专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4975720A Exposure device and images forming apparatus provided with the exposure device 失效
标题翻译：设置有曝光装置的曝光装置和图像形成装置
公开(公告)号：US4975720A
公开(公告)日：1990-12-04
申请号：US419945
申请日：1989-10-11
申请人： Masao Saito , Tsutomu Masuda
发明人： Masao Saito , Tsutomu Masuda
IPC分类号： G03B27/72 , G03B27/54 , G03G15/043
CPC分类号： G03G15/0435 , G03B27/542
摘要： An exposure device comprising a table having a plane on which an original is placed, a light emitting device for emitting a light on the original placed on the plane, a scanning device for scanning the original on the plane while the emitting device is being moved along the plane, and a light adjusting device for adjusting the quantity of light emitted from the emitting device. The light adjusting device includes a shutter adapted to narrow the path of light emitted from the emitting device and adjust the quantity of light, an urging member for urging the shutter in a predetermined direction, an operating member for operating the shutter against the urging force of the urging member, when the emitting device is being moved and the shutter abuts against the operating member, and a holding device for holding the shutter, which has been moved to a predetermined position by the operating member, until the shutter abuts against the operating member again.
摘要翻译：一种曝光装置，包括具有放置原稿的平面的台，用于在放置在平面上的原稿上发射光的发光装置，用于在发射装置移动时在平面上扫描原稿的扫描装置平面以及用于调节从发光装置发出的光量的调光装置。调光装置包括一个适于缩小从发射装置发射的光的路径并调节光量的快门，一个用于沿预定方向推动挡板的推动部件，一个操作部件，用于克服该挡板的作用力当所述发射装置被移动并且所述快门抵靠所述操作构件时，所述推动构件以及用于保持已被所述操作构件移动到预定位置的所述快门的保持装置，直到所述快门抵靠所述操作构件再次。

2. 发明授权

US4975715A Thermal printer having image editing function 失效
标题翻译：具有图像编辑功能的热敏打印机
公开(公告)号：US4975715A
公开(公告)日：1990-12-04
申请号：US407737
申请日：1989-09-15
申请人： Masao Saito , Tsutomu Masuda
发明人： Masao Saito , Tsutomu Masuda
IPC分类号： B41J2/325 , B41J17/12 , B41M5/26
CPC分类号： B41J17/12
摘要： A position in which an image of a second document is inserted into an image of a first document is designated by operating an operation panel. A scanner unit reads the image of the first document and a printing unit prints the read image of the first document on paper. That area of the first document image to be printed by the printing unit in which the image of the second document is inserted is masked. Paper on which the first docment image has been printed and an ink ribbon are set back to a position at which the printing operation for the first document image is started before the second document image is printed. The scanner unit reads the second document image and the printing unit prints the second document image read on a designated area of the paper on which the first document image has been printed by using ink of that portion of the ink ribbon which has not been used for printing the first document image.
摘要翻译：通过操作操作面板指定将第二文档的图像插入到第一文档的图像中的位置。扫描器单元读取第一文件的图像，并且打印单元将第一文档的读取图像打印在纸上。被插入第二文档的图像的打印单元要打印的第一文档图像的区域被遮蔽。在打印第二文档图像之前，已经打印了第一文档图像的打印纸和墨带被设置回到第一文档图像的打印操作开始的位置。扫描仪单元读取第二文档图像，并且打印单元通过使用未被使用的墨带的那部分的墨水打印在已经打印了第一文档图像的纸张的指定区域上读取的第二文档图像打印第一个文档图像。

