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1. 发明授权

US06895264B2 Non-invasive psychophysical measurement of glucose using photodynamics 失效
标题翻译：使用光动力学对葡萄糖进行非侵入性心理物理测量
公开(公告)号：US06895264B2
公开(公告)日：2005-05-17
申请号：US10642111
申请日：2003-08-15
申请人： Mark J. Rice , Joe W. Woods , Wilson Routt , Junli Ou
发明人： Mark J. Rice , Joe W. Woods , Wilson Routt , Junli Ou
IPC分类号： A61B3/06 , A61B3/103 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/066 , A61B3/103 , A61B5/14532
摘要： Blood glucose concentrations are measured by non-invasive methods and apparatus using visual pigment bleaching in conjunction with psychophysical methodologies. Bleaching light of selected wavelengths is projected through the pupil of the eye of an observer onto the fundus to bleach visual pigments in the eye. The observer's psychophysical response to a visual stimulus is then measured to obtain information regarding the rate of regeneration of the visual pigments. From the rate of pigment regeneration, blood glucose concentrations are measured accurately. The psychophysical methodologies that may be used with the invention include visual acuity tests and color-matching tests.
摘要翻译：通过非侵入性方法和装置使用视觉色素漂白与心理物理学方法结合来测量血糖浓度。所选波长的漂白光通过观察者的眼睛的瞳孔投射到眼底上以漂白眼睛中的视觉颜料。然后测量观察者对视觉刺激物的心理物理反应，以获得关于视觉颜料再生速率的信息。从色素再生的速度，准确测量血糖浓度。可用于本发明的心理物理学方法包括视力测试和颜色匹配测试。

2. 发明授权

US06477394B2 Non-invasive measurement of blood components using retinal imaging 失效
标题翻译：使用视网膜成像对血液成分进行非侵入性测量
公开(公告)号：US06477394B2
公开(公告)日：2002-11-05
申请号：US09952491
申请日：2001-09-12
申请人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
发明人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
IPC分类号： A61B500
CPC分类号： A61B5/14532 , A61B3/1233 , A61B3/145 , A61B5/0013 , A61B5/14546 , A61B5/1455
摘要： Illuminating light of selected wavelengths in the visible or infrared range is projected through the pupil of the eye onto the fundus, and the light reflected back and out through the pupil is detected and analyzed, preferably using the area of the optic disk for analyzing the retinal vessels overlying the optic disk. Specific wavelengths of illuminating light may be chosen for each blood component to be analyzed depending on the spectral characteristics of the substance being analyzed. The reflected image from the retina may be used to measure non-photoreactive blood components such as hemoglobin, and photoreactive components such as bilirubin. For the measurement of photoreactive components, images may be taken before and after, or during, illumination of the eye with light at wavelengths which will affect the photoreactive analyte, enabling measurements of the concentration of the analyte.
摘要翻译：可见光或红外范围内所选波长的照明光通过眼睛的瞳孔投射到眼底，并且通过瞳孔反射回来的光被检测和分析，优选地使用用于分析视网膜的视盘的区域覆盖视盘的血管。可以根据被分析物质的光谱特性，为要分析的每个血液成分选择照射光的特定波长。来自视网膜的反射图像可以用于测量非光反应性血液成分如血红蛋白和光反应性成分如胆红素。对于光反应性成分的测量，可以在影响光反应性分析物的波长处的光照射之前或之后拍摄图像，从而能够测量分析物的浓度。

3. 发明授权

US06650915B2 Non-invasive measurement of blood analytes using photodynamics 失效
公开(公告)号：US06650915B2
公开(公告)日：2003-11-18
申请号：US10012902
申请日：2001-10-22
申请人： Wilson Routt , Mark J. Rice
发明人： Wilson Routt , Mark J. Rice
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B3/12 , A61B5/14532 , A61B5/14558
摘要： The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.

4. 发明授权

US06889069B2 Non-invasive measurement of blood analytes using photodynamics 失效
标题翻译：使用光动力学对血液分析物进行非侵入性测量
公开(公告)号：US06889069B2
公开(公告)日：2005-05-03
申请号：US10642104
申请日：2003-08-15
申请人： Wilson Routt , Mark J. Rice
发明人： Wilson Routt , Mark J. Rice
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/12 , A61B5/14532 , A61B5/14558
摘要： The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.
摘要翻译：个体中的血糖的测定通过将照射光投射到个体的眼睛中来进行，以用具有被视紫红质吸收的波长的光照射视网膜，并且光的强度以规定的时间方式变化。检测从视网膜反射的光以提供对应于检测到的光的强度的信号，并且分析检测到的光信号以确定形式与照明光的变化。对于偏置正弦照明，这些变化可以用检测到的光的谐波含量表示。检测光的形式变化与视紫红质吸收光和再生的能力有关，而这又与血糖浓度有关，从而可以测定血糖的相对浓度。其他光反应性分析物也可以类似地通过将照射光投射到眼睛中，检测从视网膜反射的光，并分析所检测的光信号来确定由于光反应性分析物的吸收性变化引起的信号形式的变化来确定。

