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1. 发明申请

US20080144959A1 Method and apparatus for pre-processing scans as a preparation for segmenting the same 有权
标题翻译：用于预处理扫描的方法和装置作为分割扫描的准备
公开(公告)号：US20080144959A1
公开(公告)日：2008-06-19
申请号：US11488802
申请日：2006-07-18
申请人： Matthias Rasch , Allen Keel , Christine H. Lorenz
发明人： Matthias Rasch , Allen Keel , Christine H. Lorenz
IPC分类号： G06K9/40
CPC分类号： G06T5/004
摘要： A computer-implemented method for pre-processing image data of a three-dimensional volume includes providing the image data of a vessel, applying a super-sampling filter to the image data to generate super-sampled image data having an increased resolution as compared to the image data, applying an unsharp masking filter to the super-sampled image data for increasing contrast of an edge of the vessel, applying a de-noising filer for removing noise surrounding the edge after applying the unsharp masking filter, and storing the image data after applying the de-noising filter thereto.
摘要翻译：用于预处理三维体积图像数据的计算机实现方法包括提供容器的图像数据，对图像数据应用超采样滤波器以产生具有增加的分辨率的超采样图像数据，与将所述图像数据应用于所述超采样图像数据，以增加所述容器的边缘的对比度;对所述图像数据应用所述图像数据之后，应用去噪滤光器以除去所述边缘周围的噪声;以及存储所述图像数据在其上应用去噪滤波器之后。

2. 发明授权

US07903850B2 Method and apparatus for pre-processing scans by combining enhancement and denoising as a preparation for segmenting the same 有权
标题翻译：通过组合增强和去噪作为分割扫描的准备来预处理扫描的方法和装置
公开(公告)号：US07903850B2
公开(公告)日：2011-03-08
申请号：US11488802
申请日：2006-07-18
申请人： Matthias Rasch , Allen Keel , Christine H Lorenz
发明人： Matthias Rasch , Allen Keel , Christine H Lorenz
IPC分类号： G06K9/00
CPC分类号： G06T5/004
摘要： A computer-implemented method for pre-processing image data of a three-dimensional volume includes providing the image data of a vessel, applying a super-sampling filter to the image data to generate super-sampled image data having an increased resolution as compared to the image data, applying an unsharp masking filter to the super-sampled image data for increasing contrast of an edge of the vessel, applying a de-noising filer for removing noise surrounding the edge after applying the unsharp masking filter, and storing the image data after applying the de-noising filter thereto.
摘要翻译：用于预处理三维体积图像数据的计算机实现方法包括提供容器的图像数据，对图像数据应用超采样滤波器以产生具有增加的分辨率的超采样图像数据，与将所述图像数据应用于所述超采样图像数据，以增加所述容器的边缘的对比度;对所述图像数据应用所述图像数据之后，应用去噪滤光器以除去所述边缘周围的噪声;以及存储所述图像数据在其上应用去噪滤波器之后。

3. 发明授权

US08874213B2 System and method for monitoring diastolic function using an implantable medical device 有权
标题翻译：使用可植入医疗装置监测舒张功能的系统和方法
公开(公告)号：US08874213B2
公开(公告)日：2014-10-28
申请号：US13601569
申请日：2012-08-31
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , A61N1/37 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3712
摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.
摘要翻译：使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。来自这些代理值的度量来表示舒张功能。随着时间的推移跟踪度量以评估舒张功能的变化。在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

4. 发明授权

US08798765B2 Determination of cardiac resynchronization therapy settings 有权
标题翻译：心脏再同步治疗设置的测定
公开(公告)号：US08798765B2
公开(公告)日：2014-08-05
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365 , A61N1/372 , A61N1/368
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

