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1. 发明授权

US4985575A Process for preparing optically active tetrahydro-2-furoic acid 失效
标题翻译：光学活性四氢-2-糠酸的制备方法
公开(公告)号：US4985575A
公开(公告)日：1991-01-15
申请号：US475801
申请日：1990-02-06
申请人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Kiyoharu Nakayama , Osamu Miyahara , Kenichi Noguchi
发明人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Kiyoharu Nakayama , Osamu Miyahara , Kenichi Noguchi
IPC分类号： C07B57/00 , C07D307/24
CPC分类号： C07D307/24
摘要： A process for preparing an optically active tetrahydro-2-furoic acid is disclosed. The process comprises (i) reacting (.+-.)-tetrahydro-2-furoic acid with an optically active amine resolver of the following formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group and R.sub.2 represents an alkyl group or ar aryl group, provided that R.sub.1 and R.sub.2 are different from each other, thus producing an optically active diastereomer salt, and (ii) decomposing the diastereomer salt. According to the process, a high purity, optically active tetrahydro-2-furoic acid can be prepared at a high yield using an amine resolver. The amine resolver can be recovered at a high yield and high purity.

2. 发明授权

US5506225A Antibacterial penem compounds 失效
标题翻译：抗菌青铜化合物
公开(公告)号：US5506225A
公开(公告)日：1996-04-09
申请号：US971828
申请日：1993-02-19
申请人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
发明人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
IPC分类号： A61K31/43 , A61K31/431 , A61P31/04 , C07D499/88 , C07D499/897 , C07D499/00
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a physiological-hydrolyzable, ester-forming group. The physiologically hydrolyzable, ester-forming group useful in the penem compound of the present invention means a group which can be removed easily by in vivo hydrolysis, such as an acetyloxymethyl, 1-(acetyloxy)ethyl, pivaloyloxymethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(isopropyloxycarbonyloxy)ethyl, 1-(cyclohexyloxycarbonyloxy)ethyl or 3-phthalidyl group. Antibiotic compositions for oral administration are also described.
摘要翻译： PCT No.PCT / JP91 / 01099 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT 1991年8月16日PCT PCT。出版物WO92 / 03443 日期：1992年3月5日。抗生素penem化合物由下式表示：其中R表示生理水解性酯形成基团。可用于本发明青霉烯化合物的生理上可水解的酯形成基是指通过体内水解容易除去的基团，例如乙酰氧基甲基，1-（乙酰氧基）乙基，新戊酰氧基甲基，1-（乙氧基羰基氧基）乙基，1-（异丙氧基羰基氧基）乙基，1-（环己氧基羰基氧基）乙基或3-苯二酰基。还描述了用于口服给药的抗生素组合物。

3. 发明授权

US4997829A Penem compounds, and use thereof 失效
标题翻译： Penem化合物及其用途
公开(公告)号：US4997829A
公开(公告)日：1991-03-05
申请号：US496145
申请日：1990-03-09
申请人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka
发明人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka
IPC分类号： C07D499/897 , A61K31/425 , A61K31/43 , A61P31/04 , C07D499/00 , C07D499/06 , C07D499/88
CPC分类号： C07D499/88 , Y02P20/55
摘要： A penem compound represented by the general formula: ##STR1## (wherein R denotes hydrogen or allyl group, A denotes oxygen atom or methylene group and B denotes methylene, ethylene or carbonyl group) or a pharmacologically acceptable salt is produced through several processes.The compound exhibits stronger activities against wide variety of gram-positive and gram-negative bacteria as compared with known penem compounds.
摘要翻译：通过几个方法制备由以下通式表示的青霉烯化合物：其中R表示氢或烯丙基，A表示氧原子或亚甲基，B表示亚甲基，亚乙基或羰基）或药理学上可接受的盐。与已知的penem化合物相比，该化合物对各种革兰氏阳性和革兰氏阴性细菌表现出更强的活性。

4. 发明授权

US5885981A Antibacterial penem esters derivatives 失效
标题翻译：抗菌青蒿酯衍生物
公开(公告)号：US5885981A
公开(公告)日：1999-03-23
申请号：US470944
申请日：1995-06-06
申请人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
发明人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/88 , C07D499/887 , C07D499/893 , C07D477/06
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R.sub.1 is a hydrogen atom or linear or branched C.sub.1 --C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1-6, Y is a 5- or 6-membered heterocyclic aliphatic group having 1 or 2 oxygen atoms in the ring thereof, and Z is a specific 5-substituted 2-oxo-1,3-dioxolen-4-yl group. Antibiotic compositions for oral administration are also described.
摘要翻译：抗生素penem化合物由下式表示：其中R表示下列通式的基团：其中R 1为氢原子或直链或支链C 1 -C 6烷基，R 2为特定的取代或未取代的烷基，芳基或芳烷基，n为1-6的整数，Y为其环中具有1或2个氧原子的5或6元杂环脂族基团，Z为特定的5-取代的2-氧代 -1,3-二氧杂环戊烯-4-基。还描述了用于口服给药的抗生素组合物。

