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1. 发明授权

US5296381A Sensing elements and methods for making and using same 失效
标题翻译：感应元件和制造和使用方法
公开(公告)号：US5296381A
公开(公告)日：1994-03-22
申请号：US742002
申请日：1991-08-08
申请人： Masao Yafuso , Paul F. Korkowski , Roger A. Mader , Cheng Yan , John T. Carlock
发明人： Masao Yafuso , Paul F. Korkowski , Roger A. Mader , Cheng Yan , John T. Carlock
IPC分类号： A61B5/00 , G01N21/62 , G01N21/64 , G01N21/77
CPC分类号： G01N21/7703 , A61B5/1459 , G01N2021/772 , G01N2021/773 , G01N2021/7786
摘要： A sensing element for sensing the concentration of an analyte in a medium is disclosed. The sensing element comprises a matrix material having at least one indicator component covalently bonded thereto. The indicator component is capable of providing a signal dependent on the concentration of a analyte in a medium. The indicator component is derived from at least one indicator compound having an aromatic ring to which is directly bonded a group including a functional portion which is conjugated relative to this aromatic ring.
摘要翻译：公开了用于感测介质中分析物浓度的感测元件。感测元件包括具有至少一个与其共价键合的指示剂组分的基质材料。指示剂组分能够提供依赖于介质中分析物浓度的信号。指示剂组分衍生自至少一种具有芳环的指示剂化合物，其直接键合到包含相对于该芳环共轭的官能部分的基团上。

2. 发明授权

US5075127A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US5075127A
公开(公告)日：1991-12-24
申请号：US492550
申请日：1990-03-12
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N21/6428 , G01N31/223 , G01N2021/6434 , G01N2021/772 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

3. 发明授权

US4954318A Optical sensor 失效
标题翻译：光学传感器
公开(公告)号：US4954318A
公开(公告)日：1990-09-04
申请号：US91432
申请日：1987-08-31
申请人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
发明人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , G01N2021/772
摘要： An apparatus for measuring the concentration of a component in a medium comprising:an optical sensor including at least one optical indicator for providing an optical signal which varies in response to the presence of a component in a medium;an optical signal fiber capable of transmitting the optical signal from the optical sensor; anda supply reservoir associated with the optical sensor and acting to provide additional optical indicator to the optical sensor.
摘要翻译：一种用于测量介质中的组分的浓度的装置，包括：光学传感器，包括至少一个光学指示器，用于提供响应于介质中组分的存在而变化的光学信号; 能够从光学传感器发送光信号的光信号光纤; 以及与所述光学传感器相关联并用于向所述光学传感器提供附加光学指示器的供应储存器。

4. 发明授权

US5284775A Gas sensing element and method for making same 失效
标题翻译：气体传感元件及其制造方法
公开(公告)号：US5284775A
公开(公告)日：1994-02-08
申请号：US949771
申请日：1992-09-21
申请人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
发明人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/49 , G01N33/50
CPC分类号： G01N21/783 , G01N31/223 , Y10T436/204998
摘要： Sensing composition precursors and sensing compositions, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g., blood, are disclosed. In one embodiment, the sensing composition precursor comprises a dispersed aqueous liquid including a sensing component dissolved therein, a polymer precursor, and a hydrophilic dispersing agent selected from hydroxyalkyl celluloses and mixtures thereof in an amount effective to facilitate maintaining the dispersed aqueous liquid.
摘要翻译：公开了感测组合物前体和感测组合物，其可用于感测介质（例如血液）中的二氧化碳气体的浓度。在一个实施方案中，感测组合物前体包含分散的水性液体，其包含溶解于其中的感测组分，聚合物前体和选自羟烷基纤维素及其混合物的亲水性分散剂，其量有助于维持分散的水性液体。

5. 发明授权

US4919891A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US4919891A
公开(公告)日：1990-04-24
申请号：US49844
申请日：1987-05-15
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/643 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N21/80 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

6. 发明授权

US5345932A Method and system for monitoring of blood constituents in vivo 失效
标题翻译：体内血液成分监测方法及系统
公开(公告)号：US5345932A
公开(公告)日：1994-09-13
申请号：US5765
申请日：1993-01-15
申请人： Masao Yafuso , Laurence A. Harker
发明人： Masao Yafuso , Laurence A. Harker
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61M25/00
CPC分类号： A61B5/6852 , A61B5/14539 , A61B5/1459
摘要： A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.
摘要翻译：公开了一种用于确定在血管中的导管内或其附近使用传感器的血液成分浓度的方法，用于产生与血液成分浓度相关的信号。该改进包括获得信号，而在血管中存在以下至少之一：（1）添加的血管扩张剂组分和/或血管扩张启动子，其量可以有效地减少由导管在血液中的存在而引起的血管收缩血管和（2）增加的血小板/白细胞抑制剂组分和/或血小板/白细胞去激活启动子，其量可以有效地减少由导管在血管中的存在引起的血小板和/或白细胞活化。

