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1. 发明申请

US20070184068A1 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 审中-公开
标题翻译：免疫刺激核酸包装颗粒治疗超敏反应
公开(公告)号：US20070184068A1
公开(公告)日：2007-08-09
申请号：US11638664
申请日：2006-12-14
申请人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
IPC分类号： A61K48/00 , A61K39/12
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

2. 发明授权

US08574564B2 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 失效
标题翻译：免疫刺激核酸包装颗粒治疗超敏反应
公开(公告)号：US08574564B2
公开(公告)日：2013-11-05
申请号：US12576086
申请日：2009-10-08
申请人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
IPC分类号： A01N63/00 , A61K48/00
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

3. 发明申请

US20090123471A1 T-Cadherin antigen arrays and uses thereof 审中-公开
标题翻译： T-Cadherin抗原阵列及其用途
公开(公告)号：US20090123471A1
公开(公告)日：2009-05-14
申请号：US11666497
申请日：2005-10-31
申请人： Martin F. Bachmann , Philippe Saudan , Klaus Dietmeier , Alain Tissot
发明人： Martin F. Bachmann , Philippe Saudan , Klaus Dietmeier , Alain Tissot
IPC分类号： A61K39/395 , C07K14/00 , A61K39/00 , A61K38/16
CPC分类号： A61K39/385 , A61K47/6901 , A61K2039/6075 , A61K2039/627
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a T-cadherin domain protein, a combination of any T-cadherin domain proteins, a T-cadherin domain fragment or a combination of any T-cadherin domain fragments, linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of T-cadherin related disease, and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供了包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是T-cadherin结构域蛋白，任何T-cadherin结构域蛋白，T-钙粘蛋白结构域片段或与VLP分别连接的任何T-cadherin结构域片段的组合。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗T-钙粘蛋白相关疾病，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

4. 发明申请

US20110045013A1 CAT Allergen Conjugates and Uses Thereof 审中-公开
标题翻译： CAT过敏原共轭体及其用途
公开(公告)号：US20110045013A1
公开(公告)日：2011-02-24
申请号：US12785174
申请日：2010-05-21
申请人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
发明人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
IPC分类号： A61K39/35 , C12N7/00 , A61P37/08
CPC分类号： C07K14/005 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K2319/00
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。本发明还提供了用于制备组合物的方法。本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

5. 发明授权

US07767212B2 CAT allergen conjugates and uses thereof 有权
标题翻译： CAT过敏原共轭物及其用途
公开(公告)号：US07767212B2
公开(公告)日：2010-08-03
申请号：US11886577
申请日：2006-03-17
申请人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
发明人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
IPC分类号： A61K39/35 , A61K39/385 , C12N7/00 , C07K19/00 , C07K17/06
CPC分类号： A61K47/48776 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C07K2319/00
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。本发明还提供了用于制备组合物的方法。本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

6. 发明申请

US20090175896A1 CAT Allergen Conjugates and Uses Thereof 有权
标题翻译： CAT过敏原共轭体及其用途
公开(公告)号：US20090175896A1
公开(公告)日：2009-07-09
申请号：US11886577
申请日：2006-03-17
申请人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
发明人： Martin Bachmann , Monika Bauer , Klaus Dietmeier , Nicole Schmitz , Stephan Utzinger
IPC分类号： A61K39/385 , A61K35/76 , C12N7/00
CPC分类号： A61K47/48776 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C07K2319/00
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。本发明还提供了用于制备组合物的方法。本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

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