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1. 发明授权

US08486333B2 Centrifugal fluid analyzer rotor 有权
公开(公告)号：US08486333B2
公开(公告)日：2013-07-16
申请号：US12321359
申请日：2009-01-16
申请人： Mark Wang , Nan Zhang
发明人： Mark Wang , Nan Zhang
IPC分类号： A61M1/00
CPC分类号： G01N35/00069 , G01N2035/00257 , G01N2035/00495 , Y10T436/2575
摘要： This invention provides rotors and methods of precisely metering a sample fluid and mixing the sample with a reagent. The rotors have a metering tube of defined volume that fills until sample flow is stopped by surface tension of a meniscus at a capillarity port, while excess sample is stripped from the metering tube inlet by centripetal force of the spinning rotor. By spinning the rotor at a higher speed, a reagent can be forced from a reagent chamber to contact the meniscus, breaking the surface tension and allowing the metered sample to mix with the reagent.

2. 发明申请

US20090227041A1 Centrifugal fluid analyzer rotor 有权
标题翻译：离心流体分析仪转子
公开(公告)号：US20090227041A1
公开(公告)日：2009-09-10
申请号：US12321359
申请日：2009-01-16
申请人： Mark Wang , Nan Zhang
发明人： Mark Wang , Nan Zhang
IPC分类号： G01N1/10
CPC分类号： G01N35/00069 , G01N2035/00257 , G01N2035/00495 , Y10T436/2575
摘要： This invention provides rotors and methods of precisely metering a sample fluid and mixing the sample with a reagent. The rotors have a metering tube of defined volume that fills until sample flow is stopped by surface tension of a meniscus at a capillarity port, while excess sample is stripped from the metering tube inlet by centripetal force of the spinning rotor. By spinning the rotor at a higher speed, a reagent can be forced from a reagent chamber to contact the meniscus, breaking the surface tension and allowing the metered sample to mix with the reagent.
摘要翻译：本发明提供了精确计量样品流体并将样品与试剂混合的转子和方法。转子具有限定体积的计量管，其填充直到样品流在毛细管端口处由弯月面的表面张力停止，而多余的样品通过旋转转子的向心力从计量管入口剥离。通过以更高的速度旋转转子，试剂可以被迫从试剂室接触弯液面，破坏表面张力并允许计量的样品与试剂混合。

3. 发明授权

US08717413B2 Imaging system having a folded optical axis 有权
标题翻译：具有折叠光轴的成像系统
公开(公告)号：US08717413B2
公开(公告)日：2014-05-06
申请号：US12463488
申请日：2009-05-11
申请人： Gordon Wilson , Mark Wang
发明人： Gordon Wilson , Mark Wang
IPC分类号： H04N7/00
CPC分类号： G02B13/06 , G02B17/08 , H04N5/2254 , H04N5/23238 , H04N5/3415
摘要： An imaging system having a folded optical axis that is accomplished through the effect of a first lens group, a prism, and a second lens group wherein a second surface of the prism is a mirror wherein the folded imaging system exhibits a horizontal field of view (HFOV) greater than 160 degrees and a vertical field of view (VFOV) greater than 80 degrees. Further aspects include a conjugate ratio of the lenses to be substantially 5.47 and a ratio of the entire lens focal length to the focal length of the first lens to be substantially −0.309.
摘要翻译：一种具有通过第一透镜组，棱镜和第二透镜组的效果实现的折叠光轴的成像系统，其中棱镜的第二表面是反射镜，其中折叠成像系统呈现水平视野（ HFOV）大于160度，垂直视野（VFOV）大于80度。另外的方面包括透镜的共轭比基本上为5.47，并且整个透镜焦距与第一透镜的焦距的比率基本上为-0.309。

