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1. 发明申请

US20050244853A1 Determining relative expression for probe groups in probe arrays 审中-公开
标题翻译：确定探针组中探针组的相对表达
公开(公告)号：US20050244853A1
公开(公告)日：2005-11-03
申请号：US11043278
申请日：2005-01-25
申请人： James Aimone , Fred Gage
发明人： James Aimone , Fred Gage
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/543 , G06F19/00
CPC分类号： C12Q1/6837 , G01N33/543 , G01N33/54366 , G16B25/00
摘要： A method of determining relative expression for probe groups in probe arrays includes: determining probe values for one or more probe arrays of a baseline category and multiple probe arrays of an experimental category, where each probe array includes a plurality of probes organized by probe locations; determining, from the probe values corresponding to the probe locations, probe categories for the probe locations, where each probe category corresponds to the baseline category, the experimental category or an indefinite category; and determining, from the probe values and the probe categories, a category bias for a probe group, where the probe group includes multiple probe locations, and the category bias including a preference for the baseline category, the experimental category or the indefinite category.
摘要翻译：确定探针阵列中探针组的相对表达的方法包括：确定实验类别的基线类别和多个探针阵列的一个或多个探针阵列的探针值，其中每个探针阵列包括由探针位置组织的多个探针; 根据探针位置的探针值确定探针位置的探针类别，其中每个探针类别对应于基线类别，实验类别或不确定类别; 并且根据探针值和探针类别确定探针组的类别偏差，其中探针组包括多个探针位置，并且类别偏差包括对基线类别，实验类别或不确定类别的偏好。

2. 发明申请

US20120157457A1 COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION 有权
标题翻译：用于诱导神经元差异的组合物和方法
公开(公告)号：US20120157457A1
公开(公告)日：2012-06-21
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A61K31/426 , A61K31/5377 , A61K31/427 , C07D277/42 , C07D417/12
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

3. 发明授权

US08105581B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08105581B2
公开(公告)日：2012-01-31
申请号：US12095723
申请日：2006-12-01
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

4. 发明申请

US20070190649A1 Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells 有权
标题翻译：非胚胎多能干细胞的脉冲灌注提取方法
公开(公告)号：US20070190649A1
公开(公告)日：2007-08-16
申请号：US11654553
申请日：2007-01-18
申请人： Fred Gage
发明人： Fred Gage
IPC分类号： C12N5/02 , C12N5/00 , A01N1/02
CPC分类号： C12N5/0647 , A01N1/021 , A01N1/0236 , A01N1/0247 , A01N1/0289 , A61L27/3683 , A61L27/3834 , A61L27/507 , C12N5/0605
摘要： A method for extracting stem cells from a non-embryonic stem cell source, including providing a non-embryonic stem cell source including stem cells; perfusing the non-embryonic stem cell source with a pulsatile flow of a perfusion solution to produce a perfusate including stem cells and a perfused non-embryonic stem cell source; and isolating the stem cells from the perfusate to produce isolated stem cells, is provided. Also provided is a non-embryonic stem cell line derived from a non-embryonic stem cell obtained using the pulsatile perfusion extraction method.
摘要翻译：一种从非胚胎干细胞来源提取干细胞的方法，包括提供包括干细胞在内的非胚胎干细胞来源; 用灌注溶液的脉冲流灌注非胚胎干细胞来产生包括干细胞和灌注的非胚胎干细胞来源的灌注液; 并提供干细胞与灌注液分离以产生分离的干细胞。还提供了源自使用脉冲灌注提取方法获得的非胚胎干细胞的非胚胎干细胞系。

5. 发明申请

US20070053887A1 Method for production of neuroblasts 失效
标题翻译：神经母细胞生产方法
公开(公告)号：US20070053887A1
公开(公告)日：2007-03-08
申请号：US11592504
申请日：2006-11-03
申请人： Fred Gage , Jasodhara Ray
发明人： Fred Gage , Jasodhara Ray
IPC分类号： A61K35/30 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12M23/20 , C12N5/0618 , C12N5/0619 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
摘要翻译：提供了一种用于产生神经母细胞的方法和包含富集的成神经细胞群的细胞组合物。还公开了用于鉴定影响成神经细胞和用于治疗具有神经元障碍的受试者的组合物的方法，以及用于生产和维持神经母细胞的培养系统。

