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1. 发明授权

US6037520A Human breast carcinoma cell line capable of production of a spontaneously metastasizing tumor in animals for use in anticancer drug testing 失效
标题翻译：能够在动物中产生自发转移性肿瘤的人乳腺癌细胞系用于抗癌药物测试
公开(公告)号：US6037520A
公开(公告)日：2000-03-14
申请号：US958167
申请日：1997-10-27
申请人： Shula Raney , Dennis Emma , Josephine Hurst
发明人： Shula Raney , Dennis Emma , Josephine Hurst
IPC分类号： C12N5/09 , A61K48/00
CPC分类号： C12N5/0693
摘要： An adherent, stable, continuous human breast carcinoma cell line (GI-101A) has been produced from an infiltrating ductal breast carcinoma xenograft (GI-101) which has been grown and maintained in athymic mice for the past nine years. The GI-101A cells grow with an average doubling time of about 48 to about 72 hours. The cells display antigenic determinants consistent with those of the human breast tumor xenograft (GI-101) from which it was derived. The cell line, GI-101A, when injected subcutaneously into the subaxial area of athymic animals, such as athymic mice, produces tumors that spontaneously metastasize to distant organ sites, such as the lungs and lymph nodes. The cell line and the tumors that it produces may be used as model systems for study mechanisms responsible for metastatic behavior and for testing for new as well as screening for effective new anti-cancer drug therapies.
摘要翻译：已经在过去九年中已经在无胸腺小鼠中培养和维持的浸润性导管乳腺癌异种移植物（GI-101）产生了粘附的，稳定的，连续的人乳腺癌细胞系（GI-101A）。 GI-101A细胞以约48至约72小时的平均倍增时间生长。细胞显示与从其衍生的人乳腺肿瘤异种移植物（GI-101）的抗原决定簇一致。当皮下注射到无胸腺动物的下轴区域（如无胸腺小鼠）时，细胞系GI-101A产生自发转移到远处器官部位如肺和淋巴结的肿瘤。细胞系及其产生的肿瘤可用作负责转移行为的研究机制的模型系统，以及用于新的以及筛选有效的新的抗癌药物治疗的测试。

2. 发明申请

US20100137449A1 SUBSTITUTED 1,3-CYCLOPENTADIONE MULTI-TARGET PROTEIN KINASE MODULATORS OF CANCER, ANGIOGENESIS AND THE INFLAMMATORY PATHWAYS ASSOCIATED THEREWITH 审中-公开
标题翻译：取代的1,3-CYCLOPENTADIONE多靶点蛋白激酶调节因子与癌细胞，血管生成以及与之相关的炎症途径
公开(公告)号：US20100137449A1
公开(公告)日：2010-06-03
申请号：US12331887
申请日：2008-12-10
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
IPC分类号： A61K31/122 , A61P35/00 , A61P9/10
CPC分类号： A61K31/12 , A61K45/06 , A61K2300/00
摘要： Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds.
摘要翻译：公开了用于血管生成，癌症治疗或与这些病症相关的炎症途径的多靶向蛋白激酶调节的化合物和方法。所公开的化合物和方法是基于取代的1,3-环戊二酮化合物。

3. 发明授权

US5693533A Human breast carcinoma cell line capable of production of a spontaneously metastasizing tumor in animals for use in anticancer drug testing 失效
标题翻译：能够在动物中产生自发转移性肿瘤的人乳腺癌细胞系用于抗癌药物测试
公开(公告)号：US5693533A
公开(公告)日：1997-12-02
申请号：US350938
申请日：1994-12-07
申请人： Shula Raney , Dennis Emma , Josephine Hurst
发明人： Shula Raney , Dennis Emma , Josephine Hurst
IPC分类号： C12N5/09 , C12N5/08
CPC分类号： C12N5/0693
摘要： An adherent, stable, continuous human breast carcinoma cell line (GI-101A) has been produced from an infiltrating ductal breast carcinoma xenograft (GI-101) which has been grown and maintained in athymic mice for the past nine years. The GI-101A cells grow with an average doubling time of about 48 to about 72 hours. The cells display antigenic determinants consistent with those of the human breast tumor xenograft (GI-101) from which it was derived. The cell line, GI-101A, when injected subcutaneously into the subaxial area of athymic animals, such as athymic mice, produces tumors that spontaneously metastasize to distant organ sites, such as the lungs and lymph nodes. The cell line and the tumors that it produces may be used as model systems for study mechanisms responsible for metastatic behavior and for testing for new as well as screening for effective new anti-cancer drug therapies.
摘要翻译：已经在过去九年中已经在无胸腺小鼠中培养和维持的浸润性导管乳腺癌异种移植物（GI-101）产生了粘附的，稳定的，连续的人乳腺癌细胞系（GI-101A）。 GI-101A细胞以约48至约72小时的平均倍增时间生长。细胞显示与从其衍生的人乳腺肿瘤异种移植物（GI-101）的抗原决定簇一致。当皮下注射到无胸腺动物的下轴区域（如无胸腺小鼠）时，细胞系GI-101A产生自发转移到远处器官部位如肺和淋巴结的肿瘤。细胞系及其产生的肿瘤可用作负责转移行为的研究机制的模型系统，以及用于新的以及筛选有效的新的抗癌药物治疗的测试。

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