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1. 发明授权

US09233926B2 Compounds for stem cell differentiation 有权
标题翻译：用于干细胞分化的化合物
公开(公告)号：US09233926B2
公开(公告)日：2016-01-12
申请号：US13428647
申请日：2012-03-23
申请人： Mark Mercola , John Cashman , Marion Lanier , Erik Willems , Dennis Schade
发明人： Mark Mercola , John Cashman , Marion Lanier , Erik Willems , Dennis Schade
IPC分类号： C07D215/38 , A61K31/47 , C07D215/54
CPC分类号： C07D215/54 , A61K31/47 , A61K31/4709 , A61K31/475 , A61K38/1841 , A61K38/1875 , C07D215/20 , C07D401/10 , C07D401/12 , C12N5/0618 , C12N5/0652 , C12N5/0655 , C12N5/0657 , C12N5/067 , C12N5/0676
摘要： Small molecule compounds and methods for stem cell differentiation are provided herein. An example of a class of compounds that may be used to practice the methods disclosed herein is represented by enantiomerically pure isomers of compounds of Formula I: or a chirally pure stereoisomer, pharmaceutically acceptable salt, or solvate thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R6′, R7, R7′ are as described herein.
摘要翻译：本文提供了小分子化合物和干细胞分化方法。可用于实施本文公开的方法的一类化合物的实例由式I化合物的对映体纯的异构体或其手性纯的立体异构体，药学上可接受的盐或溶剂合物表示，其中R1，R2，R3， R4，R5，R5'，R6，R6'，R7，R7'如本文所述。

2. 发明授权

US09023340B2 Wnt inhibitors for human stem cell differentiation 有权
标题翻译： Wnt抑制剂用于人类干细胞分化
公开(公告)号：US09023340B2
公开(公告)日：2015-05-05
申请号：US13540590
申请日：2012-07-02
申请人： John Cashman , Marion Lanier , Mark Mercola , Dennis Schade , Erik Willems
发明人： John Cashman , Marion Lanier , Mark Mercola , Dennis Schade , Erik Willems
IPC分类号： A01N63/00 , C07D401/12 , C07D209/76 , C12N5/077 , A61K35/34
CPC分类号： C07D401/12 , A61K35/34 , C07D209/76 , C12N5/0657 , C12N2501/415 , C12N2503/02 , C12N2506/02
摘要： Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: or a pharmaceutically acceptable salt or solvate thereof, wherein A, X, Q, R1, R2, R3, R4 are as described herein.
摘要翻译：提供了用于具有疾病的动物的干细胞分化和治疗的方法和小分子化合物。可以使用的一类化合物的一个实例由式I和II的化合物或其药学上可接受的盐或溶剂合物表示，其中A，X，Q，R 1，R 2，R 3，R 4如本文所述。

3. 发明申请

US20130177535A1 WNT INHIBITORS FOR HUMAN STEM CELL DIFFERENTIATION 有权
标题翻译： WNT抑制剂用于人类干细胞分化
公开(公告)号：US20130177535A1
公开(公告)日：2013-07-11
申请号：US13540590
申请日：2012-07-02
申请人： John Cashman , Marion Lanier , Mark Mercola , Dennis Schade , Erik Willems
发明人： John Cashman , Marion Lanier , Mark Mercola , Dennis Schade , Erik Willems
IPC分类号： C07D401/12 , C12N5/071 , A61K35/34 , C07D209/76
CPC分类号： C07D401/12 , A61K35/34 , C07D209/76 , C12N5/0657 , C12N2501/415 , C12N2503/02 , C12N2506/02
摘要： Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: or a pharmaceutically acceptable salt or solvate thereof, wherein A, X, Q, R1, R2, R3, R4 are as described herein.
摘要翻译：提供了用于具有疾病的动物的干细胞分化和治疗的方法和小分子化合物。可以使用的一类化合物的一个实例由式I和II的化合物或其药学上可接受的盐或溶剂合物表示，其中A，X，Q，R 1，R 2，R 3，R 4如本文所述。

