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1. 发明申请

WO2007027752A1 CATALYTIC REACTIONS INVOLVING ALKENES 审中-公开
标题翻译：涉及ALKENES的催化反应
公开(公告)号：WO2007027752A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/033829
申请日：2006-08-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JAMISON, Timothy, F. , NG, Sze-Sze
发明人： JAMISON, Timothy, F. , NG, Sze-Sze
IPC分类号： C07F7/18 , C07C29/00 , B01J31/18
CPC分类号： C07F7/1892
摘要： The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods. Also, methods of the invention may reduce the number of synthetic and purification steps required to produce the reaction products, as well as reducing time, cost, and waste production.
摘要翻译：本发明涉及新的组合物和产生烯丙基醇或烯丙基醇前体（例如烯丙基醇的甲硅烷基醚）的反应。本发明的方法可以包括在过渡金属催化剂（例如镍催化剂）的存在下组合烯烃和醛以形成烯丙醇或烯丙基醇的前体。本发明的反应产物可作为药物和聚合物研究中的中间体和/或产品是有价值的。此外，本发明的方法可用作复合分子合成中的片段偶联反应。此外，本发明的方法可以包括使用试剂，其在本领域已知的反应条件下可能已经不反应，即可能不能形成反应产物。本发明中使用的试剂的成本可以低于其它方法。此外，本发明的方法可以减少生产反应产物所需的合成和纯化步骤的数量，以及减少时间，成本和废物产生。

2. 发明申请

WO2017192595A1 RECONFIGURABLE MULTI-STEP CHEMICAL SYNTHESIS SYSTEM AND RELATED COMPONENTS AND METHODS 审中-公开
标题翻译：可重构的多步化学合成系统及相关组件和方法
公开(公告)号：WO2017192595A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030649
申请日：2017-05-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ADAMO, Andrea , THOMAS III, Dale, Arlington , JENSEN, Klavs, F. , JAMISON, Timothy, F. , BEDERMANN, Aaron, A. , AROH, Kosisochukwu, C.
IPC分类号： B01L3/00 , B01L99/00 , B01J8/00 , G01N27/26 , G01N27/416
摘要： The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.
摘要翻译：本公开涉及流体分配器，流体系统以及相关的方法和物品。某些实施例涉及流体分配器，流体分配器包括包括具有基本上彼此对应的相对位置的流体连接的隔间。在一些实施例中，流体分配器可以包括具有基本上彼此对应的相对位置的具有电接口的隔间。

3. 发明申请

WO2011056929A1 CONTINUOUS FLOW SYNTHESIS OF AMINO ALCOHOLS USING MICROREACTORS 审中-公开
标题翻译：使用微生物的氨基醇的连续流动合成
公开(公告)号：WO2011056929A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055386
申请日：2010-11-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BEDORE, Matthew, W. , ZABORENKO, Nikolay , JENSEN, Klavs, F. , JAMISON, Timothy, F.
发明人： BEDORE, Matthew, W. , ZABORENKO, Nikolay , JENSEN, Klavs, F. , JAMISON, Timothy, F.
IPC分类号： C07C213/04 , C07D209/00 , C07D211/00 , B01J19/00
CPC分类号： C07C213/04 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , C07C2601/14 , C07C2602/08 , C07D209/08 , C07D215/26 , C07C215/30 , C07C215/44 , C07C217/30 , C07C217/32
摘要： The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.
摘要翻译：本发明提供了在微反应器环境中合成化学物质的各种方法。在某些情况下，本发明的反应产物可能作为药物和聚合物研究中的中间体和/或产品是有价值的。例如，该方法可以涉及在微通道内合成氨基醇。本文描述的实施方案可以允许具有显着更短的反应时间和提高效率的反应。

4. 发明申请

WO2011019789A1 THE RING OPENING OF LACTONES AND LACTAMS 审中-公开
标题翻译：睫毛和睫毛的开口
公开(公告)号：WO2011019789A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045121
申请日：2010-08-11
申请人： NOVARTIS AG , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FOLEY, Megan, Alene , JAMISON, Timothy, F. , REPIC, Oljan
发明人： FOLEY, Megan, Alene , JAMISON, Timothy, F. , REPIC, Oljan
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , C07C231/14 , Y02P20/55 , C07C237/06 , C07C237/22
摘要： The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof.
摘要翻译：本发明提供了一种用于打开内酯和/或内酰胺环的新方法。更具体地，本发明提供了在内酯环和/或内酰胺环的开放中采用新型催化剂的方法。此外，本发明还提供了存在于含内酯环和/或内酰胺环的化合物和/或其开环产物中的任何保护基的新的脱保护方法。

5. 发明公开

EP2464623A1 THE RING OPENING OF LACTONES AND LACTAMS 有权
标题翻译：内酯和内酰胺的开环
公开(公告)号：EP2464623A1
公开(公告)日：2012-06-20
申请号：EP10744805.2
申请日：2010-08-11
申请人： Novartis AG , Massachusetts Institute of Technology
发明人： FOLEY, Megan, Alene , JAMISON, Timothy, F. , REPIC, Oljan
IPC分类号： C07C231/02
摘要： The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof.

