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2. 发明授权

US4719207A CNS active substituted azetidinone compounds 失效
标题翻译： CNS活性取代的氮杂环丁酮化合物
公开(公告)号：US4719207A
公开(公告)日：1988-01-12
申请号：US747018
申请日：1985-06-20
申请人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
发明人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
IPC分类号： C07D205/08 , C07D205/085 , C07F7/10 , C07K5/097 , A61K31/415 , C07D403/12 , C07D403/14
CPC分类号： C07K5/0821 , C07D205/08 , C07D205/085 , C07F7/10
摘要： Substituted azetidinone compounds are provided which have the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or, both represent hydrogen atoms or lower alkyl groups; R.sup.3 represents a hydrogen atom or a group shown by formula: ##STR2## (wherein X represents ##STR3## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group); R.sup.4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula: --CH.sub.2 CO--A (wherein A represents an amino group or a group shown by formula: ##STR4## (wherein X and Y are as defined above), provided that when R.sup.1 and R.sup.2 are both hydrogen atoms, at least R.sup.4 represents a group other than a hydrogen atom and provided that either R.sup.3 or R.sup.4 represents a group other than a hydrogen atom. The compounds have strong CNS action.
摘要翻译：提供具有下式的取代的氮杂环丁酮化合物：其中R 1和R 2之一表示取代的低级烷基，叠氮基，氨基，低级酰氨基，巯基或低级烷硫基另一个表示氢基团，或者都表示氢原子或低级烷基; R3表示氢原子或由下式表示的基团：其中X表示（其中R5表示氢原子或低级烷基），Y表示羟基，低级烷氧基，氨基，一或二低级烷基氨基）; R 4表示氢原子，取代或未取代的低级烷基或由式-CH 2 CO-A（其中A表示氨基或由下式表示的基团：其中X和Y如上所定义）），条件是当R 1和R 2均为氢原子时，至少R 4表示氢原子以外的基团，只要R 3或R 4表示除氢原子以外的基团，则该化合物具有强CNS作用。

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