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1. 发明申请

US20050245796A1 Non-invasive measurement of blood glucose using retinal imaging 审中-公开
公开(公告)号：US20050245796A1
公开(公告)日：2005-11-03
申请号：US11177015
申请日：2005-07-07
申请人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
发明人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532 , A61B5/6821
摘要： An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.

2. 发明申请

US20050267343A1 Non-invasive measurement of blood glucose using retinal imaging 审中-公开
标题翻译：使用视网膜成像对血糖进行非侵入性测量
公开(公告)号：US20050267343A1
公开(公告)日：2005-12-01
申请号：US11176986
申请日：2005-07-07
申请人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
发明人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532 , A61B5/6821
摘要： An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.
摘要翻译：设备通过测量视网膜视觉颜料如锥形视觉颜料的再生速率，以可重复的非侵入性方式进行血糖测量。视觉色素的再生速度取决于血糖浓度，通过测定视觉色素再生率，可以准确测定血糖浓度。该设备将视网膜暴露于所选择的分布中所选择的波长的光，并随后分析来自视网膜的曝光区域的选定部分（优选为中央凹）的反射（作为颜色或黑暗）。

3. 发明申请

US20050010091A1 Non-invasive measurement of blood glucose using retinal imaging 审中-公开
公开(公告)号：US20050010091A1
公开(公告)日：2005-01-13
申请号：US10863619
申请日：2004-06-08
申请人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
发明人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532 , A61B5/6821
摘要： An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.

4. 发明授权

US06650915B2 Non-invasive measurement of blood analytes using photodynamics 失效
公开(公告)号：US06650915B2
公开(公告)日：2003-11-18
申请号：US10012902
申请日：2001-10-22
申请人： Wilson Routt , Mark J. Rice
发明人： Wilson Routt , Mark J. Rice
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B3/12 , A61B5/14532 , A61B5/14558
摘要： The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.

5. 发明申请

US20060020184A1 Non-invasive measurement of blood glucose using retinal imaging 审中-公开
标题翻译：使用视网膜成像对血糖进行非侵入性测量
公开(公告)号：US20060020184A1
公开(公告)日：2006-01-26
申请号：US11176995
申请日：2005-07-07
申请人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
发明人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532 , A61B5/6821
摘要： An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.
摘要翻译：设备通过测量视网膜视觉颜料如锥形视觉颜料的再生速率，以可重复的非侵入性方式进行血糖测量。视觉色素的再生速度取决于血糖浓度，通过测定视觉色素再生率，可以准确测定血糖浓度。该设备将视网膜暴露于所选择的分布中所选择的波长的光，并随后分析来自视网膜的曝光区域的选定部分（优选为中央凹）的反射（作为颜色或黑暗）。

6. 发明申请

US20050013010A1 Humidity tolerant scan lens 有权
标题翻译：耐湿扫描镜头
公开(公告)号：US20050013010A1
公开(公告)日：2005-01-20
申请号：US10915837
申请日：2004-08-11
申请人： Roger Cannon , Dana Dodds , Philip Heink , Robert Paterson , Daniel Pawley , Wilson Routt
发明人： Roger Cannon , Dana Dodds , Philip Heink , Robert Paterson , Daniel Pawley , Wilson Routt
IPC分类号： G02B3/02 , G02B3/00
CPC分类号： G02B3/02
摘要： A lens has a lens body (1), reinforcing extensions (3a, 3b) and a clear aperture (9) surrounded on top and bottom by lens body. The lens is suitable for spot scanning. The lens is made of a water absorbing material, such as most polymers, particularly acrylate polymers. Aluminum sheets as vapor barriers are attached on each side of the lens body. This results in excellent resistance to change or distortion in high humidity environments.
摘要翻译：透镜具有透镜体（1），加强延伸部（3a，3b）和透明孔（9），透镜体在顶部和底部包围。镜头适用于点扫。透镜由吸水材料制成，例如大多数聚合物，特别是丙烯酸酯聚合物。作为蒸气阻挡层的铝片被附着在透镜体的每一侧上。这导致在高湿度环境下优异的抗变化或变形性。