5. 发明授权

US08571642B2 Pre-ejection interval (PEI) monitoring devices, systems and methods 有权
标题翻译：预喷射间隔（PEI）监测装置，系统和方法
公开(公告)号：US08571642B2
公开(公告)日：2013-10-29
申请号：US12882084
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/02
CPC分类号： A61B5/0456 , A61B5/02028 , A61B5/0295 , A61B5/0422 , A61B5/686 , A61B5/7239 , A61N1/3684
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's pre-ejection interval (PEI). A signal indicative of cardiac electrical activity and a signal indicative of changes in arterial blood volume are obtained. One or more predetermined features of the signal indicative of cardiac electrical activity and the signal indicative of changes in arterial blood volume are detected. The patient's PEI is determined by determining an interval between the predetermined feature of the signal indicative of cardiac electrical activity and the predetermined feature of the signal indicative of changes in arterial blood volume.
摘要翻译：本文提供了可植入系统及其使用的方法，用于监测患者的预喷射间隔（PEI）。获得指示心脏电活动的信号和指示动脉血容量变化的信号。检测到指示心脏电活动的信号的一个或多个预定特征以及指示动脉血容量变化的信号。通过确定指示心脏电活动的信号的预定特征与指示动脉血容量变化的信号的预定特征之间的间隔来确定患者的PEI。

6. 发明申请

US20110098770A1 SYSTEMS AND METHODS FOR OPTIMIZING MULTI-SITE LEFT VENTRICULAR PACING BASED ON INTERELECTRODE CONDUCTION DELAYS 有权
标题翻译：基于电介质导通延迟优化多位置左心室的系统和方法
公开(公告)号：US20110098770A1
公开(公告)日：2011-04-28
申请号：US12607817
申请日：2009-10-28
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, MSLV interelectrode conduction delays are determined among the electrodes of the multi-pole LV lead. MSLV interelectrode pacing delays are then set based on the MSLV interelectrode conduction delays for use in delivering MSLV pacing. To this end, various criteria are exploited for determining optimal values for the pacing delays based on the interelectrode conduction delays. MSLV pacing is then controlled using the specified MSLV interelectrode pacing delays. In some examples, the optimization procedure is performed by the implantable device itself. In other examples, the procedure is performed by an external programmer device. In such an embodiment, the external device determines optimal MSLV interelectrode pacing delays and then transmits programming commands to the implantable device to program the device to use the pacing delays.
摘要翻译：提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。在一个示例中，在多极LV引线的电极之间确定MSLV电极间导电延迟。然后根据MSLV电极间传导延迟来设置MSLV电极间起搏延迟，以用于传递MSLV起搏。为此，利用各种标准来确定基于电极间传导延迟的起搏延迟的最佳值。然后使用指定的MSLV电极间起搏延迟来控制MSLV起搏。在一些示例中，优化过程由可植入装置本身执行。在其他示例中，该过程由外部编程器设备执行。在这样的实施例中，外部设备确定最佳MSLV电极间起搏延迟，然后将编程命令发送到可植入设备，以对设备进行编程以使用起搏延迟。

7. 发明授权

US08478388B2 Cardiac coordinate system for motion analysis 有权
标题翻译：用于运动分析的心脏坐标系
公开(公告)号：US08478388B2
公开(公告)日：2013-07-02
申请号：US12755359
申请日：2010-04-06
申请人： Thao Thu Nguyen , Kjell Norén , Allen Keel , Kyungmoo Ryu , Stuart Rosenberg , Wenbo Hou , Steve Koh , Michael Yang
发明人： Thao Thu Nguyen , Kjell Norén , Allen Keel , Kyungmoo Ryu , Stuart Rosenberg , Wenbo Hou , Steve Koh , Michael Yang
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/042 , A61B5/7203 , A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36578 , A61N1/3684 , A61N1/37258 , A61N1/37264
摘要： An exemplary method includes accessing cardiac information acquired via a catheter located at various positions in a venous network of a heart of a patient wherein the cardiac information comprises position information with respect to time for one or more electrodes of the catheter; performing a principal component analysis on at least some of the position information; and selecting at least one component of the principal component analysis to represent an axis of a cardiac coordinate system. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括访问经由位于患者心脏的静脉网络中的各个位置的导管获取的心脏信息，其中所述心脏信息包括相对于导管的一个或多个电极的时间的位置信息; 对至少一些所述位置信息进行主成分分析; 以及选择所述主成分分析的至少一个分量来表示心脏坐标系的轴。还公开了各种其它方法，装置，系统等。