6. 发明申请

WO2016025803A1 SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：用于合成化学产品的系统和方法，包括活性药物成分
公开(公告)号：WO2016025803A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045220
申请日：2015-08-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JENSEN, Klavs, F. , JAMISON, Timothy, F. , MYERSON, Allan, Stuart , MONBALIU, Jean-christophe, M. , BEHNAM, Mohsen , WONG, Shin, Yee , WEERANOPPANANT, Nopphon , REVALOR, Eve, Marie , STELZER, Torsten , CHEN, Jie , ADAMO, Andrea , SNEAD, David, R. , ZHANG, Ping
IPC分类号： B01J8/00 , B01J19/00 , B01J19/18
CPC分类号： B01J19/0093 , B01J19/004 , B01J2219/00011 , B01J2219/0004 , B01J2219/00795 , B01J2219/00799 , B01J2219/00806 , B01J2219/0081 , B01J2219/00813 , B01J2219/00817 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00909 , B01J2219/00918 , B01J2219/00986
摘要： Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
摘要翻译：提供了用于合成化学产品（包括活性药物成分）的系统和方法。本文所述的某些系统和方法能够制造多种化学产品，而无需在从一种制造化学产品切换到制造另一种化学产品时流体连接或断开单元操作。

7. 发明申请

WO2012024495A1 USE OF AZIDES IN SYNTHESIS 审中-公开
标题翻译：在合成中使用AZIDES
公开(公告)号：WO2012024495A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/048261
申请日：2011-08-18
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JAMISON, Timothy, F. , PALDE, Prakash, B.
发明人： JAMISON, Timothy, F. , PALDE, Prakash, B.
IPC分类号： C07D257/04
CPC分类号： C07D257/04 , C07D401/04 , C07D403/04
摘要： Described herein are inventive methods for synthesis of tetrazoles. In some embodiments, the method involves the use of a flow reactor. The methods provided herein are capable at being carried out in short reaction times, with high yields, with minimal side reactions, and/or with minimal chance of explosions caused by the presence of azides.
摘要翻译：本文描述了用于合成四唑的本发明的方法。在一些实施方案中，该方法涉及使用流动反应器。本文提供的方法能够在短的反应时间内以高产率，极少的副反应和/或以叠氮化物的存在引起爆炸的可能性最小。

8. 发明授权

EP2464623B1 THE RING OPENING OF LACTONES AND LACTAMS 有权
公开(公告)号：EP2464623B1
公开(公告)日：2020-11-04
申请号：EP10744805.2
申请日：2010-08-11
申请人： Novartis AG , Massachusetts Institute of Technology
发明人： FOLEY, Megan, Alene , JAMISON, Timothy, F. , REPIC, Oljan
IPC分类号： C07C231/02 , C07C231/14

9. 发明公开

EP3180118A1 SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：系统和方法化工产品的营销代理生产
公开(公告)号：EP3180118A1
公开(公告)日：2017-06-21
申请号：EP15832380.8
申请日：2015-08-14
申请人： Massachusetts Institute Of Technology
发明人： JENSEN, Klavs, F. , JAMISON, Timothy, F. , MYERSON, Allan, Stuart , MONBALIU, Jean-Christophe, M. , BEHNAM, Mohsen , WONG, Shin Yee , WEERANOPPANANT, Nopphon , REVALOR, Eve, Marie , STELZER, Torsten , CHEN, Jie , ADAMO, Andrea , SNEAD, David, R. , ZHANG, Ping
IPC分类号： B01J8/00 , B01J19/00 , B01J19/18
CPC分类号： B01J19/004 , A61K31/14 , A61K31/167 , B01J19/0093 , B01J19/18 , B01J2219/00011 , B01J2219/0004 , B01J2219/00795 , B01J2219/00799 , B01J2219/00806 , B01J2219/0081 , B01J2219/00813 , B01J2219/00817 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00909 , B01J2219/00918 , B01J2219/00986
摘要： Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
摘要翻译：用于合成化学产品，包括活性药物成分的系统和方法，提供。某些在所描述的系统和方法的是能够制造多种化工产品，而不需要流体连接或断开的单元操作。当从一个化学制品制造到制造另一种化学品切换。

10. 发明公开

EP3452220A1 RECONFIGURABLE MULTI-STEP CHEMICAL SYNTHESIS SYSTEM AND RELATED COMPONENTS AND METHODS 审中-公开
公开(公告)号：EP3452220A1
公开(公告)日：2019-03-13
申请号：EP17793166.4
申请日：2017-05-02
申请人： Massachusetts Institute of Technology
发明人： ADAMO, Andrea , THOMAS III, Dale, Arlington , JENSEN, Klavs, F. , JAMISON, Timothy, F. , BEDERMANN, Aaron, A. , AROH, Kosisochukwu, C.
IPC分类号： B01L3/00 , B01L99/00 , B01J8/00 , G01N27/26 , G01N27/416

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