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1. 发明申请

US20130068820A1 FIBRIN PAD MATRIX WITH SUSPENDED HEAT ACTIVATED BEADS OF ADHESIVE 有权
标题翻译： FIBRIN PAD MATRIX具有悬挂的热激活的胶带
公开(公告)号：US20130068820A1
公开(公告)日：2013-03-21
申请号：US13233633
申请日：2011-09-15
申请人： Matthew C. Miller , Yi-Lan Wang , Israel Nur , Aron O. Zingman
发明人： Matthew C. Miller , Yi-Lan Wang , Israel Nur , Aron O. Zingman
IPC分类号： A61B17/068
CPC分类号： A61B17/07207 , A61B17/00491 , A61B17/07292 , A61B2017/005 , A61B2017/2929
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue.
摘要翻译：手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切断组件。下颚构造成在处于打开位置时接收盒。盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。甲板限定孔，每个孔基本上设置在每个钉上。墨盒进一步接收包括悬浮在基质中的胶珠的基质。订书钉被驱动通过矩阵将矩阵固定在组织上。当基质被固定到组织上时，胶珠被活化，使得活化的粘合剂进一步固定组织中的缝合线。

2. 发明授权

US08814025B2 Fibrin pad matrix with suspended heat activated beads of adhesive 有权
标题翻译：纤维蛋白垫基质与悬浮热活化的粘合剂珠
公开(公告)号：US08814025B2
公开(公告)日：2014-08-26
申请号：US13233633
申请日：2011-09-15
申请人： Matthew C. Miller , Yi-Lan Wang , Israel Nur , Aron O. Zingman
发明人： Matthew C. Miller , Yi-Lan Wang , Israel Nur , Aron O. Zingman
IPC分类号： A61B17/068 , A61B17/00 , A61B17/072 , A61B17/29
CPC分类号： A61B17/07207 , A61B17/00491 , A61B17/07292 , A61B2017/005 , A61B2017/2929
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue.
摘要翻译：手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切断组件。下颚构造成在处于打开位置时接收盒。盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。甲板限定孔，每个孔基本上设置在每个钉上。墨盒进一步接收包括悬浮在基质中的胶珠的基质。订书钉被驱动通过矩阵将矩阵固定在组织上。当基质被固定到组织上时，胶珠被活化，使得活化的粘合剂进一步固定组织中的缝合线。

3. 发明授权

US08981058B2 Gelatin sponge comprising an active ingredient, its preparation and use 有权
标题翻译：明胶海绵含有活性成分，其制备及用途
公开(公告)号：US08981058B2
公开(公告)日：2015-03-17
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
IPC分类号： A61K38/00 , A61K9/00 , A61K9/70 , A61L15/32 , A61L15/42 , A61L15/44 , A61K38/48
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译：本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中足够量的液体即使在干燥后也保持海绵的柔韧性。然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。

4. 发明授权

US08968724B2 Compositions suitable for treatment of spinal disease, disorder or condition 有权
标题翻译：适合治疗脊髓疾病，病症或病症的组合物
公开(公告)号：US08968724B2
公开(公告)日：2015-03-03
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
IPC分类号： A01N63/00 , A61L27/38 , A61L27/36 , C12N5/077 , A61K35/16
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译：本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。

5. 发明授权

US08962033B2 Method for improved fibrin sealing 有权
标题翻译：改善纤维蛋白封闭的方法
公开(公告)号：US08962033B2
公开(公告)日：2015-02-24
申请号：US13015999
申请日：2011-01-28
申请人： Erez Ilan , Kfir Regev , Israel Nur
发明人： Erez Ilan , Kfir Regev , Israel Nur
IPC分类号： A61K9/50 , A61L24/10
CPC分类号： A61L24/043 , A61L24/0015 , A61L24/0042 , A61L24/10 , A61L24/106 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/45 , A61L2300/61 , A61L2400/04 , B65D81/32
摘要： The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.
摘要翻译：本发明涉及一种纤维蛋白基质，其制备和用途，用于有效地密封粘膜或其它潮湿组织中的缺陷。

6. 发明申请

US20130312868A1 Method and Device for Fast Dissolution of Solid Protein Composition 审中-公开
标题翻译：用于快速溶解固体蛋白质组合物的方法和装置
公开(公告)号：US20130312868A1
公开(公告)日：2013-11-28
申请号：US13722348
申请日：2012-12-20
申请人： Erez Ilan , Kfir Regev , Dana Leitman , Israel Nur , Moti Meron , John Goodman
发明人： Erez Ilan , Kfir Regev , Dana Leitman , Israel Nur , Moti Meron , John Goodman
IPC分类号： C07K14/75
CPC分类号： C07K14/75 , A61M5/19 , A61M5/284 , B01F3/12 , B01F5/0685 , B01F13/0023 , B01F13/0052 , B01F15/0225 , B01F15/0258
摘要： Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.
摘要翻译：提供了用于将固体蛋白质组合物（例如包含纤维蛋白原的固体组合物）溶解在水性溶剂中的方法和装置。所述方法包括使用含有一定体积的固体纤维蛋白原组合物的封闭容器和顶部空间，其中顶部空间内的压力低于大气压。将水溶剂引入容器中同时保持低于大气压的压力，然后加入溶剂后，顶部空间的尺寸减小，使压力达到大气压。这些装置适用于所公开的方法。

7. 发明授权

US08563288B2 Removal of plasmin or plasminogen from cryoprecipitate 有权
标题翻译：从冷沉淀物中去除纤溶酶或纤溶酶原
公开(公告)号：US08563288B2
公开(公告)日：2013-10-22
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/66 , A61K35/16
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

8. 发明申请

US20110045034A1 Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use 有权
标题翻译：明胶海绵包含活性成分，其制备和用途
公开(公告)号：US20110045034A1
公开(公告)日：2011-02-24
申请号：US12920000
申请日：2009-03-02
申请人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
发明人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
IPC分类号： A61K9/00 , A61K38/48 , A61P7/04
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The invention relates to an improved dry cross-linked gelatin sponge comprising a layer of an active ingredient, to methods of its preparation and uses thereof.
摘要翻译：本发明涉及包含活性成分层的改进的干交联明胶海绵，其制备方法及其用途。

9. 发明申请

US20100217231A1 Device for administering an at least two-component substance 审中-公开
标题翻译：用于施用至少两种组分物质的装置
公开(公告)号：US20100217231A1
公开(公告)日：2010-08-26
申请号：US12708453
申请日：2010-02-18
申请人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
发明人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
IPC分类号： A61M5/31 , A61B17/03 , A61M35/00
CPC分类号： A61M5/1582 , A61B17/00491 , A61B2017/00495 , A61M5/3297 , A61M2025/0039
摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.
摘要翻译：用于施用至少两种组分物质的装置包括同心的腔排列，其包括（i）具有在第一端具有入口开口的内腔和在其第一端相对的第二端处具有出口开口的末端的内套管，和（ii）外护套，其具有相对的第一和第二端面向所述内套管的相应的第一和第二端，并且沿着所述内套管的第一和第二端之间的轴向长度包围所述内套管，其中，其第二端密封地和固定地连接到内套管并且围绕内插管限定外腔，并且其中内插管设置有至少一个开口，用于提供围绕内插管的外腔与内套管之间的流体连通内套管。

10. 发明申请

US20090176293A1 Removal of plasmin(ogen) from protein solutions 有权
标题翻译：从蛋白质溶液中去除纤溶酶（ogen）
公开(公告)号：US20090176293A1
公开(公告)日：2009-07-09
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/68
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

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