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1. 发明授权

US5823957A D.C. biopotential sensing electrode and electroconductive medium for use therein 失效
标题翻译： D.C.生物电位感测电极和用于其中的导电介质
公开(公告)号：US5823957A
公开(公告)日：1998-10-20
申请号：US508206
申请日：1995-07-27
申请人： Mark L. Faupel , Burke T. Barrett , John D. Stephens , Seth D. Nathanson
发明人： Mark L. Faupel , Burke T. Barrett , John D. Stephens , Seth D. Nathanson
IPC分类号： A61B5/0408 , A61B5/05 , A61B5/053
CPC分类号： A61B5/04087 , A61B5/0531
摘要： A DC biopotential sensing electrode assembly is provided for an apparatus for sensing DC biopotentials present at the skin of a subject. An electroconductive medium for transmitting ions from the skin which has a chloride ion content within a range of from 6-15 grams per hundred grams of such medium is formulated for use with the electrode. To reduce the corrosive effect of this electroconductive medium, each electrode includes only one metallic component, and to provide an electrode with a low AC impedance, this metal is uniformly coated upon nonmetallic sensor and terminal bodies with a coating thickness within a range of from 0.5 to 1.5 mil. To insure a complete electrical path through both the sensor and the terminal bodies, the nonmetallic portions are formed of conductive plastic.
摘要翻译：提供DC生物电势感测电极组件用于感测存在于受试者皮肤上的DC生物电位的装置。用于将离子从皮肤传输的导电介质配制成与电极一起使用，其中氯离子含量在每克100克这种介质6-15克范围内。为了降低这种导电介质的腐蚀作用，每个电极仅包括一个金属部件，并且提供具有低AC阻抗的电极，该金属均匀涂覆在非金属传感器和端子体上，涂层厚度在0.5 至1.5密耳为了确保通过传感器和端子体的完整电路，非金属部分由导电塑料形成。

2. 发明授权

US5660177A D.C. biopotential sensing electrode assemblies for apparatus for disease, injury and bodily condition screening or sensing 失效
标题翻译： D.C.用于疾病，损伤和身体状况筛选或感测装置的生物电势感测电极组件
公开(公告)号：US5660177A
公开(公告)日：1997-08-26
申请号：US325085
申请日：1994-10-17
申请人： Mark L. Faupel , Burke T. Barrett , John D. Stephens , Seth D. Nathanson
发明人： Mark L. Faupel , Burke T. Barrett , John D. Stephens , Seth D. Nathanson
IPC分类号： A61B5/0408 , A61B5/05 , A61B5/04
CPC分类号： A61B5/0408 , A61B5/04 , A61B5/04002 , A61B5/04087 , A61B5/05 , A61B2562/0238 , A61B2562/08
摘要： A DC biopotential sensing electrode assembly is provided for an apparatus for sensing DC biopotentials present at the skin of a subject. The electrodes include an electroconductive medium for transmitting ions from the skin which has a chloride content within a range of from 6-15 grams per hundred grams of such medium. To reduce the corrosive effect of this electroconductive medium, each electrode includes only one metallic component, and to provide an electrode with a low AC impedance, this metal is uniformly coated upon nonmetallic sensor and terminal bodies with a coating thickness within a range of from 0.5 to 1.5 mil. To insure a complete electrical path through both the sensor and the terminal bodies, the nonmetallic portions are formed of conductive plastic.
摘要翻译：提供DC生物电势感测电极组件用于感测存在于受试者皮肤上的DC生物电位的装置。电极包括用于从皮肤传输离子的导电介质，其中氯含量在每克这种介质6-15克的范围内。为了降低这种导电介质的腐蚀作用，每个电极仅包括一个金属部件，并且提供具有低AC阻抗的电极，该金属均匀涂覆在非金属传感器和端子体上，涂层厚度在0.5 至1.5密耳为了确保通过传感器和端子体的完整电路，非金属部分由导电塑料形成。

