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1. 发明授权

US07569688B2 Propane-1, 3-dione derivative 有权
标题翻译：丙烷-1,3-二酮衍生物
公开(公告)号：US07569688B2
公开(公告)日：2009-08-04
申请号：US11155595
申请日：2005-06-20
申请人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
发明人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
IPC分类号： C07D235/06 , C07D401/06
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
摘要翻译：本发明提供含有丙-1,3-二酮衍生物作为活性成分，特别是GnRH受体拮抗剂的药物组合物。此外，提供具有GnRH拮抗作用的丙烷-1,3-二酮衍生物。

2. 发明申请

US20050267110A1 Propane-1, 3-dione derivative 有权
标题翻译：丙烷-1,3-二酮衍生物
公开(公告)号：US20050267110A1
公开(公告)日：2005-12-01
申请号：US11155595
申请日：2005-06-20
申请人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
发明人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61P5/24 , A61P35/00 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/53 , A61K31/385 , A61K31/423
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
摘要翻译：本发明提供含有丙-1,3-二酮衍生物作为活性成分，特别是GnRH受体拮抗剂的药物组合物。此外，提供具有GnRH拮抗作用的丙烷-1,3-二酮衍生物。

3. 发明授权

US06960591B2 Propane-1,3-dione derivative 有权
标题翻译：丙烷-1,3-二酮衍生物
公开(公告)号：US06960591B2
公开(公告)日：2005-11-01
申请号：US10311688
申请日：2001-07-04
申请人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
发明人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61P5/24 , A61P35/00 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
摘要翻译：本发明提供含有丙-1,3-二酮衍生物作为活性成分，特别是GnRH受体拮抗剂的药物组合物。此外，提供具有GnRH拮抗作用的丙烷-1,3-二酮衍生物。

4. 发明授权

US08486970B2 Tetrahydroisoquinolin-1-one derivative or salt thereof 有权
标题翻译：四氢异喹啉-1-酮衍生物或其盐
公开(公告)号：US08486970B2
公开(公告)日：2013-07-16
申请号：US12600894
申请日：2008-05-26
申请人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
发明人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/4725 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/695 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04
摘要： [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
摘要翻译： [问题]提供药物，特别是可用作肠易激综合征（IBS）治疗剂的化合物。 [解决问题的手段]发现在4-位具有酰胺基的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有优异的铃蟾肽2（BB2）受体拮抗作用。还发现四氢异喹啉-1-酮衍生物对肠运动障碍是高度有效的。从上述可以看出，本发明的四氢异喹啉-1-酮衍生物可用作与BB2受体，特别是IBS相关疾病的治疗剂。

5. 发明授权

US08273745B2 Polycyclic acid compounds useful as CRTH2 antagonists and antiallergic agents 失效
标题翻译：可用作CRTH2拮抗剂和抗过敏剂的多环酸化合物
公开(公告)号：US08273745B2
公开(公告)日：2012-09-25
申请号：US12518280
申请日：2007-12-13
申请人： Tadashi Terasaka , Tatsuya Zenkoh , Hisashi Hayashida , Hiroshi Matsuda , Junji Sato , Yoshimasa Imamura , Hiroshi Nagata , Norio Seki , Yoshiyuki Tenda , Mamoru Tasaki , Masahiro Takeda , Seiichiro Tabuchi , Minoru Yasuda , Kazunori Tsubaki
发明人： Tadashi Terasaka , Tatsuya Zenkoh , Hisashi Hayashida , Hiroshi Matsuda , Junji Sato , Yoshimasa Imamura , Hiroshi Nagata , Norio Seki , Yoshiyuki Tenda , Mamoru Tasaki , Masahiro Takeda , Seiichiro Tabuchi , Minoru Yasuda , Kazunori Tsubaki
IPC分类号： A61K31/50 , C07D413/00
CPC分类号： C07D213/64 , C07C233/18 , C07C233/20 , C07C233/60 , C07C233/73 , C07C271/50 , C07C2601/08 , C07D209/08 , C07D209/14 , C07D209/24 , C07D209/42 , C07D211/76 , C07D213/56 , C07D213/80 , C07D213/81 , C07D213/82 , C07D235/08 , C07D237/04 , C07D237/14 , C07D263/22 , C07D263/38 , C07D277/34 , C07D333/38 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D409/10 , C07D413/04 , C07D413/14
摘要： The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.
摘要翻译：本发明涉及一种新的化合物或其盐，其可用作CRTH2拮抗剂，特别是用作参与嗜酸性粒细胞的病症的药物，例如过敏性疾病如哮喘，过敏性鼻炎，过敏性皮炎，结膜炎症，荨麻疹，嗜酸性支气管炎，食物过敏，鼻窦炎，多发性硬化，血管炎或慢性阻塞性肺病（COPD）等。

