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1. 发明专利

JP2010194377A Apparatus for producing liposome 有权
标题翻译：生产脂质体的装置
公开(公告)号：JP2010194377A
公开(公告)日：2010-09-09
申请号：JP2009032624
申请日：2009-02-16
申请人： Masahiko Abe , National Institute Of Advanced Industrial Science & Technology , Katsuto Otake , Shu Uemura Keshohin:Kk , 勝人大竹 , 株式会社シュウウエムラ化粧品 , 独立行政法人産業技術総合研究所 , 正彦阿部
发明人： OTAKE KATSUTO , ABE MASAHIKO , SAKAI HIDEKI , IMURA TOMOHIRO , KAISE CHIHIRO , SAKURAI MASATOSHI , ARAI YOICHIRO , KANEKO AKIHISA
IPC分类号： B01J13/02 , A61J3/07 , A61K9/127 , B01J3/00
CPC分类号： A61K9/1277 , A61J3/07 , A61K9/127 , B01J3/008 , B01J13/02 , Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for producing liposome having high retention efficiency without using a harmful organic solvent with fewer processes. SOLUTION: The method of producing liposome is characterized in that a water phase comprising a material to be encapsulated is added into a mixture comprising phospholipid or glycolipid dissolved in carbon dioxide under a supercritical state, or under a temperature condition or a pressure condition at a critical point or higher. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产具有高保留效率的脂质体的方法和装置，而不需要使用较少工艺的有害有机溶剂。解决方案：制备脂质体的方法的特征在于，将包含待包封材料的水相加入到在超临界状态下或在温度条件或压力条件下溶解在二氧化碳中的磷脂或糖脂的混合物中在临界点或更高。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2005298407A Polycation-modified liposome and method for producing the same 有权
标题翻译：聚合改性的脂质体及其制造方法
公开(公告)号：JP2005298407A
公开(公告)日：2005-10-27
申请号：JP2004117262
申请日：2004-04-12
申请人： Masahiko Abe , National Institute Of Advanced Industrial & Technology , Nippon Boron:Kk , 株式会社日本ボロン , 独立行政法人産業技術総合研究所 , 正彦阿部
发明人： ABE MASAHIKO , SAKAI HIDEKI , OTAKE KATSUTO , OKUBO TAKAHIRO , GOTO TOSHIHIRO
IPC分类号： C12N15/09 , A61K9/127 , A61K47/24 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To provide a cationic liposome which does not have the problem of cytotoxicity and can be used as a gene carrier. SOLUTION: The polycation-modified liposome prepared by modifying the surface of a liposome containing a phospholipid as a main constituent with chitosan. The method for producing the polycation-modified liposome is characterized by dropping a solution of a liposome containing a phospholipid as a main constituent in an acidic solution of chitosan. The method for producing the polycation-modified liposome is characterized by adding an aqueous phase containing a substance to be sealed in the liposome to a mixture fluid containing a phospholipid, chitosan and carbon dioxide at a temperature higher than the critical point of the carbon dioxide and/or under a pressure. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供不具有细胞毒性问题并可用作基因载体的阳离子脂质体。解决方案：通过用壳聚糖改性含有磷脂作为主要成分的脂质体的表面制备的聚阳离子改性的脂质体。聚阳离子改性脂质体的制造方法的特征在于，将含有磷脂的脂质体作为主要成分的溶液滴加到壳聚糖的酸性溶液中。聚阳离子改性脂质体的制造方法的特征在于，在高于二氧化碳的临界点的温度下，将含有要密封的物质的水相加入到含有磷脂，壳聚糖和二氧化碳的混合液中， /或在压力下。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2013166851A Polymer/silica composite and method of producing the same 有权
标题翻译：聚合物/二氧化硅复合材料及其制造方法
公开(公告)号：JP2013166851A
公开(公告)日：2013-08-29
申请号：JP2012030570
申请日：2012-02-15
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所 , Tokyo Univ Of Science , 学校法人東京理科大学
发明人： YODA SATOSHI , FURUYA TAKESHI , OTAKE KATSUTO
IPC分类号： C08J9/36
摘要： PROBLEM TO BE SOLVED: To provide a method of producing a polymer/silica composite capable of forming a silica particle having a high filling factor inside a closed cell of the polymer/silica composite.SOLUTION: A method of producing a polymer/silica composite 40, wherein silica particles 42 are contained inside closed cells 24 of a foam 20, includes the steps of: compatibilizing a polymer having a polyester structure, silicon alkoxide and carbon dioxide together under an optional pressure condition to prepare a uniform phase 10; decompressing the uniform phase 10 to make the polymer foam for forming the foam 20 having the closed cells 24; and newly adding water to the foam 20 to hydrolyze the silicon alkoxide exuded inside the closed cells 24 to form the silica particles 42.
