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1. 发明授权

US07128911B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07128911B2
公开(公告)日：2006-10-31
申请号：US10289456
申请日：2002-11-07
申请人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/385 , A61K38/22 , A61K9/00 , C07K17/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

2. 发明申请

US20130115189A1 Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes 审中-公开
标题翻译：使用白细胞介素-1β突变蛋白偶联物治疗糖尿病
公开(公告)号：US20130115189A1
公开(公告)日：2013-05-09
申请号：US13395099
申请日：2010-09-09
申请人： Martin F. Bachmann , Gunther Spohn , Patrik Maurer
发明人： Martin F. Bachmann , Gunther Spohn , Patrik Maurer
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K39/0005 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/545
摘要： The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.
摘要翻译：本发明提供用于治疗，改善和/或预防II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含RNA噬菌体和抗原的病毒样颗粒，其中所述抗原包含白细胞介素-1β（IL-1β）突变蛋白。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对IL-1β。因此，本发明提供了通过对IL-1β的主动免疫来治疗，改善或预防II型糖尿病的方法。

3. 发明授权

US07785873B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07785873B2
公开(公告)日：2010-08-31
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12N15/63 , A61K48/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

4. 发明申请

US20070117129A1 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US20070117129A1
公开(公告)日：2007-05-24
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明申请

US20080019991A1 Carrier Conjugates Of Tnf-Peptides 审中-公开
标题翻译： Tnf肽的载体结合体
公开(公告)号：US20080019991A1
公开(公告)日：2008-01-24
申请号：US11628243
申请日：2005-06-02
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/00 , A61K45/00 , C12N7/01
CPC分类号： C12N7/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/525 , C07K2319/00 , C12N2710/00023 , C12N2730/10123 , C12N2795/00023
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。本发明还提供了用于生产修饰的VLP的方法。本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

6. 发明申请

US20120258130A1 VACCINATION REGIMEN FOR B-CELL VACCINES 审中-公开
标题翻译： B细胞疫苗的疫苗接种
公开(公告)号：US20120258130A1
公开(公告)日：2012-10-11
申请号：US13292579
申请日：2011-11-09
申请人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
发明人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
IPC分类号： A61K39/385 , A61P25/34 , A61P25/30
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
摘要翻译：本发明涉及疫苗接种和治疗或预防疾病领域。特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。本发明还提供了通过在受试者中诱导半抗原特异性抗体来预防或治疗疾病的方法，所述方法包括向所述受试者施用包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原的组合物。

7. 发明申请

US20090123414A1 Il-15 Antigen Arrays And Uses Thereof 审中-公开
标题翻译： Il-15抗原阵列及其用途
公开(公告)号：US20090123414A1
公开(公告)日：2009-05-14
申请号：US11792749
申请日：2005-12-12
申请人： Martin F. Bachmann , Patrik Maurer , Yu Zou , Alain Tissot
发明人： Martin F. Bachmann , Patrik Maurer , Yu Zou , Alain Tissot
IPC分类号： A61K48/00 , A61K39/20
CPC分类号： A61K39/0008 , A61K39/0005 , A61K2039/5258
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中所述抗原是IL-15蛋白，IL-15突变蛋白或IL-15片段。更具体地，本发明提供包含病毒样颗粒和至少一种IL-15蛋白，IL-15突变蛋白或与其连接的至少一个IL-15片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性和慢性自身免疫性疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

8. 发明授权

US08691209B2 Packaging of immunostimulatory substances into virus-like particles: method of preparation and use 有权
标题翻译：将免疫刺激物质包装成病毒样颗粒：制备和使用方法
公开(公告)号：US08691209B2
公开(公告)日：2014-04-08
申请号：US13294006
申请日：2011-11-10
申请人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： A01N63/00 , C12N1/20 , C12N7/00
CPC分类号： A61K39/12 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/39 , A61K2039/52 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2730/10122 , C12N2730/10123 , C12N2795/00034 , C12N2795/18122 , Y02A50/412 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。此外，针对VLP和抗原的T细胞应答特别针对Th1型。因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

9. 发明申请

US20130142821A1 Hapten-Carrier Conjugates and Uses Thereof 审中-公开
标题翻译：搭载运载体共轭体及其用途
公开(公告)号：US20130142821A1
公开(公告)日：2013-06-06
申请号：US13476685
申请日：2012-05-21
申请人： Martin F. BACHMANN , Patrik Maurer
发明人： Martin F. BACHMANN , Patrik Maurer
IPC分类号： C07K17/02
CPC分类号： C07K17/02 , A61K39/0013 , A61K39/385 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , A61K2039/6075 , C07K14/005 , C12N2730/10122 , C12N2795/18123
摘要： The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.
摘要翻译：本发明提供了包含有序和重复排列的半抗原与载体的缀合物的组合物，以及制备这种组合物的方法。本发明的缀合物和组合物可以包含各种半抗原，包括激素，毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和缀合物可用于诱导针对半抗原的免疫应答，其可用于各种治疗，预防和诊断方案中。在某些实施方案中，使用本发明的缀合物，组合物和方法产生的免疫应答可用于预防或治疗滥用药物的成瘾以及与药物成瘾相关的所得疾病。

10. 发明授权

US07452541B2 Hapten-carrier conjugates and uses thereof 失效
标题翻译：黑色素 - 载体缀合物及其用途
公开(公告)号：US07452541B2
公开(公告)日：2008-11-18
申请号：US11125402
申请日：2005-05-10
申请人： Martin F. Bachmann , Patrik Maurer
发明人： Martin F. Bachmann , Patrik Maurer
IPC分类号： A61K39/385 , C07D401/04
CPC分类号： C07K17/02 , A61K39/0013 , A61K39/385 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , A61K2039/6075 , C07K14/005 , C12N2730/10122 , C12N2795/18123
摘要： The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.
摘要翻译：本发明提供了包含有序和重复排列的半抗原与载体的缀合物的组合物，以及制备这种组合物的方法。本发明的缀合物和组合物可以包含各种半抗原，包括激素，毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和缀合物可用于诱导针对半抗原的免疫应答，其可用于各种治疗，预防和诊断方案中。在某些实施方案中，使用本发明的缀合物，组合物和方法产生的免疫应答可用于预防或治疗滥用药物的成瘾以及与药物成瘾相关的所得疾病。

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