6. 再颁专利

USRE43481E1 Diazepan derivatives or salts thereof 失效
标题翻译：二氮杂环庚烷衍生物或其盐
公开(公告)号：USRE43481E1
公开(公告)日：2012-06-19
申请号：US12203640
申请日：2008-09-03
申请人： Fukushi Hirayama , Hiroyuki Koshio , Tsukasa Ishihara , Norio Seki , Shunichiro Hachiya , Keizo Sugasawa , Ryota Shiraki , Yuji Koga , Yuzo Matsumoto , Takeshi Shigenaga , Souichirou Kawazoe
发明人： Fukushi Hirayama , Hiroyuki Koshio , Tsukasa Ishihara , Norio Seki , Shunichiro Hachiya , Keizo Sugasawa , Ryota Shiraki , Yuji Koga , Yuzo Matsumoto , Takeshi Shigenaga , Souichirou Kawazoe
IPC分类号： A61P7/02 , A61K31/55 , C07D223/04 , C07D401/00
CPC分类号： C07D401/04 , A61K31/551 , C07D243/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04
摘要： To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-methyl-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4′-methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.
摘要翻译：提供具有基于活化凝血因子X的抑制的抗凝作用的化合物，并且可用作抗凝血剂或用于预防和治疗由血栓或栓塞引起的疾病的药剂。二氮杂环丁烷衍生物如4 - [（3-氨甲酰氨基）甲基] -3- [4-（4-甲基-1,4-二氮杂环庚烷-1-基）苯甲酰基氨基]苯甲酸和3-羟基-4'-甲氧基 - 2 - {[4-（4-甲基-1,4-二氮杂环庚烷-1-基）苯甲酰基]氨基} -N-苯甲酰苯胺或其盐是有效成分。

7. 发明授权

US4490020A Coupling system for output light of semiconductor laser 失效
标题翻译：半导体激光器输出光耦合系统
公开(公告)号：US4490020A
公开(公告)日：1984-12-25
申请号：US267554
申请日：1981-05-27
申请人： Haruo Sakaguchi , Norio Seki , Shu Yamamoto
发明人： Haruo Sakaguchi , Norio Seki , Shu Yamamoto
IPC分类号： G02B6/32 , G02B6/42 , G02B27/09 , H01S5/00 , G02B5/172
CPC分类号： G02B19/0009 , G02B19/0052 , G02B27/09 , G02B27/0966 , G02B6/32 , G02B6/4203 , G02B6/4204 , G02B6/4206
摘要： A coupling system for the output light of a semiconductor laser, characterized in that an end portion of an optical fiber is made as a focusing lens to be coupled with the output light from an active layer of the semiconductor laser is formed so that, at least in a plane parallel to the optical axis of the output light and perpendicular to the junction plane of the semiconductor laser, the width of the end portion continuously decreases towards its tip to provide a required curvature at the tip and that the distribution of light of the semiconductor laser and that of the optical fiber and the focusing lens are matched with each other in the plane perpendicular to the junction plane of the semiconductor laser. The end portion of the optical fiber defining the focusing lens may be formed to have a fixed width in a plane parallel to the junction plane of the semiconductor laser. The end portion of the optical fiber or focusing lens may be formed so that it has a required curvature in a plane parallel to the plane of junction of the semiconductor laser and that the distribution of light of the semiconductor laser and that of the optical fiber and focusing lens are matched with each other also in a plane parallel to the junction plane of the semiconductor laser.
摘要翻译：一种用于半导体激光器的输出光的耦合系统，其特征在于，将光纤的端部制成为与来自半导体激光器的有源层的输出光耦合的聚焦透镜，使得至少在平行于输出光的光轴并且垂直于半导体激光器的结面的平面中，端部的宽度朝向其尖端连续地减小，以在尖端处提供所需的曲率，并且，半导体激光器和光纤和聚焦透镜的半导体激光器在垂直于半导体激光器的结面的平面中彼此匹配。限定聚焦透镜的光纤的端部可以形成为在平行于半导体激光器的接合面的平面中具有固定的宽度。光纤或聚焦透镜的端部可以形成为使得其在平行于半导体激光器的结的平面的平面中具有所需的曲率，并且半导体激光器和光纤的光分布聚焦透镜在平行于半导体激光器的结面的平面中彼此匹配。

