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    • 6. 发明申请
    • DIMERIC BENZYLIDENE MALONATES
    • 二甲苯胆碱
    • US20110038815A1
    • 2011-02-17
    • US12867777
    • 2009-03-04
    • Markus HanschThomas EhlisBarbara Wagner
    • Markus HanschThomas EhlisBarbara Wagner
    • A61K8/37C07C67/31A61Q17/04
    • A61Q17/04A61K8/37A61K8/585C07C67/03C07C67/31C07C67/343C07C69/734C07C2601/14C07F7/0889C07C69/732
    • Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is —C1-C20alkylene-, —CH2CH(OH)CH2—, —C5-C20cycloalkylene, —C2-C20alkenylene-, —C5-C10arylene-, or —C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from —O, —S— or —NH—; for the protection of human and animal hair and skin against UV radiation.
    • 公开了式(1)的亚苄基丙二酸酯的用途,其中R 1和R 2彼此独立地为氢; 哦; C 1 -C 12烷基; C1-C12烷氧基; C 1 -C 12烷基氨基; C1-C12二烷基氨基; 选自羧酸盐,磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7,R 4为COOR 8; COR9; CONR8R9; CN; 或SO2R10; R 5,R 6,R 7,R 8,R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代或取代的-C 1 -C 20亚烷基 - , - CH 2 CH(OH)CH 2 - , - C 5 -C 20亚环烷基,-C 2 -C 20亚烯基,-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - (C 1 -C 10亚烷基) 直链或支链,任选被一个或多于一个选自-O,-S-或-NH-的杂原子中断; 用于保护人和动物的头发和皮肤免受紫外线辐射。
    • 7. 发明授权
    • UV filter combinations comprising benzylidene malonates
    • US09764169B2
    • 2017-09-19
    • US13381965
    • 2010-06-29
    • Julie GrumelardThomas EhlisMarkus HanschMyriam Sohn
    • Julie GrumelardThomas EhlisMarkus HanschMyriam Sohn
    • A61Q17/04A61K8/37
    • A61Q17/04A61K8/37
    • Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;(b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.