8. 发明申请

US20120330371A1 SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗装置监测脱脂功能的系统和方法
公开(公告)号：US20120330371A1
公开(公告)日：2012-12-27
申请号：US13601569
申请日：2012-08-31
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3712
摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.
摘要翻译：使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。来自这些代理值的度量来表示舒张功能。随着时间的推移跟踪度量以评估舒张功能的变化。在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

9. 发明申请

US20120191154A1 System and Method for ATP Treatment Utilizing Multi-Electrode Left Ventricular Lead 审中-公开
标题翻译：使用多电极左心室铅的ATP治疗的系统和方法
公开(公告)号：US20120191154A1
公开(公告)日：2012-07-26
申请号：US13012574
申请日：2011-01-24
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Richard Williamson , Mark Carlson
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Richard Williamson , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3622 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： An implantable medical device includes a lead configured to be located proximate to the left ventricle (LV) of the heart, the lead including multiple LV electrodes to sense cardiac activity at multiple LV sensing sites. The a detection module to detect an arrhythmia that represents at least one of a tachycardia and fibrillation based at least in part on the cardiac activity sensed at the multiple LV sensing sites. The ATP therapy module to identify at least one of an ATP configuration or an ATP therapy site based on the cardiac sensed activity at the LV sensing sites, the ATP therapy module to control delivery of antitachycardia pacing (ATP) therapy at the ATP therapy site. The ATP therapy module delivers a stimulus to electrodes at one or more of an LV site, right ventricular (RV) site and right atrial (RA) site, the detection module to sense evoked responses at the LV sensing sites, the ATP therapy module to designate the ATP therapy site to include at least the LV sensing site with a shortest activation time relative to the one or more LV site, RV site and RA site where the stimulus is delivered.
摘要翻译：可植入医疗装置包括被配置为位于心脏左心室（LV）附近的引线，该引线包括多个LV电极以感测多个LV感测部位的心脏活动。该检测模块至少部分地基于在多个LV感测位点处感测到的心脏活动来检测代表心动过速和颤动中的至少一种的心律失常。 ATP治疗模块基于LV感测位点处的心脏感测活动来鉴定ATP配置或ATP治疗部位中的至少一个，ATP治疗模块用于控制ATP治疗部位的抗心动过速起搏（ATP）治疗的递送。 ATP治疗模块向LV位点，右心室（RV）位点和右心房（RA）位点的一个或多个处的电极施加刺激，检测模块用于感测LV感测位点处的诱发反应，ATP治疗模块指定ATP治疗部位至少包括相对于传递刺激物的一个或多个LV部位，RV部位和RA部位具有最短激活时间的LV感测部位。

10. 发明授权

US08195292B2 Cardiac resynchronization therapy optimization using parameter estimation from realtime electrode motion tracking 有权
标题翻译：心脏再同步治疗优化使用实时电极运动跟踪的参数估计
公开(公告)号：US08195292B2
公开(公告)日：2012-06-05
申请号：US12398460
申请日：2009-03-05
申请人： Stuart Rosenberg , Kjell Noren , Kyungmoo Ryu , Wenbo Hou , Allen Keel , Michael Yang
发明人： Stuart Rosenberg , Kjell Noren , Kyungmoo Ryu , Wenbo Hou , Allen Keel , Michael Yang
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/0422 , A61B5/06 , A61B34/20 , A61N1/36578 , A61N1/3684 , A61N1/37235 , G06F19/00 , G06F19/3481 , G16H40/63 , G16H50/50
摘要： An exemplary method includes providing at least two-dimensional position information, for at least two points in time, for an electrode located in a cardiac space; determining a local estimator based on the position information; and, based at least in part on the determined local estimator, selecting a configuration for delivering a cardiac pacing therapy or diagnosing a cardiac condition. Exemplary methods for regional estimators and exemplary methods for global estimators are also disclosed along with devices and systems configured to perform various methods.
摘要翻译：一种示例性方法包括为至少两个时间点为位于心脏空间中的电极提供至少二维位置信息; 基于所述位置信息确定本地估计器; 并且至少部分地基于所确定的本地估计器，选择用于递送心脏起搏治疗或诊断心脏病症的配置。还公开了用于全局估计器的区域估计器和示例性方法的示例性方法以及被配置为执行各种方法的设备和系统。

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