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1. 发明申请

US20130237435A1 GENE CLUSTER, GENE SEARCHING/IDENTIFICATION METHOD, AND APPARATUS FOR THE METHOD 审中-公开
标题翻译：基因组，基因组搜索/鉴定方法和方法的装置
公开(公告)号：US20130237435A1
公开(公告)日：2013-09-12
申请号：US13825453
申请日：2011-09-22
申请人： Masayuki Machida , Hideaki Koike , Maiko Umemura , Kiyoshi Asai , Katsuhisa Horimoto , Totai Mitsuyama
发明人： Masayuki Machida , Hideaki Koike , Maiko Umemura , Kiyoshi Asai , Katsuhisa Horimoto , Totai Mitsuyama
IPC分类号： G06F19/18
CPC分类号： G16B20/00 , G16B25/00
摘要： The present invention provides a method for searching for or identifying a useful gene logically, systematically, and efficiently in an extremely short time without largely relying on searcher's knowledge, experience, or the like and even without sequentially conducting gene disruption experiments as in conventional techniques of searching for a useful gene. The present invention also provides an apparatus for the method. Virtual gene clusters each comprising two or more genes are individually scored by summing the respective pieces of differential expression information (obtained using, for example, microarrays) of genomic genes on a per-cluster basis. On the basis of the obtained scores of the virtual gene clusters, a gene cluster containing a useful gene and the useful gene contained in the cluster are searched for.
摘要翻译：本发明提供了一种用于在非常短的时间内逻辑，系统和有效地搜索或鉴定有用基因的方法，而不需要大量依赖于搜索者的知识，经验等，并且甚至没有依次进行基因破坏实验，如常规技术寻找有用的基因。本发明还提供了一种用于该方法的装置。通过在基于每个簇的基础上对基因组基因的差异表达信息（例如，微阵列获得）的各个片段进行求和来分别计算每个包含两个或更多个基因的虚拟基因簇。在获得的虚拟基因簇得分的基础上，搜索包含有用基因的基因簇和簇中包含的有用基因。

2. 发明申请

US20120316332A1 Novel Dextrin Fatty Acid Ester that Does Not Cause Gelation of Liquid Oil, and Uses Thereof 有权
标题翻译：不会引起液体油凝胶化的新型糊精脂肪酸酯及其用途
公开(公告)号：US20120316332A1
公开(公告)日：2012-12-13
申请号：US13578412
申请日：2011-02-16
申请人： Hideaki Koike , Takanao Suzuki , Daisuke Tsukioka , Satsuki Miyagawa , Yuriko Tomita , Keiji Igarashi
发明人： Hideaki Koike , Takanao Suzuki , Daisuke Tsukioka , Satsuki Miyagawa , Yuriko Tomita , Keiji Igarashi
IPC分类号： C08B37/00
CPC分类号： C08B31/04 , A61K8/73 , A61K2800/10 , A61Q19/00 , C07H13/06 , C08B30/18 , C09D7/45 , C09D11/14 , C11C3/00
摘要： An object of the present invention is to provide novel dextrin fatty acid ester that is excellent in tackiness and useful as a base for cosmetics and the like. The novel dextrin fatty acid ester is prepared by esterification between dextrin and fatty acids, wherein the dextrin has an average degree of glucose polymerization of 3 to 150; the fatty acids comprise more than 50 mol % and 100 mol % or less, based on the total amount of the fatty acids, of one or more saturated branched fatty acids having 4 to 26 carbon atoms, and 0 mol % or more and less than 50 mol %, based on the total amount of the fatty acids, of one or more fatty acids selected from the group consisting of saturated linear fatty acids having 2 to 22 carbon atoms, unsaturated linear or branched fatty acids having 6 to 30 carbon atoms, and saturated or unsaturated cyclic fatty acids having 6 to 30 carbon atoms; and the degree of substitution by the fatty acids is 1.0 to 3.0 per glucose unit.
摘要翻译：本发明的目的是提供一种粘合性优异且用作化妆品等的基质的新型糊精脂肪酸酯。所述糊精的脂肪酸酯通过糊精与脂肪酸的酯化而制备，其中糊精的平均葡萄糖聚合度为3〜150; 脂肪酸占脂肪酸总量的50摩尔％以上100摩尔％以下，1个以上碳原子数为4〜26的饱和支链脂肪酸和0摩尔％以上且小于等于0摩尔％以上 50mol％，基于脂肪酸的总量，一种或多种选自碳原子数2〜22的饱和直链脂肪酸，碳原子数6〜30的不饱和直链或支链脂肪酸，和具有6至30个碳原子的饱和或不饱和环状脂肪酸; 并且脂肪酸的取代度为每个葡萄糖单元1.0-3.0。