4. 发明申请

US20060270755A1 Three-dimensional optical data storage in fluorescent dye-doped photopolymer 失效
标题翻译：荧光染料掺杂光聚合物中的三维光学数据存储
公开(公告)号：US20060270755A1
公开(公告)日：2006-11-30
申请号：US11337741
申请日：2006-01-23
申请人： Mark Wang , Sadik Esener
发明人： Mark Wang , Sadik Esener
IPC分类号： C03C17/00
CPC分类号： G11B7/246 , B82Y10/00 , G03H1/02 , G03H2001/026 , G03H2260/12 , G11B7/00455 , G11B7/24038 , G11B7/245 , G11B2007/24624 , G11C13/0014 , G11C13/0016 , G11C13/041
摘要： A host matrix—normally a binder such as cellulose acetate propionate in a solvent such as acetone—contains a radiation-polymerizable photopolymer—normally a monomer like dipentaerythritol pentaacrylate in combination with a crosslinker like 1-vinyl-2-pyrrolidinone, an initiator like N-phenyl glycine, and/or a photosensitizer like camphor quinine—that is initially uniformly doped with a stable dye—typically Rhodamine B and/or Bodipy Red—that photoinitiates photopolymerization. Upon selective exposure of certain regions of the matrix by radiation, most normally laser light radiation, the dye will initially migrate and redistribute itself to radiatively-exposed regions until, dye migration being substantially complete, photopolymerization will occur, locking the migrated dye in place at a relatively higher concentration at the selectively exposed regions. The dye therein stably located can be optically detected by, preferably, light-radiation-stimulated fluorescence. The medium thus serves as an optical memory, including of the volume type, that can be reliably permanently written quickly and inexpensively at high density.
摘要翻译：主要基质 - 通常为粘合剂，如溶剂如丙酮中的乙酸丙酸纤维素，含有辐射聚合光聚合物 - 通常为单体，如二季戊四醇五丙烯酸酯与交联剂如1-乙烯基-2-吡咯烷酮，N， - 苯基甘氨酸和/或光敏剂如樟脑奎宁，其最初均匀掺杂有稳定的染料 - 通常为罗丹明B和/或Bodipy Red - 光引发光聚合。通过辐射选择性地暴露基质的某些区域，大多数通常是激光辐射，染料将首先迁移并重新分布到辐射暴露的区域，直到染料迁移基本上完成，将发生光聚合，将迁移的染料锁定在在选择性暴露区域的浓度相对较高。其中稳定位置的染料可以通过优选光辐射刺激的荧光进行光学检测。该介质因此用作包括体积型的光学存储器，其能够以高密度快速且廉价地可靠地永久地写入。

5. 发明授权

US07049579B2 Manipulation of live cells and inorganic objects with optical micro beam arrays 有权
公开(公告)号：US07049579B2
公开(公告)日：2006-05-23
申请号：US09917139
申请日：2001-07-26
申请人： Mihrimah Ozkan , Sadik Esener , Mark Wang
发明人： Mihrimah Ozkan , Sadik Esener , Mark Wang
IPC分类号： H01S3/081
CPC分类号： H05H3/04 , G02B21/32
摘要： One or more microbeams derived from a corresponding number of Vertical Cavity Surface Emitting Lasers (VCSELs) are used to manipulate and to transport inorganic and organic objects. The optical tweezing apparatus and method is compact size, and suitable to manipulate multiple objects in an array concurrently, and in parallel.

6. 发明授权

US06778724B2 Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices 有权
标题翻译：在微流体装置中运输的生物样品和微粒的光学切换和分选，包括集成的生物芯片装置
公开(公告)号：US06778724B2
公开(公告)日：2004-08-17
申请号：US09998012
申请日：2001-11-28
申请人： Mark Wang , Erhan Polatkon Ata , Sadik C. Esener
发明人： Mark Wang , Erhan Polatkon Ata , Sadik C. Esener
IPC分类号： G02B626
CPC分类号： H05H3/04 , Y10T428/24744
摘要： Small particles, for example 5 &mgr;m diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel, low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips.
摘要翻译：选择性地操纵在通常模制的PDMS透明塑料的辐射透明基底内的微流体通道内流动的流体（通常为水）内的微粒，例如5微米直径的微球或细胞，通常是通过通过激光照射，优选地是以在Laguerre-Gaussian模式下操作的VCSEL产生的激光照射在微流体通道中的分支结处，从而进入选择的下游分支，从而实现包括并行的粒子切换和分选。因此，通过微流体传输小颗粒，而以光学镊子的方式进行操作会由于光学散射力的推动或由于有吸引力的光学梯度力而引起拉动。无论是推动还是拉动，流动流体中的颗粒可以被光学感测，并且高度并行，低成本的细胞和颗粒分析装置被有效地实现，包括集成在生物芯片上。

7. 发明申请

US20120168644A1 CONFOCAL IMAGING METHODS AND APPARATUS 有权
标题翻译：协同成像方法和装置
公开(公告)号：US20120168644A1
公开(公告)日：2012-07-05
申请号：US13417474
申请日：2012-03-12
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