摘要翻译：要解决的问题：提供一种能够在聚合物/二氧化硅复合材料的闭孔内形成具有高填充率的二氧化硅颗粒的聚合物/二氧化硅复合材料的方法。解决方案：一种聚合物/二氧化硅复合材料40的制造方法其中二氧化硅颗粒42包含在泡沫20的闭孔24内，包括以下步骤：在任选的压力条件下使具有聚酯结构的聚合物，硅醇盐和二氧化碳相容，以制备均相10; 对均匀相10进行减压以使聚合物泡沫形成具有闭孔24的泡沫20; 并向泡沫20中新添加水以水解渗出到闭孔24内的硅醇盐以形成二氧化硅颗粒42。

4. 发明专利

JP2004275986A Gas separation membrane and method for manufacturing the same 有权
标题翻译：气体分离膜及其制造方法
公开(公告)号：JP2004275986A
公开(公告)日：2004-10-07
申请号：JP2003074774
申请日：2003-03-19
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： YODA SATOSHI , SUDA HIROYUKI , UCHIMARU YUKO , OTAKE KATSUTO , HARATANI KENJI , HASEGAWA ATSUSHI , TSUJI TOMOYA , NICHIAKI TOSHIHIKO
IPC分类号： B01D71/00 , B01D53/22 , B01D69/12 , B01D71/02 , B01D71/64 , B01J3/00 , C01B3/56 , C01B31/02
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a method for manufacturing a composite polymer membrane suitable for a separation membrane, which is improved in gas selectivity and excels in all of heat resistance, weatherability, chemical resistance, or the like, and gas separation performance or a carbon membrane formed by heat treating the composite polymer membrane further at a high temperature. SOLUTION: The method for manufacturing the composite polymer membrane comprises immersing a polymer membrane into supercritical carbon dioxide in which an organic metal compound is dissolved to carry the organic metal compound on the membrane, then performing the decomposition of the organic metal compound to form fine metallic superfine particles or metal oxide superfine particles in the membrane. The method for manufacturing the carbon membrane comprises heat treating the composite polymer membrane further at the high temperature. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：解决方案：提供一种制造适合于分离膜的复合聚合物膜的方法，其提高了气体选择性并且具有优异的耐热性，耐候性，耐化学性等，并且气体分离性能或通过在高温下进一步热处理复合聚合物膜形成的碳膜。解决方案：制造复合聚合物膜的方法包括将聚合物膜浸入其中溶解有机金属化合物的超临界二氧化碳中以在膜上携带有机金属化合物，然后将有机金属化合物分解成在膜中形成细金属超细颗粒或金属氧化物超细颗粒。制造碳膜的方法包括在高温下进一步热处理复合聚合物膜。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2003062462A Photocatalyst included between clay layers and method for producing the same 审中-公开
标题翻译：粘合层之间的光催化剂及其制造方法
公开(公告)号：JP2003062462A
公开(公告)日：2003-03-04
申请号：JP2001256390
申请日：2001-08-27
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： YODA SATOSHI , OTAKE KATSUTO , YAGISHITA HIROSHI , TSUCHIYA TOSHIO , SAKURAI YUICHIRO
IPC分类号： A61L9/00 , B01J3/00 , B01J21/16 , B01J35/02 , B01J37/02 , C01B33/44
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a photocatalyst material composed of crystalline titanium oxide having highly controlled particle diameters which is highly dispersed between layers of the clay mineral, and prepared by a process using a supercritical fluid. SOLUTION: The photocatalyst included between clay layers is prepared by introducing hydrophobic-group-containing cations between the layers of a layered clay compound, immersing the treated product in a supercritical carbon dioxide in which a titanium compound is dissolved to intercalate the titanium compound into the layers, hydrolyzing the titanium compound with the water adsorbed between the layers, and firing the product to form fine crystal titanium oxide between the layers of the clay.