3. 发明授权

US09193805B2 Dextrin fatty acid ester that does not cause gelation of liquid oil, and uses thereof 有权
标题翻译：不会引起液体油凝胶化的糊精脂肪酸酯及其用途
公开(公告)号：US09193805B2
公开(公告)日：2015-11-24
申请号：US13578412
申请日：2011-02-16
申请人： Hideaki Koike , Takanao Suzuki , Daisuke Tsukioka , Satsuki Miyagawa , Yuriko Tomita , Keiji Igarashi
发明人： Hideaki Koike , Takanao Suzuki , Daisuke Tsukioka , Satsuki Miyagawa , Yuriko Tomita , Keiji Igarashi
IPC分类号： C08B31/04 , C09D103/06 , A61K8/73 , A61Q19/00 , C07H13/06 , C08B30/18 , C09D7/02 , C09D11/14 , C11C3/00
CPC分类号： C08B31/04 , A61K8/73 , A61K2800/10 , A61Q19/00 , C07H13/06 , C08B30/18 , C09D7/45 , C09D11/14 , C11C3/00
摘要： An object of the present invention is to provide novel dextrin fatty acid ester that is excellent in tackiness and useful as a base for cosmetics and the like. The novel dextrin fatty acid ester is prepared by esterification between dextrin and fatty acids, wherein the dextrin has an average degree of glucose polymerization of 3 to 150; the fatty acids comprise more than 50 mol % and 100 mol % or less, based on the total amount of the fatty acids, of one or more saturated branched fatty acids having 4 to 26 carbon atoms, and 0 mol % or more and less than 50 mol %, based on the total amount of the fatty acids, of one or more fatty acids selected from the group consisting of saturated linear fatty acids having 2 to 22 carbon atoms, unsaturated linear or branched fatty acids having 6 to 30 carbon atoms, and saturated or unsaturated cyclic fatty acids having 6 to 30 carbon atoms; and the degree of substitution by the fatty acids is 1.0 to 3.0 per glucose unit.
摘要翻译：本发明的目的是提供一种粘合性优异且用作化妆品等的基质的新型糊精脂肪酸酯。所述糊精的脂肪酸酯通过糊精与脂肪酸的酯化而制备，其中糊精的平均葡萄糖聚合度为3〜150; 脂肪酸占脂肪酸总量的50摩尔％以上100摩尔％以下，1个以上碳原子数为4〜26的饱和支链脂肪酸和0摩尔％以上且小于等于0摩尔％以上 50mol％，基于脂肪酸的总量，一种或多种选自碳原子数2〜22的饱和直链脂肪酸，碳原子数6〜30的不饱和直链或支链脂肪酸，和具有6至30个碳原子的饱和或不饱和环状脂肪酸; 并且脂肪酸的取代度为每个葡萄糖单元1.0-3.0。

