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1. 发明授权

US07610093B2 Implantable optical pressure sensor for sensing urinary sphincter pressure 有权
标题翻译：植入式光学压力传感器，用于感测尿路括约肌压力
公开(公告)号：US07610093B2
公开(公告)日：2009-10-27
申请号：US11117064
申请日：2005-04-28
申请人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
发明人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
IPC分类号： A61N1/00
CPC分类号： A61B5/202 , A61B5/205 , A61N1/36007
摘要： The disclosure describes an optical fiber pressure sensor to measure sphincter pressure which may be incorporated into a therapeutic sphincter control system. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of an optical fiber connected to flexible tube section placed through the sphincter, where properties of the emitted light are changed proportional to the pressure on the tube section. The light is returned to a light detector to measure light properties and create an electrical signal representative of the pressure on the tube section. The signal may then be sent by wireless telemetry to an implanted stimulator or external programmer.
摘要翻译：本公开描述了一种用于测量括约肌压力的光纤压力传感器，该压力传感器可并入治疗括约肌控制系统中。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。通过使用连接到通过括约肌放置的柔性管部分的光纤来实现测量括约肌压力，其中发射的光的性质与管部分上的压力成比例地变化。光返回到光检测器以测量光性质并产生代表管部分上的压力的电信号。然后可以通过无线遥测将信号发送到植入的刺激器或外部编程器。

2. 发明授权

US08478411B2 Flexible tube sensor for sensing urinary sphincter pressure 有权
标题翻译：柔性管传感器用于感测尿路括约肌压力
公开(公告)号：US08478411B2
公开(公告)日：2013-07-02
申请号：US13279826
申请日：2011-10-24
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/076 , A61B5/202 , A61B5/205 , A61B5/6882
摘要： The disclosure describes a therapeutic sphincter control system with a fluid tube pressure sensor. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a fluid-filled tube placed through the sphincter and attached to a module implanted within the bladder. Pressure within the tube is transduced to generate an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Pressure information and stimulation information may be recorded and reviewed for continued patient monitoring. In addition, the system may only include the pressure sensor to monitor patient pressure information.
摘要翻译：本公开描述了具有流体管压力传感器的治疗括约肌控制系统。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。测量括约肌压力是通过使用通过括约肌放置的流体填充管并附接到植入膀胱内的模块来实现的。所述管内的压力被传导以产生电信号，所述电信号被无线地发送到连接到靠近盆底神经的引线的植入刺激器。外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。可以记录和审查压力信息和刺激信息以进行持续的患者监测。另外，该系统可能只包括用于监测患者压力信息的压力传感器。

3. 发明授权

US07933653B2 Implantable optical pressure sensor for sensing urinary sphincter pressure 有权
标题翻译：植入式光学压力传感器，用于感测尿路括约肌压力
公开(公告)号：US07933653B2
公开(公告)日：2011-04-26
申请号：US12576881
申请日：2009-10-09
申请人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
发明人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
IPC分类号： A61N1/00
CPC分类号： A61B5/202 , A61B5/205 , A61N1/36007
摘要： The disclosure describes an optical fiber pressure sensor to measure sphincter pressure which may be incorporated into a therapeutic sphincter control system. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of an optical fiber connected to flexible tube section placed through the sphincter, where properties of the emitted light are changed proportional to the pressure on the tube section. The light is returned to a light detector to measure light properties and create an electrical signal representative of the pressure on the tube section. The signal may then be sent by wireless telemetry to an implanted stimulator or external programmer.
摘要翻译：本公开描述了一种用于测量括约肌压力的光纤压力传感器，该压力传感器可并入治疗括约肌控制系统中。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。通过使用连接到通过括约肌放置的柔性管部分的光纤来实现测量括约肌压力，其中发射的光的性质与管部分上的压力成比例地变化。光返回到光检测器以测量光性质并产生代表管部分上的压力的电信号。然后可以通过无线遥测将信号发送到植入的刺激器或外部编程器。

