FOV and a scatter-free source is disposed at the outer edge of the FOV. The method computes the normalization array through several steps which evaluate the geometric profile, the axial profile, and the correction factor. A count rate correction is introduced to extend the normalization array to any count rate.
    • 一种具有面板检测器的PET扫描仪的归一化装置和方法,用于获得归一化阵列的估计,用于校正对归一化阵列的计数率影响,以及用于测量归一化阵列与计数率之间的关系。 本发明的方法是基于两个准独立的径向和轴向分量,其由于检测器块两端的灵敏度变化而依次计数。 散射源设置在FOV的中心,并且不分散源设置在FOV的外边缘处。 该方法通过评估几何轮廓,轴向轮廓和校正因子的几个步骤来计算归一化阵列。 引入计数率校正以将归一化数组扩展到任何计数率。
    • 4. 发明授权
    • Transmission attenuation correction method for PET and SPECT
    • PET和SPECT传输衰减校正方法
    • US06429434B1
    • 2002-08-06
    • US09398497
    • 1999-09-17
    • Charles C. WatsonStephen D. MillerRonald NuttMichael E. CaseyJames J. Hamill
    • Charles C. WatsonStephen D. MillerRonald NuttMichael E. CaseyJames J. Hamill
    • G01T1166
    • G01T1/2985A61B6/037G01T1/1648G21K1/02
    • A transmission source serves to detect activity from a radiation source for correcting attenuation in either PET mode or SPECT mode. The transmission source includes a detector dedicated to collecting attenuation data in PET mode. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The transmission source can either be a coincidence transmission source or a singles transmission source and includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. In a dual head tomograph device, one transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera. In SPECT mode, the point source is selected to have sufficiently high energy to shine through the patient and the collimators associated with the imaging detector.
    • 传输源用于检测来自辐射源的活动以校正PET模式或SPECT模式中的衰减。 传输源包括专用于在PET模式下收集衰减数据的检测器。 准直辐射源和检测器相对于断层摄影装置定位,使得只有层析成像仪的成像检测器的选定条带被照亮,从而消除与衰减无关的事件。 传输源可以是重合传输源或单个传输源,并且包括准直仪,其中设置有辐射源。 由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。 相对于成像检测器定位在辐射源之后,是专用的衰减检测器。 在双头断层摄影装置中,本发明的一个发射源与每一组成像检测器相对设置。 源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。 源和检测器相对于成像头是固定的。 为了以与发射扫描相同的方式获得视场(FOV)的全面覆盖,头部和源围绕照相机的中心旋转。 在SPECT模式中,点源被选择为具有足够高的能量以照射通过患者和与成像检测器相关联的准直仪。
    • 6. 发明授权
    • Normalization apparatus for PET and SPECT scanners and method for using same
    • PET和SPECT扫描仪的归一化装置及其使用方法
    • US06774358B2
    • 2004-08-10
    • US10103276
    • 2002-03-21
    • James J. HamillMichael E. CaseyTimothy G. GremillionWing K. LukStephen Miller
    • James J. HamillMichael E. CaseyTimothy G. GremillionWing K. LukStephen Miller
    • G01K500
    • G01T1/2985A61B6/037G01T1/1644
    • Apparatus and methods for simulating a sheet source with a line source for determining normalization coefficients for the detectors in positron emission tomography (PET) scanners and single photon emission computed tomography (SPECT) scanners. A line source, oriented perpendicular to the axis of a scanner gantry, is moved along the axis while the detectors are stationary and positioned substantially parallel to the plane in which the source moves. In another embodiment, an axially mounted line source moves parallel to a diameter of the gantry while the stationary detectors are positioned substantially parallel to the plane in which the source moves. In still another embodiment, the line source is stationary and positioned parallel to the gantry axis and off center while the detectors move relative to the line source. A shaped attenuator is placed around the source in this last embodiment.
    • 用于模拟具有用于确定正电子发射断层摄影(PET)扫描仪和单光子发射计算机断层摄影(SPECT)扫描仪中的检测器的归一化系数的线源的片材源的装置和方法。 垂直于扫描仪台架的轴线定向的线源沿轴线移动,同时检测器是固定的并且基本上平行于源移动的平面定位。 在另一个实施例中,轴向安装的线源平行于台架的直径移动,而固定检测器基本上平行于源移动的平面定位。 在另一个实施例中,线源固定并且平行于台架轴定位并且离开中心,同时检测器相对于线源移动。 在最后一个实施例中,围绕源设置成形的衰减器。
    • 9. 发明授权
    • Fourier re-binning of time-of-flight positron emission tomography data
    • 飞行时间正电子发射断层扫描数据的傅里叶重新分组
    • US07417231B2
    • 2008-08-26
    • US11316590
    • 2005-12-22
    • Michel DefriseMichael E. CaseyChristian J. MichelMaurizio Conti
    • Michel DefriseMichael E. CaseyChristian J. MichelMaurizio Conti
    • G01T1/166
    • G01T1/2985A61B6/037
    • Fast reconstruction methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data re-binning. Starting from pre-corrected 3D TOF data, a re-binning algorithm estimates for each transaxial slice the 2D TOF sinogram. The re-binned sinograms can then be reconstructed using any algorithm for 2D TOF reconstruction. A TOF-FORE (Fourier re-binning of TOF data) algorithm is provided as an approximate re-binning algorithm obtained by extending the Fourier re-binning method for non-TOF data. In addition, two partial differential equations are identified that must be satisfied by consistent 3D TOF data, and are used to derive exact re-binning algorithms and to characterize the degree of the approximation in TOF-FORE. Numerical simulations demonstrate that TOF-FORE is more accurate than two different TOF extensions of the single-slice re-binning method, and suggest that TOF-FORE will be a valuable tool for practical TOF PET in the range of axial apertures and time resolutions typical of current scanners.
    • 基于2D数据重新分组,为3D飞行时间(TOF)正电子发射断层扫描(PET)提供了快速重建方法。 从预校正的3D TOF数据开始,对于每个横轴切片2D TOF正弦图进行重新分类算法。 然后可以使用用于2D TOF重建的任何算法来重构重新合并的正弦图。 提供TOF-FORE(TOF数据的傅里叶重新分组)算法作为通过扩展用于非TOF数据的傅里叶重新分组方法而获得的近似再分类算法。 此外,识别出必须通过一致的3D TOF数据来满足两个偏微分方程,并且用于导出精确的重新分组算法并且表征TOF-FORE中的近似程度。 数值模拟表明,TOF-FORE比单片重新合并方法的两种不同的TOF扩展更为准确,并且表明TOF-FORE将成为实际TOF PET在轴向孔径和时间分辨率范围内的有价值的工具 的当前扫描仪。