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1. 发明申请

US20050271695A1 Cross-linked apatite/collagen porous body containing self-organized apatite/collagen composite and its production method 有权
标题翻译：含有自组织磷灰石/胶原复合材料的交联磷灰石/胶原多孔体及其制备方法
公开(公告)号：US20050271695A1
公开(公告)日：2005-12-08
申请号：US11123203
申请日：2005-05-06
申请人： Masanori Kikuchi , Junzo Tanaka , Hisatoshi Kobayashi , Daisuke Shoji
发明人： Masanori Kikuchi , Junzo Tanaka , Hisatoshi Kobayashi , Daisuke Shoji
IPC分类号： A61L27/46 , A61L27/56 , A61K38/39 , A61K33/42 , C07K14/78
CPC分类号： A61L27/56 , A61L27/46 , C08L89/06
摘要： A method for producing a cross-linked apatite/collagen porous body comprising the steps of gelling and then freeze-drying a dispersion containing an apatite/collagen composite and collagen to form a porous body, and further cross-linking collagen in the porous body, and a cross-linked apatite/collagen porous body produced by this method.
摘要翻译：一种交联磷灰石/胶原多孔体的制造方法，其特征在于，包括以下步骤：将含有磷灰石/胶原复合物和胶原的分散体凝胶化，然后冷冻干燥，形成多孔体，进一步与多孔体交联胶原，和通过该方法生产的交联磷灰石/胶原多孔体。

2. 发明授权

US07153938B2 Cross-linked apatite/collagen porous body containing self-organized apatite/collagen composite and its production method 有权
标题翻译：含有自组织磷灰石/胶原复合材料的交联磷灰石/胶原多孔体及其制备方法
公开(公告)号：US07153938B2
公开(公告)日：2006-12-26
申请号：US11123203
申请日：2005-05-06
申请人： Masanori Kikuchi , Junzo Tanaka , Hisatoshi Kobayashi , Daisuke Shoji
发明人： Masanori Kikuchi , Junzo Tanaka , Hisatoshi Kobayashi , Daisuke Shoji
IPC分类号： A61K38/17
CPC分类号： A61L27/56 , A61L27/46 , C08L89/06
摘要： A method for producing a cross-linked apatite/collagen porous body comprising the steps of gelling and then freeze-drying a dispersion containing an apatite/collagen composite and collagen to form a porous body, and further cross-linking collagen in the porous body, and a cross-linked apatite/collagen porous body produced by this method.
摘要翻译：一种交联磷灰石/胶原多孔体的制造方法，其特征在于，包括以下步骤：将含有磷灰石/胶原复合物和胶原的分散体凝胶化，然后冷冻干燥，形成多孔体，进一步与多孔体交联胶原，和通过该方法生产的交联磷灰石/胶原多孔体。

3. 发明申请

US20060128948A1 Biological low-molecular-weight derivatives 失效
标题翻译：生物低分子量衍生物
公开(公告)号：US20060128948A1
公开(公告)日：2006-06-15
申请号：US10527694
申请日：2003-09-11
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
IPC分类号： C08B37/08 , C08B37/00
CPC分类号： C07D207/02 , C07D207/46
摘要： The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
摘要翻译：已经用于生物粘合剂和治疗医疗装置如心脏瓣膜的交联剂和缩合剂是人工合成的非天然化合物。因此，它们不会在体内代谢并对活体表现出毒性。因此，这些化合物仅在临床部位中仅限于有限的目的和用途。本发明提供一种通过用N-羟基琥珀酰亚胺，N-羟基磺基琥珀酰亚胺或其衍生物修饰生物低分子量化合物的羧基得到的生物学低分子量衍生物和通过以下方法得到的交联的高分子量产物：用该衍生物交联各种高分子量化合物。

4. 发明申请

US20070254013A1 Medical Material and Process for Producing the Same 审中-公开
标题翻译：医疗材料及其生产工艺
公开(公告)号：US20070254013A1
公开(公告)日：2007-11-01
申请号：US10588309
申请日：2005-02-01
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61L27/3604 , A61L27/3641 , A61L27/3687 , A61L27/3839 , A61L2430/16
摘要： [Object] A medical material that improves therapeutic effects in epithelial cells such as keratoconjunctival epithelial cells with the use of an amnion, and a process for producing the same are provided. [Solving Means] A medical material includes an amnion, which is a placental tissue, a polymer film bonded to one surface of the amnion and crosslinked, and cells adhered to the other surface of the amnion. A process for producing the medical material includes the steps of preparing an amnion from which the spongy layer is removed, bonding a biocompatible polymer film to one surface of the amnion followed by crosslinking, adhering epithelial stem cells to the other surface of the amnion, and proliferating epithelial cells from the epithelial stem cells on the surface of the amnion.
摘要翻译：提供了一种使用羊膜改善上皮细胞如角膜结膜上皮细胞治疗效果的医疗材料及其制造方法。 [解决方案]药物材料包括羊膜，羊膜组织，与羊膜的一个表面结合并交联的聚合物膜，以及附着在羊膜的另一表面的细胞。制造医疗材料的方法包括以下步骤：制备从其中除去海绵层的羊膜，将生物相容性聚合物膜粘合到羊膜的一个表面，然后交联，将上皮干细胞粘附到羊膜的另一个表面，以及从羊膜表面的上皮干细胞增殖上皮细胞。

