专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130012865A1 CODON-OPTIMZED HEPATITIS B VIRUS CORE ANTIGEN (HBCAG) 审中-公开
标题翻译： CODON-OPTIMZED HEPATITIS B病毒核抗原（HBCAG）
公开(公告)号：US20130012865A1
公开(公告)日：2013-01-10
申请号：US13514269
申请日：2010-12-14
申请人： Matti Sällberg , Lars Frelin
发明人： Matti Sällberg , Lars Frelin
IPC分类号： A61M5/32 , A61M37/00
CPC分类号： A61M5/3298 , A61M5/19 , A61M5/2033 , A61M5/3158 , A61M5/32 , A61M5/3291 , A61M2005/206 , A61M2005/2414 , A61M2005/3152 , A61M2202/206
摘要： A needle device for the delivery of therapeutic material into tissue comprising a connection to a pressure generation element, a lumen adapted for the passage of a therapeutic material, and a needle barrel, wherein each needle barrel comprises an opening adapted to control and deliver a pressure transmitted from the pressure generation element into a tissue to cause an increase in the permeability of a cell membrane to the therapeutic material.
摘要翻译：一种用于将治疗材料输送到组织中的针装置，包括与压力产生元件的连接，适于治疗材料通过的内腔和针筒，其中每个针筒包括适于控制和递送压力的开口从压力产生元件传递到组织中以引起细胞膜对治疗材料的渗透性的增加。

2. 发明申请

US20110150922A1 IMMUNOGEN PLATFORM 有权
标题翻译：免疫平台
公开(公告)号：US20110150922A1
公开(公告)日：2011-06-23
申请号：US13009824
申请日：2011-01-19
申请人： Matti Sällberg , Jonas Soderholm , Lars Frelin
发明人： Matti Sällberg , Jonas Soderholm , Lars Frelin
IPC分类号： A61K39/35 , C07H21/04 , A61P37/04
CPC分类号： A61K39/12 , A61K39/292 , A61K2039/5152 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55516 , A61K2039/57 , C07K14/005 , C07K2319/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines.
摘要翻译：本发明的方面涉及包括HCV NS3 / 4A序列和T细胞表位的嵌合多肽。实施方案包括编码嵌合NS3 / 4A多肽的核酸，编码的多肽，含有所述核酸的组合物，含有所述嵌合多肽的组合物，以及制备和使用上述组合物的方法，包括但不限于药物和疫苗。

3. 发明授权

US08445663B2 Compositions and methods that enhance an immune response 失效
标题翻译：增强免疫反应的组合物和方法
公开(公告)号：US08445663B2
公开(公告)日：2013-05-21
申请号：US13146755
申请日：2010-01-29
申请人： Matti Sällberg , Lars Frelin
发明人： Matti Sällberg , Lars Frelin
IPC分类号： A61K48/00 , A61K50/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K39/292 , A61K39/39 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55527 , A61K2039/55538 , C07K14/02 , C07K14/1833 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed herein are isolated nucleic acids, compositions of isolated nucleic acids, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune response to a target antigen. Some embodiments of the compositions include hepatitis B core antigen (HBcAg) protein and a heterologous protein antigen. In some embodiments, an isolated nucleic acid encoding hepatitis B core antigen (HBcAg) protein and a heterologous protein antigen is disclosed. Also disclosed herein are methods of administering the composition or isolated nucleic acid to generate an immune response, where HBcAg acts as adjuvant to improve the immune response to the heterologous protein. In certain embodiments, the HBcAg is as a stork or heron hepatitis antigen.
摘要翻译：本文公开了分离的核酸，分离的核酸的组合物和可用于产生，增强或改善对靶抗原的免疫应答的多肽组合物。组合物的一些实施方案包括乙型肝炎核心抗原（HBcAg）蛋白和异源蛋白质抗原。在一些实施方案中，公开了编码乙型肝炎核心抗原（HBcAg）蛋白和异源蛋白质抗原的分离的核酸。本文还公开了施用组合物或分离的核酸以产生免疫应答的方法，其中HBcAg用作佐剂以改善对异源蛋白的免疫应答。在某些实施方案中，HBcAg是鹳或苍鹭肝炎抗原。