4. 发明申请

US20110281356A1 COMPOUNDS FOR STEM CELL DIFFERENTIATION 审中-公开
标题翻译：用于干细胞分化的化合物
公开(公告)号：US20110281356A1
公开(公告)日：2011-11-17
申请号：US13107592
申请日：2011-05-13
申请人： Mark Mercola , John Cashman , Marion Lanier , Erik Willems
发明人： Mark Mercola , John Cashman , Marion Lanier , Erik Willems
IPC分类号： C12N5/0735 , C12N5/074 , C07D215/54
CPC分类号： C07D215/54 , C07D235/06 , C07D279/20 , C07D279/22 , C07D279/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/04
摘要： Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R6′, R7, R7′ are as described herein.
摘要翻译：提供了干细胞分化的方法和小分子化合物。可以使用的一类化合物的一个实例由式I化合物或其药学上可接受的盐或溶剂合物表示，其中R1，R2，R3，R4，R5，R5'，R6，R6'，R7， R7'如本文所述。

5. 发明授权

US09403800B2 Compounds for inhibition of cancer cell proliferation 有权
标题翻译：用于抑制癌细胞增殖的化合物
公开(公告)号：US09403800B2
公开(公告)日：2016-08-02
申请号：US13748770
申请日：2013-01-24
申请人： John Cashman , Mark Mercola , Dennis Schade , Masanao Tsuda
发明人： John Cashman , Mark Mercola , Dennis Schade , Masanao Tsuda
IPC分类号： C07D403/12 , C07D487/00 , A61K31/635 , C07D401/12 , C07D413/12 , C07H17/02 , A61K45/06 , A61K31/706 , A61K31/4745 , A61K31/513 , A61K31/555
CPC分类号： C07D403/12 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/635 , A61K31/706 , A61K45/06 , C07D401/12 , C07D413/12 , C07D487/00 , C07H17/02 , A61K2300/00
摘要： Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, E, F, G, I, J, R, R1, R2, R2′, R3, R4, R5, R6, R7, R8, R9 are as described herein.
摘要翻译：提供了抑制癌细胞增殖的方法和小分子化合物。可以使用的一类化合物的一个实例由式I化合物或其药学上可接受的盐，N-氧化物或溶剂化物表示，其中A，B，D，E，F，G，I，J，R ，R1，R2，R2'，R3，R4，R5，R6，R7，R8，R9如本文所述。

6. 发明授权

US09012217B2 Benzimidazole compounds differentiate a mammalian stem cell into mesodermal or cardiomyocyte cells 有权
标题翻译：苯并咪唑化合物将哺乳动物干细胞分化成中胚层或心肌细胞
公开(公告)号：US09012217B2
公开(公告)日：2015-04-21
申请号：US12561235
申请日：2009-09-16
申请人： Mark Mercola , Marcia Dawson , John Cashman , Paul J. Bushway
发明人： Mark Mercola , Marcia Dawson , John Cashman , Paul J. Bushway
IPC分类号： C12N5/0735 , C12N5/074 , C07D215/54 , C12N5/0797 , C12N5/073 , C07D235/06 , C07D279/20 , C07D279/22 , C07D279/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/04
CPC分类号： C07D215/54 , C07D235/06 , C07D279/20 , C07D279/22 , C07D279/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/04 , C12N5/0603 , C12N5/0606 , C12N5/0623
摘要： Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2′ is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofurylmethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5′, R6, R6′, R7, R7′, are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.
摘要翻译：提供了干细胞分化的方法和小分子化合物。可以使用的一类化合物的一个实例由具有游离碱或其药学上可接受的盐，水合物，溶剂合物或N-氧化物形式的结构IA或IB的化合物表示：R1独立地是氢或（C1 -C 6）烷基; R2独立地是氢，（C1-C6）烷基，芳基或杂芳基; R2'独立地是氢，（C1-C6）烷基，CF3或C2F5; R3独立地为（C1-C6）烷基，芳基，2-四氢呋喃基甲基，脂肪族叔胺或4-甲氧基苄基; 或者R 2和R 3可以连接在一起以形成5或6元环内酯; R4独立地为氢，（C1-C6）烷基，选自4-R5-苯基或2-R5-5-吡啶基，芳基，杂芳基，脂族叔胺或卤素的2或4-R 5 - 取代的芳环 ; 和R 5，R 5'，R 6，R 6'，R 7，R 7'各自独立地为氢，（C 1 -C 6）烷基，芳基，任选取代的苯基，杂芳基，杂环，脂族叔胺或卤素。

