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1. 发明申请

US20090082333A1 REMEDY FOR XANTHOMA 审中-公开
标题翻译：补救为XANTHOMA
公开(公告)号：US20090082333A1
公开(公告)日：2009-03-26
申请号：US11912262
申请日：2006-04-21
申请人： Masashi Shiomi , Takashi Ito , Ryuichi Tozawa , Yuichiro Amano
发明人： Masashi Shiomi , Takashi Ito , Ryuichi Tozawa , Yuichiro Amano
IPC分类号： C07D267/14 , A61K31/553 , A61P17/00
CPC分类号： A61K31/553 , C07D267/14 , C07D413/06
摘要： A preventive/remedy for xanthoma which contains a compound having an inhibitory effect on squalene synthase, its prodrug or its salt.
摘要翻译：含有对角鲨烯合酶，其前药或其盐具有抑制作用的化合物的黄瘤的预防/补救措施。

2. 发明申请

US20080058310A1 High-density lipoprotein-cholesterol level elevating agent 审中-公开
标题翻译：高密度脂蛋白胆固醇水平升高剂
公开(公告)号：US20080058310A1
公开(公告)日：2008-03-06
申请号：US11810887
申请日：2007-06-07
申请人： Tomoyuki Nishimoto , Ryuichi Tozawa , Masakuni Kori , Yuichiro Amano
发明人： Tomoyuki Nishimoto , Ryuichi Tozawa , Masakuni Kori , Yuichiro Amano
IPC分类号： A61K31/553 , A61P3/00
CPC分类号： C07D267/14 , A61K31/553
摘要： A novel high-density lipoprotein(HDL)-cholesterol level elevating agent containing a compound which has a squalene synthase inhibitory activity.
摘要翻译：一种含有具有角鲨烯合酶抑制活性的化合物的新型高密度脂蛋白（HDL） - 胆固醇水平升高剂。

3. 发明申请

US20060100261A1 Furan or thiopene derivative and medicinal use thereof 失效
标题翻译：呋喃或噻吩衍生物及其医药用途
公开(公告)号：US20060100261A1
公开(公告)日：2006-05-11
申请号：US10526507
申请日：2003-09-04
申请人： Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
发明人： Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
IPC分类号： A61K31/40 , A61K31/381 , A61K31/34 , C07D333/22 , C07D207/30
CPC分类号： C07D307/42 , C07D307/38 , C07D307/54 , C07D307/68 , C07D307/79 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.
摘要翻译：本发明提供由式（I）表示的化合物：[其中R是任选取代的烃基或任选取代的杂环基，p是0,1或2，当p是2时，每个R可以相同或不同的R 1是氢原子或任选取代的烃基，R 2是任选取代的芳族基团，环A是任选取代的单环芳环或任选取代的芳环取代的双环芳族稠合环，X 1是氧原子或硫原子，X 2是一个键，氧原子或-S（O）n （其中n为0,1或2），Y为键，氧原子，-S（O）m - ， - C（-O）-N（R （O） - （R 3）是氢原子，任选取代的烃基团或任选取代的杂环基，m为0,1或2），M 1，M 2和M 3可以是相同或不同，各自独立键或任选取代的二价脂族烃基，M 4是任选取代的二价脂族烃基]或其盐，其可用作脂质代谢异常的预防和/或治疗剂，动脉硬化疾病及其后遗症，糖尿病等。

4. 发明授权

US07553867B2 Furan or thiophene derivative and medicinal use thereof 失效
标题翻译：呋喃或噻吩衍生物及其医药用途
公开(公告)号：US07553867B2
公开(公告)日：2009-06-30
申请号：US10526507
申请日：2003-09-04
申请人： Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
发明人： Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
IPC分类号： A61K31/341 , A61K31/381 , C07D307/40 , C07D333/14 , C07D333/18
CPC分类号： C07D307/42 , C07D307/38 , C07D307/54 , C07D307/68 , C07D307/79 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.
摘要翻译：本发明提供由式（I）表示的化合物：[其中R是任选取代的烃基或任选取代的杂环基，p是0,1或2，当p是2时，每个R可以相同或不同的，R 1是氢原子或任选取代的烃基，R 2是任选取代的芳族基团，环A是任选取代的单环芳族环或任选取代的双环芳族稠环，X 1是氧原子或硫原子， X 2是键，氧原子或-S（O）n - （其中n是0,1或2），Y是键，氧原子，-S（O）m - ， - C（-O） -N（R3） - 或-N（R3）-C（-O） - （R3是氢原子，任选取代的烃基或任选取代的杂环基，m是0,1或2），M1， M2和M3可以相同或不同，并且各自独立地为键或任选取代的二价脂族烃基，M4是任选取代的二价脂族氢羰基]或其盐，其可用作脂质代谢异常的预防和/或治疗剂，动脉硬化疾病及其后遗症，糖尿病等。

5. 发明申请

US20060242716A1 Disease model animal carrying foreign ppar alpha gene transferred thereinto and use thereof 审中-公开
标题翻译：携带携带外来pparα基因的疾病模型动物及其使用
公开(公告)号：US20060242716A1
公开(公告)日：2006-10-26
申请号：US10521174
申请日：2003-07-14
申请人： Yuichiro Amano , Yasuo Sugiyama , Mayumi Nishida , Shigehisa Taketomi
发明人： Yuichiro Amano , Yasuo Sugiyama , Mayumi Nishida , Shigehisa Taketomi
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/705 , C07K14/70567 , G01N33/5088
摘要： The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPARα in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPARα activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPARα using the animal.
摘要翻译：本发明提供了一种非人哺乳动物或其一部分活体，其可稳定地保留编码可表达状态的异源PPARα的DNA，并具有一种或多种不同的遗传修饰，导致病理状况与与PPARα活性调节相关的疾病或在具有PPRE的启动子控制下的外源DNA，以及使用该动物筛选异源PPARα的激动剂/拮抗剂的方法。

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