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1. 发明授权

US08263139B2 Protein kinase modulation by hops and Acacia products 有权
标题翻译：蛋白激酶调制由啤酒花和相思产品
公开(公告)号：US08263139B2
公开(公告)日：2012-09-11
申请号：US11501393
申请日：2006-08-09
申请人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
IPC分类号： A61K36/00
CPC分类号： A61K36/185 , A61K31/12 , A61K36/48 , A61K45/06 , A61K2300/00
摘要： Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
摘要翻译：公开了调节激酶活性的植物化合物。所公开的化合物和方法还抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并且选择性地抑制炎症反应。组合物含有至少一个分离或衍生自啤酒花或金合欢的馏分。

2. 发明授权

US07736677B2 Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment 失效
标题翻译：黄酮和四氢异恶唑酸蛋白激酶调节癌症治疗
公开(公告)号：US07736677B2
公开(公告)日：2010-06-15
申请号：US11820568
申请日：2007-06-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译：公开了用于癌症治疗的蛋白激酶调节的化合物和方法。所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。

3. 发明申请

US20110021637A1 XANTHOHUMOL AND TETRAHYDRO-ISOALPHA ACID BASED PROTEIN KINASE MODULATION CANCER TREATMENT 审中-公开
标题翻译：甘氨酸和四氢叶酸 - 基于醋酸的蛋白质激酶调控癌症治疗
公开(公告)号：US20110021637A1
公开(公告)日：2011-01-27
申请号：US12754820
申请日：2010-04-06
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
IPC分类号： A61K31/12 , A61P35/00
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译：公开了用于癌症治疗的蛋白激酶调节的化合物和方法。所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。

4. 发明申请

US20100137449A1 SUBSTITUTED 1,3-CYCLOPENTADIONE MULTI-TARGET PROTEIN KINASE MODULATORS OF CANCER, ANGIOGENESIS AND THE INFLAMMATORY PATHWAYS ASSOCIATED THEREWITH 审中-公开
标题翻译：取代的1,3-CYCLOPENTADIONE多靶点蛋白激酶调节因子与癌细胞，血管生成以及与之相关的炎症途径
公开(公告)号：US20100137449A1
公开(公告)日：2010-06-03
申请号：US12331887
申请日：2008-12-10
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
IPC分类号： A61K31/122 , A61P35/00 , A61P9/10
CPC分类号： A61K31/12 , A61K45/06 , A61K2300/00
摘要： Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds.
摘要翻译：公开了用于血管生成，癌症治疗或与这些病症相关的炎症途径的多靶向蛋白激酶调节的化合物和方法。所公开的化合物和方法是基于取代的1,3-环戊二酮化合物。

5. 发明授权

US08206753B2 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes 有权
标题翻译：用于治疗代谢综合征和糖尿病的抗炎植物产品
公开(公告)号：US08206753B2
公开(公告)日：2012-06-26
申请号：US11635305
申请日：2006-12-07
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Linda M. Pacioretty
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Linda M. Pacioretty
IPC分类号： A01N65/00
CPC分类号： A61K36/48 , A61K36/185 , A61K36/23 , A61K36/282 , A61K36/31 , A61K36/73 , A61K36/80 , A61K2300/00
摘要： Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions, kits, and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs.
摘要翻译：公开了用于治疗代谢综合征和类型2的糖尿病的基于植物学的组合物和方法。另外公开了组合物，试剂盒和方法，以增加鉴定的葡萄糖和胰岛素调节药物的活性。

6. 发明申请

US20130064913A1 ANTI-INFLAMMATORY BOTANICAL PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES 审中-公开
标题翻译：用于治疗代谢综合征和糖尿病的抗炎药物
公开(公告)号：US20130064913A1
公开(公告)日：2013-03-14
申请号：US13486505
申请日：2012-06-01
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Linda M. Pacioretty
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Linda M. Pacioretty
IPC分类号： A61K36/48 , A61K31/122 , A61P3/00 , C07D311/32 , C07C49/84 , C07C49/794 , A61K31/12 , A61K31/353
CPC分类号： A61K36/48 , A61K36/185 , A61K36/23 , A61K36/282 , A61K36/31 , A61K36/73 , A61K36/80 , A61K2300/00
摘要： Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions, kits, and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs.
摘要翻译：公开了用于治疗代谢综合征和类型2的糖尿病的基于植物学的组合物和方法。另外公开了组合物，试剂盒和方法，以增加鉴定的葡萄糖和胰岛素调节药物的活性。

7. 发明申请

US20100215782A1 NOVEL MITOCHONDRIAL UNCOUPLING METHODS AND COMPOSITIONS FOR ENHANCING ADIPOCYTE THERMOGENESIS 审中-公开
标题翻译：新型麻醉解除方法和组合物，用于增强ADIPOCYTE THERMOGENESIS
公开(公告)号：US20100215782A1
公开(公告)日：2010-08-26
申请号：US12581967
申请日：2009-10-20
申请人： John G. Babish , Linda M. Pacioretty , Matthew L. Tripp , Jeffrey S. Bland
发明人： John G. Babish , Linda M. Pacioretty , Matthew L. Tripp , Jeffrey S. Bland
IPC分类号： A61K36/00 , A61K36/185 , A61K36/82 , A61K36/38 , A61K36/899 , A61K31/235 , A61K31/12 , A61K31/05 , A61P3/00 , A61K36/48 , A61K36/72
CPC分类号： A61K31/05 , A61K36/00 , A61K2300/00
摘要： Disclosed are methods, compounds, and compositions comprising botanically based drugs, medical foods, and dietary supplements for the prevention and treatment of metabolic disorders, in particular obesity, weight gain, insulin resistance syndromes, diabetes, fasting hyperlipidemia and osteoarthritis. More specifically, the invention relates to pharmaceutical therapeutic methods and compositions utilizing phytochemicals, natural plant extracts and combinations to modify adipocyte physiology to enhance thermogenesis and modify cytokine secretion.
摘要翻译：本发明涉及用于预防和治疗代谢紊乱，特别是肥胖，体重增加，胰岛素抵抗综合征，糖尿病，禁食性高脂血症和骨关节炎的基于植物药物的药物，医疗食品和膳食补充剂的方法，化合物和组合物。更具体地，本发明涉及利用植物化学物质，天然植物提取物和组合来改变脂肪细胞生理学以增强产热和修饰细胞因子分泌的药物治疗方法和组合物。