7. 发明申请

US20100159596A1 SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION 有权
标题翻译：小分子化合物用于干细胞分化
公开(公告)号：US20100159596A1
公开(公告)日：2010-06-24
申请号：US12561235
申请日：2009-09-16
申请人： Mark Mercola , Marcia Dawson , John Cashman
发明人： Mark Mercola , Marcia Dawson , John Cashman
IPC分类号： C12N5/074 , C07D215/14 , C07D491/04 , C07D403/12 , C07D413/12 , C07D417/06 , C07D223/18
CPC分类号： C07D215/54 , C07D235/06 , C07D279/20 , C07D279/22 , C07D279/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/04 , C12N5/0603 , C12N5/0606 , C12N5/0623
摘要： Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2′ is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofurylmethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5′, R6, R6′, R7, R7′, are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.
摘要翻译：提供了干细胞分化的方法和小分子化合物。可以使用的一类化合物的一个实例由具有游离碱或其药学上可接受的盐，水合物，溶剂合物或N-氧化物形式的结构IA或IB的化合物表示：R1独立地是氢或（C1 -C 6）烷基; R2独立地是氢，（C1-C6）烷基，芳基或杂芳基; R2'独立地是氢，（C1-C6）烷基，CF3或C2F5; R3独立地为（C1-C6）烷基，芳基，2-四氢呋喃基甲基，脂肪族叔胺或4-甲氧基苄基; 或者R 2和R 3可以连接在一起以形成5或6元环内酯; R4独立地为氢，（C1-C6）烷基，选自4-R5-苯基或2-R5-5-吡啶基，芳基，杂芳基，脂族叔胺或卤素的2或4-R 5 - 取代的芳环 ; 和R 5，R 5'，R 6，R 6'，R 7，R 7'各自独立地为氢，（C 1 -C 6）烷基，芳基，任选取代的苯基，杂芳基，杂环，脂族叔胺或卤素。

8. 发明申请

US20090215690A1 Compositions and Methods for Inhibiting Cell Migration 失效
标题翻译：抑制细胞迁移的组成和方法
公开(公告)号：US20090215690A1
公开(公告)日：2009-08-27
申请号：US12333133
申请日：2008-12-11
申请人： Mark Mercola , Ruchika Gupta
发明人： Mark Mercola , Ruchika Gupta
IPC分类号： A61K38/16 , A61P35/00 , A61P17/02
CPC分类号： A61K38/1709
摘要： The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention.
摘要翻译： Dickkopf1（Dkk1）是双功能蛋白的发现证明了在发育和病理过程中协调细胞迁移和Wnt /β-连环蛋白信号的拮抗作用的机制。由人类乳腺癌表达的Dkk蛋白的特征与结果指标相关：Dkk1与预后不良的标志物相关，而单功能Dkk2或Dkk3（分别抑制Wnt /β-连环蛋白信号传导和促进迁移）的表达与反映的表型相关预后良好。因此，这里鉴定的Dkk1和3的亲迁移活动为乳腺癌进展提供了新的见解，也是治疗干预的潜在途径。

9. 发明授权

US07910305B2 Methods for screening for compounds that modulate insulin promoter activity 有权
标题翻译：筛选调节胰岛素启动子活性的化合物的方法
公开(公告)号：US07910305B2
公开(公告)日：2011-03-22
申请号：US11992028
申请日：2006-09-14
申请人： Mark Mercola , Fred Levin , Pamela Itkin-Ansari
发明人： Mark Mercola , Fred Levin , Pamela Itkin-Ansari
IPC分类号： C12Q1/68
CPC分类号： C07K14/62
摘要： Compositions and methods are provided for screening for compounds that modulate insulin promoter activity. Vectors that express green fluorescent protein under the control of the human insulin promoter are introduced into mouse and human cells in which the insulin promoter is expressed in a glucose-responsive manner. Such cells are then used to screen for compounds that modulate insulin promoter activity.
摘要翻译：提供组合物和方法用于筛选调节胰岛素启动子活性的化合物。将表达在人胰岛素启动子控制下的绿色荧光蛋白的载体导入小鼠和人胰岛素启动子以葡萄糖反应方式表达的细胞。然后将这样的细胞用于筛选调节胰岛素启动子活性的化合物。

10. 发明授权

US10001470B2 Method, system and composition for optically inducing cardiomyocyte contraction 有权
公开(公告)号：US10001470B2
公开(公告)日：2018-06-19
申请号：US12960313
申请日：2010-12-03
申请人： Mark Mercola , Fabio Cerignoli , Jeffrey Price
发明人： Mark Mercola , Fabio Cerignoli , Jeffrey Price
IPC分类号： C12Q1/18 , C12N13/00 , C12M1/42 , G01N33/50
CPC分类号： G01N33/5061 , G01N2333/705 , G01N2333/726
摘要： The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization, and/or the propagation of action potentials.

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