8. 发明授权

US11169395B2 Frame for bifocal eyeglasses 有权
公开(公告)号：US11169395B2
公开(公告)日：2021-11-09
申请号：US16338774
申请日：2017-08-23
申请人： Norio Seki
发明人： Norio Seki
IPC分类号： G02C3/00 , G02C5/04 , G02C3/02 , G02C5/12 , G02C7/06
摘要： A frame includes: a pair of temples; a connecting bar connecting respective ends of the pair of temples; at least one hanging shaft located at a middle of the connecting bar; nose pads fixed to the hanging shaft; a slide attached to the hanging shaft for a sliding movement; a pair of lens-holding frames vertically slidable in front of the connecting bar, the lens-holding frames being each configured to hold vertically arranged upper and lower lenses; and a bridge coupling the lens-holding frames. The bridge is attached at a level lower than a center of the lower lens in each of the lens-holding frames, and the lens-holding frames are slidable for a distance at least corresponding to a distance between a center of the upper lens and the center of the lower lens.

9. 发明授权

US08802679B2 Glycine compound 有权
标题翻译：甘氨酸化合物
公开(公告)号：US08802679B2
公开(公告)日：2014-08-12
申请号：US13394505
申请日：2010-09-15
申请人： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
发明人： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
IPC分类号： A61K31/497 , C07D403/14
CPC分类号： C07D401/06 , C07C237/06 , C07C237/08 , C07C237/10 , C07C237/12 , C07C237/42 , C07C255/60 , C07C271/28 , C07C275/40 , C07C311/05 , C07C311/21 , C07C311/46 , C07C317/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds of formula (I) defined herein exhibit VAP-1 inhibitory activity, and as a result, are useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention.
摘要翻译：本文定义的式（I）化合物表现出VAP-1抑制活性，结果可用于预防和/或治疗VAP-1相关疾病，特别是糖尿病性肾病或糖尿病性黄斑水肿，从而完成本发明。

10. 发明申请

US20110164075A1 DISPLAY DEVICE 审中-公开
标题翻译：显示设备
公开(公告)号：US20110164075A1
公开(公告)日：2011-07-07
申请号：US12600077
申请日：2008-05-16
申请人： Satoshi Suzuki , Norio Seki
发明人： Satoshi Suzuki , Norio Seki
IPC分类号： G09G5/10
CPC分类号： G09G3/3406 , G02F2001/133601 , G02F2001/133612 , G09G2310/08 , G09G2320/0606 , G09G2320/0633 , G09G2320/0653
摘要： A display device is provided that can eliminate feeling of discomfort of a user while preventing cost from being increased. The display device includes display means 1, control means 3 that causes the display means 1 to display predetermined display information and updates the display information at a predetermined display update cycle (timing), illumination means 2 that illuminates the display means 1, and dimming means 4 that changes brightness of the illumination means 2. The control means 3 chooses the brightness of the illumination means 2 on the basis of input information from the dimming means 4 and changes the brightness of the illumination means 2 at a timing corresponding to the display update cycle for updating the display information.
摘要翻译：提供一种可以消除使用者的不适感，同时防止成本增加的显示装置。显示装置包括显示装置1，使显示装置1显示预定显示信息并以预定显示更新周期（定时）更新显示信息的控制装置3，照亮显示装置1的照明装置2和调光装置改变照明装置2的亮度。控制装置3基于来自调光装置4的输入信息选择照明装置2的亮度，并在对应于显示更新的定时改变照明装置2的亮度循环，用于更新显示信息。

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