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1. 发明申请

US20080183254A1 DUAL SPIRAL LEAD CONFIGURATIONS 有权
标题翻译：双螺旋引导配置
公开(公告)号：US20080183254A1
公开(公告)日：2008-07-31
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

2. 发明授权

US07949409B2 Dual spiral lead configurations 有权
标题翻译：双螺旋引线配置
公开(公告)号：US07949409B2
公开(公告)日：2011-05-24
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop
IPC分类号： A61N1/00 , A61B18/04
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

3. 发明申请

US20080183265A1 TRANSVASCULAR LEAD WITH PROXIMAL FORCE RELIEF 审中-公开
标题翻译：具有临时强制救助的横向导弹
公开(公告)号：US20080183265A1
公开(公告)日：2008-07-31
申请号：US11669039
申请日：2007-01-30
申请人： Mark J. Bly , Randy W. Westlund
发明人： Mark J. Bly , Randy W. Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573
摘要： A medical electrical lead for implantation in a patient's internal jugular vein at a target location and adjacent a vagus nerve. The lead comprises a proximal region having a proximal stiffness and a distal region. The distal region has a distal stiffness and a first spiral configured to retain the distal region in the internal jugular vein. A transition region is interposed between the proximal and distal regions and has a transitional stiffness. An electrode is coupled to the distal region. The proximal stiffness is less than the distal stiffness so as to reduce an amount of force transferred from the proximal region to the distal region. The transitional stiffness is less than the distal stiffness and greater than the proximal stiffness.
摘要翻译：一种用于在目标位置处植入患者颈内静脉并邻近迷走神经的医用电线。引线包括具有近端刚度和远侧区域的近端区域。远端区域具有远端刚度，第一螺旋构造成将远侧区域保持在颈内静脉内。过渡区域介于近端区域和远端区域之间，具有过渡刚度。电极连接到远端区域。近端刚度小于远端刚度，以便减少从近端区域传递到远端区域的力的量。过渡刚度小于远端刚度，大于近端刚度。

4. 发明申请

US20080183186A1 METHOD AND APPARATUS FOR DELIVERING A TRANSVASCULAR LEAD 审中-公开
标题翻译：用于输送透明导线的方法和装置
公开(公告)号：US20080183186A1
公开(公告)日：2008-07-31
申请号：US11669042
申请日：2007-01-30
申请人： Mark J. Bly , Randy W. Westlund
发明人： Mark J. Bly , Randy W. Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/36114 , A61N1/372
摘要： A lead delivery system for delivering a medical electrical lead to an internal jugular vein (IJV) through a subclavian vein. An inner catheter extends from a proximal end to a distal end. The inner catheter includes an inner catheter curve configured to direct the distal end to the IJV when positioned in the subclavian vein. The stiffness of the inner catheter decreases in an inner catheter transition region in a direction from the proximal end to the distal end. An outer catheter extends from a proximal end to a distal end and is sized to slide over the inner catheter. The outer catheter includes an outer catheter curve. The stiffness of the outer catheter decreases in an outer catheter transition region in a direction from the proximal end to the distal end. The system further comprises a guidewire having a distal end and a proximal end. The guidewire is sized to slide through the inner catheter to a desired location in the IJV and the guidewire stiffness decreases in a guidewire transition region in a direction from the guidewire proximal end to the guidewire distal end. A method of delivering a medical electrical lead to a target location within an IJV.
摘要翻译：一种用于通过锁骨下静脉将医用电导线输送到颈内静脉（IJV）的引导系统。内导管从近端延伸到远端。内导管包括内导管曲线，其构造成当定位在锁骨下静脉中时将远端引导至IJV。内导管的刚度在从近端到远端的方向上在内导管过渡区域中减小。外导管从近端延伸到远端，并且其尺寸设计成在内导管上滑动。外导管包括外导管曲线。外导管的刚度在从近端到远端的方向上在外导管过渡区域中减小。该系统还包括具有远端和近端的导丝。导丝的尺寸设计成能够通过内导管滑动到IJV中的所需位置，并且导丝刚度在从导丝线近端到导丝线远端的方向上在导丝过渡区域中减小。将医用电导线传送到IJV内的目标位置的方法。

5. 发明授权

US08244378B2 Spiral configurations for intravascular lead stability 失效
标题翻译：血管内铅稳定性的螺旋构型
公开(公告)号：US08244378B2
公开(公告)日：2012-08-14
申请号：US11668926
申请日：2007-01-30
申请人： Mark J. Bly , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop , Paul E. Zarembo
发明人： Mark J. Bly , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop , Paul E. Zarembo
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes an expandable distal portion having one or more spirals for securing and stabilizing the lead within the vessel.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括具有一个或多个螺旋的可扩展远端部分，用于固定和稳定血管内的引线。