3. 发明授权

US5678547A Method and apparatus for screening or sensing bodily conditions using DC biopotentials 失效
标题翻译：使用DC生物电位筛选或检测身体状况的方法和装置
公开(公告)号：US5678547A
公开(公告)日：1997-10-21
申请号：US429138
申请日：1995-04-26
申请人： Mark L. Faupel , Charles Leonard Gordon , John D. Stephens , Seth D. Nathanson , Kenneth E. Doe , Steven Erik Hagstrom
发明人： Mark L. Faupel , Charles Leonard Gordon , John D. Stephens , Seth D. Nathanson , Kenneth E. Doe , Steven Erik Hagstrom
IPC分类号： A61B5/04 , A61B5/0408 , A61B5/05 , A61B5/053 , G06N3/04
CPC分类号： A61B5/04002 , A61B5/04 , A61B5/04085 , A61B5/05 , A61B5/0531 , A61B5/7264 , G06N3/0454 , A61B2562/0209 , A61B2562/046 , A61B5/7267
摘要： A method and apparatus for screening or sensing disease states, injury sites or bodily conditions in a human or animal subject by separately detecting the DC biopotential of the electromagnetic field at a plurality of test points in a test area. The DC biopotentials are converted by analog to digital converters connected to DC biopotential test sensors at the test points into digital test signals, and the DC biopotential test sensors and analog to digital converters form a biopotential sensing section which is separate from a processing section that receives and processes the digital test signals. Signals between the processing section and the bopotential sensing section are transmitted by a transmission network which electrically isolates the two sections. The conversions performed by the analog to digital converters are synchronized with the AC line frequency of the apparatus power supply, and the digital test signals are filtered in the processing section by digital filters, each of which is dedicated to an individual DC biopotential test sensor.
摘要翻译：一种用于通过单独检测测试区域中的多个测试点处的电磁场的DC生物电位来筛选或感测人或动物受试者中的疾病状态，损伤部位或身体状况的方法和装置。直流生物电位由连接到测试点处的直流生物电势测试传感器的模数转换器转换为数字测试信号，直流生物电势测试传感器和模数转换器形成生物电位感测部分，该部分与接收的处理部分分离并处理数字测试信号。处理部分和机电感测部分之间的信号由电气隔离两部分的传输网络传输。由模拟数字转换器执行的转换与设备电源的AC线路频率同步，数字测试信号在处理部分通过数字滤波器进行滤波，每个滤波器专用于单个DC生物电势测试传感器。

4. 外观设计

USD374184S DC biopotential measuring unit 失效
公开(公告)号：USD374184S
公开(公告)日：1996-10-01
申请号：US41326
申请日：1995-06-07
申请人： John D. Stephens , Seth D. Nathanson , LeRoy J. LaCelle , Ted F. Pierson , Laura Welland
设计人： John D. Stephens , Seth D. Nathanson , LeRoy J. LaCelle , Ted F. Pierson , Laura Welland

5. 发明授权

US4986274A Fetal anatomic sex assignment by ultrasonography during early pregnancy 失效
标题翻译：通过超声检查在怀孕早期进行胎儿解剖性别分配
公开(公告)号：US4986274A
公开(公告)日：1991-01-22
申请号：US453123
申请日：1989-12-04
申请人： John D. Stephens
发明人： John D. Stephens
IPC分类号： A61B8/02 , A61B8/08 , A61B10/00
CPC分类号： A61B8/02 , A61B10/00 , A61B8/0866
摘要： A method and apparatus are disclosed for fetal anatomic sex assignment by ultrasound during early pregnancy based on pattern recognition that allows identification of external genitalia during the gestational age range of 12 to 14 weeks. The pattern recognition derives from knowledge of the embryology of the developing external genitalia of the fetus and the relationship between embryologic events and recognizing patterns specific for male and female obtained by ultrasonic imaging. Fetal anatomic sex has been accurately diagnosed using high resolution digital linear-array real-time ultrasound in over 500 pregnancies that were scheduled for ultrasound except for detected cases of sex reversal, sex chromosome mosaicism, prior to genetic amniocentesis, and ambiguous sex chromosomes, except as noted, ultrasonic imaging of the penile or clitoral structure corresponded to later sex determination by karyotype. Imaging of the external genitalia can be included as part of a complete fetal anatomic survey, which includes gestational age dating and inspection for gross abnormalities. Sex assignment requires 30 seconds to 10 minutes. Fetal anatomic sex assignment can be performed by ultrasound early in pregnancy, that is, during the twelfth to fourteenth weeks from the last menstrual period of the mother, yet the results are as accurate as those obtained by chromosome analysis from genetic amniocentesis which can be safely performed only after the sixteenth week of pregnancy. Fetal anatomic sex assignment is particularly useful in genetic counseling with regard to X-linked disorders and can be clinically important when either sex reversal, sex chromosome mosaicism, or ambiguous sex chromosomes are detected by prenatal diagnosis. Other features are also disclosed.
摘要翻译：公开了一种方法和装置，用于基于模式识别的早期怀孕期间的超声胎儿解剖性别分配，其允许在12至14周的孕龄范围内鉴定外生殖器。模式识别源自于胎儿发育外生殖器胚胎学知识，以及通过超声成像获得的男性和女性特异性识别胚胎事件与识别模式之间的关系。在超过500例怀孕中，使用高分辨率数字线性阵列实时超声检查胎儿解剖性别已被准确诊断，除了检测到性别逆转，性染色体嵌合，遗传羊膜穿刺术之外的检测病例以及模糊性染色体外，如上所述，阴茎或阴蒂结构的超声成像对应于核型的晚期性别决定。外部生殖器的成像可以作为完整的胎儿解剖学调查的一部分包括，其中包括胎龄年龄和大体异常检查。性别分配需要30秒到10分钟。胎儿解剖性别分配可以通过妊娠早期，即从母亲的最后月经周期的第十二至第十四周进行超声检查，但结果与通过遗传羊膜穿刺术的染色体分析获得的结果一样准确，可以安全仅在怀孕第16周后进行。胎儿解剖性别分配在X联合障碍的遗传咨询中特别有用，并且当通过产前诊断检测到性别逆转，性染色体嵌合或模糊性染色体时，临床上可能具有重要意义。还公开了其他特征。

