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1. 发明申请

US20120157457A1 COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION 有权
标题翻译：用于诱导神经元差异的组合物和方法
公开(公告)号：US20120157457A1
公开(公告)日：2012-06-21
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A61K31/426 , A61K31/5377 , A61K31/427 , C07D277/42 , C07D417/12
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

2. 发明授权

US08105581B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08105581B2
公开(公告)日：2012-01-31
申请号：US12095723
申请日：2006-12-01
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

3. 发明申请

US20100166710A1 Compositions and Methods for Inducing Neuronal Differentiation 有权
标题翻译：诱导神经元分化的组成和方法
公开(公告)号：US20100166710A1
公开(公告)日：2010-07-01
申请号：US12095723
申请日：2006-12-01
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A61K35/12 , C07D277/34 , C07D417/12 , C12N5/02 , A61K31/426 , A61K31/5377 , C12Q1/68 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

4. 发明授权

US08394798B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08394798B2
公开(公告)日：2013-03-12
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

5. 发明申请

US20050226848A1 Transcriptional regulation of gene expression by small double-stranded modulatory RNA 有权
标题翻译：通过小双链调节RNA的基因表达的转录调控
公开(公告)号：US20050226848A1
公开(公告)日：2005-10-13
申请号：US10857784
申请日：2004-05-28
申请人： Tomoko Kuwabara , Fred Gage
发明人： Tomoko Kuwabara , Fred Gage
IPC分类号： A61K48/00 , C12N5/0793 , C12N15/867 , C12Q20060101
CPC分类号： C12N5/0619 , C12N2501/60 , C12N2799/027
摘要： The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the association results in altered expression of the one or more genes. The invention is further directed to method for directing the differentiation of neuronal stem cells into neurons by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes involved in neuronal differentiation and directing the transcription of the one or more genes. In related embodiments, the invention provides particular compositions of double-stranded ribonucleic acid molecules as well as therapeutic and screening applications of the invention.
摘要翻译：本发明提供了一种通过使细胞系统与能够与控制一种或多种基因转录的调节机制缔合的双链核糖核酸分子来调节基因表达的方法，其中所述缔合导致一个或多个基因。本发明还涉及通过使细胞系统与能够与控制一种或多种参与神经元分化的基因的转录的调节机制缔合的双链核糖核酸分子的方式来指导神经元干细胞分化为神经元的方法并指导一个或多个基因的转录。在相关实施方案中，本发明提供了双链核糖核酸分子的特定组合物以及本发明的治疗和筛选应用。

6. 发明申请

US20060234378A1 Molecular switch regulating neurogenesis 审中-公开
标题翻译：分子开关调节神经发生
公开(公告)号：US20060234378A1
公开(公告)日：2006-10-19
申请号：US11400473
申请日：2006-04-06
申请人： Tomoko Kuwabara , Fred Gage
发明人： Tomoko Kuwabara , Fred Gage
IPC分类号： C12N5/08 , C07H21/04 , C12N15/09
CPC分类号： C12N15/1086
摘要： The present disclosure relates to a novel transcription regulatory master switch involved in neural development. The disclosure provides compositions and methods for regulating neural lineage specific genes and modulating the differentiation of stem cells into neural lineage cells.
摘要翻译：本公开涉及涉及神经发育的新型转录调控主开关。本公开提供了用于调节神经谱系特异性基因并调节干细胞分化成神经谱系细胞的组合物和方法。