5. 发明授权

US06305804B1 Non-invasive measurement of blood component using retinal imaging 失效
标题翻译：使用视网膜成像对血液成分进行非侵入性测量
公开(公告)号：US06305804B1
公开(公告)日：2001-10-23
申请号：US09534782
申请日：2000-03-24
申请人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
发明人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
IPC分类号： A61B310
CPC分类号： A61B5/14532 , A61B3/1233 , A61B3/145 , A61B5/0013 , A61B5/14546 , A61B5/1455
摘要： Illuminating light of selected wavelengths in the visible or infrared range is projected through the pupil of the eye onto the fundus, and the light reflected back and out through the pupil is detected and analyzed, preferably using the area of the optic disk for analyzing the retinal vessels overlying the optic disk. Specific wavelengths of illuminating light may be chosen for each blood component to be analyzed depending on the spectral characteristics of the substance being analyzed. The reflected image from the retina may be used to measure non-photoreactive blood components such as hemoglobin, and photoreactive components such as bilirubin. For the measurement of photoreactive components, images may be taken before and after, or during, illumination of the eye with light at wavelengths which will affect the photoreactive analyte, enabling measurements of the concentration of the analyte.
摘要翻译：可见光或红外范围内所选波长的照明光通过眼睛的瞳孔投射到眼底，并且通过瞳孔反射回来的光被检测和分析，优选地使用用于分析视网膜的视盘的区域覆盖视盘的血管。可以根据被分析物质的光谱特性，为要分析的每个血液成分选择照射光的特定波长。来自视网膜的反射图像可以用于测量非光反应性血液成分如血红蛋白和光反应性成分如胆红素。对于光反应性成分的测量，可以在影响光反应性分析物的波长处的光照射之前或之后拍摄图像，从而能够测量分析物的浓度。

6. 发明授权

US06537207B1 Identification of protective covers for medical imaging devices 失效
标题翻译：识别医疗成像设备的保护盖
公开(公告)号：US06537207B1
公开(公告)日：2003-03-25
申请号：US09958280
申请日：2001-10-05
申请人： Mark J. Rice , Steve Spanoudis
发明人： Mark J. Rice , Steve Spanoudis
IPC分类号： A61B100
CPC分类号： A61B1/00142 , A61B1/00055 , A61B2560/0276
摘要： A protective cover for medical imaging devices of the type having a probe with an optical system at a distal end includes a sheath of plastic material formed to enclose at least a portion of the probe and a transparent head secured to the sheath at a distal end of the cover. The transparent head provides a transparent window at the distal end of the probe to allow light to enter the probe and be imaged in a normal manner. Indicia are formed on the transparent head and are imaged by the medical imaging device. The image is then analyzed to determine if the indicia as shown in the image correspond to a preselected pattern, which may be one of a group of patterns which provide indications concerning the nature of the cover. If a pattern is recognized, the information corresponding to that pattern can be provided to an operator; if no pattern is recognized or if the pattern corresponds to an improper cover for the particular imaging device, a warning can be provided to the operator or the device disabled. The protective cover can be disposed after use with a patient, and a new cover applied to enclose the portions of the probe that will contact another patient, thereby minimizing potential spread of infection.
摘要翻译：用于具有在远端具有光学系统的探针的类型的医疗成像装置的保护盖包括塑料材料的护套，所述护套被形成为封闭探针的至少一部分，并且在远端处固定到护套的透明头封面。透明头在探针的远端提供透明窗口，以允许光进入探针并以正常方式成像。标记形成在透明头上，并由医学成像装置成像。然后分析图像以确定图像中所示的标记是否对应于预选图案，其可以是提供关于盖的性质的指示的一组图案之一。如果识别出图案，则可以向操作者提供与该图案相对应的信息; 如果没有识别出图案，或者如果图案对应于特定成像装置的不正确的盖子，则可以向操作者或装置提供警告。保护盖可以在使用后与患者配置，并且应用新的盖子以封闭将接触另一患者的探针部分，从而最小化感染的潜在扩散。

7. 发明授权

US5743849A Disposable protective sleeve for a laryngoscope and method of using the same 失效
标题翻译：喉镜一次性保护套及其使用方法
公开(公告)号：US5743849A
公开(公告)日：1998-04-28
申请号：US694776
申请日：1996-08-09
申请人： Mark J. Rice , William T. Kearney, III , William T. Williams , Ganesh V. Phatak , Timothy P. Maupin
发明人： Mark J. Rice , William T. Kearney, III , William T. Williams , Ganesh V. Phatak , Timothy P. Maupin
IPC分类号： A61B1/00 , A61B1/267 , A61B1/32
CPC分类号： A61B1/267 , A61B1/00142
摘要： A disposable protective sleeve used for covering laryngoscopes has a sheath and a shield integrally formed of a flexible material. The sheath defines a hollow cavity adapted to enclose a laryngoscope blade. The shield is attached to the sheath and is suited to cover a portion of the laryngoscope handle. The disposable sleeve is molded of a flexible plastic in a size and shape to conform to a particular size and shape of laryngoscope blade. After use, the sleeve is disposed of and the laryngoscope is covered with a new sleeve before being used again.
摘要翻译：用于覆盖喉镜的一次性保护套具有由柔性材料一体形成的护套和护罩。护套限定适于封闭喉镜刀片的中空腔。护罩附着在护套上，适用于覆盖喉镜手柄的一部分。一次性套筒由尺寸和形状的柔性塑料模制，以符合特定尺寸和形状的喉镜刀片。使用后，再次使用套筒，并用新的套筒覆盖喉镜。

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