5. 发明授权

US5830889A Antibacterial penem esters derivatives 失效
标题翻译：抗菌青蒿酯衍生物
公开(公告)号：US5830889A
公开(公告)日：1998-11-03
申请号：US971829
申请日：1993-02-19
申请人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
发明人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/88 , C07D499/887 , C07D499/893 , C07D499/32
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R.sub.1 is a linear or branched C.sub.1 -C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1-6, Y is a 5- or 6-membered heterocyclic aliphatic group having 1 or 2 oxygen atoms in the ring thereof, and Z is a specific 5-substituted 2-oxo-1,3-dioxolen-4-yl group. Antibiotic compositions for oral administration are also described.
摘要翻译： PCT No.PCT / JP91 / 01098 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT 1991年8月16日PCT PCT。第WO92 / 03442号公报日期：1992年3月5日抗生素Penem化合物由下式表示：其中R表示通式：其中R 1为直链或支链C 1 -C 6烷基，R 2为特定取代基或未取代的烷基，芳基或芳烷基，n为1-6的整数，Y为其环中具有1或2个氧原子的5或6元杂环脂族基团，Z为特定的5-取代的2 - 氧代-1,3-二氧杂环戊烯-4-基。还描述了用于口服给药的抗生素组合物。

6. 发明授权

US5703068A Penem compounds 失效
标题翻译： Penem化合物
公开(公告)号：US5703068A
公开(公告)日：1997-12-30
申请号：US971827
申请日：1993-02-19
申请人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
发明人： Hiromitsu Iwata , Takashi Nakatsuka , Rie Tanaka , Masaji Ishiguro
IPC分类号： A61K31/43 , A61K31/431 , A61P31/04 , C07D499/88 , C07D499/883 , C07D499/893 , C07D499/897 , C07D499/00
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the following formula: ##STR2## in which R.sub.1 is a linear or branched, C.sub.1 -C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1 or 2, and R.sub.3 represents a specific substituted or unsubstituted alkyl, aryl or aralkyl group. Antibiotic compositions for oral administration are also described.
摘要翻译： PCT No.PCT / JP91 / 01100 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT 1991年8月16日PCT PCT。第WO92 / 03444号公报日期：1992年3月5日抗生素penem化合物由下式表示：其中R表示下式的基团：其中R 1是直链或支链的C 1 -C 6烷基，R 2 是特定的取代或未取代的烷基，芳基或芳烷基，n为1或2的整数，R 3表示特定的取代或未取代的烷基，芳基或芳烷基。还描述了用于口服给药的抗生素组合物。

7. 发明授权

US5026844A Process for the preparation of 4-acyloxy-2-azetidinone derivatives 失效
标题翻译：制备4-酰氧基-2-氮杂环丁酮衍生物的方法
公开(公告)号：US5026844A
公开(公告)日：1991-06-25
申请号：US421331
申请日：1989-10-13
申请人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Yasuo Yamada
发明人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Yasuo Yamada
IPC分类号： C07D205/08 , C07F7/18
CPC分类号： C07F7/186 , C07D205/08
摘要： A process for producing 3-[1'-(R)-hydroxyethyl]-4-acyloxyazetidinone from 3-[1'-(R)-hydroxyethyl]-4-alkyl (or aryl) thioazetidinone using a copper salt of aliphatic or aromatic carboxylic acid is disclosed. The process is an effective route for producing 3-[1'-(R)-hydroxyethyl]-4-acyloxyazetidinone, and intermediate for synthesizing penems or carbapenems, without using a mercury salt which can cause an environmental hazard.
摘要翻译：使用脂族或芳族的铜盐从3- [1分钟 - （R） - 羟乙基] -4-烷基（或芳基）硫代氮杂环丁酮生产3- [1分钟 - （R） - 羟基乙基] -4-酰氧基氮杂环丁酮的方法羧酸。该方法是生产3- [1分钟 - （R） - 羟乙基] -4-酰氧基氮杂环丁酮的有效途径，它是一种用于合成青霉烯或碳青霉烯类的中间体，不使用会引起环境危害的汞盐。

