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1. 发明申请

US20120109259A1 LOW-POWER SYSTEM CLOCK CALIBRATION BASED ON A HIGH- ACCURACY REFERENCE CLOCK 有权
标题翻译：基于高精度参考时钟的低功率系统时钟校准
公开(公告)号：US20120109259A1
公开(公告)日：2012-05-03
申请号：US12915832
申请日：2010-10-29
申请人： Matthew Bond , Charles R. Gordon , Weizheng Liang , James D. Reinke , Jonathan P. Roberts
发明人： Matthew Bond , Charles R. Gordon , Weizheng Liang , James D. Reinke , Jonathan P. Roberts
IPC分类号： A61N1/08 , H03L7/00
CPC分类号： A61N1/37264 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37276 , G06F1/04 , G06F1/12
摘要： Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.
摘要翻译：描述了各种技术，用于周期性地执行校准例程以基于也包括在IMD中的高精度参考时钟校准可植入医疗设备（IMD）内的低功率系统时钟。系统时钟连续供电，参考时钟仅在校准程序中打开电源。这些技术包括基于系统时钟的频率和固定数量的时钟周期上的参考时钟之间的差异来确定系统时钟的时钟误差，以及调整系统时钟的修整值以补偿时钟误差。例如，用delta-sigma循环校准系统时钟可以减少时间误差。这允许系统时钟的精确调整，以补偿由于调整分辨率，电路噪声和温度引起的误差。

2. 发明授权

US08825170B2 Low-power system clock calibration based on a high-accuracy reference clock 有权
标题翻译：基于高精度参考时钟的低功耗系统时钟校准
公开(公告)号：US08825170B2
公开(公告)日：2014-09-02
申请号：US12915832
申请日：2010-10-29
申请人： Matthew Bond , Charles R. Gordon , Weizheng Liang , James D. Reinke , Jonathan P. Roberts
发明人： Matthew Bond , Charles R. Gordon , Weizheng Liang , James D. Reinke , Jonathan P. Roberts
IPC分类号： A61N1/00 , A61N1/08 , A61N1/02 , G06F1/12 , A61N1/372
CPC分类号： A61N1/37264 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37276 , G06F1/04 , G06F1/12
摘要： Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.
摘要翻译：描述了各种技术，用于周期性地执行校准例程以基于也包括在IMD中的高精度参考时钟校准可植入医疗设备（IMD）内的低功率系统时钟。系统时钟连续供电，参考时钟仅在校准程序中打开电源。这些技术包括基于系统时钟的频率和固定数量的时钟周期上的参考时钟之间的差异来确定系统时钟的时钟误差，以及调整系统时钟的修整值以补偿时钟误差。例如，用delta-sigma循环校准系统时钟可以减少时间误差。这允许系统时钟的精确调整，以补偿由于调整分辨率，电路噪声和温度引起的误差。

3. 发明申请

US20120245864A1 STRAIN COMPENSATION FOR PRESSURE SENSORS 有权
标题翻译：压力传感器的应变补偿
公开(公告)号：US20120245864A1
公开(公告)日：2012-09-27
申请号：US13428108
申请日：2012-03-23
申请人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
发明人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
IPC分类号： G06F19/00
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.
摘要翻译：压力感测系统提供表示选定部位压力大小的信号。传感器模块包括第一传感器，其产生具有对施加到传感器模块的压力和应变的相关联的第一响应的第一信号，以及产生具有对施加到传感器模块的压力和应变的相关联的第二响应的第二信号的第二传感器。响应于第一信号和第二信号计算计算压力，弯曲压力误差和弯曲补偿压力。

4. 发明授权

US08275435B2 Co-location of emitters and detectors and method of operation 有权
标题翻译：发射器和探测器的共同定位和操作方法
公开(公告)号：US08275435B2
公开(公告)日：2012-09-25
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test.
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少一个以作为光检测组件进行操作。

