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1. 发明申请

WO2018200236A8 RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2018200236A8
公开(公告)日：2018-11-01
申请号：PCT/US2018/027750
申请日：2018-04-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JENSEN, Klavs, F. , THOMAS III, Dale, Arlington
IPC分类号： B01J19/00 , B01J8/00 , B01L99/00 , G01N1/28 , G01N1/31 , G01N35/00
摘要： Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator.

2. 发明申请

WO2017192595A1 RECONFIGURABLE MULTI-STEP CHEMICAL SYNTHESIS SYSTEM AND RELATED COMPONENTS AND METHODS 审中-公开
标题翻译：可重构的多步化学合成系统及相关组件和方法
公开(公告)号：WO2017192595A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030649
申请日：2017-05-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ADAMO, Andrea , THOMAS III, Dale, Arlington , JENSEN, Klavs, F. , JAMISON, Timothy, F. , BEDERMANN, Aaron, A. , AROH, Kosisochukwu, C.
IPC分类号： B01L3/00 , B01L99/00 , B01J8/00 , G01N27/26 , G01N27/416
摘要： The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.
摘要翻译：本公开涉及流体分配器，流体系统以及相关的方法和物品。某些实施例涉及流体分配器，流体分配器包括包括具有基本上彼此对应的相对位置的流体连接的隔间。在一些实施例中，流体分配器可以包括具有基本上彼此对应的相对位置的具有电接口的隔间。

3. 发明公开

EP3452220A1 RECONFIGURABLE MULTI-STEP CHEMICAL SYNTHESIS SYSTEM AND RELATED COMPONENTS AND METHODS 审中-公开
公开(公告)号：EP3452220A1
公开(公告)日：2019-03-13
申请号：EP17793166.4
申请日：2017-05-02
申请人： Massachusetts Institute of Technology
发明人： ADAMO, Andrea , THOMAS III, Dale, Arlington , JENSEN, Klavs, F. , JAMISON, Timothy, F. , BEDERMANN, Aaron, A. , AROH, Kosisochukwu, C.
IPC分类号： B01L3/00 , B01L99/00 , B01J8/00 , G01N27/26 , G01N27/416

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