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1. 发明申请

WO2016070136A1 DELIVERY OF BIOMOLECULES TO IMMUNE CELLS 审中-公开
标题翻译：生物分子递送到免疫细胞
公开(公告)号：WO2016070136A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/058489
申请日：2015-10-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： SHAREI, Armon, R. , MAO, Shirley , HARTOULAROS, George , LIU, Sophia , HEIMANN, Megan , BASTO, Pamela , SZETO, Gregory , JHUNJHUNWALA, Siddharth , IRVINE, Darrell , LANGER, Robert, S. , JENSEN, Klavs, F. , VON ANDRIAN, Ulrich, H.
IPC分类号： C12N5/078 , C12N5/0783 , C12N15/89 , C12M3/02 , B07B1/00 , B01D37/00
CPC分类号： C12M35/04 , A61K39/00 , A61K45/06 , A61K49/0017 , A61K2039/5158 , C12M23/16 , C12M35/00 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N15/87 , C12N2501/05 , C12N2501/998 , C12N2510/00 , C12N2527/00 , G01N33/5047
摘要： A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
摘要翻译：用于优先将化合物如抗原递送至免疫细胞的胞质溶胶的方法和装置。该方法包括使包含目标免疫细胞的细胞悬浮液通过微流体装置并将悬浮液与要递送的化合物或有效载体接触。

2. 发明公开

EP3212772A1 DELIVERY OF BIOMOLECULES TO IMMUNE CELLS 审中-公开
标题翻译：生物分子免疫细胞的传递
公开(公告)号：EP3212772A1
公开(公告)日：2017-09-06
申请号：EP15855640.7
申请日：2015-10-30
申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College
发明人： SHAREI, Armon, R. , MAO, Shirley , HARTOULAROS, George , LIU, Sophia , HEIMANN, Megan , BASTO, Pamela , SZETO, Gregory , JHUNJHUNWALA, Siddharth , IRVINE, Darrell , LANGER, Robert, S. , JENSEN, Klavs, F. , VON ANDRIAN, Ulrich, H.
IPC分类号： C12N5/078 , C12N5/0783 , C12N15/89 , C12M3/02 , B07B1/00 , B01D37/00
CPC分类号： C12M35/04 , A61K39/00 , A61K45/06 , A61K49/0017 , A61K2039/5158 , C12M23/16 , C12M35/00 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N15/87 , C12N2501/05 , C12N2501/998 , C12N2510/00 , C12N2527/00 , G01N33/5047
摘要： A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
摘要翻译：用于优先将化合物如抗原递送至免疫细胞的胞质溶胶的方法和装置。该方法包括使包含靶免疫细胞的细胞悬浮液通过微流体装置并使悬浮液与待递送的化合物或有效负荷接触。

3. 发明申请

WO2021108025A1 CELL-BASED CANCER VACCINES AND CANCER THERAPIES 审中-公开
公开(公告)号：WO2021108025A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/052775
申请日：2020-09-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： IRVINE, Darrell , YAFFE, Michael , SRIRAM, Ganapathy , MILLING, Lauren
IPC分类号： A61K39/00 , C12N5/09 , G01N33/50 , A61P35/00
摘要： Described are cell-based cancer vaccines and anti-cancer immunotherapies. The vaccines include isolated tumor cells activated with one or more genotoxic drugs, and, optionally, treated with one or more MK2 inhibitors. The activated cells are highly immunogenic non-proliferative cells, and may be tested for immunogenicity ex vivo for priming T cells by co-incubating the isolated activated cells with dendritic cells and T cells. The vaccines are typically administered into patient's tumor to provide an intratumoral immune activation. Immune checkpoint inhibitor(s) (ICI) may be administered before, during, or after vaccine administration. ICI may be a component of the vaccine. The vaccines confer heightened cytotoxic immune response against the cancer cells, induce tumor regression, and enhance survival from cancer. The vaccines prevent tumor recurrence and induce a long-lasting anti-tumor immunological memory.

4. 发明申请

WO2014059269A2 MULTILAYER COMPOSITIONS, COATED DEVICES AND USE THEREOF 审中-公开
标题翻译：多层组合物，涂层装置及其用途
公开(公告)号：WO2014059269A2
公开(公告)日：2014-04-17
申请号：PCT/US2013/064530
申请日：2013-10-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： DEMUTH, Peter , MIN, Younjin , IRVINE, Darrell , HAMMOND, Paula, T.
IPC分类号： A61K48/00 , A61K9/70
CPC分类号： A61K9/7007 , A61K9/0021 , A61K9/5084 , A61K39/21 , A61K47/32 , A61K47/34 , A61K2039/53 , A61K2039/55511 , B05D1/36 , C12N7/00 , C12N15/89 , C12N2740/16234
摘要： The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a release layer and one or more layer-by-layer films. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for delivery.
摘要翻译：本发明尤其提供了多层膜涂料组合物，涂覆的基材及其方法。在一些实施例中，一种包括衬底和在衬底上的多层膜的结构，其中所述多层膜包括剥离层和一层或多层逐层膜。在一些实施例中，包括微针基底和涂覆在微针基底的至少部分上的多层膜的结构，其中多层膜包含用于递送的试剂。