4. 发明授权

US08857063B2 Rotary electric shaver 有权
标题翻译：旋转式电动剃须刀
公开(公告)号：US08857063B2
公开(公告)日：2014-10-14
申请号：US13007122
申请日：2011-01-14
申请人： Hideaki Koike
发明人： Hideaki Koike
IPC分类号： B26B19/14
CPC分类号： B26B19/14 , B26B19/145
摘要： A rotary electric shaver provided with a plurality of cutter units, each of which has an outer cutter (72) and an inner cutter (84), which rotates while elastically contacting the outer cutter from below. The shaver comprising: a plurality of outer cutter assemblies (70), each of which is made integral with a cutter circumferential rim (74) having the outer cutter of each cutter unit secured thereto and which is movably retained in a mounting port formed in the cutter frame (66), a pushup plate (92) which contacts the outer cutter assembly from below to push up the outer cutter assembly, a cutter retaining plate (90) which is retained by the cutter frame and which is positioned below the pushup plate, and an outer cutter float spring (94) which is compressively interposed between the cutter retaining plate and the pushup plate to impart an upward return tendency to the pushup plate. Each outer cutter can independently move, thus ensuring smooth vertical movement or rocking of the outer cutter and also permitting an increased shaving area.
摘要翻译：一种设置有多个切割器单元的旋转电动剃须刀，每个切割器单元具有外切割器（72）和内切割器（84），所述外切割器（72）和内切割器（84）在从下方弹性接触外切割器时旋转。剃须刀包括：多个外刀片组件（70），每个外刀片组件（70）与刀具圆周边缘（74）制成一体，刀具圆周边缘（74）具有固定到其上的每个切割器单元的外刀片，并且可移动地保持在形成在切割器框架（66），从下方接触外部切割器组件以推动外部切割器组件的上推板（92）;切割器保持板（90），其由切割器框架保持并且位于上推板以及压缩地插入在切割器保持板和上推板之间的外切割器浮子弹簧（94），以向上推板提供向上的返回趋势。每个外刀片可以独立地移动，从而确保外刀片的平滑的垂直运动或摆动，并且还允许增加剃须面积。

5. 发明申请

US20050241153A1 Electric rotary shaver 有权
标题翻译：电动旋转剃须刀
公开(公告)号：US20050241153A1
公开(公告)日：2005-11-03
申请号：US11114437
申请日：2005-04-26
申请人： Hideaki Koike
发明人： Hideaki Koike
IPC分类号： B26B19/14
CPC分类号： B26B19/14 , B26B19/145
摘要： An electric shaver including an outer cutter holder (30) that holds the outer cutters (24), an inner cutter holder (42) which has a plurality of projections (50) that pass through the outer cutter holder (30) and press the outer circumferential edges of the outer cutters (24) and which holds the inner cutters (36) so that the inner cutters are rotatable, a single shaft member (62) which passes through the inner cutter holder (42) and outer cutter holder (30) and whose tip end is positioned in the cutter frame (20) so as to be located between the mutually adjacent outer cutters (24), and a cutter retaining assembly (60), which the shaft member (62) passes through and is detachably anchored to the cutter frame (20) and further elastically presses the inner cutter holder (42) toward the outer cutters.
摘要翻译：一种电动剃须刀，其包括保持所述外刀具（24）的外刀架（30），具有穿过所述外刀架（30）的多个突起（50）的内切刀保持架（42）外刀片（24）的圆周边缘并且保持内切割器（36）使得内刀片是可旋转的，穿过内刀片保持器（42）和外刀架（30）的单个轴构件（62）并且其末端位于所述切割器框架（20）中以便位于相互相邻的外切割器（24）之间;以及切割器保持组件（60），所述轴构件（62）穿过并可拆卸地锚定到所述切割器框架（20）并且进一步向所述外切割器弹性地按压所述内刀片保持器（42）。