6. 发明申请

US20080228194A1 METHOD AND APPARATUS FOR ENDOSCOPIC ACCESS TO THE VAGUS NERVE 有权
标题翻译： VAGUS神经内窥镜获取的方法和装置
公开(公告)号：US20080228194A1
公开(公告)日：2008-09-18
申请号：US11685476
申请日：2007-03-13
申请人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
发明人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
IPC分类号： A61N1/02
CPC分类号： A61N1/0556 , A61B17/3468
摘要： An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described.
摘要翻译：用于在迷走神经区域中执行微创外科手术的装置包括套管，内窥镜解剖工具和可滑动地设置在套管腔中的支架组件。支架组件包括C形环，设置在C形环的外表面上的电极套，以及展开装置。当使用展开装置从C形环展开时，电极套套适于围绕目标神经区域或神经分支进行包围。还描述了执行微创外科手术的方法。

7. 发明授权

US07819883B2 Method and apparatus for endoscopic access to the vagus nerve 有权
标题翻译：用于内窥镜进入迷走神经的方法和装置
公开(公告)号：US07819883B2
公开(公告)日：2010-10-26
申请号：US11685476
申请日：2007-03-13
申请人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
发明人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
IPC分类号： A61N1/02
CPC分类号： A61N1/0556 , A61B17/3468
摘要： An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described.
摘要翻译：用于在迷走神经区域中执行微创外科手术的装置包括套管，内窥镜解剖工具和可滑动地设置在套管腔中的支架组件。支架组件包括C形环，设置在C形环的外表面上的电极套，以及展开装置。当使用展开装置从C形环展开时，电极套套适于围绕目标神经区域或神经分支进行包围。还描述了执行微创外科手术的方法。

8. 发明申请

US20080183259A1 SPIRAL CONFIGURATIONS FOR INTRAVASCULAR LEAD STABILITY 失效
标题翻译：用于血管引导稳定性的螺旋配置
公开(公告)号：US20080183259A1
公开(公告)日：2008-07-31
申请号：US11668926
申请日：2007-01-30
申请人： Mark J. Bly , Randy W. Westlund , Ronald W. Heil , Brendan E. Koop , Paul E. Zarembo
发明人： Mark J. Bly , Randy W. Westlund , Ronald W. Heil , Brendan E. Koop , Paul E. Zarembo
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes an expandable distal portion having one or more spirals for securing and stabilizing the lead within the vessel.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括具有一个或多个螺旋的可扩展远端部分，用于固定和稳定血管内的引线。

9. 发明授权

US08688190B2 Adherent device for sleep disordered breathing 有权
标题翻译：睡眠呼吸障碍的粘附装置
公开(公告)号：US08688190B2
公开(公告)日：2014-04-01
申请号：US13543660
申请日：2012-07-06
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
IPC分类号： A61B5/053 , A61B5/113
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.
摘要翻译：贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。该装置包括耦合到至少四个电极的阻抗电路，并且被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足。阻抗电路可以用于测量患者的水合。加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

10. 发明申请

US20110178530A1 DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD 有权
标题翻译：直升机系统
公开(公告)号：US20110178530A1
公开(公告)日：2011-07-21
申请号：US13079512
申请日：2011-04-04
申请人： Mark J. Bly
发明人： Mark J. Bly
IPC分类号： A61B19/00
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A lead delivery system for delivering a neurostimulation lead to a patient's internal jugular vein using a percutaneous stick. The system comprises a neurostimulation lead adapted to stimulate a vagus nerve from the internal jugular vein. The lead includes a proximal end, a distal end, a generally spiral shaped retaining structure interposed between the proximal and distal ends and configured to retain the lead in the internal jugular vein, an electrode coupled to the retaining structure, and a side port interposed between the retaining structure and the proximal end. The side port provides access to a lumen extending from the distal end to the side port. A guidewire is sized to fit within the side port and lumen and reduce a force exerted by the retaining structure against the internal jugular vein, thereby allowing rotation of the lead and orientation of the electrode by applying a torque to the lead. A catheter has a lumen sized to slideably receive the medical electrical lead and configured to provide access to the internal jugular vein from the percutaneous stick site. A method of delivering a medical electrical lead to a patient's internal jugular vein.
摘要翻译：用于使用经皮棒递送神经刺激导致患者颈内静脉的引导递送系统。该系统包括适于从颈内静脉刺激迷走神经的神经刺激引线。引线包括近端，远端，插入在近端和远端之间的大致螺旋形的保持结构，并且构造成将引线保持在颈内静脉内，连接到保持结构的电极和插入在保持结构和近端。侧端口提供进入从远端延伸到侧端口的内腔。导丝的尺寸设置成适合于侧端口和内腔，并且减小由保持结构抵抗颈内静脉施加的力，由此通过向引线施加扭矩来允许引线的引导和取向的旋转。导管具有尺寸适于可滑动地接收医疗电引线并且被配置为提供从经皮粘连部位进入颈内静脉的内腔。将医用电导线递送到患者的颈内静脉的方法。

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