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    • 6. 发明授权
    • Process for producing biocompatible implant material
    • 用于生产生物相容性植入材料的方法
    • US06235225B1
    • 2001-05-22
    • US09635500
    • 2000-08-09
    • Kohji OkadaTsunetoshi OkuraJun SugimotoMasahiko Okuyama
    • Kohji OkadaTsunetoshi OkuraJun SugimotoMasahiko Okuyama
    • B22F510
    • C04B38/065A61L27/12A61L27/56A61L2400/18C04B2111/00836C04B35/01C04B38/067C04B41/0018C04B35/447
    • A process for producing a biocompatible implant material which can be suitably shaped into a variety of forms. A binder is added to a mixture of hydroxylapatite powder and calcium phosphate glass frit (5 wt. %), to thereby prepare a slurry, and the resultant slurry is granulated, to prepare spherical raw material granules. Separately, spherical polyisobutyl methacrylate particles are prepared, and the particles are dry-mixed with the above-prepared granules, to thereby obtain a powder mixture. The powder mixture is compacted using a mold press, to thereby form a cuboid sample. The resultant compact is heated in a drier at 170° C. for three hours, to thereby melt spherical polyisobutyl methacrylate particles. Thereafter, the compact is allowed to cool, to thereby bind the raw material granules together via the polyisobutyl methacrylate that solidifies after melting. After the compact is allowed to cool, the compact is subjected to shaping by use of a copy machining machine and also to drilling. Thereafter, the compact is heated at a rate of 300° C. hour, and fired at 1,250° C. for three hours, to thereby produce a biocompatible implant material.
    • 一种生物相容性植入材料的制造方法,其可适当地成形为各种形式。 向羟基磷灰石粉末和磷酸钙玻璃料(5重量%)的混合物中加入粘合剂,制备浆料,将得到的浆料造粒,制备球状原料颗粒。 分别制备甲基丙烯酸球形聚异丁烯酸颗粒,将颗粒与上述制备的颗粒干混,得到粉末混合物。 使用模压机将粉末混合物压实,从而形成长方体样品。 将所得的压块在170℃的干燥器中加热3小时,从而熔化球形的聚异丁烯酸甲酯颗粒。 此后,使压坯冷却,从而通过熔融后固化的聚甲基丙烯酸异丁酯将原料颗粒粘合在一起。 在压实体冷却后,通过使用复印加工机进行成型,并进行钻孔。 此后,以300℃的时间加热压块,并在1250℃下烧制3小时,从而制备生物相容的植入材料。