6. 发明申请

US20050037495A1 Human CNS cell lines and methods of use therefor 审中-公开
标题翻译：人类CNS细胞系及其使用方法
公开(公告)号：US20050037495A1
公开(公告)日：2005-02-17
申请号：US10813203
申请日：2004-03-29
申请人： Dinah Sah , Fred Gage , Jasodhara Ray
发明人： Dinah Sah , Fred Gage , Jasodhara Ray
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P25/00 , C12N5/0797 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/68 , C12N5/08 , C12N15/85
CPC分类号： C12N5/0623 , A61K48/00 , C12N2501/11 , C12N2501/13 , C12N2501/135
摘要： Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
摘要翻译：提供有条件永生化的人类CNS祖细胞系。这些可能是克隆的细胞系可用于产生神经元和/或星形胶质细胞。这样的细胞系和/或分化细胞可用于开发治疗剂以预防和治疗各种CNS相关疾病。此类细胞系和/或分化细胞也可用于测定和CNS细胞发育，死亡和异常的一般研究。

7. 发明授权

US09944900B2 Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells 有权
公开(公告)号：US09944900B2
公开(公告)日：2018-04-17
申请号：US11654553
申请日：2007-01-18
申请人： Fred Gage
发明人： Fred Gage
IPC分类号： C12N5/0789 , A61L27/36 , A61L27/38 , A61L27/50 , C12N5/073 , A01N1/02
CPC分类号： C12N5/0647 , A01N1/021 , A01N1/0236 , A01N1/0247 , A01N1/0289 , A61L27/3683 , A61L27/3834 , A61L27/507 , C12N5/0605
摘要： A method for extracting stem cells from a non-embryonic stem cell source, including providing a non-embryonic stem cell source including stem cells; perfusing the non-embryonic stem cell source with a pulsatile flow of a perfusion solution to produce a perfusate including stem cells and a perfused non-embryonic stem cell source; and isolating the stem cells from the perfusate to produce isolated stem cells, is provided. Also provided is a non-embryonic stem cell line derived from a non-embryonic stem cell obtained using the pulsatile perfusion extraction method.

8. 发明授权

US08394798B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08394798B2
公开(公告)日：2013-03-12
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

9. 发明申请

US20070003524A1 Targeted retrograde gene delivery to motor neurons 有权
标题翻译：靶向逆行基因转运到运动神经元
公开(公告)号：US20070003524A1
公开(公告)日：2007-01-04
申请号：US11442504
申请日：2006-05-25
申请人： Brian Kaspar , Fred Gage , Jeffrey Rothstein
发明人： Brian Kaspar , Fred Gage , Jeffrey Rothstein
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0075 , C12N2750/14143
摘要： Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.
摘要翻译：公开了通过使由神经元支配的肌肉组织与包含异源基因的病毒载体接触将异源基因递送至神经元的细胞体的方法，其中病毒载体进入所述神经元并逆行移动至细胞体。此外，描述了用于从神经细胞体表达分泌蛋白的方法以及用于治疗神经变性疾病如肌萎缩性侧索硬化的方法。

10. 发明申请

US20060234378A1 Molecular switch regulating neurogenesis 审中-公开
标题翻译：分子开关调节神经发生
公开(公告)号：US20060234378A1
公开(公告)日：2006-10-19
申请号：US11400473
申请日：2006-04-06
申请人： Tomoko Kuwabara , Fred Gage
发明人： Tomoko Kuwabara , Fred Gage
IPC分类号： C12N5/08 , C07H21/04 , C12N15/09
CPC分类号： C12N15/1086
摘要： The present disclosure relates to a novel transcription regulatory master switch involved in neural development. The disclosure provides compositions and methods for regulating neural lineage specific genes and modulating the differentiation of stem cells into neural lineage cells.
摘要翻译：本公开涉及涉及神经发育的新型转录调控主开关。本公开提供了用于调节神经谱系特异性基因并调节干细胞分化成神经谱系细胞的组合物和方法。

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