3. 发明申请

US20120277238A1 PHARMACEUTICAL COMPOSITION CONTAINING FUSED HETERO-RING DERIVATIVE 审中-公开
标题翻译：含有金属杂环衍生物的药物组合物
公开(公告)号：US20120277238A1
公开(公告)日：2012-11-01
申请号：US13388296
申请日：2010-07-29
申请人： Yuuki Tachibana , Masayoshi Miyagawa , Tsutomu Masuda , Tsuyoshi Hasegawa
发明人： Yuuki Tachibana , Masayoshi Miyagawa , Tsutomu Masuda , Tsuyoshi Hasegawa
IPC分类号： A61K31/496 , C07D471/04 , C07D491/052 , C07D487/04 , A61K31/4985 , A61K31/404 , A61K31/437 , A61P11/06 , A61P37/08 , A61P11/00 , A61P29/00 , A61P17/06 , A61P1/00 , A61P9/10 , A61P25/00 , C07D403/06
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/1652 , A61K9/2054 , A61K9/4866 , A61K31/496 , A61K31/4985 , C07C2601/02 , C07D207/34 , C07D209/42 , C07D209/52 , C07D235/24 , C07D401/06 , C07D403/06 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound which indicates a histamine H4 receptor modulating activity.A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R1 is substituted or unsubstituted alkyl, etc., W is —O—, etc., n is an integer of 0 to 6; X is —N(R7)— or —O—; R7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is —C(R8)═ or —N═; R8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is ═O, ═S, etc.; B ring is a ring represented by the following formula: wherein R10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R11, R12a and R12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：本发明提供了表示组胺H 4受体调节活性的化合物。由式（I）表示的化合物：其中A环是由下式表示的环：其中R1是取代或未取代的烷基等，W是-O-等，n是0-6的整数 ; X是-N（R 7） - 或-O-; R7是氢，取代或未取代的烷基等; Y是-C（R8）=或-N =; R8是氢，取代或未取代的烷基等; Z是═O，═S等; B环是由下式表示的环：其中R 10各自独立地是取代或未取代的烷基，卤素，羟基，取代或未取代的烷氧基，取代或未取代的氨基; R11，R12a和R12b各自独立地为氢或取代或未取代的烷基等; p为0〜4的整数，或其药学上可接受的盐或其溶剂合物。

4. 发明授权

US08173841B2 Tetrahydro-naphthalene derivatives 失效
标题翻译：四氢萘衍生物
公开(公告)号：US08173841B2
公开(公告)日：2012-05-08
申请号：US13052482
申请日：2011-03-21
申请人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
发明人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
IPC分类号： C07C273/00 , A61K31/17
CPC分类号： C07D295/088 , C07C233/29 , C07C233/75 , C07C235/42 , C07C237/40 , C07C275/32 , C07C275/38 , C07C275/40 , C07C275/42 , C07C317/32 , C07C323/44 , C07C2602/10 , C07D207/27 , C07D211/22 , C07D211/46 , C07D211/62 , C07D295/135
摘要： This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢萘衍生物及其盐。本发明的四氢萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，膀胱过度活动症，急迫性尿失禁，慢性疼痛，神经性疼痛，手术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。

5. 发明申请

US20090298811A1 BENZIMIDAZOLONE DERIVATIVES 审中-公开
公开(公告)号：US20090298811A1
公开(公告)日：2009-12-03
申请号：US12440646
申请日：2007-09-03
申请人： Kazuo Ando , Ingrid Price Buchler , Shridhar Gajanan Hedge , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
发明人： Kazuo Ando , Ingrid Price Buchler , Shridhar Gajanan Hedge , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/4965 , A61K31/437 , A61K31/4245 , A61K31/4184 , C07D405/14 , C07D413/06 , C07D403/08 , C07D471/04 , C07D413/12 , C07D235/24
CPC分类号： C07D413/06 , A61K31/16 , C07D235/26 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12 , C07D413/14 , C07D471/04
摘要： This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tourette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasodialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.

6. 发明授权

US07435743B2 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US07435743B2
公开(公告)日：2008-10-14
申请号：US11240867
申请日：2005-09-30
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshiro , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuiyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshiro , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuiyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/4436 , C07D213/22 , C07D409/04 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents hydrogen, —CR31R32R33; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1 -C 6烷基， 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基，（C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基，，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示氢，-CR 31，32，32，33， R 4是氢，氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。该化合物具有优异的抗炎活性和其他生物活性。

7. 发明申请

US20060166989A1 2-naphthamide derivatives 审中-公开
标题翻译： 2-萘甲酰胺衍生物
公开(公告)号：US20060166989A1
公开(公告)日：2006-07-27
申请号：US10517677
申请日：2003-05-30
申请人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
发明人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
IPC分类号： A61K31/537 , A61K31/44 , A61K31/195 , C07D213/55 , C07D265/30 , C07C237/40
CPC分类号： C07C235/66
摘要： The present invention relates to 2-naphthamides, which are useful as an active ingredient of pharmaceutical preparations. The 2-naphthamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benign prostatic hypertrophy (BPH), pro-statitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the disease is also alleviated by treatment with an IP receptor antagonist.
摘要翻译：本发明涉及可用作药物制剂活性成分的2-萘甲酰胺。本发明的2-萘甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体活性相关的疾病。这些疾病包括尿路疾病或病症如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大），pro-statitis，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺增生症，膀胱炎或自发性膀胱过敏反应。本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压血友病和出血; 和炎症，因为该疾病也通过用IP受体拮抗剂治疗而缓解。

