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1. 发明申请

US20120263743A1 INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：流感嗜血红蛋白组合物及其用途
公开(公告)号：US20120263743A1
公开(公告)日：2012-10-18
申请号：US13318099
申请日：2010-04-30
申请人： Martin Bachmann , Andrea Jegerlehner , Philippe Saudan
发明人： Martin Bachmann , Andrea Jegerlehner , Philippe Saudan
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11
CPC分类号： A61K47/6901 , A61K47/646
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and/or preventing influenza virus infection.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段流感病毒血凝素蛋白。当给予动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选所述抗体应答针对流感病毒。因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。

2. 发明申请

US20060286035A1 Methods and compositions for modulating the interaction between adiponectin and its receptor 审中-公开
标题翻译：调节脂联素及其受体之间相互作用的方法和组合物
公开(公告)号：US20060286035A1
公开(公告)日：2006-12-21
申请号：US10555058
申请日：2004-04-28
申请人： Philippe Saudan , Martin Bachmann
发明人： Philippe Saudan , Martin Bachmann
IPC分类号： A61K49/00 , A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号： G01N33/566 , A61K38/00 , A61K38/2264 , A61K49/0004 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2319/43 , G01N2333/705 , A61K2300/00
摘要： The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.
摘要翻译：本发明涉及用于鉴定模拟或调节脂联素及其受体之间相互作用的试剂的方法。特别地，本发明涉及用于模拟或调节脂连蛋白-T-钙粘蛋白相互作用以便治疗与脂联素缺乏或过量相关的疾病和病症的方法。这些疾病包括例如肥胖症，神经性厌食症，I型和II型糖尿病，冠状动脉疾病和动脉粥样硬化。本发明还提供分离的脂联素-T-钙粘蛋白复合物和用于鉴定与脂连蛋白相互作用的多肽的方法。

3. 发明申请

US20060088550A1 Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof 失效
标题翻译：胃抑制多肽（GIP）抗原阵列及其用途
公开(公告)号：US20060088550A1
公开(公告)日：2006-04-27
申请号：US11257498
申请日：2005-10-25
申请人： Martin Bachmann , Alma Fulurija , Philippe Saudan
发明人： Martin Bachmann , Alma Fulurija , Philippe Saudan
IPC分类号： A61K39/12 , A61K31/4439 , C12N7/00
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。

4. 发明申请

US20110262472A1 VACCINE COMPOSITIONS FOR THE TREATMENT OF DENGUE FEVER AND USES THEREOF 审中-公开
标题翻译：用于治疗登革热的疫苗组合物及其用途
公开(公告)号：US20110262472A1
公开(公告)日：2011-10-27
申请号：US12989186
申请日：2009-04-22
申请人： Martin Bachmann , Adrian Huber , Lidia Ivanova , Martin Bachmann
发明人： Martin Bachmann , Adrian Huber , Lidia Ivanova , Martin Bachmann
IPC分类号： A61K39/12 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/55505 , A61K2039/6075 , A61K2039/62 , A61K2039/64 , A61K2039/70 , C12N2770/24122 , C12N2770/24134 , C12N2795/18123 , Y02A50/386
摘要： The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of dengue fever. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is a dengue antigen. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against dengue virus, preferably against dengue virus of any one of serotypes 1 to 4. Thus, the invention further provides methods of treating, ameliorating and/or preventing dengue virus infection by way of active immunization against domain III of the dengue virus envelope protein E, or against antigenic fragments thereof.
摘要翻译：本发明提供用于治疗，改善和/或预防登革热的组合物，疫苗组合物和药物组合物。本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是登革热抗原。当给予动物，优选给人时，所述组合物，疫苗组合物和药物组合物诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对登革热病毒，优选针对登革热病毒，因此，本发明还提供了通过针对登革病毒包膜蛋白E的结构域III的主动免疫或其抗原性片段来治疗，改善和/或预防登革病毒感染的方法。