4. 发明申请

US20120027795A1 SIMPLE VACCINES FROM DNA LAUNCHED SUICIDAL FLAVIVIRUSES 审中-公开
标题翻译：从DNA推出的简单的疫苗的简单疫苗
公开(公告)号：US20120027795A1
公开(公告)日：2012-02-02
申请号：US13104909
申请日：2011-05-10
申请人： Matti Sallberg , Lars Frelin , Magnus Johansson
发明人： Matti Sallberg , Lars Frelin , Magnus Johansson
IPC分类号： A61K39/295 , A61P31/18 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/545 , C12N2730/10134 , C12N2770/24134 , C12N2770/24234 , C12N2770/28134 , Y02A50/396
摘要： Immunogenic compositions relating to DNA launched suicidal flaviviruses and methods of administering the same are described herein.
摘要翻译：涉及DNA的自杀性黄病毒的免疫原性组合物及其施用方法在本文中描述。

5. 发明申请

US20120010394A1 IMMUNOGEN PLATFORM 有权
标题翻译：免疫平台
公开(公告)号：US20120010394A1
公开(公告)日：2012-01-12
申请号：US13178373
申请日：2011-07-07
申请人： Matti Sällberg , Jonas Soderholm , Lars Frelin
发明人： Matti Sällberg , Jonas Soderholm , Lars Frelin
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/575 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines.
摘要翻译：本发明的方面涉及包括HCV NS3 / 4A序列和T细胞表位的嵌合多肽。实施方案包括编码嵌合NS3 / 4A多肽的核酸，编码的多肽，含有所述核酸的组合物，含有所述嵌合多肽的组合物，以及制备和使用上述组合物的方法，包括但不限于药物和疫苗。

6. 发明授权

US08883169B2 Immunogen platform 有权
标题翻译：免疫原平台
公开(公告)号：US08883169B2
公开(公告)日：2014-11-11
申请号：US13178373
申请日：2011-07-07
申请人： Matti Sällberg , Jonas Soderholm , Lars Frelin
发明人： Matti Sällberg , Jonas Soderholm , Lars Frelin
IPC分类号： A61K48/00 , A61K39/29 , C07K14/005 , A61K50/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/575 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines.
摘要翻译：本发明的方面涉及包括HCV NS3 / 4A序列和T细胞表位的嵌合多肽。实施方案包括编码嵌合NS3 / 4A多肽的核酸，编码的多肽，含有所述核酸的组合物，含有所述嵌合多肽的组合物，以及制备和使用上述组合物的方法，包括但不限于药物和疫苗。

7. 发明申请

US20140121587A1 INJECTION NEEDLE AND DEVICE 有权
标题翻译：注射针和装置
公开(公告)号：US20140121587A1
公开(公告)日：2014-05-01
申请号：US14125905
申请日：2012-06-13
申请人： Matti Sallberg , Lars Frelin
发明人： Matti Sallberg , Lars Frelin
IPC分类号： A61N1/30
CPC分类号： A61N1/0502 , A61K9/0019 , A61K39/29 , A61K2039/53 , A61K2039/54 , A61M5/3291 , A61M5/3298 , A61M5/46 , A61N1/306 , A61N1/327 , C12M35/02 , C12N7/00 , C12N2730/10134 , C12N2770/24234
摘要： Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a Y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles.
摘要翻译：公开了用于将预防和/或治疗材料（即递送的试剂）递送到受试者的组织中的几个针组件和细胞内递送装置。优选地，针组件和/或细胞内递送装置包括排列成阵列的针和/或针电极（例如，具有三个外针和中心针的Y型阵列），其中阵列中的每个针具有围绕每个针筒的封闭端和多个孔，并且阵列的外针的针筒上的孔定位成将输送的药剂输送到中心针和/或相邻针的孔，但是不在由针阵列内的区域限定的活动区域的外侧，并且中心针的针筒上的孔定位成将输送的药剂朝向外针输送。