6. 发明授权

US06351666B1 Method and apparatus for sensing and processing biopotentials 失效
标题翻译：用于感测和处理生物电位的方法和装置
公开(公告)号：US06351666B1
公开(公告)日：2002-02-26
申请号：US09256294
申请日：1999-02-24
申请人： Jack A. Cuzick , Richard J. Davies , John D. Stephens , Vera Borgwardt , Craig M. Housworth , Xingye Lei , Peter D. Gadsby , Abe Iskac
发明人： Jack A. Cuzick , Richard J. Davies , John D. Stephens , Vera Borgwardt , Craig M. Housworth , Xingye Lei , Peter D. Gadsby , Abe Iskac
IPC分类号： A61B505
CPC分类号： A61B5/04002 , A61B5/04 , A61B5/04282 , Y10S128/92 , Y10S128/925
摘要： In accordance with the apparatus and method of the present invention, a biopotential lesion sensor is placed directly over a lesion in a symptomatic breast and a reference sensor is located away from the symptomatic breast. A plurality of electropotential test measurements are taken during a test period with the lesion sensor and averaged to obtain a primary test potential. This primary test potential can be weighted to compensate for one or more biologic variables such as patient age, time in the patient menstrual cycle, and the time of day during which the measurement is taken. To provide noise enhancement of the primary test potential average measurement, the symptomatic breast is divided into four equal quadrants with one quadrant containing the lesion. One, two or all three of the remaining three non-lesion quadrants is provided with at least one non-lesion test sensor, and during the test period a number of electropotential measurements equal to those taken by the sensor over the lesion are taken and averaged. The processor may then obtain the median value of the averages for the non-lesion quadrants or alternatively the mean value, and it will then subtract this median or mean value from the primary test potential to provide the differential value.
摘要翻译：根据本发明的装置和方法，将生物电位病变传感器直接放置在有症状的乳房中的病变上，并且将参考传感器放置在远离有症状的乳房。在与病变传感器的测试期间进行多次电位测试测量，并平均以获得主要测试电位。该主要测试潜力可以被加权以补偿一个或多个生物学变量，例如患者年龄，患者月经周期中的时间和进行测量的时间。为了提供主要测试电位平均测量的噪声增强，症状乳房被分为四个相等的象限，其中一个象限包含病变。剩余的三个非病变象限中的一个，两个或全部三个被设置有至少一个非病变测试传感器，并且在测试期间，获取等于传感器对病变所采取的电位测量的多个电位测量并取平均值。然后，处理器可以获得非损伤象限的平均值的中值或可选的平均值，然后从主要测试电位中减去该中值或平均值以提供差分值。

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