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    • 5. 发明申请
    • INJECTION NEEDLE AND DEVICE
    • 注射针和装置
    • US20140121587A1
    • 2014-05-01
    • US14125905
    • 2012-06-13
    • Matti SallbergLars Frelin
    • Matti SallbergLars Frelin
    • A61N1/30
    • A61N1/0502A61K9/0019A61K39/29A61K2039/53A61K2039/54A61M5/3291A61M5/3298A61M5/46A61N1/306A61N1/327C12M35/02C12N7/00C12N2730/10134C12N2770/24234
    • Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a Y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles.
    • 公开了用于将预防和/或治疗材料(即递送的试剂)递送到受试者的组织中的几个针组件和细胞内递送装置。 优选地,针组件和/或细胞内递送装置包括排列成阵列的针和/或针电极(例如,具有三个外针和中心针的Y型阵列),其中阵列中的每个针 具有围绕每个针筒的封闭端和多个孔,并且阵列的外针的针筒上的孔定位成将输送的药剂输送到中心针和/或相邻针的孔,但是 不在由针阵列内的区域限定的活动区域的外侧,并且中心针的针筒上的孔定位成将输送的药剂朝向外针输送。