4. 发明授权

US08068910B2 Flexible tube sensor for sensing urinary sphincter pressure 有权
标题翻译：柔性管传感器用于感测尿路括约肌压力
公开(公告)号：US08068910B2
公开(公告)日：2011-11-29
申请号：US11116952
申请日：2005-04-28
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/076 , A61B5/202 , A61B5/205 , A61B5/6882
摘要： The disclosure describes a therapeutic sphincter control system with a fluid tube pressure sensor. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a fluid-filled tube placed through the sphincter and attached to a module implanted within the bladder. Pressure within the tube is transduced to generate an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Pressure information and stimulation information may be recorded and reviewed for continued patient monitoring. In addition, the system may only include the pressure sensor to monitor patient pressure information.
摘要翻译：本公开描述了具有流体管压力传感器的治疗括约肌控制系统。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。测量括约肌压力是通过使用通过括约肌放置的流体填充管并附接到植入膀胱内的模块来实现的。所述管内的压力被传导以产生电信号，所述电信号被无线地发送到连接到靠近盆底神经的引线的植入刺激器。外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。可以记录和审查压力信息和刺激信息以进行持续的患者监测。另外，该系统可能只包括用于监测患者压力信息的压力传感器。

5. 发明申请

US20100030297A1 IMPLANTABLE OPTICAL PRESSURE SENSOR FOR SENSING URINARY SPHINCTER PRESSURE 有权
标题翻译：用于感应尿素压力的可植入光学压力传感器
公开(公告)号：US20100030297A1
公开(公告)日：2010-02-04
申请号：US12576881
申请日：2009-10-09
申请人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
发明人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
IPC分类号： A61N1/05
CPC分类号： A61B5/202 , A61B5/205 , A61N1/36007
摘要： The disclosure describes an optical fiber pressure sensor to measure sphincter pressure which may be incorporated into a therapeutic sphincter control system. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of an optical fiber connected to flexible tube section placed through the sphincter, where properties of the emitted light are changed proportional to the pressure on the tube section. The light is returned to a light detector to measure light properties and create an electrical signal representative of the pressure on the tube section. The signal may then be sent by wireless telemetry to an implanted stimulator or external programmer.
摘要翻译：本公开描述了一种用于测量括约肌压力的光纤压力传感器，该压力传感器可并入治疗括约肌控制系统中。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。通过使用连接到通过括约肌放置的柔性管部分的光纤来实现测量括约肌压力，其中发射的光的性质与管部分上的压力成比例地变化。光返回到光检测器以测量光性质并产生代表管部分上的压力的电信号。然后可以通过无线遥测将信号发送到植入的刺激器或外部编程器。

6. 发明授权

US07328070B2 Multi-tube sensor for sensing urinary sphincter and urethral pressure 失效
标题翻译：用于感应尿路括约肌和尿道压力的多管传感器
公开(公告)号：US07328070B2
公开(公告)日：2008-02-05
申请号：US11117079
申请日：2005-04-28
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/00 , A61B5/00 , A61B5/103 , A61B5/117
CPC分类号： A61N1/36007 , A61B5/205 , A61B5/208
摘要： The disclosure describes a multi-tube pressure sensor to measure the pressure at two sites that may be used in a therapeutic incontinence control system. The system senses urinary sphincter pressure and urethral pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a tube placed through the sphincter and urethral pressure is measured by a second tube placed within the urethra, both tubes may be attached to a single module implanted within the bladder. Pressure within the tube generates an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Additionally, the pressure information and stimulation information may be recorded and reviewed for continued patient monitoring.
摘要翻译：本公开描述了一种多管压力传感器，用于测量可用于治疗性失禁控制系统的两个位置处的压力。该系统感测尿括约肌压力和尿道压力，并将信息发送到能够刺激治疗以控制括约肌收缩力的刺激器，从而减少不必要的尿失禁。通过使用放置在括约肌中的管来实现测量括约肌压力，并且尿道压力通过放置在尿道内的第二管测量，两个管可以附接到植入膀胱内的单个模块。管内的压力产生电信号，其被无线发送到连接到位于骨盆底部神经附近的引线的植入刺激器。外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。此外，压力信息和刺激信息可被记录和审查，以便继续进行患者监测。