摘要翻译：要解决的问题：提供由结晶二氧化钛组成的光催化剂材料，该结晶二氧化钛具有高度分散在粘土矿物层之间的高度受控的粒径，并且通过使用超临界流体的方法制备。解决方案：粘土层之间包含的光催化剂是通过在层状粘土化合物的层之间引入含疏水基团的阳离子，将经处理的产物浸入其中溶解钛化合物的超临界二氧化碳中以将钛化合物插入到层，水分吸附在层之间的水分，并且在该粘土层之间焙烧产物以形成细晶体氧化钛。

6. 发明专利

JP2006232572A Apparatus for forming fine particle of chemically combined explosive, apparatus for manufacturing chemically combined fine particle explosive, and method for manufacturing chemicaly combined fine particle explosive 有权
标题翻译：用于形成化学爆炸的微粒的装置，用于制造化学组合的微粒爆炸的装置以及用于制造化学组合的细颗粒爆炸物的方法
公开(公告)号：JP2006232572A
公开(公告)日：2006-09-07
申请号：JP2005045729
申请日：2005-02-22
申请人： National Institute Of Advanced Industrial & Technology , Nippon Koki Co Ltd , 日本工機株式会社 , 独立行政法人産業技術総合研究所
发明人： MATSUZAKI SHINICHI , OTAKE KATSUTO , MATSUNAGA TAKEHIRO , FUJIWARA SHUZO
IPC分类号： C06B21/00
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To facilitate the controlling of the particle shape and the particle size of a chemically combined fine particle explosive when performing the recrystallization of the chemically combined explosive using a supercritical CO 2 . SOLUTION: There are provided a first conduit that introduces a solution of the chemically combined explosive being dissolved in an organic solvent, and a second conduit that is arranged coaxially with the first conduit and so as to surround the first conduit and that introduces the supercritical CO 2 , wherein the exit end of the second conduit is longer than the exit end of the first conduit by 5 mm or more, whereby the second conduit forms a single flow channel for performing the recrystallization of the chemically combined explosive by contacting the supercritical CO 2 with the solution. In the single flow channel the second conduit has the same inner diameter and a length of 5-200 mm. When the pressure within the second conduit reaches to a given pressure during introducing the supercritical CO 2 into the second conduit, the solution is introduced into the first conduit and in the single flow channel the recrystallization to the chemically combined fine particle explosive having a spherical shape is occurred by contacting the supercritical CO 2 with the solution, and the recrystallized chemically combined fine particle explosive is recovered. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了便于使用超临界CO 2 SB进行化学组合爆炸物的再结晶时，控制化学组合的微粒炸药的颗粒形状和颗粒尺寸。解决方案：提供了一种第一导管，其引入溶解在有机溶剂中的化学组合炸药的溶液，以及与第一导管同轴布置并且围绕第一导管并且引入超临界CO 2 ，其中第二导管的出口端比第一导管的出口端长5mm以上，由此第二导管形成用于进行重结晶的单个流动通道通过使超临界CO 2 与溶液接触而形成化学组合的爆炸物。在单流道中，第二导管具有相同的内径和5-200mm的长度。当将第二导管内的超临界CO 2 引入第二导管内时，第二导管内的压力达到给定的压力，将溶液引入第一导管中，并在单流道中将再结晶化学组合通过使超临界CO 2 与溶液接触，发生具有球形形状的微粒炸药，并回收重结晶的化学组合的微粒炸药。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006028145A Preparation method of monosubstituted n-alkylanilines 审中-公开
标题翻译：单核苷酸N-烷基酯的制备方法
公开(公告)号：JP2006028145A
公开(公告)日：2006-02-02
申请号：JP2004213776
申请日：2004-07-22
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： TAKEBAYASHI YOSHIHIRO , SUGATA TAKESHI , YODA SATOSHI , OTAKE KATSUTO , MORITA YOSHINORI , SAKAI HIDEKI , ABE MASAHIKO
IPC分类号： C07C209/60 , C07B61/00 , C07C211/48
