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1. 发明授权

US08449874B2 Interleukin-1 muteins linked to virus-like particles to treat IL-1 associated diseases 失效
标题翻译：白细胞介素-1突变蛋白与病毒样颗粒相连以治疗IL-1相关疾病
公开(公告)号：US08449874B2
公开(公告)日：2013-05-28
申请号：US12443344
申请日：2007-03-29
申请人： Martin F. Bachmann , Gunther Spohn , Alain Tissot
发明人： Martin F. Bachmann , Gunther Spohn , Alain Tissot
IPC分类号： A61K38/20 , A61K39/12
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 mutein. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 mutein linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1突变蛋白。更具体地，本发明提供了包含病毒样颗粒和与其连接的至少一种IL-1突变蛋白的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

2. 发明申请

US20110091411A1 Interleukin-1 Muteins Linked to Virus-Like Particles to Treat IL-1 Associated Diseases 失效
标题翻译：与病毒样颗粒相关的IL-1相关疾病的白介素-1突变蛋白
公开(公告)号：US20110091411A1
公开(公告)日：2011-04-21
申请号：US12443344
申请日：2007-03-29
申请人： Martin F. Bachmann , Gunther Spohn , Alain Tissot
发明人： Martin F. Bachmann , Gunther Spohn , Alain Tissot
IPC分类号： A61K38/20 , C07K14/545 , A61P37/00 , A61P37/08 , A61P25/00 , A61P19/08 , A61P19/02 , A61P9/00 , A61P9/10
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 mutein. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 mutein linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1突变蛋白。更具体地，本发明提供了包含病毒样颗粒和与其连接的至少一种IL-1突变蛋白的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

3. 发明申请

US20130115189A1 Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes 审中-公开
标题翻译：使用白细胞介素-1β突变蛋白偶联物治疗糖尿病
公开(公告)号：US20130115189A1
公开(公告)日：2013-05-09
申请号：US13395099
申请日：2010-09-09
申请人： Martin F. Bachmann , Gunther Spohn , Patrik Maurer
发明人： Martin F. Bachmann , Gunther Spohn , Patrik Maurer
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K39/0005 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/545
摘要： The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.
摘要翻译：本发明提供用于治疗，改善和/或预防II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含RNA噬菌体和抗原的病毒样颗粒，其中所述抗原包含白细胞介素-1β（IL-1β）突变蛋白。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对IL-1β。因此，本发明提供了通过对IL-1β的主动免疫来治疗，改善或预防II型糖尿病的方法。

4. 发明授权

US07128911B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07128911B2
公开(公告)日：2006-10-31
申请号：US10289456
申请日：2002-11-07
申请人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/385 , A61K38/22 , A61K9/00 , C07K17/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明申请

US20110027220A1 Interleukin-1 Conjugates and Uses Thereof 审中-公开
标题翻译：白细胞介素-1共轭体及其用途
公开(公告)号：US20110027220A1
公开(公告)日：2011-02-03
申请号：US11992731
申请日：2006-09-28
申请人： Martin Bachmann , Gunther Spohn , Alain Tissot
发明人： Martin Bachmann , Gunther Spohn , Alain Tissot
IPC分类号： A61K39/00 , C07K14/54 , A61P25/00 , A61P19/00 , A61P19/06 , A61P9/10 , A61P37/08 , A61P29/00
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

6. 发明申请

US20130230484A1 Interleukin-1 Conjugates and Uses Thereof 审中-公开
标题翻译：白细胞介素-1共轭体及其用途
公开(公告)号：US20130230484A1
公开(公告)日：2013-09-05
申请号：US13564576
申请日：2012-08-01
申请人： Martin BACHMANN , Gunther Spohn , Alain Tissot
发明人： Martin BACHMANN , Gunther Spohn , Alain Tissot
IPC分类号： C07K14/545
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

7. 发明申请

US20070248617A1 Medical Uses of Carrier Conjugates of Non-Human Tnf -Peptides 审中-公开
标题翻译：非人类Tnf肽载体结合体的医学应用
公开(公告)号：US20070248617A1
公开(公告)日：2007-10-25
申请号：US11628244
申请日：2005-06-02
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/12 , A61P1/02 , A61P1/16 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P3/10 , A61P31/00 , A61P35/04 , A61P37/00 , A61P43/00 , A61P7/00 , A61P9/10
CPC分类号： A61K39/0005 , A61K39/0008 , A61K39/385 , A61K47/6901 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K14/70575 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising—a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto for use in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了修饰的病毒样颗粒（VLP），其包含VLP和源自与其连接的TNF-超家族的多肽的特定肽，用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，以及以有效地诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

8. 发明授权

US07785873B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07785873B2
公开(公告)日：2010-08-31
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12N15/63 , A61K48/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

9. 发明申请

US20070117129A1 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US20070117129A1
公开(公告)日：2007-05-24
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

10. 发明申请

US20110318300A1 User of Interleukin-1 Conjugates in the Treatment of Diabetes 审中-公开
标题翻译：白细胞介素-1缀合物在糖尿病治疗中的用户
公开(公告)号：US20110318300A1
公开(公告)日：2011-12-29
申请号：US12921038
申请日：2009-03-05
申请人： Martin Bachmann , Gunther Spohn
发明人： Martin Bachmann , Gunther Spohn
IPC分类号： A61K38/20 , A61P3/10
CPC分类号： C07K14/545 , A61K38/2006 , A61K2039/5258 , C12N2795/18123
摘要： The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-1) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-1.
摘要翻译：本发明提供用于治疗，改善和/或预防糖尿病，优选II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含核心颗粒和抗原，其中所述抗原包含白细胞介素-1（IL-1）分子。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对IL-1。因此，本发明提供了通过对IL-1的主动免疫来治疗，改善或预防糖尿病，优选II型糖尿病的方法。

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