8. 发明授权

US5116832A Penem derivatives production and use thereof 失效
标题翻译： PENEM衍生物生产和使用
公开(公告)号：US5116832A
公开(公告)日：1992-05-26
申请号：US652242
申请日：1991-02-05
申请人： Masaji Ishiguro , Hiromitsu Iwata , Rie Tanaka
发明人： Masaji Ishiguro , Hiromitsu Iwata , Rie Tanaka
IPC分类号： C07D499/897 , A61K31/43 , A61P31/04 , C07D499/06 , C07D499/88
CPC分类号： C07D499/88 , Y02P20/55
摘要： Novel penem compounds of the formula, ##STR1## wherein R is hydrogen or allyl, and A is an aliphatic 5- or 6-membered heterocyclic group having one or two oxygens in the ring and their pharmaceutically acceptable salts are produced from the compounds of the formula, ##STR2## wherein A is the same as above and respective R.sup.1 and R.sup.2 are protective groups for hydroxyl and carboxyl groups, through several steps. The compounds and their salts are useful as antibacterial agents.

9. 发明授权

US5289231A Apparatus for manufacturing disc medium 失效
标题翻译：光盘介质制造装置
公开(公告)号：US5289231A
公开(公告)日：1994-02-22
申请号：US992772
申请日：1992-12-18
申请人： Nobutaka Magome , Hiromitsu Iwata , Junichi Morino , Toru Kiuchi
发明人： Nobutaka Magome , Hiromitsu Iwata , Junichi Morino , Toru Kiuchi
IPC分类号： G03F7/20 , G11B7/26 , G03B27/42
CPC分类号： G11B7/261 , G03F7/201 , G03F7/70075 , G03F7/70358 , G03F7/70366
摘要： This specification discloses a method of and an apparatus for manufacturing a disc medium which utilize the projection exposure technique of a stopper for lithography, rotate a circular photosensitive substrate which provides the disc medium at the same speed as a circular reticle having a pattern of information tracks while rotating the reticle, and irradiate the reticle with illuminating light of a slit-like shape or a sectoral shape extending in the diametrical direction of the circular reticle to thereby effect rotation scan exposure.
摘要翻译：本说明书公开了一种制造盘式介质的方法和装置，其利用用于光刻的止动器的投影曝光技术，旋转圆形感光基片，以与具有信息轨迹图案的圆形掩模版相同的速度提供光盘介质同时旋转掩模版，并用沿着圆形掩模版的直径方向延伸的狭缝状或扇形的照明光照射光罩，从而进行旋转扫描曝光。

10. 发明授权

US5939902A Integrating circuit internally included in semiconductor device 失效
标题翻译：集成电路内部包含在半导体器件中
公开(公告)号：US5939902A
公开(公告)日：1999-08-17
申请号：US15985
申请日：1998-01-30
申请人： Hiromitsu Iwata
发明人： Hiromitsu Iwata
IPC分类号： G06G7/184 , G01R19/255 , G01R29/02
CPC分类号： G01R19/255
摘要： An integrating circuit internally included in a semiconductor device includes a constant voltage circuit 11 for generating a predetermined constant voltage VREF, and a voltage-to-current converting circuit 12 for converting the voltage VREF into a constant current I0, which is supplied to a capacitor 15 externally connected to a connection terminal CPT. In order to detect an integral potential charged in the capacitor 15, a voltage comparator 14 having one input connected to the capacitor connection terminal CPT and the other input connected to an input terminal IN for receiving a signal VIN to be measured, inverts its output voltage when both the input voltages becomes consistent with each other. The integrating circuit also includes a switching circuit 13 having an input connected to an output terminal of the constant voltage circuit 11, an output connected to the capacitor connection terminal CPT. When this switching circuit 13 is activated in response to a control signal, the switching circuit 13 forcibly maintains a potential of the capacitor at a constant potential obtained from the constant voltage circuit. When the switching circuit 13 is deactivated in response to the control signal, the switching circuit 13 causes the capacitor to be charged from the constant potential with the constant current I0 supplied from the voltage-to-current converting circuit 12.
摘要翻译：内部包括在半导体器件中的积分电路包括用于产生预定的恒定电压VREF的恒压电路11和用于将电压VREF转换成恒定电流I0的电压 - 电流转换电路12，该电流被提供给电容器 15外部连接到连接端子CPT。为了检测在电容器15中充入的积分电位，电压比较器14具有连接到电容器连接端子CPT的一个输入端和连接到输入端子IN的另一个输入端，用于接收待测量的信号VIN，将其输出电压当两个输入电压彼此一致时。积分电路还包括开关电路13，其具有连接到恒压电路11的输出端子的输入端，连接到电容器连接端子CPT的输出端。当该开关电路13响应于控制信号被激活时，开关电路13强制地将电容器的电位保持在从恒压电路获得的恒定电位。当开关电路13响应于控制信号被去激活时，开关电路13使得从电压 - 电流转换电路12提供的恒定电流I0从恒定电位充电电容器。

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