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing monosubstituted N-alkylanilines with a high conversion rate and a high selectivity, by using anilines and an alcohol as raw materials, even when the anilines are present in high molar ratios. SOLUTION: The anilines of formula (1) (wherein R 1 is a 1-10C linear or branched alkyl group; and n is an integer of 0-5, provided that multiple R 1 's are identical to or different from each other when n is ≥2) are reacted with the alcohol of the formula: R 2 -OH (wherein R 2 is a 1-10C linear or branched alkyl group) by using an alkali as a catalyst under a condition wherein the alcohol takes a supercritical state to prepare the monosubstituted N-alkylanilines of formula (2) (wherein R 1 and R 2 are as defined above). COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：即使当苯胺以高摩尔比存在时，通过使用苯胺和醇作为原料，提供一种制备具有高转化率和高选择性的单取代的N-烷基苯胺的方法。解决方案：式（1）的苯胺（其中R 1 是1-10C直链或支链烷基; n是0-5的整数，条件是多个R 1 彼此相同或不同）与下式的醇反应：其中R 2 / SB>是1-10C直链或支链烷基），其中醇处于超临界状态以制备式（2）的单取代的N-烷基苯胺（其中R SB 1 和R 2 如上所定义）。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2005343993A Method for producing polymer fine powder 审中-公开
标题翻译：生产聚合物粉末的方法
公开(公告)号：JP2005343993A
公开(公告)日：2005-12-15
申请号：JP2004164510
申请日：2004-06-02
申请人： Dainippon Ink & Chem Inc , National Institute Of Advanced Industrial & Technology , 大日本インキ化学工業株式会社 , 独立行政法人産業技術総合研究所
发明人： OTAKE KATSUTO , MAEKAWA FUMIHIKO , ITOTANI KAZUO
IPC分类号： C08F2/12 , C08F20/28
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a polymer fine powder having a low glass transition temperature, and to provide a simple method for producing the polymer fine powder at a high yield and causing low environment load. SOLUTION: The method comprises polymerizing a vinyl monomer represented by general formula (I) in supercritical carbon dioxide. In formula (I), X is H or methyl; Y is a structure having a structural unit represented by general formula (II) and having a terminal hydroxyl. In formula (II), m and n are each an integer of ≥1. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种具有低玻璃化转变温度的聚合物细粉的制备方法，并且提供以高产率制备聚合物细粉并引起低环境负荷的简单方法。解决方案：该方法包括在超临界二氧化碳中聚合由通式（I）表示的乙烯基单体。在式（I）中，X是H或甲基; Y是具有由通式（II）表示的结构单元并具有末端羟基的结构。在式（II）中，m和n各自为≥1的整数。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2006131567A Method for producing liposome suspension and application using liposome 有权
标题翻译：生产脂质体悬浮液的方法和使用脂质体的应用
公开(公告)号：JP2006131567A
公开(公告)日：2006-05-25
申请号：JP2004323697
申请日：2004-11-08
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： OTAKE KATSUTO , IMURA TOMOHIRO
IPC分类号： A61K8/02 , A61K8/30 , A61K8/55 , A61K8/58 , A61K8/63 , A61K8/67 , A61K8/72 , A61K8/96 , A61K9/127 , A61K31/375 , A61K45/00 , A61K47/10 , A61K47/28 , A61K47/36 , A61K47/42 , A61P17/00
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently obtaining a liposome without using an organic solvent, to provide a stable chitosan-modified liposome using the method and to provide applications of the liposome obtained by the method for production. SOLUTION: A suspension in which the liposome is dispersed in an aqueous phase is obtained as follows. A phospholipid and/or a glycolipid are used as a membrane lipid and one or more kinds of hydrophilic medicinally effective ingredients and/or lipophilic medicinally effective ingredients are used as an included substance. Water, the included substance and a low- or a high-molecular modifying substance for modifying the liposome and/or an aqueous solution prepared by dissolving or dispersing one or more kinds of dissolving adjuvants therein and gaseous carbon dioxide are sealed in a pressure vessel and stirred