8. 发明授权

US08258275B2 Immunogen platform 有权
标题翻译：免疫原平台
公开(公告)号：US08258275B2
公开(公告)日：2012-09-04
申请号：US13009824
申请日：2011-01-19
申请人： Matti Sällberg , Jonas Soderholm , Lars Frelin
发明人： Matti Sällberg , Jonas Soderholm , Lars Frelin
IPC分类号： C07H23/00 , A61K39/00 , C07K14/00
CPC分类号： A61K39/12 , A61K39/292 , A61K2039/5152 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55516 , A61K2039/57 , C07K14/005 , C07K2319/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines.
摘要翻译：本发明的方面涉及包括HCV NS3 / 4A序列和T细胞表位的嵌合多肽。实施方案包括编码嵌合NS3 / 4A多肽的核酸，编码的多肽，含有所述核酸的组合物，含有所述嵌合多肽的组合物，以及制备和使用上述组合物的方法，包括但不限于药物和疫苗。

9. 发明授权

US09457183B2 Injection needle and device 有权
标题翻译：注射针和装置
公开(公告)号：US09457183B2
公开(公告)日：2016-10-04
申请号：US14125905
申请日：2012-06-13
申请人： Matti Sallberg , Lars Frelin
发明人： Matti Sallberg , Lars Frelin
IPC分类号： A61N1/30 , A61N1/05 , A61N1/32 , C12M1/42 , A61M5/32
CPC分类号： A61N1/0502 , A61K9/0019 , A61K39/29 , A61K2039/53 , A61K2039/54 , A61M5/3291 , A61M5/3298 , A61M5/46 , A61N1/306 , A61N1/327 , C12M35/02 , C12N7/00 , C12N2730/10134 , C12N2770/24234
摘要： Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a Y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles.
摘要翻译：公开了用于将预防和/或治疗材料（即递送的试剂）递送到受试者的组织中的几个针组件和细胞内递送装置。优选地，针组件和/或细胞内递送装置包括排列成阵列的针和/或针电极（例如，具有三个外针和中心针的Y型阵列），其中阵列中的每个针具有围绕每个针筒的封闭端和多个孔，并且阵列的外针的针筒上的孔定位成将输送的药剂输送到中心针和/或相邻针的孔，但是不在由针阵列内的区域限定的活动区域的外侧，并且中心针的针筒上的孔定位成将输送的药剂朝向外针输送。

10. 发明申请

US20120039842A1 COMPOSITIONS AND METHODS THAT ENHANCE AN IMMUNE RESPONSE 失效
标题翻译：提供免疫应答的组合物和方法
公开(公告)号：US20120039842A1
公开(公告)日：2012-02-16
申请号：US13146755
申请日：2010-01-29
申请人： Matti Sallberg , Lars Frelin
发明人： Matti Sallberg , Lars Frelin
IPC分类号： A61K39/29 , A61P37/04 , A61P31/14 , C07H21/04 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K39/292 , A61K39/39 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55527 , A61K2039/55538 , C07K14/02 , C07K14/1833 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed herein are isolated nucleic acids, compositions of isolated nucleic acids, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune response to a target antigen. Some embodiments of the compositions include hepatitis B core antigen (HBcAg) protein and a heterologous protein antigen. In some embodiments, an isolated nucleic acid encoding hepatitis B core antigen (HBcAg) protein and a heterologous protein antigen is disclosed. Also disclosed herein are methods of administering the composition or isolated nucleic acid to generate an immune response, where HBcAg acts as adjuvant to improve the immune response to the heterologous protein. In certain embodiments, the HBcAg is as a stork or heron hepatitis antigen.
摘要翻译：本文公开了分离的核酸，分离的核酸的组合物和可用于产生，增强或改善对靶抗原的免疫应答的多肽组合物。组合物的一些实施方案包括乙型肝炎核心抗原（HBcAg）蛋白和异源蛋白质抗原。在一些实施方案中，公开了编码乙型肝炎核心抗原（HBcAg）蛋白和异源蛋白质抗原的分离的核酸。本文还公开了施用组合物或分离的核酸以产生免疫应答的方法，其中HBcAg用作佐剂以改善对异源蛋白的免疫应答。在某些实施方案中，HBcAg是鹳或苍鹭肝炎抗原。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式