8. 发明授权

US06733793B2 Oral composition with insulin-like activities and methods of use 失效
标题翻译：具有胰岛素样活性的口服组合物和使用方法
公开(公告)号：US06733793B2
公开(公告)日：2004-05-11
申请号：US10163254
申请日：2002-06-04
申请人： Linda M. Pacioretty , John G. Babish
发明人： Linda M. Pacioretty , John G. Babish
IPC分类号： A61K3324
CPC分类号： A61K31/28 , A23L33/10 , A23L33/16 , A23V2002/00 , A61K31/185 , A61K31/385 , A61K33/24 , Y10S514/866 , Y10S514/904 , Y10S514/905 , Y10S514/909 , A61K2300/00 , A23V2250/1636 , A23V2250/026 , A23V2250/0644 , A23V2250/1586 , A23V2250/0612
摘要： An orally administered, novel dietary supplement or therapeutic composition capable of insulin-like activity in animals, preferably humans, is provided. Contained in the composition are therapeutically effective amounts of vanadyl sulfate, alpha-lipoic acid, taurine, and chromium carnitine. The composition is preferably orally administered on a daily basis for at least about 4 weeks and can be used by normal, healthy individuals as well as diabetics.
摘要翻译：提供了一种口服给药的新型膳食补充剂或能够在动物，优选人类中具有胰岛素样活性的治疗组合物。组合物中含有治疗有效量的硫酸氧钒，α-硫辛酸，牛磺酸和铬肉碱。组合物优选每天口服给药至少约4周，并且可由正常健康个体以及糖尿病患者使用。

9. 发明授权

US06780596B2 Methods for determining the activity of complex mixtures 失效
标题翻译：确定复杂混合物活性的方法
公开(公告)号：US06780596B2
公开(公告)日：2004-08-24
申请号：US09156741
申请日：1998-09-17
申请人： John G. Babish , Linda M. Pacioretty , M. Lisa Lee
发明人： John G. Babish , Linda M. Pacioretty , M. Lisa Lee
IPC分类号： G01N3303
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/505 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： According to the present invention, the biological or pharmacological activity of a test material like a plant or herbal material, an extract of a plant or herbal material, a natural or synthetic compound or some combination thereof, can be quantified by observing the pattern of structural changes induced in a eukaryotic cell's proteins. These structural changes may be evidenced by protein phosphorylation, by protein-protein interactions and the like. The amount and nature of protein phosphorylation is qualitatively and quantitatively related to the in vitro concentration of biologically/pharmacologically active components to which the mammalian cells are exposed. Additionally, formation or loss of protein-protein complexes may be determined in whole cell homogenates through the use of non-denaturing electrophoresis and staining for proteins or protein phosphorylation. The present invention allows natural products to be formulated into nutritional supplements and pharmacological preparations of consistent biological/pharmacological activity without the need to identify any of the chemical constituents responsible for the biological or pharmacological response.
摘要翻译：根据本发明，可以通过观察结构的图案来量化测试材料如植物或草药材料，植物提取物或草药材料，天然或合成化合物或其组合的生物或药理学活性在真核细胞的蛋白质中诱导的变化。这些结构变化可以通过蛋白质磷酸化，蛋白质 - 蛋白质相互作用等来证明。蛋白质磷酸化的量和性质定性和定量地与哺乳动物细胞暴露于其中的生物/药理学活性组分的体外浓度有关。另外，通过使用非变性电泳和蛋白质或蛋白质磷酸化的染色，可以在全细胞匀浆中测定蛋白质 - 蛋白质复合物的形成或损失。本发明允许将天然产物配制成具有一致生物/药理学活性的营养补充剂和药物制剂，而不需要鉴定负责生物或药理学应答的任何化学成分。

10. 发明授权

US08093292B2 Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology 失效
标题翻译：治疗HIV-1相关脂肪分布异常，空腹高脂血症和脂肪细胞生理改变的方法
公开(公告)号：US08093292B2
公开(公告)日：2012-01-10
申请号：US11821221
申请日：2007-06-22
申请人： Linda M. Pacioretty , John G. Babish
发明人： Linda M. Pacioretty , John G. Babish
IPC分类号： A61K31/19 , A61K31/415 , A61K31/28 , A61K31/20 , A61K31/16 , A61K31/095
CPC分类号： A61K31/045 , A61K31/198 , A61K31/20 , A61K31/28 , A61K31/426 , A61K31/43 , A61K2300/00
摘要： Methods for treating or preventing metabolic dysregulation of adipocytes resulting from HIV-1 infection or chronic inflammation are disclosed. The compositions contain a conjugated fatty acid, a thiol-containing compound and a bioavailable form of trivalent chromium.
摘要翻译：公开了用于治疗或预防由HIV-1感染或慢性炎症引起的脂肪细胞代谢失调的方法。组合物含有共轭脂肪酸，含硫醇的化合物和三价铬的生物可利用形式。

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