while being held at 0-100°C temperature under 30-500 atm pressure for 0.5-5 h. Thereby, an emulsion of CO 2 /H 2 O in which the emulsion of the gaseous carbon dioxide is dispersed in water is obtained. The gaseous carbon dioxide is taken out of the pressure vessel to afford a suspension in which the liposome is dispersed in the aqueous phase remaining in the pressure vessel or in the aqueous phase discharged while being accompanied with the carbon dioxide. The method for producing the liposome and the applications of the liposome obtained by the method for production are provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种在不使用有机溶剂的情况下有效获得脂质体的方法，使用该方法提供稳定的壳聚糖修饰脂质体并提供通过该制备方法获得的脂质体的应用。解决方案：如下获得其中脂质体分散在水相中的悬浮液。使用磷脂和/或糖脂作为膜脂质，并且使用一种或多种亲水性药物有效成分和/或亲脂性药用有效成分作为包括的物质。水，包含的物质和用于改性脂质体的低分子或高分子改性物质和/或通过将一种或多种溶解佐剂溶解或分散在其中而制备的水溶液和气态二氧化碳密封在压力容器中，搅拌，同时在0-100℃的温度下在30-500atm压力下保持0.5-5小时。由此得到其中气态二氧化碳的乳液分散在水中的CO 2 / H 2 SBB的乳液。将气态二氧化碳从压力容器中取出，得到悬浮液，其中脂质体分散在残留在压力容器中的水相中，或在伴随着二氧化碳的水相中排出。提供了生产脂质体的方法和通过该方法得到的脂质体的应用。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2007054693A Particulate-dispersed tubular membrane and its manufacturing method 审中-公开
标题翻译：颗粒状分散管膜及其制造方法
公开(公告)号：JP2007054693A
公开(公告)日：2007-03-08
申请号：JP2005240464
申请日：2005-08-22
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： SUDA HIROYUKI , YODA SATOSHI , OTAKE KATSUTO , HARATANI KENJI
IPC分类号： B01D69/04 , B01D69/12 , B01D71/02 , B01D71/64 , C01B31/02
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide a tubular composite membrane of an organic high molecular compound and a tubular composite carbon membrane produced by imparting an arbitrary practical membrane form, e.g. a tubular form, and then a substance-separating function with particulates dispersed within the membrane in a controlled state and their manufacturing method. SOLUTION: The tubular composite membrane of a tubular organic high molecular compound membrane is produced by sealing a tubular membrane of an organic high molecular compound in such a state as to be fixed to and held in a pressure container, causing an organic metal compound to be carried in the tubular membrane of the organic high molecular compound by causing the organic metal compound and the tubular membrane of the organic high molecular compound to coexist in supercritical carbon dioxide in the pressure container, taking out the resultant membrane and decomposing the organic metal compound with a reduction or heat treatment to introduce particulates of the metal or metal compound into the tubular membrane of the organic high molecular compound. A tubular composite carbon membrane produced by decomposing the tubular composite membrane of the organic high molecular compound thermally, a method of manufacturing the tubular membrane of the organic high molecular compound and a method of manufacturing the tubular composite carbon membrane are also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供有机高分子化合物的管状复合膜和通过赋予任意实际的膜形式，例如，制备的管状复合碳膜。管状，然后以受控状态分散在膜内的颗粒物质分离功能及其制造方法。解决方案：管状有机高分子化合物膜的管状复合膜通过将有机高分子化合物的管状膜密封在固定并保持在压力容器中的状态下来制造，从而形成有机金属通过使有机金属化合物和有机高分子化合物的管状膜在压力容器中的超临界二氧化碳中共存而在有机高分子化合物的管状膜中携带的化合物，取出所得膜并分解有机物金属化合物进行还原或热处理以将金属或金属化合物的颗粒引入有机高分子化合物的管状膜中。还提供了通过热分解有机高分子化合物的管状复合膜制备的管状复合碳膜，制造有机高分子化合物的管状膜的方法和制造管状复合碳膜的方法。版权所有（C）2007，JPO＆INPIT

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