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1. 发明授权

US08563288B2 Removal of plasmin or plasminogen from cryoprecipitate 有权
标题翻译：从冷沉淀物中去除纤溶酶或纤溶酶原
公开(公告)号：US08563288B2
公开(公告)日：2013-10-22
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/66 , A61K35/16
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

2. 发明申请

US20090176293A1 Removal of plasmin(ogen) from protein solutions 有权
标题翻译：从蛋白质溶液中去除纤溶酶（ogen）
公开(公告)号：US20090176293A1
公开(公告)日：2009-07-09
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/68
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

3. 发明授权

US07641918B2 Plasma cryoprecipitate substantially free of plasminogen 有权
标题翻译：基本上不含纤溶酶原的血浆冷沉淀物
公开(公告)号：US07641918B2
公开(公告)日：2010-01-05
申请号：US11581753
申请日：2006-10-17
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： A61K35/16
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

4. 发明申请

US20070092959A1 Removal of plasmin(ogen) from protein solutions 有权
标题翻译：从蛋白质溶液中去除纤溶酶（ogen）
公开(公告)号：US20070092959A1
公开(公告)日：2007-04-26
申请号：US11581753
申请日：2006-10-17
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C07K14/75 , C12N9/64
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

5. 发明授权

US07125569B2 Removal of plasmin(ogen) from protein solutions 有权
公开(公告)号：US07125569B2
公开(公告)日：2006-10-24
申请号：US10150490
申请日：2002-05-20
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/68 , A61K35/16
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6–8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

6. 发明授权

US09365635B2 Intravenous immunoglobulin composition 有权
标题翻译：静脉内免疫球蛋白组成
公开(公告)号：US09365635B2
公开(公告)日：2016-06-14
申请号：US13619011
申请日：2012-09-14
申请人： Israel Nur , Liliana Bar , Orgad Laub
发明人： Israel Nur , Liliana Bar , Orgad Laub
IPC分类号： A61K38/00 , C07K16/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism; (b) identifying very high titer individuals by determining the level of specific antibodies immunoreactive with the pathogenic microorganism in the blood of the individuals; (c) combining blood from the very high titer individuals; and (d) purifying and/or concentrating the product of step (c). A concentrated immunoglobulin composition can include specific antibodies immunoreactive with a pathogenic microorganism, wherein the titer of specific antibodies is at least 5 times higher than the average titer of specific antibodies of a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates. The pathogenic microorganism is preferably smallpox virus or vaccinia virus.
摘要翻译：用于治疗接种疫苗或感染致病微生物的受试者的浓缩的免疫球蛋白组合物是通过（a）选择先前针对与病原微生物相关的抗原进行接种的个体群体; （b）通过确定与个体血液中的病原微生物免疫反应的特异性抗体的水平来鉴定非常高的滴度个体; （c）结合来自极高滴度个体的血液; 和（d）纯化和/或浓缩步骤（c）的产物。浓缩的免疫球蛋白组合物可以包括与病原微生物免疫反应的特异性抗体，其中特异性抗体的滴度比先前接种抗原与病原微生物相关抗原的个体群体的特异性抗体的平均滴度高至少5倍。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体。病原微生物优选为天花病毒或痘苗病毒。

7. 发明申请

US20130011388A1 INTRAVENOUS IMMUNOGLOBULIN COMPOSITION 有权
标题翻译：内脏免疫组织化学
公开(公告)号：US20130011388A1
公开(公告)日：2013-01-10
申请号：US13619011
申请日：2012-09-14
申请人： Israel Nur , Liliana Bar , Orgad Laub
发明人： Israel Nur , Liliana Bar , Orgad Laub
IPC分类号： A61K39/395 , C07K16/08 , A61P31/20 , C07K16/00
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism; (b) identifying very high titre individuals by determining the level of specific antibodies immunoreactive with the pathogenic microorganism in the blood of the individuals; (c) combining blood from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c). A concentrated immunoglobulin composition can include specific antibodies immunoreactive with a pathogenic microorganism, wherein the titre of specific antibodies is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates. The pathogenic microorganism is preferably smallpox virus or vaccinia virus.
摘要翻译：用于治疗接种疫苗或感染致病微生物的受试者的浓缩的免疫球蛋白组合物是通过（a）选择先前针对与病原微生物相关的抗原进行接种的个体群体; （b）通过确定与个体血液中的病原微生物免疫反应的特异性抗体的水平来鉴定非常高的滴度个体; （c）结合极高滴度个体的血液; 和（d）纯化和/或浓缩步骤（c）的产物。浓缩的免疫球蛋白组合物可以包括与病原微生物免疫反应的特异性抗体，其中特异性抗体的滴度比先前接种抗原与病原微生物相关抗原的个体群体的特异性抗体的平均滴度高至少5倍。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体。病原微生物优选为天花病毒或痘苗病毒。

8. 发明申请

US20100310524A1 Compositions Suitable for Treatment of Spinal Disease, Disorder or Condition 有权
标题翻译：适用于治疗脊髓疾病，疾病或病症的组合物
公开(公告)号：US20100310524A1
公开(公告)日：2010-12-09
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
IPC分类号： A61K35/16 , C12N5/02 , A61K38/43 , A61P19/00
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译：本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。

9. 发明申请

US20100203033A1 Kits, formulations and solutions having enzymatically- permissive amounts of visualization agents and uses thereof 审中-公开
标题翻译：具有酶允许量的可视化试剂的试剂盒，制剂和溶液及其用途
公开(公告)号：US20100203033A1
公开(公告)日：2010-08-12
申请号：US12665810
申请日：2008-07-01
申请人： Israel Nur , Roberto Meidler , Liliana Bar
发明人： Israel Nur , Roberto Meidler , Liliana Bar
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61L24/043 , A61L24/108 , A61L31/046 , C08L89/00
摘要： The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.
摘要翻译：本发明涉及当与纤维蛋白原反应时能够形成纤维蛋白的蛋白水解酶，纤维蛋白胶试剂盒和包含酶允许浓度的可视化试剂的纤维蛋白胶制剂，以及它们在预防和/ 或减少用于促进血液凝固密封或填充体表面的粘合和/或方法。

10. 发明申请

US20060257458A1 Reinforced absorbable multilayered hemostatis wound dressing 有权
标题翻译：增强吸收性多层切割伤口敷料
公开(公告)号：US20060257458A1
公开(公告)日：2006-11-16
申请号：US11400849
申请日：2006-04-10
申请人： Anne Gorman , Sanyog Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
发明人： Anne Gorman , Sanyog Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
IPC分类号： A61L15/00
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.
摘要翻译：本发明涉及包含第一可吸收无纺布，第二可吸收编织物或针织物，凝血酶和/或纤维蛋白原的增强可吸收多层止血伤口敷料。

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