7. 发明授权

US5120510A Sensor and method for sensing the concentration of a component in a medium 失效
标题翻译：用于感测介质中组分浓度的传感器和方法
公开(公告)号：US5120510A
公开(公告)日：1992-06-09
申请号：US624200
申请日：1990-12-06
申请人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
发明人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
IPC分类号： A61B5/00 , G01N21/64 , G01N21/77 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N21/80 , G01N21/81
摘要： An apparatus for sensing the concentration of a component such as oxygen in a medium such as blood. The apparatus includes an elongated signal transmitter and a sensing element at one end thereof. A substantially rigid sleeve is secured around such end to provide a pocket for the sensing element.
摘要翻译：用于感测诸如血液的介质中诸如氧的组分的浓度的装置。该装置包括细长的信号发射器和在其一端的感测元件。围绕该端部固定有基本刚性的套筒，以提供感测元件的口袋。

8. 发明授权

US4886338A Optical fiber event sensor 失效
标题翻译：光纤事件传感器
公开(公告)号：US4886338A
公开(公告)日：1989-12-12
申请号：US256305
申请日：1988-10-11
申请人： Masao Yafuso , Henry K. Hui
发明人： Masao Yafuso , Henry K. Hui
IPC分类号： G01N21/64 , G01N21/80
CPC分类号： G01N21/643 , G01N2021/6434 , G01N2021/6439 , G01N2021/6484 , G01N2021/7786
摘要： A micro pH sensor is constructed by reacting powdered aminoalkylated cellulose with a dye to covalently bond the dye to the aminoalkyl groups on the cellulose. Any excess unreacted aminoalkyl groups are blocked with a blocking agent and the dye containing powdered cellulose is taken up in a solvent. A portion of the solvated dye containing cellulose is deposited in association with an optical fiber. The cellulose is regenerated into a solid matrix by acid treatment of the solvated dye containing cellulose to deposit the dye containing celllulose matrix on the optical fiber.
摘要翻译：通过使粉末氨基烷基化纤维素与染料反应，将染料共价结合到纤维素上的氨基烷基上来构建微pH传感器。任何多余的未反应的氨基烷基用封闭剂封闭，含有粉末状纤维素的染料溶于溶剂中。含有纤维素的溶剂化染料的一部分与光纤相关联地沉积。通过酸处理含有纤维素的溶剂化染料将纤维素再生成固体基质，以将含有染料的纤维素基质沉积在光纤上。

9. 发明授权

US4798738A Micro sensor 失效
标题翻译：微型传感器
公开(公告)号：US4798738A
公开(公告)日：1989-01-17
申请号：US917913
申请日：1986-10-10
申请人： Masao Yafuso , Henry K. Hui
发明人： Masao Yafuso , Henry K. Hui
IPC分类号： G01N21/64 , G01N21/80 , B05D5/06
CPC分类号： G01N21/643 , G01N2021/6434 , G01N2021/6439 , G01N21/80
摘要： A micro pH sensor is constructed by reacting powdered aminoalkylated cellulose with a dye to covalently bond the dye to the aminoalkyl groups on the cellulose. Any excess unreacted aminoalkyl groups are blocked with a blocking agent and the dye containing powdered cellulose is taken up in a solvent. A portion of the solvated dye containing cellulose is deposited in association with an optical fiber. The cellulose is regenerated into a solid matrix by acid treatment of the solvated dye containing cellulose to deposit the dye containing cellulose matrix on the optical fiber.
摘要翻译：通过使粉末氨基烷基化纤维素与染料反应，将染料共价结合到纤维素上的氨基烷基上来构建微pH传感器。任何多余的未反应的氨基烷基用封闭剂封闭，含有粉末状纤维素的染料溶于溶剂中。含有纤维素的溶剂化染料的一部分与光纤相关联地沉积。通过对含有纤维素的溶剂化染料进行酸处理将纤维素再生成固体基质，以将含纤维素基质的染料沉积在光纤上。

10. 发明授权

US5958782A Cation-sensing composite structure and compounds for use therein 失效
标题翻译：阳离子检测复合结构和其中使用的化合物
公开(公告)号：US5958782A
公开(公告)日：1999-09-28
申请号：US810969
申请日：1997-02-27
申请人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
发明人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
IPC分类号： G01N21/64 , C07D498/18 , C09B23/10 , G01N31/22 , G01N33/20 , G01N33/487
CPC分类号： C07D498/18 , C09B23/102 , G01N31/22 , G01N31/221
摘要： A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
摘要翻译：公开了一种荧光离子化合物，其包括络合部分，例如穴状或冠醚部分，以及荧光部分如香豆素部分。香豆素部分可以在3位被吸电子或可极化基团取代，例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。

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