7. 发明申请

US20120041510A1 FLEXIBLE TUBE SENSOR FOR SENSING URINARY SPHINCTER PRESSURE 有权
标题翻译：柔性管传感器用于感应尿素压力
公开(公告)号：US20120041510A1
公开(公告)日：2012-02-16
申请号：US13279826
申请日：2011-10-24
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/076 , A61B5/202 , A61B5/205 , A61B5/6882
摘要： The disclosure describes a therapeutic sphincter control system with a fluid tube pressure sensor. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a fluid-filled tube placed through the sphincter and attached to a module implanted within the bladder. Pressure within the tube is transduced to generate an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Pressure information and stimulation information may be recorded and reviewed for continued patient monitoring. In addition, the system may only include the pressure sensor to monitor patient pressure information.
摘要翻译：本公开描述了具有流体管压力传感器的治疗括约肌控制系统。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。测量括约肌压力是通过使用通过括约肌放置的流体填充管并附接到植入膀胱内的模块来实现的。所述管内的压力被传导以产生电信号，所述电信号被无线地发送到连接到靠近盆底神经的引线的植入刺激器。外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。可以记录和审查压力信息和刺激信息以进行持续的患者监测。另外，该系统可能只包括用于监测患者压力信息的压力传感器。

8. 发明授权

US07623923B2 Tube sensor for penile tumescence 有权
标题翻译：管传感器用于阴茎勃起
公开(公告)号：US07623923B2
公开(公告)日：2009-11-24
申请号：US11117054
申请日：2005-04-28
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/08 , A61F5/41
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/4393
摘要： The disclosure describes a tube pressure sensor to measure penile tumescence which may be used in a therapeutic penile tumescence control system. The system senses penile pressure and sends the information to a stimulator that is capable of stimulation therapy to control an erectile state, thus treating sexual dysfunction or, more specifically, erectile dysfunction. Measuring penile tumescence pressure is accomplished through the use of a tube placed within the urethra of the penis and attached to a module implanted within the bladder. Pressure on the tube generates an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves that stimulate erections. An external device may be used to wirelessly send information to the implanted stimulator to start or stop stimulation in order for the patient to conduct normal sexual activity. In addition, pressure information and stimulation information may be recorded and reviewed by a physician for continued therapy monitoring.
摘要翻译：本公开内容描述了用于测量阴茎肿胀的管压力传感器，其可用于治疗性阴茎肿胀控制系统。该系统感测阴茎压力并将信息发送到能够刺激治疗以控制勃起状态的刺激器，从而治疗性功能障碍，或更具体地说是勃起功能障碍。测量阴茎肿胀压力是通过使用放置在阴茎尿道内的管并附着在植入膀胱内的模块来实现的。管上的压力产生电信号，该电信号被无线地发送到植入的刺激器，其连接到位于骨盆底部神经附近的引导件，该刺激器刺激勃起。可以使用外部设备来将信息无线地发送到植入的刺激器以开始或停止刺激，以使患者进行正常的性活动。此外，医师可以记录和审查压力信息和刺激信息以进行持续的治疗监测。

9. 发明授权

US08731656B2 Closed-loop therapy adjustment 有权
公开(公告)号：US08731656B2
公开(公告)日：2014-05-20
申请号：US13154309
申请日：2011-06-06
申请人： Duane L. Bourget , Keith A. Miesel
发明人： Duane L. Bourget , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/36071 , A61N1/37247 , A61N1/37252 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

10. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

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