6. 发明授权

US07487592B2 Electric rotary shaver 有权
标题翻译：电动旋转剃须刀
公开(公告)号：US07487592B2
公开(公告)日：2009-02-10
申请号：US11114437
申请日：2005-04-26
申请人： Hideaki Koike
发明人： Hideaki Koike
IPC分类号： B26B19/14
CPC分类号： B26B19/14 , B26B19/145
摘要： An electric shaver including an outer cutter holder (30) that holds the outer cutters (24), an inner cutter holder (42) which has a plurality of projections (50) that pass through the outer cutter holder (30) and press the outer circumferential edges of the outer cutters (24) and which holds the inner cutters (36) so that the inner cutters are rotatable, a single shaft member (62) which passes through the inner cutter holder (42) and outer cutter holder (30) and whose tip end is positioned in the cutter frame (20) so as to be located between the mutually adjacent outer cutters (24), and a cutter retaining assembly (60), which the shaft member (62) passes through and is detachably anchored to the cutter frame (20) and further elastically presses the inner cutter holder (42) toward the outer cutters.
摘要翻译：一种电动剃须刀，其包括保持所述外刀具（24）的外刀架（30），具有穿过所述外刀架（30）的多个突起（50）的内切刀保持架（42）外刀片（24）的圆周边缘并且保持内切割器（36）使得内刀片是可旋转的，穿过内刀片保持器（42）和外刀架（30）的单个轴构件（62）并且其末端位于所述切割器框架（20）中以便位于相互相邻的外切割器（24）之间;以及切割器保持组件（60），所述轴构件（62）穿过并可拆卸地锚定到所述切割器框架（20）并且进一步向所述外切割器弹性地按压所述内刀片保持器（42）。

7. 发明授权

US07222428B2 Electric rotary shaver 有权
标题翻译：电动旋转剃须刀
公开(公告)号：US07222428B2
公开(公告)日：2007-05-29
申请号：US11232355
申请日：2005-09-21
申请人： Hideaki Koike
发明人： Hideaki Koike
IPC分类号： B26B19/04 , B26B19/14
CPC分类号： B26B19/145 , B26B19/14
摘要： An electric rotary shaver including: a locking member (50) having a plurality of arms (54) outwardly extending from the center, a cutter retaining plate (38) that engages with outer circumferential rims of outer cutters (24) and rotatably holds inner cutters (32), guide pins (56) provided on the tip ends of the arms (54) and slidably pass through the cutter retaining plate (38), permanent magnets (62) fastened to the cutter frame (20) and attach the guide pins (56) by magnetic attraction in a detachable manner, compression coil springs (64) mounted on the guide pins (56) and provided in a compressed state between the arms (54) and the cutter retaining plate (38), and anchoring elements (66, 68) which prevents a locking member (50) from being separated from the cutter retaining plate (38) by more than a predetermined gap.
摘要翻译：一种电动旋转剃须刀，包括：具有从中心向外延伸的多个臂（54）的锁定构件（50），与外切割器（24）的外圆周边缘啮合的切割器保持板（38），并且可旋转地保持内切割器（32），设置在所述臂（54）的末端并且可滑动地穿过所述切割器保持板（38）的引导销（56），紧固到所述切割器框架（20）的永磁体（62）并且将所述引导销（56）以可拆卸的方式通过磁吸引，安装在所述引导销（56）上并且在所述臂（54）和所述切割器保持板（38）之间以压缩状态设置的压缩螺旋弹簧（64））和锚定元件 66，68）防止锁定构件（50）从切割器保持板（38）分离超过预定间隙。