7. 发明授权

US06477394B2 Non-invasive measurement of blood components using retinal imaging 失效
标题翻译：使用视网膜成像对血液成分进行非侵入性测量
公开(公告)号：US06477394B2
公开(公告)日：2002-11-05
申请号：US09952491
申请日：2001-09-12
申请人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
发明人： Mark J. Rice , Robert H. Sweat, Jr. , James M. Rioux , William T. Williams , Wilson Routt
IPC分类号： A61B500
CPC分类号： A61B5/14532 , A61B3/1233 , A61B3/145 , A61B5/0013 , A61B5/14546 , A61B5/1455
摘要： Illuminating light of selected wavelengths in the visible or infrared range is projected through the pupil of the eye onto the fundus, and the light reflected back and out through the pupil is detected and analyzed, preferably using the area of the optic disk for analyzing the retinal vessels overlying the optic disk. Specific wavelengths of illuminating light may be chosen for each blood component to be analyzed depending on the spectral characteristics of the substance being analyzed. The reflected image from the retina may be used to measure non-photoreactive blood components such as hemoglobin, and photoreactive components such as bilirubin. For the measurement of photoreactive components, images may be taken before and after, or during, illumination of the eye with light at wavelengths which will affect the photoreactive analyte, enabling measurements of the concentration of the analyte.
摘要翻译：可见光或红外范围内所选波长的照明光通过眼睛的瞳孔投射到眼底，并且通过瞳孔反射回来的光被检测和分析，优选地使用用于分析视网膜的视盘的区域覆盖视盘的血管。可以根据被分析物质的光谱特性，为要分析的每个血液成分选择照射光的特定波长。来自视网膜的反射图像可以用于测量非光反应性血液成分如血红蛋白和光反应性成分如胆红素。对于光反应性成分的测量，可以在影响光反应性分析物的波长处的光照射之前或之后拍摄图像，从而能够测量分析物的浓度。

8. 发明申请

US20050267344A1 Non-invasive measurement of blood glucose using retinal imaging 审中-公开
公开(公告)号：US20050267344A1
公开(公告)日：2005-12-01
申请号：US11176993
申请日：2005-07-07
申请人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
发明人： Joe Woods , John Smith , Mark Rice , Wilson Routt , Robert Messerschmidt , Junli Ou
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532 , A61B5/6821
摘要： An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.

9. 发明申请

US20050101847A1 Non-invasive measurement of blood analytes using photodynamics 审中-公开
公开(公告)号：US20050101847A1
公开(公告)日：2005-05-12
申请号：US11005767
申请日：2004-12-06
申请人： Wilson Routt , Mark Rice
发明人： Wilson Routt , Mark Rice
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/12 , A61B5/14532 , A61B5/14558
摘要： The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.

10. 发明授权

US06889069B2 Non-invasive measurement of blood analytes using photodynamics 失效
标题翻译：使用光动力学对血液分析物进行非侵入性测量
公开(公告)号：US06889069B2
公开(公告)日：2005-05-03
申请号：US10642104
申请日：2003-08-15
申请人： Wilson Routt , Mark J. Rice
发明人： Wilson Routt , Mark J. Rice
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/1455 , A61B3/12 , A61B5/14532 , A61B5/14558
摘要： The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.
摘要翻译：个体中的血糖的测定通过将照射光投射到个体的眼睛中来进行，以用具有被视紫红质吸收的波长的光照射视网膜，并且光的强度以规定的时间方式变化。检测从视网膜反射的光以提供对应于检测到的光的强度的信号，并且分析检测到的光信号以确定形式与照明光的变化。对于偏置正弦照明，这些变化可以用检测到的光的谐波含量表示。检测光的形式变化与视紫红质吸收光和再生的能力有关，而这又与血糖浓度有关，从而可以测定血糖的相对浓度。其他光反应性分析物也可以类似地通过将照射光投射到眼睛中，检测从视网膜反射的光，并分析所检测的光信号来确定由于光反应性分析物的吸收性变化引起的信号形式的变化来确定。

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