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1. 发明申请

US20120094972A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 失效
公开(公告)号：US20120094972A1
公开(公告)日：2012-04-19
申请号：US13377210
申请日：2010-06-25
申请人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号： A61K31/5415 , C07D491/107 , C07D471/04 , C07D401/14 , C07D491/20 , C07D473/00 , C07D417/14 , C07D513/04 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/52 , A61K31/538 , A61P19/08 , A61P19/02 , A61P27/02 , A61P29/00 , A61P17/06 , A61P1/00 , A61P13/10 , A61P17/00 , A61P35/00 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

2. 发明授权

US08765940B2 Heterocyclic compounds and their uses 失效
公开(公告)号：US08765940B2
公开(公告)日：2014-07-01
申请号：US13377210
申请日：2010-06-25
申请人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/20 , C07D513/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

3. 发明授权

US08761209B1 System and method for the aggregation of 10GBASE-R signals into pseudo 100GBASE-R signals 有权
标题翻译：将10GBASE-R信号聚合成伪100GBASE-R信号的系统和方法
公开(公告)号：US08761209B1
公开(公告)日：2014-06-24
申请号：US13285562
申请日：2011-10-31
申请人： Matthew Brown , Dimitrios Giannakopoulos
发明人： Matthew Brown , Dimitrios Giannakopoulos
IPC分类号： H04J3/02 , H04L12/54 , H04L29/06
CPC分类号： H04L12/413
摘要： An Ethernet physical layer (PHY) module is provided with a method for transceiving between a 10GBASE-R client interface and a 100G attachment interface. On each of ten client interface logical lanes a 10GBASE-R signal is accepted. Each 10GBASE-R logical lane is demultiplexed into two 5 gigabit per second (Gbps) pseudo 100GBASE-R logical lanes, creating a total of twenty pseudo 100GBASE-R logical lanes. The pseudo 100GBASE-R logical lanes are arranged into n groups of 20/n pseudo 100GBASE-R logical lanes. Further, the pseudo 100GBASE-R logical lanes from each group are arranged into a 100G attachment logical lane. Finally, a 100G attachment logical lane is transmitted at an attachment interface on each of n physical lanes. In the reverse direction, each of n physical lanes accepts a 100G attachment logical lane at the attachment interface, and a de-aggregation process supplies a 10GBASE-R signal on each of ten client interface logical lanes.
摘要翻译：以太网物理层（PHY）模块提供了一种用于在10GBASE-R客户端接口和100G附件接口之间进行收发的方法。在10个客户端界面逻辑通道中的每一个上接受10GBASE-R信号。每个10GBASE-R逻辑通道被解复用为两个5千兆位/秒（Gbps）伪100GBASE-R逻辑通道，共创建了20个伪100GBASE-R逻辑通道。伪100GBASE-R逻辑通道被排列成n组20 / n个伪100GBASE-R逻辑通道。此外，来自每组的伪100GBASE-R逻辑通道被排列成100G附件逻辑通道。最后，在n个物理通道中的每一个上的附着接口上发送100G附件逻辑通道。在相反的方向上，n个物理通道中的每一个在附接接口处接受100G的连接逻辑通道，并且去聚合处理在十个客户端接口逻辑通道中的每一个上提供10GBASE-R信号。

4. 发明授权

US08753100B2 Multiple rotor fluid transfer engine 有权
标题翻译：多转子流体传动引擎
公开(公告)号：US08753100B2
公开(公告)日：2014-06-17
申请号：US13494674
申请日：2012-06-12
申请人： William R. Peitzke , Matthew Brown , James G. P. Dehlsen , Christopher J. Grieco
发明人： William R. Peitzke , Matthew Brown , James G. P. Dehlsen , Christopher J. Grieco
IPC分类号： F04C2/00 , F04C18/00
CPC分类号： F02B53/00 , F01C1/20 , F02B55/02 , F02B57/00 , F02B2730/015 , Y02T10/17
摘要： A fluid transfer engine employs a case with a cylindrical inner wall having an operating radius extending from a case axis. A main rotor is carried within the case and incorporates a lobe with a major radius equal to and concentric with the operating radius of the case, the main rotor having a minor radius defining a body. Two peripheral rotors are diametrically opposed with respect to the case axis and rotate within rotor chambers extending from the case. Each peripheral rotor has a radius equal to the minor radius and a center of rotation located at twice the minor radius from the case axis. Each of the peripheral rotors rotates in uniform circular motion with the main rotor in sealing contact with the body and incorporates a sculpted recess for receiving the lobe of the main rotor.
摘要翻译：流体传递发动机采用具有从壳体轴线延伸的操作半径的圆柱形内壁的壳体。主转子承载在壳体内并且包括具有等于并与壳体的操作半径同心的大半径的凸角，主转子具有限定主体的小半径。两个周向转子相对于壳体轴线在直径方向上相对，并在从壳体延伸的转子室内旋转。每个外围转子具有等于小半径的半径，并且旋转中心位于距壳体轴线的小半径的两倍。每个外围转子以均匀的圆周运动旋转，主转子与主体密封接触，并且包括用于接收主转子的凸角的雕刻凹槽。