5. 发明授权

US07741454B2 Biological low-molecular-weight derivatives 失效
标题翻译：生物低分子量衍生物
公开(公告)号：US07741454B2
公开(公告)日：2010-06-22
申请号：US10527694
申请日：2003-09-11
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C07K16/00 , C08H1/00 , A61F2/00 , A61K31/74 , A61F13/15 , A61F13/20
CPC分类号： C07D207/02 , C07D207/46
摘要： The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
摘要翻译：已经用于生物粘合剂和治疗医疗装置如心脏瓣膜的交联剂和缩合剂是人工合成的非天然化合物。因此，它们不会在体内代谢并对活体表现出毒性。因此，这些化合物仅在临床部位中仅限于有限的目的和用途。本发明提供一种通过用N-羟基琥珀酰亚胺，N-羟基磺基琥珀酰亚胺或其衍生物修饰生物低分子量化合物的羧基得到的生物学低分子量衍生物和通过以下方法得到的交联的高分子量产物：用该衍生物交联各种高分子量化合物。

6. 发明申请

US20060239958A1 Biodegradable and pressure-sensitive material for medical use 审中-公开
标题翻译：用于医疗用途的可生物降解和压敏材料
公开(公告)号：US20060239958A1
公开(公告)日：2006-10-26
申请号：US10543156
申请日：2004-02-05
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
IPC分类号： A61K38/16 , A61K38/38 , C08L89/00 , C08G63/91 , C08G63/48
CPC分类号： A61L24/043 , A61L24/0042 , A61L2430/36
摘要： Disclosed is a two-component, bio-degradable/absorbable adhesive medical material, which has a bonding component comprising a biodegradable polymer, and a hardening component comprising a low-molecular-weight derivative prepared by modifying a carboxyl group in a di- or tri-carboxylic acid of the citric acid cycle, with an electron-attracting group (one or a combination of two or more selected from the group consisting of a succinimidyl group, a sulfosuccinimidyl group, a maleimidyl group, a phthalimidyl group, an imidazolyl group, a nitrophenyl group and a tresyl group, and derivatives thereof). The present invention is intended to meet the need for developing a biological tissue adhesive having strong bonding force and low biological toxicity, in the situation where a conventional hemostatic material, blood-vessel embolizing material, sealant or aneurysm closing material has been liable to peel off from its applied site and has not been able to achieve sufficient hemostatic effect or sealing/closing strength in occluding a blood vessel, stopping bleeding, sealing air-leak or closing an aneurysm.
摘要翻译：公开了一种双组分生物可降解/可吸收的粘合剂医疗材料，其具有包含可生物降解的聚合物的粘合组分和包含通过改性二 - 或三（C）中的羧基制备的低分子量衍生物的硬化组分 - 具有吸电子基团（一种或两种或更多种选自琥珀酰亚胺基，磺基琥珀酰亚胺基，马来酰亚胺基，苯二酰亚胺基，咪唑基，咪唑基，硝基苯基和甲酚基，及其衍生物）。本发明旨在满足在常规止血材料，血管栓塞材料，密封剂或动脉瘤闭合材料易于剥离的情况下开发具有强结合力和低生物毒性的生物组织粘合剂的需要从其应用场所，并且在闭塞血管，停止出血，密封空气泄漏或闭合动脉瘤方面未能达到充分的止血效果或密封/闭合强度。

7. 发明授权

US08887621B2 Reciprocating compressor 有权
标题翻译：往复式压缩机
公开(公告)号：US08887621B2
公开(公告)日：2014-11-18
申请号：US13039718
申请日：2011-03-03
申请人： Akito Ohata , Hisatoshi Kobayashi
发明人： Akito Ohata , Hisatoshi Kobayashi
IPC分类号： F16J9/00 , F04B39/00
CPC分类号： F04B39/0016
摘要： A reciprocating compressor including an oscillation-type piston mechanism is provided with a piston ring which is mounted in a piston ring groove to seal a space between a piston and a cylinder. A ring groove other than the piston ring groove is provided at an outer periphery of the piston on a side away from the piston ring groove and closer to a crank shaft. A guide ring, which is inhibited from radial movement and shaped like a skirt opened toward the crank shaft, is mounted in the ring groove. Thus, the oscillation-type reciprocating compressor is adapted to maintain long-term durability even under high-pressure compression condition and to prevent heat propagation to a large end portion.
摘要翻译：包括振荡式活塞机构的往复式压缩机设置有活塞环，其安装在活塞环槽中以密封活塞和气缸之间的空间。除活塞环槽以外的环形槽设置在活塞外侧的远离活塞环槽的一侧的外周，更靠近曲轴。导向环被阻止径向运动并形状为朝向曲轴敞开的裙部，安装在环形槽中。因此，振荡式往复式压缩机即使在高压压缩条件下也能够保持长期耐久性，并且防止热量向大端部传播。

