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    • 7. 发明申请
    • Inhibitors of Dimethylarginine Dimethylaminohydrolase
    • 二甲基精氨酸二甲基氨基水解酶抑制剂
    • US20110294878A1
    • 2011-12-01
    • US13133799
    • 2009-12-08
    • Bernd ClementJürke KotthausDennis Schade
    • Bernd ClementJürke KotthausDennis Schade
    • A61K31/27C07C279/24C07C271/20A61P35/00A61P7/00A61P11/06A61P25/28A61P25/00A61P9/10C07C335/28A61P29/00
    • A61K31/155A61K31/17C07C257/14C07C279/12
    • The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; R1 is selected from the group of structures (i-vii), wherein R2, R3 and R4 are selected from the group consisting of hydrogen, an alkyl or aryl radical, R5 and R6 are selected from the group consisting of hydrogen, a hydrocarbon chain having a chain length of 1 to 8 and an aryl radical, R7, R8, R9 and R10 are selected from the group consisting of hydrogen, and alkyl or aryl radical; W is oxygen (O) or nitrogen (N); and X is a methylene group (CH2) or a secondary amino group (NH); Y is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; Z is hydrogen (H) or a methoxyl group; and the radical (B) carrying the amino group has no carboxyl group.
    • 本发明涉及一般结构式(I)的二甲基精氨酸二甲氨基水解酶(DDAH)抑制剂,其中B是链长为1-6的支链或非支链,取代或未取代的饱和或不饱和烃链和/或 具有3至6个环的取代或未取代的芳族体系; R1选自结构式(i-vii),其中R2,R3和R4选自氢,烷基或芳基,R5和R6选自氢,烃链 具有1至8个链长和芳基,R 7,R 8,R 9和R 10选自氢和烷基或芳基; W是氧(O)或氮(N); 并且X是亚甲基(CH 2)或仲氨基(NH); Y是链长为1至6的支链或非支链,取代或未取代的饱和或不饱和烃链和/或具有3至6个环的取代或未取代的芳族体系; Z是氢(H)或甲氧基; 并且带有氨基的基团(B)没有羧基。
    • 9. 发明授权
    • Inhibitors of dimethylarginine dimethylaminohydrolase
    • 二甲基精氨酸二甲氨基水解酶抑制剂
    • US08921421B2
    • 2014-12-30
    • US13133799
    • 2009-12-08
    • Bernd ClementJürke KotthausDennis Schade
    • Bernd ClementJürke KotthausDennis Schade
    • A61K31/22A01N37/12A01N37/44A61K31/155A61K31/17C07C257/14C07C279/12
    • A61K31/155A61K31/17C07C257/14C07C279/12
    • The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; R1 is selected from the group of structures (i-vii), wherein R2, R3 and R4 are selected from the group consisting of hydrogen, an alkyl or aryl radical, R5 and R6 are selected from the group consisting of hydrogen, a hydrocarbon chain having a chain length of 1 to 8 and an aryl radical, R7, R8, R9 and R10 are selected from the group consisting of hydrogen, and alkyl or aryl radical; W is oxygen (O) or nitrogen (N); and X is a methylene group (CH2) or a secondary amino group (NH); Y is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; Z is hydrogen (H) or a methoxyl group; and the radical (B) carrying the amino group has no carboxyl group.
    • 本发明涉及一般结构式(I)的二甲基精氨酸二甲氨基水解酶(DDAH)抑制剂,其中B是链长为1-6的支链或非支链,取代或未取代的饱和或不饱和烃链和/或 具有3至6个环的取代或未取代的芳族体系; R1选自结构式(i-vii),其中R2,R3和R4选自氢,烷基或芳基,R5和R6选自氢,烃链 具有1至8个链长和芳基,R 7,R 8,R 9和R 10选自氢和烷基或芳基; W是氧(O)或氮(N); 并且X是亚甲基(CH 2)或仲氨基(NH); Y是链长为1至6的支链或非支链,取代或未取代的饱和或不饱和烃链和/或具有3至6个环的取代或未取代的芳族体系; Z是氢(H)或甲氧基; 并且带有氨基的基团(B)没有羧基。