5. 发明授权

US08404722B2 Oxazole compounds compositions and methods of use 有权
标题翻译：恶唑化合物组合物和使用方法
公开(公告)号：US08404722B2
公开(公告)日：2013-03-26
申请号：US12920258
申请日：2009-03-13
申请人： Matthew Brown , Michael G. Johnson
发明人： Matthew Brown , Michael G. Johnson
IPC分类号： A61K31/4439 , A61K31/42 , C07D263/34 , C07D413/04
CPC分类号： C07D263/50 , C07D263/32 , C07D413/12
摘要： The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要翻译：本发明一般涉及式（I）表示的化合物，包含它们的药物组合物和治疗诸如癌症的疾病或病症的方法。

6. 发明授权

US08237304B2 Multi-point tethering and stability system and control method for underwater current turbine 有权
标题翻译：水下涡轮机的多点系链和稳定系统及控制方法
公开(公告)号：US08237304B2
公开(公告)日：2012-08-07
申请号：US12666531
申请日：2008-05-20
申请人： James G. P. Dehlsen , Matthew Brown , Christopher Grieco
发明人： James G. P. Dehlsen , Matthew Brown , Christopher Grieco
IPC分类号： F03B13/00
CPC分类号： F03B13/264 , B63B21/50 , B63B22/18 , B63B2035/4466 , F03B15/00 , F03B17/061 , F05B2240/915 , F05B2240/917 , F05B2240/97 , F05B2250/21 , F05B2260/70 , Y02E10/28
摘要： A method of controlling a tethered, underwater, water current-driven turbine, power-generating device. The device is comprised of dual turbines and dual rotor blades turned by fluid flow, each turbine including one or more generators driven by rotor blades. The device is connected by device tethers to a strut, which is moveable to control depth of the device. The strut is connected to the ocean floor by tripodal tethers: a main tether, a left side tether and a right side tether, which are strut control tethers. One or more winches are controlled to maintain operation of the device within set parameters by varying the tension on one or more of the strut control tethers.
摘要翻译：一种控制拴系，水下，水流驱动的涡轮机，发电装置的方法。该装置由双涡轮机和由流体流动转动的双转子叶片组成，每个涡轮机包括由转子叶片驱动的一个或多个发电机。该设备通过设备系绳连接到支柱，该支柱可移动以控制设备的深度。支柱通过三脚架系绳连接到海底：主系绳，左侧系绳和右侧系绳，是支柱控制系绳。控制一个或多个绞盘以通过改变一个或多个支柱控制系绳上的张力来将装置的操作保持在设定参数内。

7. 发明申请

US20120135525A1 REPROGRAMMING T CELLS AND HEMATOPOIETIC CELLS 有权
标题翻译：转染细胞和细胞培养细胞
公开(公告)号：US20120135525A1
公开(公告)日：2012-05-31
申请号：US13376361
申请日：2010-06-04
申请人： Matthew Brown , Elizabeth Rondon Dominguez , Randy Learish , Emile Nuwaysir , Deepika Rajesh , Amanda Mack
发明人： Matthew Brown , Elizabeth Rondon Dominguez , Randy Learish , Emile Nuwaysir , Deepika Rajesh , Amanda Mack
IPC分类号： C12N5/071 , C12N15/85 , C12N15/86 , C12N5/02
CPC分类号： C12N5/0696 , C12N5/0637 , C12N15/85 , C12N2501/2302 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2502/1114 , C12N2506/11 , C12N2510/00 , C12N2800/108
摘要： Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
摘要翻译：公开了与诱导性多能干细胞（iPS细胞）的产生有关的方法和组合物。例如，可以从CD34 +造血细胞例如人CD34 +血液祖细胞或T细胞产生诱导的多能干细胞。还提供了各种iPS细胞系。在某些实施方案中，本发明提供具有包含T细胞受体的遗传重排的基因组的新型诱导多能干细胞。