5. 发明申请

WO2016025645A1 SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND AN IMMUNE CHECKPOINT BLOCKER 审中-公开
标题翻译：具有IL-2，治疗性抗体和免疫检查点块的协同肿瘤治疗
公开(公告)号：WO2016025645A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/044924
申请日：2015-08-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： WITTRUP, Karl, Dane , IRVINE, Darrell , OPEL, Cary, Francis , MOYNIHAN, Kelly, Dare
IPC分类号： A61K38/20 , A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： A61K38/2013 , A61K39/0011 , A61K39/39541 , A61K2039/507 , C07K16/2818 , C07K16/3053 , C07K2317/76 , A61K2300/00
摘要： The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and an immune checkpoint blocker. The methods of the invention can be used to treat a broad range of cancer types.
摘要翻译：本发明提供了一种用IL-2（例如延长的PK IL-2），治疗性抗体或其片段和免疫检测点阻断剂组合治疗癌症的方法。本发明的方法可用于治疗广泛范围的癌症类型。

6. 发明申请

WO2017155981A1 PROTEIN-CHAPERONED T-CELL VACCINES 审中-公开
标题翻译：蛋白质辅助的T细胞疫苗
公开(公告)号：WO2017155981A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021136
申请日：2017-03-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： IRVINE, Darrell , WITTRUP, Karl, Dane , MEHTA, Naveen, K. , RAKHRA, Kavya , ZHU, Eric, Franklin
IPC分类号： A61K39/00 , A61K39/39
摘要： Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a "chaperone-antigen" that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation of differentiation and/or effector functions, promotion of survival, rescue from exhaustion and/or anergy of T cells, or a combination thereof. Chaperon-antigens can also be used to induce tolerance and increase immune suppressive responses. In the most preferred embodiments, the peptide antigen is fused to the chaperone protein to form a fusion protein. The "chaperone-antigen" can be combined with an adjuvant to form a vaccine and administered to a subject to modulate an immune response to the antigen. Methods of increasing immune responses, treating cancer and infectious diseases and inducing tolerance are also provided.
摘要翻译：提供蛋白质抗原。蛋白质抗原通常包括与分子伴侣蛋白缀合或融合以形成“分子伴侣 - 抗原”的肽抗原。增加淋巴结摄取; 改善免疫反应; 或其相对于单独的肽抗原的组合。免疫应答可以是例如增加的抗原特异性增殖，增强的细胞因子产生，刺激分化和/或效应器功能，促进存活，从T细胞耗尽和/或无反应性挽救，或其组合。伴侣抗原也可用于诱导耐受并增加免疫抑制反应。在最优选的实施方案中，肽抗原与伴侣蛋白融合形成融合蛋白。 “分子伴侣 - 抗原” 可与佐剂组合以形成疫苗并施用于受试者以调节对抗原的免疫应答。还提供了增加免疫应答，治疗癌症和感染性疾病以及诱导耐受性的方法。

7. 发明申请

WO2015061719A1 METHOD AND APPARATUS FOR TRACKING CELL IDENTITY 审中-公开
标题翻译：跟踪细胞识别的方法和装置
公开(公告)号：WO2015061719A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/062231
申请日：2014-10-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： CASTELLARNAU, Marc , SZETO, Gregory, Lee , IRVINE, Darrell , LOVE, John, Christopher , VOLDMAN, Joel
IPC分类号： C12Q1/68
CPC分类号： G01N15/1463 , G01N15/10 , G01N15/1484 , G01N35/00732 , G01N2015/0065 , G01N2015/008 , G01N2015/1006 , G01N2015/149 , G01N2035/00811 , G01N2035/00831
摘要： A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtitre plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.
摘要翻译：通过分析平台跟踪细胞身份的方法使用随机条形码（SB）。 SB使用随机生成的代码，其基于与感兴趣的一组单元格一起封装的珠的数量，颜色和位置中的一个或多个。 SB的使用在其中将细胞从微孔阵列转移到微量滴定板同时保持其同一性的应用中得到证明，并且获得了100个块的转移的平均识别精度为96％。该方法的模型缩放高达1000块，证明SB能够实现大约90％的精度。

8. 发明公开

EP3849521A1 NANOPARTICLE VACCINE ADJUVANT AND METHODS OF USE THEREOF 审中-实审
公开(公告)号：EP3849521A1
公开(公告)日：2021-07-21
申请号：EP19746295.5
申请日：2019-07-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , La Jolla Institute for Immunology
发明人： IRVINE, Darrell , SILVA, Murillo , CROTTY, Shane , KATO, Yu
IPC分类号： A61K9/127 , A61K9/51 , A61K39/00

9. 发明申请

WO2020055503A1 NANOPARTICLE VACCINE ADJUVANT AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020055503A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/041580
申请日：2019-07-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
发明人： IRVINE, Darrell , SILVA, Murillo , CROTTY, Shane , KATO, Yu
IPC分类号： A61K9/127 , A61K9/51 , A61K39/00
摘要： Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related methods of treatment. Preferred lipids, additional adjuvants including TLR4 agonists, sterols, and saponins, methods of making the nanocages, and method of using them are also provided.

10. 发明申请

WO2016025647A1 SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND A CANCER VACCINE 审中-公开
标题翻译：具有IL-2，治疗性抗体和癌症疫苗的协同治疗肿瘤治疗
公开(公告)号：WO2016025647A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/044927
申请日：2015-08-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： WITTRUP, Karl, Dane , IRVINE, Darrell , OPEL, Cary, Francis , MOYNIHAN, Kelly, Dare
IPC分类号： A61K38/20 , A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： A61K38/2013 , A61K39/0011 , A61K39/39541 , A61K2039/507 , C07K16/2818 , C07K16/3053 , C07K2317/76 , A61K2300/00
摘要： The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
摘要翻译：本发明提供了用IL-2（例如扩展型PK IL-2），治疗性抗体或其片段和癌症疫苗的组合来治疗癌症的方法。本发明的方法可用于治疗广泛范围的癌症类型。

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