8. 发明申请

US20100303645A1 Reciprocative Compressor 有权
标题翻译：往复式压缩机
公开(公告)号：US20100303645A1
公开(公告)日：2010-12-02
申请号：US12652954
申请日：2010-01-06
申请人： Akito OHATA , Hisatoshi Kobayashi
发明人： Akito OHATA , Hisatoshi Kobayashi
IPC分类号： F04B25/00 , F04B39/00 , F16J9/12
CPC分类号： F04B39/0016
摘要： This invention provides a swing-type reciprocative compressor capable of maintaining long durability and preventing propagation of heat to the large end portion of a piston, even under high-compression.In the reciprocative compressor having a swing-type piston mechanism, a piston ring is attached to a piston ring groove to seal between a piston and a cylinder. A ring groove is provided separately from the piston ring groove on the outer circumferential side of the piston and on the crankshaft side of the piston ring groove. A guide ring restricted from moving in a radial direction and shaped like a skirt opening toward the crankshaft side is provided in the ring groove.
摘要翻译：本发明提供一种摆动式往复式压缩机，即使在高压缩下，也能够保持长时间的耐久性并防止热量传递到活塞的大端部。在具有摆动式活塞机构的往复式压缩机中，活塞环附接到活塞环槽以在活塞和气缸之间进行密封。在活塞的外周侧和活塞环槽的曲轴侧上与活塞环槽分开设置环槽。导向环设置在环形槽中，该导向环限制在径向移动并形成为朝向曲轴侧的裙部开口。

9. 发明授权

US09200393B2 Process of making a polymer fiber 有权
标题翻译：制造聚合物纤维的方法
公开(公告)号：US09200393B2
公开(公告)日：2015-12-01
申请号：US13696863
申请日：2011-05-10
申请人： Hisatoshi Kobayashi , Dohiko Terada
发明人： Hisatoshi Kobayashi , Dohiko Terada
IPC分类号： D06M10/00 , D04H1/728 , D01D5/00 , D01F9/00 , B29C47/00
CPC分类号： D04H1/728 , B29C47/0004 , B29C47/0014 , B29C47/0021 , D01D5/0038 , D01D5/0092 , D01F9/00 , Y10T428/298 , Y10T442/626
摘要： A polymer electrolyte fiber having a high molecular weight is produced with ease by an electrospinning method. In an electrospinning method which comprises applying a voltage to a solution of a polymer electrolyte to allow a jet of the solution to spurt, forming a polymer fiber, the voltage applied to the solution of the polymer electrolyte is a voltage having the opposite polarity to the charge of molecular chains of the polymer electrolyte in the solution, and the voltage is applied to increase the viscosity of the solution to be higher than that of the solution before applying the voltage, allowing the solution to spurt.
摘要翻译：通过静电纺丝法容易地制备高分子量的聚合物电解质纤维。在电纺丝方法中，包括向聚合物电解质溶液施加电压以使溶液喷射，形成聚合物纤维，施加到聚合物电解质溶液的电压是与溶液中的聚合物电解质的分子链的电荷，并施加电压以在施加电压之前将溶液的粘度提高到高于溶液的粘度，使溶液喷出。

10. 发明授权

US4887687A Motorcycle frame 失效
标题翻译：摩托车架
公开(公告)号：US4887687A
公开(公告)日：1989-12-19
申请号：US207967
申请日：1988-06-17
申请人： Susumu Asai , Haruhide Sugimoto , Masaru Fujisaki , Tadatoshi Shigetomi , Hisatoshi Kobayashi
发明人： Susumu Asai , Haruhide Sugimoto , Masaru Fujisaki , Tadatoshi Shigetomi , Hisatoshi Kobayashi
IPC分类号： B62K19/04 , B62K19/12 , B62K19/30
CPC分类号： B62K19/30 , B62K19/04 , B62K19/12
摘要： A motorcycle frame is cast in two parts which are bolted together along the longitudinal centerline of the motorcycle. The frame has a transverse section in the form of an inverted "U", the space defined by the "U" being arranged to receive a motorcycle engine. An upper wall provides a separating partition between a fuel tank and the engine for defining a longitudinal space of reduced transverse sectional area towards the rear of the frame.
摘要翻译：摩托车车架（5）铸造在沿着摩托车的纵向中心线螺栓连接的两个部分（10,11）中。框架具有倒U形形式的横截面，5由“U”限定的空间被布置成接收摩托车发动机。

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