8. 发明授权

US08037932B2 Pipe handling device and safety mechanism 有权
标题翻译：管道处理装置和安全机构
公开(公告)号：US08037932B2
公开(公告)日：2011-10-18
申请号：US12683222
申请日：2010-01-06
申请人： William Carr , Matthew Brown , Per G. Angman
发明人： William Carr , Matthew Brown , Per G. Angman
IPC分类号： E21B19/18
CPC分类号： E21B19/16 , E21B19/06 , E21B19/08
摘要： A pipe handling assembly includes a pipe engaging apparatus having a pipe gripping mechanism connectable to a top drive such that the top drive transmits rotational movement and axial movement to the pipe gripping mechanism. A pipe handling device is mounted onto the pipe engaging apparatus, the pipe handling device including a link hanger mounted on the pipe engaging apparatus. A link arm has a first end pivotally connectable to the link hanger and an outboard end selected to carry a pipe into a position to be gripped by the pipe engaging apparatus. A bearing isolates rotational movement to the pipe gripping mechanism from the link hanger. A connection rigidly connects the link hanger to the pipe engaging apparatus during operation of the pipe handling assembly. The connection is selected to substantially prevent the link hanger from rotating with the pipe gripping mechanism should the bearing seize.
摘要翻译：管道处理组件包括管接合装置，其具有可连接到顶部驱动器的管夹持机构，使得顶部驱动器将旋转运动和轴向运动传递到管道夹持机构。管道处理装置安装在管道接合装置上，管道处理装置包括安装在管道接合装置上的连接悬挂器。连杆臂具有可枢转地连接到连杆悬挂器的第一端和被选择用于将管道运送到被管接合装置夹持的位置的外侧端。轴承将连杆悬挂器的旋转运动与管夹持机构隔离开。在管道处理组件的操作期间，连接件将连杆架连接到管接合装置。如果轴承卡住，连接被选择为基本上防止连杆架与管夹持机构一起旋转。

9. 发明申请

US20110153103A1 SYSTEMS AND METHODS FOR PREDICTIVE BUILDING ENERGY MONITORING 有权
标题翻译：用于预测建筑能源监测的系统和方法
公开(公告)号：US20110153103A1
公开(公告)日：2011-06-23
申请号：US12646764
申请日：2009-12-23
申请人： Matthew Brown , Christopher Barrington-Leigh , Christopher Porter
发明人： Matthew Brown , Christopher Barrington-Leigh , Christopher Porter
IPC分类号： G06F1/26 , G08B21/00
CPC分类号： H02J13/0062 , F24F11/46 , F24F2140/60 , G06Q10/04 , G06Q50/06 , H02J3/00 , H02J2003/003 , Y02B90/2638 , Y04S40/124
摘要： A system and method for predictive modeling of building energy consumption provides predicted building energy load values which are determined using kernel smoothing of historical building energy load values for a building using defined scaling factors for scaling predictor variables associated with building energy consumption. Predictor variables may include temperature, humidity, windspeed or direction, occupancy, time, day, date, and solar radiation. Scaling factor values may be defined by optimization training using historical building energy load values and measured predictor variable values for a building. Predicted and measured building energy load values are compared to determine if a preset difference threshold has been exceeded, in which case an alert signal or message is generated and transmitted to electronically and/or physically signal a user. The building energy monitoring system may be integrated with a building automation system, or may be operated as a separate system receiving building energy and predictor variable values.
摘要翻译：建筑能耗预测建模的系统和方法提供了预测的建筑物能量负荷值，其使用内部平滑建筑物的历史建筑物能量负荷值确定的建筑物能量负荷值，使用定义的缩放因子来缩放与建筑能耗相关联的预测变量。预测变量可能包括温度，湿度，风速或方向，占用率，时间，日期，日期和太阳辐射。缩放因子值可以通过使用历史建筑物能量负荷值和建筑物的测量预测变量值的优化训练来定义。比较预测和测量的建筑物能量负载值以确定是否已经超过预设的差异阈值，在这种情况下，生成警报信号或者将信息发送到电子和/或物理地向用户发出信号。建筑能量监测系统可以与楼宇自动化系统集成，或者可以作为接收建筑能量和预测变量值的单独系统来操作。

10. 发明授权

US07936915B2 Focal length estimation for panoramic stitching 有权
标题翻译：全景拼接焦距估计
公开(公告)号：US07936915B2
公开(公告)日：2011-05-03
申请号：US11754945
申请日：2007-05-29
申请人： Matthew Brown , Richard Hartley
发明人： Matthew Brown , Richard Hartley
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T7/30 , G06K2009/2045 , G06T7/80
摘要： A focal length estimation technique is presented that estimates the focal length used to capture each of a pair of overlapping images taken by a camera rotating about its center. When it is known that the focal length is the same for both images, it is estimated using just two pairs of corresponding points between the images. When it is either unknown whether the focal lengths are the same or it is known that they vary, the focal length of each image is estimated using just three pairs of corresponding points between the images.
摘要翻译：提出了一种焦距估计技术，其估计用于捕获由围绕其中心旋转的相机拍摄的一对重叠图像中的每一个的焦距。当已知两个图像的焦距是相同的时，估计在图像之间仅使用两对对应的点。当不确定焦距是否相同或已知其变化时，每个图像的焦距仅使用图像之间的三对对应点来估计。

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