5. 发明申请

US20110318300A1 User of Interleukin-1 Conjugates in the Treatment of Diabetes 审中-公开
标题翻译：白细胞介素-1缀合物在糖尿病治疗中的用户
公开(公告)号：US20110318300A1
公开(公告)日：2011-12-29
申请号：US12921038
申请日：2009-03-05
申请人： Martin Bachmann , Gunther Spohn
发明人： Martin Bachmann , Gunther Spohn
IPC分类号： A61K38/20 , A61P3/10
CPC分类号： C07K14/545 , A61K38/2006 , A61K2039/5258 , C12N2795/18123
摘要： The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-1) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-1.
摘要翻译：本发明提供用于治疗，改善和/或预防糖尿病，优选II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含核心颗粒和抗原，其中所述抗原包含白细胞介素-1（IL-1）分子。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对IL-1。因此，本发明提供了通过对IL-1的主动免疫来治疗，改善或预防糖尿病，优选II型糖尿病的方法。

6. 发明申请

US20110027220A1 Interleukin-1 Conjugates and Uses Thereof 审中-公开
标题翻译：白细胞介素-1共轭体及其用途
公开(公告)号：US20110027220A1
公开(公告)日：2011-02-03
申请号：US11992731
申请日：2006-09-28
申请人： Martin Bachmann , Gunther Spohn , Alain Tissot
发明人： Martin Bachmann , Gunther Spohn , Alain Tissot
IPC分类号： A61K39/00 , C07K14/54 , A61P25/00 , A61P19/00 , A61P19/06 , A61P9/10 , A61P37/08 , A61P29/00
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

7. 发明授权

US07767212B2 CAT allergen conjugates and uses thereof 有权
标题翻译： CAT过敏原共轭物及其用途
公开(公告)号：US07767212B2
公开(公告)日：2010-08-03
申请号：US11886577
申请日：2006-03-17
申请人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
发明人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
IPC分类号： A61K39/35 , A61K39/385 , C12N7/00 , C07K19/00 , C07K17/06
CPC分类号： A61K47/48776 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C07K2319/00
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。本发明还提供了用于制备组合物的方法。本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

8. 发明申请

US20080019991A1 Carrier Conjugates Of Tnf-Peptides 审中-公开
标题翻译： Tnf肽的载体结合体
公开(公告)号：US20080019991A1
公开(公告)日：2008-01-24
申请号：US11628243
申请日：2005-06-02
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/00 , A61K45/00 , C12N7/01
CPC分类号： C12N7/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/525 , C07K2319/00 , C12N2710/00023 , C12N2730/10123 , C12N2795/00023
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。本发明还提供了用于生产修饰的VLP的方法。本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

9. 发明申请

US20070184068A1 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 审中-公开
标题翻译：免疫刺激核酸包装颗粒治疗超敏反应
公开(公告)号：US20070184068A1
公开(公告)日：2007-08-09
申请号：US11638664
申请日：2006-12-14
申请人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
IPC分类号： A61K48/00 , A61K39/12
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

10. 发明申请

US20070087409A1 Angiotensin peptide-carrier conjugates and uses thereof 失效
标题翻译：血管紧张素肽 - 载体缀合物及其用途
公开(公告)号：US20070087409A1
公开(公告)日：2007-04-19
申请号：US11540969
申请日：2006-10-02
申请人： Martin Bachmann
发明人： Martin Bachmann
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： A61K39/0005 , A61K38/00 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , C07K5/1021 , C07K7/14 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
摘要翻译：本发明提供了哺乳动物肽激素血管紧张素原，血管紧张素I和血管紧张素II的肽衍生物的缀合物，其通过将肽衍生物偶联到载体，特别是病毒样颗粒（VLP）而呈现在重复的支架中。本发明还提供了产生这种缀合物的方法，以及所得到的免疫原缀合物的免疫治疗用途，用于治疗和预防与肾素激活的血管紧张素系统相关的病症。

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