7. 发明申请

US20050244853A1 Determining relative expression for probe groups in probe arrays 审中-公开
标题翻译：确定探针组中探针组的相对表达
公开(公告)号：US20050244853A1
公开(公告)日：2005-11-03
申请号：US11043278
申请日：2005-01-25
申请人： James Aimone , Fred Gage
发明人： James Aimone , Fred Gage
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/543 , G06F19/00
CPC分类号： C12Q1/6837 , G01N33/543 , G01N33/54366 , G16B25/00
摘要： A method of determining relative expression for probe groups in probe arrays includes: determining probe values for one or more probe arrays of a baseline category and multiple probe arrays of an experimental category, where each probe array includes a plurality of probes organized by probe locations; determining, from the probe values corresponding to the probe locations, probe categories for the probe locations, where each probe category corresponds to the baseline category, the experimental category or an indefinite category; and determining, from the probe values and the probe categories, a category bias for a probe group, where the probe group includes multiple probe locations, and the category bias including a preference for the baseline category, the experimental category or the indefinite category.
摘要翻译：确定探针阵列中探针组的相对表达的方法包括：确定实验类别的基线类别和多个探针阵列的一个或多个探针阵列的探针值，其中每个探针阵列包括由探针位置组织的多个探针; 根据探针位置的探针值确定探针位置的探针类别，其中每个探针类别对应于基线类别，实验类别或不确定类别; 并且根据探针值和探针类别确定探针组的类别偏差，其中探针组包括多个探针位置，并且类别偏差包括对基线类别，实验类别或不确定类别的偏好。

8. 发明申请

US20070190649A1 Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells 有权
标题翻译：非胚胎多能干细胞的脉冲灌注提取方法
公开(公告)号：US20070190649A1
公开(公告)日：2007-08-16
申请号：US11654553
申请日：2007-01-18
申请人： Fred Gage
发明人： Fred Gage
IPC分类号： C12N5/02 , C12N5/00 , A01N1/02
CPC分类号： C12N5/0647 , A01N1/021 , A01N1/0236 , A01N1/0247 , A01N1/0289 , A61L27/3683 , A61L27/3834 , A61L27/507 , C12N5/0605
摘要： A method for extracting stem cells from a non-embryonic stem cell source, including providing a non-embryonic stem cell source including stem cells; perfusing the non-embryonic stem cell source with a pulsatile flow of a perfusion solution to produce a perfusate including stem cells and a perfused non-embryonic stem cell source; and isolating the stem cells from the perfusate to produce isolated stem cells, is provided. Also provided is a non-embryonic stem cell line derived from a non-embryonic stem cell obtained using the pulsatile perfusion extraction method.
摘要翻译：一种从非胚胎干细胞来源提取干细胞的方法，包括提供包括干细胞在内的非胚胎干细胞来源; 用灌注溶液的脉冲流灌注非胚胎干细胞来产生包括干细胞和灌注的非胚胎干细胞来源的灌注液; 并提供干细胞与灌注液分离以产生分离的干细胞。还提供了源自使用脉冲灌注提取方法获得的非胚胎干细胞的非胚胎干细胞系。

9. 发明申请

US20070053887A1 Method for production of neuroblasts 失效
标题翻译：神经母细胞生产方法
公开(公告)号：US20070053887A1
公开(公告)日：2007-03-08
申请号：US11592504
申请日：2006-11-03
申请人： Fred Gage , Jasodhara Ray
发明人： Fred Gage , Jasodhara Ray
IPC分类号： A61K35/30 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12M23/20 , C12N5/0618 , C12N5/0619 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
摘要翻译：提供了一种用于产生神经母细胞的方法和包含富集的成神经细胞群的细胞组合物。还公开了用于鉴定影响成神经细胞和用于治疗具有神经元障碍的受试者的组合物的方法，以及用于生产和维持神经母细胞的培养系统。

10. 发明申请

US20050037495A1 Human CNS cell lines and methods of use therefor 审中-公开
标题翻译：人类CNS细胞系及其使用方法
公开(公告)号：US20050037495A1
公开(公告)日：2005-02-17
申请号：US10813203
申请日：2004-03-29
申请人： Dinah Sah , Fred Gage , Jasodhara Ray
发明人： Dinah Sah , Fred Gage , Jasodhara Ray
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P25/00 , C12N5/0797 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/68 , C12N5/08 , C12N15/85
CPC分类号： C12N5/0623 , A61K48/00 , C12N2501/11 , C12N2501/13 , C12N2501/135
摘要： Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
摘要翻译：提供有条件永生化的人类CNS祖细胞系。这些可能是克隆的细胞系可用于产生神经元和/或星形胶质细胞。这样的细胞系和/或分化细胞可用于开发治疗剂以预防和治疗各种CNS相关疾病。此类细胞系和/或分化细胞也可用于测定和CNS细胞发育，死亡和异常的一般研究。

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