8. 发明申请

US20110001789A1 IMAGING SYSTEM HAVING A FOLDED OPTICAL AXIS 有权
标题翻译：具有折叠光轴的成像系统
公开(公告)号：US20110001789A1
公开(公告)日：2011-01-06
申请号：US12877220
申请日：2010-09-08
申请人： Gordon Wilson , Mark Wang
发明人： Gordon Wilson , Mark Wang
IPC分类号： H04N5/225
CPC分类号： G02B13/06 , A61B1/041 , G02B17/08 , H04N5/2254 , H04N5/23238 , H04N5/3415
摘要： An optical imaging system having a folded optical axis.
摘要翻译：具有折叠光轴的光学成像系统。

9. 发明授权

US07439009B2 Three-dimensional optical data storage in fluorescent dye-doped photopolymer 失效
标题翻译：荧光染料掺杂光聚合物中的三维光学数据存储
公开(公告)号：US07439009B2
公开(公告)日：2008-10-21
申请号：US11337741
申请日：2006-01-23
申请人： Mark Wang , Sadik Esener
发明人： Mark Wang , Sadik Esener
IPC分类号： G03C1/72 , G03H1/04
CPC分类号： G11B7/246 , B82Y10/00 , G03H1/02 , G03H2001/026 , G03H2260/12 , G11B7/00455 , G11B7/24038 , G11B7/245 , G11B2007/24624 , G11C13/0014 , G11C13/0016 , G11C13/041
摘要： A host matrix—normally a binder such as cellulose acetate propionate in a solvent such as acetone—contains a radiation-polymerizable photopolymer—normally a monomer like dipentaerythritol pentaacrylate in combination with a crosslinker like 1-vinyl-2-pyrrolidinone, an initiator like N-phenyl glycine, and/or a photosensitizer like camphor quinine—that is initially uniformly doped with a stable dye—typically Rhodamine B and/or Bodipy Red—that photoinitiates photopolymerization. Upon selective exposure of certain regions of the matrix by radiation, most normally laser light radiation, the dye will initially migrate and redistribute itself to radiatively-exposed regions until, dye migration being substantially complete, photopolymerization will occur, locking the migrated dye in place at a relatively higher concentration at the selectively exposed regions. The dye therein stably located can be optically detected by, preferably, light-radiation-stimulated fluorescence. The medium thus serves as an optical memory, including of the volume type, that can be reliably permanently written quickly and inexpensively at high density.
摘要翻译：主要基质 - 通常为粘合剂，如溶剂如丙酮中的乙酸丙酸纤维素，含有辐射聚合光聚合物 - 通常为单体，如二季戊四醇五丙烯酸酯与交联剂如1-乙烯基-2-吡咯烷酮，N， - 苯基甘氨酸和/或光敏剂如樟脑奎宁，其最初均匀掺杂有稳定的染料 - 通常为罗丹明B和/或Bodipy Red - 光引发光聚合。通过辐射选择性地暴露基质的某些区域，大多数通常是激光辐射，染料将首先迁移并重新分布到辐射暴露的区域，直到染料迁移基本上完成，将发生光聚合，将迁移的染料锁定在在选择性暴露区域的浓度相对较高。其中稳定位置的染料可以通过优选光辐射刺激的荧光进行光学检测。该介质因此用作包括体积型的光学存储器，其能够以高密度快速且廉价地可靠地永久地写入。

10. 发明申请

US20080117518A1 Microarray line scanning method and system 有权
标题翻译：微阵列扫描方法和系统
公开(公告)号：US20080117518A1
公开(公告)日：2008-05-22
申请号：US11602887
申请日：2006-11-21
申请人： Mark Wang , Wenyi Feng , Robert Kain
发明人： Mark Wang , Wenyi Feng , Robert Kain
IPC分类号： G02B27/10
CPC分类号： G01N21/6452 , G01N2021/6484 , G02B21/0032 , G02B21/0036
摘要： A line scanning arrangement for imaging microarrays includes a line illuminator that converts output from one or more lasers to a radiation line. The laser output passes through a single mode fiber and a module that converts the laser light to the radiation line. The line is confocally directed to sites on the microarray, and retrobeams returned from the sites are collected on an imaging detector. The microarray is moved in the imaging apparatus so as to progressively illuminate an array or matrix of sites for imaging.
摘要翻译：用于成像微阵列的线扫描装置包括将一个或多个激光器的输出转换成辐射线的线照明器。激光输出通过单模光纤和将激光转换成辐射线的模块。该线与微阵列上的位点一致，并将从该位点返回的逆行器收集在成像检测器上。微阵列在成像装置中移动，以逐渐照射用于成像的位点的阵列或矩阵。

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