8. 发明授权

US06984649B1 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US06984649B1
公开(公告)日：2006-01-10
申请号：US10402500
申请日：2003-03-28
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4545 , C07D409/14 , C07D211/68 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents 1.2.3.6-tetrahydro-pyridine, or —CR31R32R33 wherein R31 represents H or C1-6 alkyl and R32 and R33 are joined to form a 5-8 membered saturated ring optionally containing up to three heteroatoms; R4 is carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译：吡啶化合物，其通式如下：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基，（C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基，，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示1.2.3.6-四氢 - 吡啶或-CR 31，其中R 1，R 2，R 3， SUP> 31表示H或C 1-6烷基，R 32和R 33连接形成5-8 任选地含有至多三个杂原子的饱和环; R 4是氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。该化合物具有优异的抗炎活性和其他生物活性。

9. 发明授权

US4348478A Method for preparation of a recombinant DNA phage 失效
标题翻译：重组DNA噬菌体的制备方法
公开(公告)号：US4348478A
公开(公告)日：1982-09-07
申请号：US87167
申请日：1979-10-22
申请人： Eiichi Nakano , Tsutomu Masuda , Narimasa Saito , Danji Fukushima
发明人： Eiichi Nakano , Tsutomu Masuda , Narimasa Saito , Danji Fukushima
IPC分类号： C12N15/09 , C12N15/00 , C12P19/34 , C12R1/91
CPC分类号： C12N15/00
摘要： A method for the preparation of a novel recombinant DNA, which comprises (1) cleaving with an endonuclease a temperate phage DNA having an endonuclease-sensitive region not in the DNA segment participating in the replication of phage DNA and the integration of phage DNA into a host chromosome but at least in the DNA segment carrying genetic information for the coat protein production and another DNA carrying intended genetic information, (2) adding DNA-ligase to the mixture of both cleft DNA's, and (3) recovering from the mixture a phage DNA having its coat protein producing ability deleted by the replacement of the DNA segments carrying genetic information for the coat protein production with a DNA fragment carrying the intended information.
摘要翻译：一种制备新的重组DNA的方法，其包括（1）用核酸内切酶切割温和的噬菌体DNA，所述温带噬菌体DNA具有参与噬菌体DNA复制的DNA片段中不具有内切核酸酶敏感区域，并将噬菌体DNA整合到宿主染色体，但至少在DNA片段中携带外壳蛋白生产的遗传信息和携带预期遗传信息的另一个DNA，（2）向裂解DNA的混合物中加入DNA连接酶，和（3）从混合物中回收噬菌体通过用携带预期信息的DNA片段替代携带用于外壳蛋白生产的遗传信息的DNA片段，缺失其外壳蛋白产生能力的DNA。

10. 发明授权

US07544716B2 Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists 失效
标题翻译：四氢萘衍生物作为香草素受体拮抗剂
公开(公告)号：US07544716B2
公开(公告)日：2009-06-09
申请号：US10537217
申请日：2003-11-28
申请人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
发明人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
IPC分类号： A61K31/17
CPC分类号： C07C275/32 , C07C2602/10 , C07D207/27 , C07D211/22 , C07D211/46 , C07D211/62 , C07D295/135
摘要： This invention relates to tetrahydro-naphthalene derivatives of formula (I) in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. The compounds, pharmaceutical compositions containing them, and methods of treatment using them are disclosed and claimed.
摘要翻译：本发明涉及式（I）的四氢 - 萘衍生物，其中可变基团如说明书和权利要求中所定义，以及其可用作药物制剂活性成分的互变异构体和立体异构形式及其盐。本发明的四氢 - 萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，敦促性尿失禁，膀胱过度活动症，慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。公开并要求保护所述化合物，含有它们的药物组合物和使用它们的治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式