5. 发明授权

US08155758B2 Fault tolerant implantable pulse generators and implantable cardioverter-defibrillators incorporating physiologic sensors and methods for implementing fault tolerance in same 有权
标题翻译：容错植入式脉冲发生器和植入式心律转复除颤器，其结合生理传感器和实现相同容错的方法
公开(公告)号：US08155758B2
公开(公告)日：2012-04-10
申请号：US11380567
申请日：2006-04-27
申请人： Glenn M. Roline , Michael B. Terry , Jonathan P. Roberts , James D. Reinke , Robert A. Corey
发明人： Glenn M. Roline , Michael B. Terry , Jonathan P. Roberts , James D. Reinke , Robert A. Corey
IPC分类号： A61N1/37
CPC分类号： A61N1/36564 , A61N1/3605 , A61N1/36514 , A61N1/36557 , A61N2001/083
摘要： This disclosure relates to fault tolerant instantiations of a cardiac therapy delivery device such as an implantable cardiac stimulator (e.g., an implantable pulse generator, IPG, and/or an implantable cardioverter-defibrillator, ICD) coupled to an implantable physiologic sensor (IPS). According to the disclosure delivery of cardiac pacing and/or cardioversion-defibrillator therapy delivery can cause errors in output signals from an IPS. Resolution of such errors involves selectively energizing (or disconnecting the output signal from) the IPS during pacing and/or defibrillation therapy delivery. Programmable signal “blanking” in lieu of or in addition to the foregoing also improves the integrity of the output signal (i.e., continuously energize the IPS and ignore parts of the output signal). An ICD having a transient weakness in an insulated conductor used for the IPS signal can likewise have the IPS de-energized and/or blank the IPS output signal during high voltage therapy delivery.
摘要翻译：本公开涉及心脏治疗递送装置的容错实例，例如可植入的心脏刺激器（例如，可植入脉冲发生器，IPG和/或植入式心律转复除颤器，ICD），其与可植入生理传感器（IPS）耦合。根据心脏起搏和/或心脏复律 - 除颤器治疗传递的披露递送可能导致来自IPS的输出信号的错误。这种错误的解决涉及在起搏和/或除颤治疗递送期间选择性地激励（或断开输出信号）IPS。代替或除了上述之外的可编程信号“消隐”还提高了输出信号的完整性（即，连续地激励IPS并忽略输出信号的部分）。在IPS信号中使用的绝缘导体具有瞬时弱点的ICD同样可以在高电压治疗传送期间使IPS不通电和/或空白IPS输出信号。

6. 发明授权

US07935935B2 Radiation-based timer for implantable medical devices 有权
标题翻译：用于可植入医疗器械的基于辐射的计时器
公开(公告)号：US07935935B2
公开(公告)日：2011-05-03
申请号：US12394179
申请日：2009-02-27
申请人： Jonathan P. Roberts , James D. Reinke , Jeffrey D. Wilkinson
发明人： Jonathan P. Roberts , James D. Reinke , Jeffrey D. Wilkinson
IPC分类号： G01J1/42
CPC分类号： A61N1/372 , A61N1/025 , A61N1/3702 , A61N1/37276 , G04F5/16
摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.
摘要翻译：用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。辐射源在被称为放射性衰变的过程中发射辐射粒子。辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。当检测到的辐射粒子的数量达到阈值时，产生定时器信号。以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。

7. 发明授权

US09958351B2 Strain compensation for pressure sensors 有权
公开(公告)号：US09958351B2
公开(公告)日：2018-05-01
申请号：US13428108
申请日：2012-03-23
申请人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
发明人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
IPC分类号： G01L9/12 , G01L19/02 , A61B5/00 , A61B5/03 , G01L19/14 , G01L15/00 , A61B5/0215 , A61B5/20
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.

8. 发明申请

US20100219351A1 RADIATION-BASED TIMER FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的基于辐射的定时器
公开(公告)号：US20100219351A1
公开(公告)日：2010-09-02
申请号：US12394179
申请日：2009-02-27
申请人： Jonathan P. Roberts , James D. Reinke , Jeffrey D. Wilkinson
发明人： Jonathan P. Roberts , James D. Reinke , Jeffrey D. Wilkinson
IPC分类号： G01J1/42 , G04B47/00
CPC分类号： A61N1/372 , A61N1/025 , A61N1/3702 , A61N1/37276 , G04F5/16
摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.
摘要翻译：用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。辐射源在被称为放射性衰变的过程中发射辐射粒子。辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。当检测到的辐射粒子的数量达到阈值时，产生定时器信号。以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。

9. 发明申请

US20090156918A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR USE 有权
标题翻译：可植入的光学传感器及其使用方法
公开(公告)号：US20090156918A1
公开(公告)日：2009-06-18
申请号：US11955025
申请日：2007-12-12
申请人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
发明人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/0233 , A61B2562/043
摘要： An implantable medical device includes a hermetically sealed housing and a first light emitting diode (LED) enclosed within the housing configured to detect light corresponding to a selected light wavelength. A conductive element extends from the LED for carrying a current signal corresponding to the light detected by the LED, the intensity of the detected light being correlated to a change in a physiological condition in a body fluid volume or a tissue volume proximate the LED.
摘要翻译：可植入医疗装置包括密封的壳体和封装在壳体内的第一发光二极管（LED），其被配置为检测对应于所选择的光波长的光。导电元件从LED延伸，用于承载对应于由LED检测到的光的电流信号，检测到的光的强度与体液体积或接近LED的组织体积的生理状态的变化相关。

10. 发明授权

US08452402B2 Optical sensing device for use in a medical device 有权
标题翻译：用于医疗设备的光学感测装置
公开(公告)号：US08452402B2
公开(公告)日：2013-05-28
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
IPC分类号： A61B5/1455
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

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