8. 发明申请

US20060059690A1 Electric rotary shaver 有权
标题翻译：电动旋转剃须刀
公开(公告)号：US20060059690A1
公开(公告)日：2006-03-23
申请号：US11232355
申请日：2005-09-21
申请人： Hideaki Koike
发明人： Hideaki Koike
IPC分类号： B26B19/14
CPC分类号： B26B19/145 , B26B19/14
摘要： An electric rotary shaver including: a locking member (50) having a plurality of arms (54) outwardly extending from the center, a cutter retaining plate (38) that engages with outer circumferential rims of outer cutters (24) and rotatably holds inner cutters (32), guide pins (56) provided on the tip ends of the arms (54) and slidably pass through the cutter retaining plate (38), permanent magnets (62) fastened to the cutter frame (20) and attach the guide pins (56) by magnetic attraction in a detachable manner, compression coil springs (64) mounted on the guide pins (56) and provided in a compressed state between the arms (54) and the cutter retaining plate (38), and anchoring elements (66, 68) which prevents a locking member (50) from being separated from the cutter retaining plate (38) by more than a predetermined gap.
摘要翻译：一种电动旋转剃须刀，包括：具有从中心向外延伸的多个臂（54）的锁定构件（50），与外切割器（24）的外圆周边缘啮合的切割器保持板（38），并且可旋转地保持内切割器（32），设置在所述臂（54）的末端并且可滑动地穿过所述切割器保持板（38）的引导销（56），紧固到所述切割器框架（20）的永磁体（62）并且将所述引导销（56）以可拆卸的方式通过磁吸引，安装在所述引导销（56）上并且在所述臂（54）和所述切割器保持板（38）之间以压缩状态设置的压缩螺旋弹簧（64））和锚定元件 66，68）防止锁定构件（50）从切割器保持板（38）分离超过预定间隙。

9. 发明申请

US20050208463A1 Method of screening drug 审中-公开
标题翻译：药物筛选方法
公开(公告)号：US20050208463A1
公开(公告)日：2005-09-22
申请号：US10499126
申请日：2002-12-17
申请人： Masashi Suzuki , Hideaki Koike
发明人： Masashi Suzuki , Hideaki Koike
IPC分类号： G01N23/20 , A61K45/00 , A61P31/04 , C12N15/09 , C12Q1/18 , C12Q1/68 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/68 , G06F17/30 , C12Q3/00
CPC分类号： G01N33/6803 , C07K2299/00 , C12Q1/18 , G01N2333/195
摘要： This invention provides a method of screening for pharmaceutical agents that regulate at least one of metabolism or growth of, or infection by microorganisms, which comprises selecting ligands of an Lrp-like protein based on 3D structural information of the protein.
摘要翻译：本发明提供了一种筛选调节微生物的代谢或生长或感染的至少一种的药物的方法，其包括基于蛋白质的3D结构信息选择Lrp样蛋白质的配体。

10. 发明申请

US20050202522A1 Method of screening for antimicrobial agents 审中-公开
标题翻译：筛选抗微生物剂的方法
公开(公告)号：US20050202522A1
公开(公告)日：2005-09-15
申请号：US10793746
申请日：2004-03-08
申请人： Masashi Suzuki , Hideaki Koike
发明人： Masashi Suzuki , Hideaki Koike
IPC分类号： G01N33/15 , C07K14/195 , C07K14/21 , C07K14/245 , C12Q1/18 , G01N33/48 , G01N33/50 , G01N33/543 , G06F19/00
CPC分类号： C07K14/4702
摘要： [Object] To identify FFRPs which are prospective targets of antimicrobial agents, and by using the FFRPs, to provide a pharmaceutical agent and a novel method for screening for a pharmaceutical agent, in particular, an agent that acts against P. aeruginosa. [Solving Means] Using the genomic sequence of a bacterium, FFRPs coded therein are identified on the basis of correlation between FFRPs summarized in a multiple alignment shown in FIG. 1. By specifying chemical compounds that can specifically interact with the identified FFRPs or their assemblies, thereby changing their 3D structures, candidates for antimicrobial agents are screened.
摘要翻译： [目的]鉴定作为抗微生物剂的前瞻性靶标的FFRP以及通过使用FFRP提供药剂和用于筛选药剂，特别是对铜绿假单胞菌作用的药剂的新方法。 [解决方案]使用细菌的基因组序列，基于在图中所示的多重比对中总结的FFRP之间的相关性来鉴定其中编码的FFRP。 1 。通过指定可以与识别的FFRP或其组件特异性相互作用的化合物，从而改变其3D结构，筛选抗微生物剂的候选物。

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